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8877747 Indenone derivative and pharmaceutical composition comprising same  
An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising...
8859539 Compositions of dual thyrointegrin antagonists and use in vascular-associated disorders  
A dual thyrointegrin antagonist and a method for treating an angiogenesis-mediated disorder and/or a hyperthyroidism disorders by introducing the dual thyrointegrin antagonist into animals (e.g.,...
8802669 Dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof  
Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their...
8703828 Antimicrobial compositions and methods of use  
In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one...
8604025 Heterocyclic sulfonamides  
Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure...
8575155 Composition and method to modify sperm function and increase male gender ratio in mammals  
A composition and method is provided for modifying sperm fertility in mammals for the purpose of biasing the gender in favor of male offspring. The composition includes an amount of a class of...
8563544 2,5-disubstituted arylsulfonamide CCR3 antagonists  
Provided herein are 2,5-disubstituted arylsulfonamide CCR3 antagonists, e.g., compounds of Formula I, and pharmaceutical compositions thereof: Also provided herein are methods of their use for...
8541410 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them  
The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically active compounds for the therapy...
8530465 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof  
The invention provides a series of novel 1,2-disubstituted amido-anthraquinone derivatives. Further, the invention also provides the preparation method and application of said derivatives, said...
8501812 Therapeutic methods for type I diabetes  
The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying...
8399456 2,5-disubstituted arylsulfonamide CCR3 antagonists  
Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for...
8389583 Antimicrobial compositions and methods of use  
In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one...
8343963 Sulfamoyl-phenyl-ureido compounds and their use as medicament  
The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of...
8207157 Methods and compositions for repelling arthropods  
A method for repelling arthropods involving treating an object or area with an arthropod repelling effective amount of at least one compound having the formula wherein X is O, S, NH, N-NH2, N-CH3...
8202513 Aryl potassium channel blockers and uses thereof  
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also...
8173643 N-substituted thiomorpholine derivatives as the inhibitors of dipeptidyl peptidase IV and the pharmaceutical uses thereof  
The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs...
8088763 Cyclohexyl-1, 4-diamine compounds  
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical...
RE42700 Induction of apoptosis in cancer cells  
The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
8012962 Substituted thiomorpholine derivatives  
The present invention relates to thiomorpholine derivatives of formula I or pharmaceutically acceptable salts thereof and their use in treating seizure disorders, anxiety disorders, bipolar...
RE42562 EP4 receptor agonist, compositions and methods thereof  
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
7964592 2,4-di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders  
Novel pyrimidine derivatives of formula I to process for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
7947675 Trifluoromethylbenzamide derivatives and therapeutic uses thereof  
Compounds of the formula (I), in which the radicals R1 to R3 and AR are as defined in the description, processes for the preparation thereof, the use thereof in the treatment of cardiovascular...
7902239 Diaminotriazoles useful as inhibitors of protein kinases  
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the...
7858610 Preventive and/or remedy for lower urinary tract diseases containing EP4 agonist  
(1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving...
7834003 5-aminopyrazole derivatives as pesticidal compounds  
The invention relates to 5-Aminopyrazole derivatives of formula (I) or salts thereof, a process for their preparation, to compositions thereof and to their use for the control of pests, including...
7795315 N-(2-amino-phenyl)-amide derivatives  
The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments...
7767666 Butyl and butynyl benzyl amine compounds  
Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or...
7705052 Sulfonamide derivatives for the treatment of diabetes  
The present invention is related to the use of sulfonamide derivatives in the treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II,...
7696198 Phosphodiesterase 4 inhibitors  
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show...
7683054 Galenic formulations of organic compounds  
The present invention relates to a solid oral dosage form comprising a therapeutically effective amount of aliskiren or a pharmaceutically acceptable salt thereof, and wherein the active...
7683055 Lanthionine-related compounds for the treatment of inflammatory diseases  
The present invention provides compositions comprising lanthionine ketimine derivatives and thiomorpholine dicarboxylic acid derivatives, as well as processes for the preparation of such...
7572790 Biphenyl carboxylic amide p38 kinase inhibitors  
Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
7514428 Pesticidal 1-aryl-3-amidoxime-pyrazole derivatives  
1-Arylpyrazole-3-substituted-amidoxime derivatives of formula (Ia) or (Ib): or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof,...
7511036 Dihydrothiazine prodrugs of thiazolium agents  
Provided are compounds of the formula (and pharmaceutically acceptable salts thereof): wherein: R is hydrogen, methyl, hydroxymethyl or α-hydroxyethyl; R1 and R2 are independently selected from...
7498334 Pyrrolopyrimidines as phosphodiesterase VII inhibitors  
Pyrrolopyrimidine derivatives of the formula I in which R3, R4, R5, R6 and X are as defined in claim 1, act as phosphodiesterase VII inhibitors and can be employed for the treatment of...
7482340 Pyridine derivatives useful for inhibiting sodium/calcium exchange system  
Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof....
7435732 Crystalline polymorphs of (3S)-N-hydroxy-4-({4-[-(4-hydroxy-2-butynyl)oxy]phenyl}sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxamide  
This invention relates to crystalline polymorphs of (3S)-N-hydroxy4-({4-[(4-hydroxy-2-butynyl)oxy]phenyl}sulfony l)-2,2-dimethyl-3-thiomorpholine carboxamide, and preparation and uses thereof.
7429581 Pyrazole-derivatives as factor Xa inhibitors  
The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is a pharmacologically active...
7393852 Piperazine derivatives and methods of use  
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
7381719 Diaryl ethers as opioid receptor antagonist  
A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate,...
7378421 Chromenone derivatives  
Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of tumours,...
7351703 Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators  
The present invention relates to compounds of the formula I in which A1, A2, R2 and R3 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds for the therapy...
7329655 Nitrogenous heterocyclic compounds  
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which...
7304057 Substituted 6-membered N-heterocyclic compounds and method for their use as neurological regulator  
This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, X, Y, and Z are as...
7285565 Benzamides and related inhibitors of factor Xa  
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
7282496 Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors  
Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's...
7279469 Diaminotriazoles useful as inhibitors of protein kinases  
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the...
7273863 Benzophenones as inhibitors of reverse transcriptase  
The present invention includes benzophenone compounds (I) which are useful in the treatment of HIV infections.
7250412 PH sensitive prodrugs of 2,6-Diisopropylphenol  
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol...
7214714 20-hydroxyeicosatetraenoic acid production inhibitors  
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino...

Matches 1 - 50 out of 321 1 2 3 4 5 6 7 >