|
Match
|
Document |
Document Title |
|
|
7361662 |
Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
A compound of formula (I):
wherein:
R 1 , R 2 , R 3 , R 4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a pharmaceutically...
|
|
|
7326699 |
4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives
The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the...
|
|
|
7317006 |
Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
The invention relates to thieno[2,3-d]pyrimidine derivatives according to general formula I, or a pharmaceutically acceptable salt thereof,
wherein N(R1)R2 are joined in a...
|
|
|
7314871 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension
The application claims a method for treating hypertension by administering an effective amount of a compound of the formula (I)
wherein the variable groups are as defined in the specification...
|
|
|
7312212 |
Aminopiperidine derivatives
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
|
|
|
7268131 |
Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed.
|
|
|
7268128 |
1,3,5-trisubstituted-5-phenyl and 5-pyridyl pyrazolopyrimidinone derivatives having PDE7 inhibiting action
Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB):
where the symbols are as disclosed in the specification, are provided as desired compounds. These...
|
|
|
7229990 |
Bicyclic heteroaromatic compounds
A bicyclic heteroaromatic compound according to general formula I, or a pharmaceutically acceptable salt thereof,
wherein
R 1 is (3–8C)cycloalkyl, (2–7C)heterocycloalkyl, (6–14C)aryl or...
|
|
|
7229989 |
Blue 3H-naphtho[2,1-b]pyran compounds and use thereof in photochromic articles
Photochromic 3H-naphtho[2,1-b]pyran compounds corresponding to formula I
in which the groups R 1 to R 7 and B′ have defined meanings and the use of such photochromic compounds in synthetic...
|
|
|
7226928 |
Methods for the treatment of periodontal disease
The disclosure provides methods for the treatment and prevention of periodontal disease. In preferred embodiments, the invention provides for local treatment of periodontal tissues with a...
|
|
|
7217702 |
Selective antagonists of A2A adenosine receptors
Selective antagonists of A 2A adenosine receptors like those of formula I are provided, wherein Y forms a ring.
The novel A 2A blockers are useful for the treatment of Parkinsons disease and...
|
|
|
7196078 |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
|
|
|
7176214 |
Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I),
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. The present invention...
|
|
|
7157451 |
Heterocyclic dihydropyrimidine compounds
Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors...
|
|
|
7141565 |
Substituted quinobenzoxazine analogs
The present invention relates to quinobenzoxazines analogs having the general formula:
and pharmaceutically acceptable salts, esters and prodrugs thereof;
wherein A, U, V, W, X and Z are...
|
|
|
7122540 |
2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
|
|
|
7064119 |
Fused bicyclic pyrimidine derivatives
A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following...
|
|
|
7026317 |
Pyrazolotriazines as CRF antagonists
The present invention relates to pyrazolotriazines according to formula (I)
and stereoisomers, isomers and salts thereof wherein R 1 -R 5 are selected from certain alkyl, aryl and heteroaryl...
|
|
|
6933294 |
Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
Compounds having the formula (I),
and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R 1 , R 2 , and R 3 are hydrogen,...
|
|
|
6908916 |
C-5 modified indazolylpyrrolotriazines
The present invention provides compounds of formula I
and pharmaceutically acceptable salts thereof.
The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such...
|
|
|
6890922 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
|
|
|
6884800 |
Imidazole compounds used as phosphodiesterase VII inhibitors
Imidazole compounds of the formula I
in which
R 1 and R 2 , independently of one another, each denote A 1 , OA 1 , SA 1 or Hal, A 1 denotes H, A, alkenyl, cycloalkyl or...
|
|
|
6861422 |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
The present invention relates to new dihydropteridinones of general formula (I):
wherein the groups L and R 1 -R 5 have the meanings given in the claims and specification, the isomers...
|
|
|
6828315 |
1-Amino triazoloc4,3-a&excl quinazoline-5-ones and/or -5-thiones inhibiting phosphodiesterase IV
The present invention relates to triazolo[4,3-a]quinazoline-5-ones and 5-thiones of Formula I and Formula II, whereby I and II are position isomers of group R on nitrogen 3 or 4. Optionally, the...
|
|
|
6806268 |
Method for treating glaucoma V
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the...
|
|
|
6750214 |
Quinoline and quinazoline compounds useful in therapy
The invention provides compounds of formula (I), wherein R 1 represents C 1-4 alkoxy optionally substituted by one or more fluorine atoms; R 2 represents H or C 1-6 alkoxy optionally...
|
|
|
6743798 |
Substituted pyrazole derivatives condensed with six-membered heterocyclic rings
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R 1 , R 2 , R 3 and A are each as defined, and to processes for their preparation and...
|
|
|
6743794 |
Methods and compounds for inhibiting MRP1
The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
|
|
|
6740650 |
Heterocyclic cytotoxic agents
The invention provides compounds of formula I: wherein R 1 -R 8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also...
|
|
|
6730676 |
Pyrazino-pyridazine derivatives as ligands for GABA receptors
A class of pyrazino[2,3-d]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 5-position, a substituted alkoxy moiety at the 3-position,...
|
|
|
6713477 |
Hydroxamic acid derivatives
A hydroxamic acid derivative represented by formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which has a matrix metalo-proteinase inhibitor.
|
|
|
6713474 |
Pyrrolopyrimidines as therapeutic agents
Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the...
|
|
|
6693116 |
Adenosine receptor ligands
The present application relates to compounds of the formula wherein R 1 is hydrogen, halogen or lower alkoxy; R 2 is hydrogen or is —C(O)-lower alkyl or —C(O)-phenyl, wherein the phenyl...
|
|
|
6689790 |
Substituted triazolopyridine compounds
A compound of formula wherein R 1 is —NR′R″, wherein R′ and R″ are independently selected from the group consisting of lower alkyl, —(CH 2 ) n —C(O)NR a R b , —(CH 2 ) n...
|
|
|
6677349 |
Sulfonamide and sulfamide substituted imidazoquinolines
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and...
|
|
|
6664252 |
4-aminopyrrolo&lsqb 2,3-d&rsqb pyrimidine compounds specific to adenosine A2a receptor and uses thereof
This invention pertains to compounds having the structure: wherein NR 1 R 2 is a substituted or unsubstituted 4-8 membered ring; wherein R 3 is a substituted or unsubstituted four to six...
|
|
|
6608078 |
Antibacterial chiral 8-(substituted piperidino)-benzo &lsqb i,j&rsqb quinolizines, processes, compositions and methods of treatment
The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to...
|
|
|
6583146 |
Thiazolopyrimidine compounds, its production and use
Compounds represented by general formula (I): and salts thereof, exhibiting excellent adenosine A 3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further...
|
|
|
6518265 |
1H-imidazopyridine derivatives
1H-Imidazopyridine derivatives represented by the following general formula or salts thereof: wherein R 1 represents hydrogen atom, hydroxyl group, an alkyl group, a cycloalkyl group, styryl...
|
|
|
6509338 |
Pyrazolo&lsqb 1,5-A&rsqb triazine corticotropin releasing factor antagonists
The present invention describes novel pyrazolo[1,5-a]triazines of formula: wherein R 3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof,...
|
|
|
6506772 |
Substituted &lsqb 1,2,4&rsqb triazolo&lsqb 1,5a&rsqb pyridine derivatives with activity as adenosine receptor ligands
Substituted [1,2,4]triazolo[1,5a]pyridine derivatives and pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are useful for treatment...
|
|
|
6476022 |
Oxathiepino&lsqb 6,5-b&rsqb dihydropyridines, and related compositions and methods
This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity....
|
|
|
6472398 |
Spiropiperidine derivatives as melanocortin receptor agonists
Certain novel spiropiperidine derivatives of structural formula Ia wherein the substituents are as defined herein are agonists of the human melanocortin receptor(s) and, in particular, are...
|
|
|
6444666 |
Triazolopyridazine Derivatives for treating anxiety and enhancing cognition
A compound of formula I, or a salt or prodrug thereof: wherein: Z represents C 1-6 alkyl, C 3-7 cycloalkyl, C 4-7 cycloalkenyl, aryl, C 3-7 heterocycloalkyl, heteroaryl or di(C 1-6...
|
|
|
6362178 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
|
|
|
6329148 |
Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
A synergistic combination of ligands that interact with death domain receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the...
|
|
|
6326379 |
Fused pyridine inhibitors of cGMP phosphodiesterase
Compounds of the formulas ##STR1## are useful as inhibitors of cGMP PDE, especially type V.
|
|
|
6316444 |
SRC kinase inhibitor compounds
Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same,...
|
|
|
6313124 |
Tetrazine bicyclic compounds
Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of...
|
|
|
6306872 |
6-substituted 1,2,4a,5a,8a,8b-hexahydro- and 1,2,3,4,4a,5a,8a,8b-octahydro-6H-pyrrolo[3',4': 4,5]furo[3,2-b]pyrid-8(7H)-one derivatives and their use in combatting endoparasites
The present invention relates to 6-substituted 1,2,4a,5a,8a,8b-hexahydro- and 1,2,3,4,4a,5a,8a,8b-octahydro-6H-pyrrolo[3',4': 4,5]furo[3,2-b]pyrid-8(7H)-one derivatives of the general formula (I)...
|