|
Match
|
Document |
Document Title |
|
|
7629338 |
Substituted monocyclic CGRP receptor antagonists
Compounds of formula I:
(wherein variables A 1 , A 2 , A 3 , A 4 , m, n, J, Q, R 4 , E a , E b , E c , R 6 , R 7 , R e , R f , R PG and Y are as described herein) which are antagonists of CGRP...
|
|
|
7612067 |
Imidazopyridazine compounds
The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing...
|
|
|
7605156 |
Methods for the use of inhibitors of cytosolic phospholipase A2
This invention provides methods for the use of substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms thereof. The invention provides methods for the...
|
|
|
7576088 |
Benzodioxole derivatives
The present invention relates to compounds of the general formula
and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such...
|
|
|
7560546 |
Tyrosine kinase inhibitors
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The...
|
|
|
7534788 |
Benzofuran and benzothiophene-2-carboxylic acid amide derivatives
The present invention relates to compounds of formula I
wherein X, A and R 1 to R 4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds...
|
|
|
7495007 |
Spiroindolinone derivatives
The present invention relates to spiroindolinone derivatives of the formula
and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 ,...
|
|
|
7465726 |
Substituted pyrrolo[2.3-B]pyridines
Compounds represented by Formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3,...
|
|
|
7456196 |
Bicyclic-substituted amines as histamine-3 receptor ligands
Compounds of formula (I)
are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
|
|
|
7432276 |
ABCA1 elevating compounds
The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of...
|
|
|
7432255 |
1H-indol-5-yl-piperazin-1-yl-methanone derivatives
The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein in formula I is:
wherein R 1 to R 4 are as defined in the description and claims....
|
|
|
7402579 |
Quinobenzoxazine analogs and compositions
The present invention relates to quinobenzoxazines analogs having the general formula:
and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, L, R 1...
|
|
|
7399760 |
Pyrimidinedione derivatives
Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and...
|
|
|
7384940 |
Method of treating cancer using kinase inhibitors
Described herein are methods for treating cancer and other disease conditions in individuals who have either developed a resistance to conventional tyrosine kinase inhibitor (TKI) therapy or who...
|
|
|
7361682 |
Indole derivatives as H3 inverse agonists
The present invention relates to compounds of formula I:
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof,...
|
|
|
7358244 |
Azabicycloalkane compounds
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
|
|
|
7351704 |
Indazole-carboxamide compounds as 5-HT4 receptor agonists
The invention provides novel indazole-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such...
|
|
|
7320984 |
Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group
The invention provides a morphinan derivative of the Formula (I):
wherein R 1 is methyl, cyclopropylmethyl or the like; R 2 and R 3 are hydroxy, methoxy, acetoxy or the like; both Y and Z...
|
|
|
7312209 |
Acridone inhibitors of IMPDH enzyme
Compounds having the formula (I),
wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2...
|
|
|
7312212 |
Aminopiperidine derivatives
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
|
|
|
7294629 |
Quinazoline derivatives
A compound of the formula (I)
or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer...
|
|
|
7205309 |
Quinazoline derivatives
Compounds of formula I
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 , R 2 , R 3 and A have the significance given in the specification are provided. The...
|
|
|
7183276 |
Azole compounds
The present invention provides a compound represented by the formula (I)
wherein R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted...
|
|
|
7163949 |
4-phenyl substituted tetrahydroisoquinolines and use thereof
Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure:
wherein R 1 –R 8 for compounds of each of the formulae IA, IB,...
|
|
|
7138398 |
Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to compounds of formula (I) wherein R 1 , R 2 and R 3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the...
|
|
|
7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
|
|
|
7094779 |
Piperazine oxime dervatives having NK-1 receptor antagonistic activity
The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity. The invention relates to compounds of the general formula (1) wherein:...
|
|
|
7087602 |
Cinnoline derivatives and use as medicine
The invention relates to the use of cinnoline derivatives of formula (I)
wherein Z represents —O—, —NH—, —S— or —CH 2 —; m is an integer from 1 to 5; R 1 represents hydrogen,...
|
|
|
7071187 |
Naphthyridine derivatives
The present invention provides a novel naphthyridine derivative that is effective for relieving pain, less toxic, and also is effective for treating diabetic neuropathy, the derivative being...
|
|
|
7067515 |
Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease
The invention provides compounds of Formula I:
where in W is
These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The...
|
|
|
7049309 |
3-Thia-4-arylquinolin-2-one potassium channel modulators
This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including...
|
|
|
7045526 |
Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to compounds of formula I:
wherein R 1 , R 2 , and R 3 have the meanings indicated in the specification, which are valuable pharmaceutical active compounds for...
|
|
|
7045518 |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention...
|
|
|
7041664 |
2-aminoquinolinecarboxamides: neurokinin receptor ligands
Disclosed are compounds of the formula:
or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof,
wherein R 1 , R 2 , R 3 , X, Q 1 and Q 2 are defined herein,
...
|
|
|
7026314 |
Therapeutic chromone compounds
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating,...
|
|
|
7015217 |
Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
The present application describes novel cyclic sulfone derivatives of formula I:
or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of matrix...
|
|
|
6992092 |
Anti-diabetic agents
The present invention provides compounds of formula (I)
the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein...
|
|
|
6960580 |
Nitrogenous heterocyclic substituted quinoline compounds
The present invention relates to nitrogen-containing heterocyclic quinoline compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases,...
|
|
|
6939866 |
Quinazoline derivatives
The invention concerns quinazoline derivatives of Formula (I)
wherein each of m, R 1 , n, R 2 and R 3 have any of the meanings defined in the description; process for the preparation,...
|
|
|
6924278 |
Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists
This invention relates to piperazine derivatives of the formula:
wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation...
|
|
|
6924283 |
4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents
The invention provides a compound of formula I:
wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well...
|
|
|
6921759 |
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
|
|
|
6897210 |
Quinazoline derivatives and pharmaceutical compositions containing them
The invention relates to quinazoline derivatives of formula (I) wherein m is an integer from 1 to 2; R 1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, C 1-3 alkyl, C 1-3...
|
|
|
6864259 |
Antibacterial agents
The present invention provides compounds of Formula (I):
wherein R 1 -R 6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
|
|
|
6855710 |
Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
The present invention relates to new substituted indolinones of general formula
wherein
X and R 1 to R 5 are defined as in claim 1, the isomers and the salts thereof which have valuable...
|
|
|
6849640 |
Therapeutic 1H-pyrido [4,3-b] indoles
The present invention provides 2,3,4,4 a ,5,9 b -hexahydro-1H-pyrido[4,3-b]indoles and 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. These compounds are 5-HT ligands that are useful for treating...
|
|
|
6846818 |
Selective inhibitors of cyclooxygenase-2
The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I:
pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The...
|
|
|
6846817 |
Nicotine receptor ligands
The invention provides nicotine receptor agonists of formula I:
wherein R 1 , x, y, and n have any of the values given in the specification, or a pharmaceutically acceptable salt thereof, as...
|
|
|
6844336 |
4-fluoroalkyl-2h-benzopyrans with anti-estogenic activity
This invention describes the new 4-fluoroalkyl-2H-benzopyrans of general formula I,
in which
Z is a straight-chain or branched-chain alkyl group with up to 5 carbon atoms that is...
|
|
|
6800636 |
Farnesyl protein transferase inhibitors
Disclosed are compounds of the formula: wherein R 8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R 9 represents a carbamate, urea, amide or sulfonamide group; and the...
|