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7625891 |
Heterocylic antiviral compounds
This invention relates to piperidine derivatives of formula I wherein R 1 , R 2 , R 3 and R 4 are as defined herein useful in the treatment of a variety of disorders, including those in which the...
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7605261 |
Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use
The invention relates to new products of formula (I):
in which: Y represents oxygen or sulphur, Z represents C═CH2, CH—CH3 or CH2, R1 represents hydrogen, morpholinyl or the
radical. In...
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7598241 |
Carboxamide derivatives and their use as factor Xa inhibitors
Novel compounds of the formula (I) in which R 1 , D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the...
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7595310 |
Glucuronate salt of a piperazine compound
The present invention provides a salt form, and compositions thereof, useful as a modulator of one or more GPCRs and which exhibits desirable characteristics for the same. The present invention...
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7572793 |
3-Substituted-4-pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:
wherein R 1 represents...
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7553815 |
Therapeutic use
A method of chemoprevention of the onset of invasive breast cancer in a high risk patient comprises administering to the patient an effective amount of an EGFR tyrosine kinase inhibitor.
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7547694 |
Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
The present invention relates to the CGRP antagonists of general formula
wherein A and R 1 to R 3 are defined as in claim 1 , the tautomers, the diastereomers, the enantiomers, the hydrates...
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7547693 |
Piperidine derivative
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
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7538107 |
Oxazinan-2-one derivatives useful as PR modulators
Compounds of the following structure are described:
wherein R 1 -R 6 , m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof....
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7531651 |
Benzenesulphonate salt of a morpholine urea derivative for use as a CCR-3 antagonist in the treatment of inflammatory conditions
Compounds of formula (I):
wherein A − represents the benzenesulphonate (besylate) anion;.
R represents H or C 1-6 alkyl; and
n is a number from 0.8 to 2.2 are CCR3 antagonists and...
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7465811 |
Indoline compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
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7338949 |
Mycobacterial inhibitors
The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib)
salts, quaternary amines, stereochemically isomeric...
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7259157 |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I):
or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7183238 |
[1,2]-oxazine-3,5-diones
The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I)
in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a plurality of...
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7179794 |
Multivalent macrolide antibiotics
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial...
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7176209 |
Fungicidal formulation
Adjuvants selectes from mon/ionic water/soluble mixed polyalkoxy-lated aliphatic alcohol surfactants, non ionic water soluble ethoxylated aliphatic alcohol surfactants, amine ethoxylates, and...
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7166609 |
Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
Pyrimidine-4,6-dicarboxylic acid diamides of the formula I
are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7115601 |
HIV integrase inhibitors
Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds....
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7094778 |
Heterocyclylalkylamines as muscarinic receptor antagonists
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I:
wherein X, Y, and Z are O, S or NR 5 , and the other...
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7084151 |
5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5H-chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such...
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7053085 |
EP4 receptor agonist, compositions and methods thereof
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
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7030110 |
Cyclic oxyguanidine pyrazinones as protease inhibitors
Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I:
wherein R 3 , R 4 , R 5 , W, and A are as set forth in the specification, as well as hydrates,...
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7008903 |
Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I)
wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active...
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6987129 |
Compounds and methods for the treatment of urogenital disorders
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial...
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6911477 |
Muscarinic receptor agonists
This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or...
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6900202 |
Di-substituted imineheterocyclic compounds
There is provided di-substituted iminoheterocyclic compounds of the following formula (I):
in which, A is optionally substituted alkyl group, optionally substituted aryl group or...
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6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
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6861416 |
Oxazinones and methods for their use and synthesis
The invention pertains, at least in part, to new intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The...
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6841551 |
Brain, spinal, and nerve injury treatment
A treatment for brain, spinal and nerve injury comprising use of a substance P receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use...
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6835743 |
Pesticidal pyrazoles and derivatives
Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said...
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6818638 |
Melvinolin derivatives
Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1...
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6812226 |
P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease
The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R 1 and R 2 are as defined in the specification, their use as medicaments, compositions containing...
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6777404 |
Use of corticotropin releasing factor antagonists and related compositions
The present invention relates to compositions and methods of achieving a therapeutic effect including, the treatment or prevention of Syndrome X in an animal, preferably a mammal including a human...
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6767907 |
4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH 2 and...
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6759402 |
Cyclic felbamate derived compounds
The present invention relates to novel felbamate derivatives and their use to treat neurological diseases such as epilepsy and to treat tissue damage resulting form ischemic events. The felbamate...
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6759408 |
Combination regimens using progesterone receptor modulators
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general...
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6756370 |
Piperidine alcohols
The invention relates to compounds of formula (I), wherein R 1 , R 2 and A have the meanings given in claim 1, are potent 5-HT 2A antagonists and are suitable for treating psychoses,...
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6743771 |
Methods and compositions for controlling protein assembly or aggregation
Compositions and methods for controlling prepathological and pathological protein assembly or aggregation using picolinic acid, analogs, or derivatives thereof are described. The compositions of...
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6740651 |
Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, and the use thereof for treating diseases, particularly tumoral diseases, diseases of...
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6734143 |
2-methoxyimino-2(pyridinyloxymethyl)phenyl acetamides useful as fungicides
The present invention provides 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides according to formula (I) as well as their use as fungicidal compounds.
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6730681 |
Triazolo-pyrimidine derivatives as ligands for gaba receptors
A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-α]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an...
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6730668 |
6,7-dihydro-5H-pyrazolo&lsqb 1,2-a&rsqb pyrazol-1-ones which control inflammatory cytokines
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
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6727244 |
Mammalian metabolites of a tachykinin receptor antagonist
This invention is concerned with mammalian metabolites of the compound...
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6713473 |
Tricyclic compounds
A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR 3 —CO—, —CO—NR 3 — and the like (R 3 represents a hydrogen atom, a...
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6699898 |
Substituted N,N-disubstituted non-fused heterocyclo amino compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6660734 |
Oxazinones having antibacterial activity
The invention relates to novel oxazinones designed to bind to the penicillin receptor, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents. The compounds...
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