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7511026 |
Therapeutic agent for nerve damage
The present invention provides a therapeutic agent for nerve damages such as those caused by spinal cord injury or nerve trauma, which includes, as an active ingredient, a low-molecular-weight...
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7511022 |
Substituted indole-O-glucosides
Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
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7511095 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs...
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7501399 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7498311 |
Treatment of migraine
A method for treating migraine in non-epileptic subjects which involves administering to subjects an effective amount of a pharmaceutical composition comprising a sulfamate of the following formula:
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7491709 |
Treatment with hyaluronic acid
The present invention relates, generally, to methods of providing long-term minimization of wrinkles or folds in the skin by injecting a bolus of hyaluronic acid deep into the skin. The methods of...
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7482330 |
Substituted fused heterocyclic C-glycosides
This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and...
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7479493 |
Substituted benzyl amine compounds
Certain substituted benzyl amine compounds are histamine H 3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H 3 receptor- and/or serotonin-mediated diseases.
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7473683 |
Nonpolar thymidine analogs
Nonpolar thymidine analogs are provided comprising a dihalogenated or trihalogenated base of the structure:
where R 1 is a sugar moiety; R 2 is H or CH 3 ; an imaging moiety or a...
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7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
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7465712 |
Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula:
wherein R 1 represents a hydrogen atom or a hydroxy(lower alkyl) group; and R 2 ...
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7449571 |
Halogenated aminoquinolines and oligonucleotides containing the same
Novel synthetic monomers that have the capacity to be assembled into defined oligomers which bind with sequence specificity to duplex Watson-Crick DNA via a triple helix motif are provided.
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7449448 |
Composition and uses therefor for combating hangovers
The present invention relates generally to a composition for use in the prophylaxis and/or treatment of one or more symptoms caused or exacerbated by consumption of alcohol which composition...
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7445801 |
Stable bicarbonate-based solution in a single container
Stable single bicarbonate-based solutions are provided. The bicarbonate-based single solution of the present invention includes at least calcium and bicarbonate and is stored or packaged in a...
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7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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7435431 |
Method for controlling body weight in estrogen-insufficient women
Disclosed are methods of controlling body weight in estrogen-insufficient women by administering compositions comprising (A) those dried fruit solids that inherently comprise flavonoids,...
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7435722 |
Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous...
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7435726 |
Compositions and methods for the treatment of cancer
This invention relates to compositions comprising thalidomide and another anti-cancer drug which can be used in the treatment or prevention of cancer. Preferred anti-cancer drugs are topoisomerase...
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7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
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7431940 |
Methods for treatment of human skin damaged by laser treatment or chemical peelings and compositions useful in such methods
Methods for treatment of human skin damaged by laser treatment or chemical peelings comprise the topical application of an effective amount of a lamellar oil-in-water system. In accordance with the...
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7429390 |
Stable pharmaceutical compositions, processes for making the same and methods of their use
The present invention is generally related to alcohol free, liquid ranitidine formulations for oral administration. In particular, the present invention is related to stable, syrup formulations...
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7427607 |
Drug administration method
A method of administering a drug whereby a fine drug powder can be accurately administered to a target site (in particular, a target site in the body cavity) via fluidization and spraying with a...
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7425573 |
Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration
Treating or preventing degeneration or destruction of articular cartilage and/or subchondral bone in the affected joint of a mammal is accomplished by administering a compound of formula (I),...
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7419959 |
D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
D-pyranosyl-substituted phenyls of general formula I
wherein the groups R 1 to R 5 , X, Z and R 7a , R 7b , R 7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent...
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7419958 |
Method of attenuating reactions to skin irritants
The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful...
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7417031 |
Use of algae-derived physiologically active substances for treating a carcinomatous disease
Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1):
foods, drinks, cosmetics, etc. containing as...
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7417032 |
D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture
D-Glucopyranosyl-phenyl-substituted cycles of general formula I
wherein the groups R 1 to R 6 , Z, Cy and R 7a , R 7b , R 7c , R 7d are defined as in claim 1 , have an inhibiting effect on...
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7414072 |
Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
There is provided a 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate...
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7402569 |
Treatment of Helicobacter with isothiocyanates
The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative...
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7393836 |
D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
A D-Xylopyranosyl-substituted phenyl compound of general formula I
wherein the groups R 1 to R 5 , X, Z and R 7a , R 7b , R 7c are defined as in claim 1, have an inhibiting effect on the...
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7390782 |
Methods and products related to metabolic interactions in disease
The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The...
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7384920 |
Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases
This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or...
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7381416 |
Selenohydroxy acids and their derivatives, applications in nutrition, cosmetics and pharmaceutics
The purpose of this invention is:
new selenohydroxy acid compounds and their derivatives; their process for the preparation; use of the new compounds as precursors of L(+)-selenomethionine...
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7375089 |
Rehydration composition
The invention relates to a fluid that can be used for preventing or treating hypohydration and the secondary consequences thereof. The fluid comprises one or more carbohydrates and minerals and is...
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7375081 |
Therapeutic combination of a pneumocandin derivative and an antifungal agent
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention...
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7375064 |
Functionalized polymeric surfactants based upon alkyl polyglycosides
The invention relates to a series of multifunctional polyglycosides derivatives that are made by the polymerized by the reaction of polyoxyalkylene containing crosslinking reagent and...
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7368422 |
Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the...
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7358279 |
Emulsions of oil-in-water for cosmetic and pharmaceutical compositions
Emulsions suitable for use in cosmetic and pharmaceutical compositions are disclosed. Various substrates for body care, such as wipes and pads, are disclosed, which substrates are impregnated with...
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7354906 |
Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human
The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated...
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7351695 |
Topiramate salts and compositions comprising and methods of making and using the same
The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as...
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7351581 |
In vivo method for producing female offsprings in bovines
The invention provides an in'vivo method whereby female offsprings can be produced in bovines said method comprising the step of administering a therapeutically effective amount of a material...
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7348313 |
Method for targeting cells involved in sclerotic and/or fibrotic diseases
A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion...
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7335627 |
Polymeric alkylpolyglycoside carboxylates
The products of the invention are polymers of carboxylated alkylpolyglycosides. The products are very mild surfactants that are useful in personal care applications.
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7332173 |
Group A streptococcal polysaccharide immunogenic compositions and methods
This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The...
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7332184 |
Colonic cleansing composition and method
A colonic cleansing kit comprises an osmotic colonic evacuant, and an oral rehydration mixture. The oral rehydration mixture comprises sugar, and salt. The sugar comprises a glucose containing...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7309502 |
Pharmaceutical compositions for treating and saving and the method for the preparation thereof
The present invention relates to a pharmaceutical composition and the method for the preparation thereof. The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium...
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7306813 |
Nonwoven webs treated with fixed mobile materials
The present invention describes a means for fixing skin care ingredients on the surface of non-woven webs and cellulosic mats. The active ingredients can be released (deposited) onto the skin by...
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7303767 |
Personal care compositions comprising coated/treated metal silicate absorbent particles
Coated particles of metal (such as calcium) silicate that exhibit excellent odor neutralization and sebum absorption properties when present within certain cosmetic and/or personal care...
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7304039 |
Glucose-based compounds with affinity to P-selectin
The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation...
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