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7482339 2-Naphthylimino-1,3-thiazine derivative  
The formula (I): wherein each of R 2 and R 3 is, same or different, C2-C4 alkyl or the like; or R 2 and R 3 are taken together with the adjacent carbon atom to form a 5 to 8 membered...
7452879 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds  
The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms...
7375102 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use  
Compounds are provided having the formula: wherein variables A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , R 3 , R 4 , Q and L are as described herein. The subject compounds are useful for treatment of...
7223754 Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders  
The invention relates to methods of using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat lower urinary tract and...
7183275 2-imino-1,3-thiazine derivatives  
The present invention relates to 2-imino-1,3-thiazine derivatives, in specific, 2-imino-1,3-thiazine derivatives having a selective antagonistic activity or agonistic activity to a cannabinoid type...
7132451 Inhibition of TNF-α-initiated neutrophil response  
The impact of lipoxin A 4 (LXA 4 ) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFα)-initiated neutrophil (PMN) responses in vitro and in vivo using...
7094778 Heterocyclylalkylamines as muscarinic receptor antagonists  
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR 5 , and the other...
7087627 Combinations for the treatment of diseases involving angiogenesis  
Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or...
7084137 Thiazines and thiazoles as agents for protecting materials  
The novel and known thiazines and thiazoles of the formula (I) in which R 1 , R 2 and n are as defined in the description, are highly suitable for use as biocides for protecting industrial...
7053085 EP4 receptor agonist, compositions and methods thereof  
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
6916806 Medicinal composition containing 1,3-thiazine derivative  
A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor: wherein R 1 is optionally substituted heterocyclic group or the like; R 2 and R 2 each is...
6827942 Composition and method of use  
A liquid composition comprising an alcohol or mixture thereof in sufficient quantity to grow hair in an area of canine or feline skin wherein alopecia has occurred.
6806291 Analgesic compounds, their synthesis and pharmaceutical compositions containing them  
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
6794406 Indole derivatives  
The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments.
6767907 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines  
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH 2 and...
6610720 Method for treating or preventing emesis  
Alpha-2 adrenoreceptor agonists are useful for the treatment and/or prevention of emesis in patients.
6512004 Promoters of neural regeneration  
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
6469000 1,3-diheterocyclic metalloprotease inhibitors  
Disclosed are compounds which are inhibitors of metalloproteases having the following structure: where Ar, W, X, Y, Z, R 1 and R 2 have the meanings described in the specification and optical...
6448286 Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors  
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
6303638 Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor  
Novel compounds are provided that modulate the neuronal nicotinic acetylcholine receptor (nAChR), particularly the mammalian nAChR (m-nAChR). The compounds are substituted pyridine derivatives such...
6218394 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines  
4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1## wherein one of X and Y is CH 2...
6114327 Anti-viral compounds  
The present application provides a series of benzimidazole compounds of formula I: ##STR1## which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such...
6107293 Tachykinin antagonists  
Compounds of formula (I) wherein X is --CH 2 --, --CO-- or direct linkage, Y is --O--, --S-- or --NH--, R 1 is phenyl, R 2 H or phenyl and R 3 is H or --CH 3 -- and their pharmaceutically...
6071906 Imidino piperidine derivatives useful as nitric oxide synthase inhibitors  
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
6054454 Method of controlling fish parasites  
The present invention relates to the use of compounds of formula ##STR1## wherein A is an unsubstituted or mono- to tetrasubstituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic...
6008223 Therapeutic compounds  
Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , and Q 4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
5908852 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation  
A class of 1,3,5-substituted pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I...
5861380 Serine protease inhibitors-keto and di-keto containing ring systems  
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
5854234 Amidino dervatives useful as nitric oxide synthase inhibitors  
The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
5821242 Anti-viral compounds  
The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B...
5698553 Benzylpiperidine derivatives  
A benzylpiperidine compound of formula I ##STR1## in which R 1 is H, Hal or nitro, R 2 is a benzyl group, which is unsubstituted or substituted by Hal on the aromatic portion, in the 2-, 3- or...
5686454 Camphorcarbonyl  
The invention is directed to a series of novel compounds of the formula ##STR1## where Y is carbonyl or sulfonyl; R 7 and R 8 are alkyl, or R 7 and R 8 , together with the carbon to which they...
5672599 Compounds containing a fused bicycle ring  
Compounds of the formula ##STR1## wherein X is O or S--(O) t ; n is one; m is zero or one; Y is CH 2 , O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is ##STR2## are...
5654294 Spiro lactam dual action inhibitors  
Compounds of the formula ##STR1## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular...
5641776 Substituted thiosemicarbazone derivatives  
The present invention relates to novel substituted thiosemicarbazone derivatives of formula (I) wherein R 1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R 2 is...
5639745 Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors  
Disclosed are compounds, compositions and methods for inhibiting interleukin-1β protease activity. The compounds, bicyclic derivatives of aldehydes and α-substituted methyl ketones, have the...
5604224 Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5569655 Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5567700 Therapeutic heterocycles which antagonize neurokinin receptors  
Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
5565450 5-aryl-1,3-thiazine derivatives  
The present invention relates to the new substituted 5-aryl-1,3-thiazine derivatives of general formula (I) ##STR1## in which A, G, X, Y and Z are defined in the specification and their use as...
5543433 Azine-substituted phenylacetic acid derivatives and fungicides containing these  
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
5510386 Aminosulfonylphenyl compounds for treating urinary incontinence  
Compounds of formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and A-B have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the...
5510353 Certain aminoguanidine compounds, pharmaceutical compositions containing them and their use in treating gastrointestinal motility disorders and disorders associated with cephalic pain  
Compounds of formula A--X--Y--NH--B wherein A is derived from optionally substituted benzothiophene, indole, 4-aza-and 7-aza-benzothiophene or-indole, A bearing in position 5 hydrogen, halogen,...
5508272 Compounds containing a fused bicycle ring and processes therefor  
Compounds of the formula ##STR1## wherein X is O or S--(O) t ; n is one or two; m is zero or one; Y is CH 2 , O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is...
5462948 Treatment of addiction to drugs and substances of abuse  
1-Aryl-3-(4-1piperidyl)-indole derivatives having general formula (I), ##STR1## wherein R 1 is hydrogen, halogen, alkyl, alkoxy, hydroxy, cyano, nitro, alkylthio, trifluoromethyl,...
5451564 Antimicrobial composition comprising N-hydroxy heterocyclic thiones  
A composition comprising (a) a metal salt or complex with an organic compound of the general formula ##STR1## and (b) an oxy-phosphorus compound where W may be --SH or an optionally substituted...
5424307 1,3-/1,4-thiomorpholino-terminated non-peptidyl α-succinamidoacyl aminodiols as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as α-succinamidoacyl aminodiols having a 1,3-thiomorpholino-type group or a 1,4-thiomorpholino-type group at the N-terminus are useful as renin...
5420164 Cycloalkylurea compounds  
A cycloalkylurea compound of the formula (I): ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, which compound inhibits ACAT and is...
5393754 Organophosphorus compounds, and insecticides, acaricides and nematocides containing same  
Insecticidal, acaricidal or nematocidal compositions which comprise a series of organophosphorus compounds represented by the following representative structural formulae: ##STR1## show excellent...
5344829 Use of OB-101 to treat inflammation  
A novel compound for the treatment and prevention of ocular and other types of inflammation is disclosed. The compound, OB-101, is effective at both the early and late phases of inflammation. The...
Matches 1 - 50 out of 107 1 2 3 >