Patents in Class 514/225.800

Matches 1 - 50 out of 65

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Match	Document	Document Title
1	7148216	Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts...
2	7119089	Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer,...
3	6992082	Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer,...
4	6846816	Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts...
5	6583146	Thiazolopyrimidine compounds, its production and use Compounds represented by general formula (I): and salts thereof, exhibiting excellent adenosine A 3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further...
6	6583138	Heterocyclic-ring condensed benzothiazine compound The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate....
7	6566389	Therapeutic uses of melatonin A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an...
8	6509335	Benzoxazinoes/benzothiazinones as serine protease inhibitors This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also...
9	6468971	Maintaining kidney function during surgery or trauma Kappa-opioid agonists prevent the impairment of renal function otherwise caused by the combination of gaseous anesthesia and surgery or severe trauma. Not only do these agents preserve renal...
10	6423707	Nitroimidazole ester analogues and therapeutic applications Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These...
11	6159966	Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R 3 , R 4 , R...
12	6034079	Nicotine antagonists for nicotine-responsive neuropsychiatric disorders Nicotine-responsive neuropsychiatric disorders can be treated by administering a nicotine antagonist, particularly mecamylamine. Combination therapy of mecamylamine with a neuroleptic drug also is...
13	5902609	Composition for the control of wound scar production This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars,...
14	5863912	Method of treatment of hormone-unresponsive metastiatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
15	5837701	Composition and method for treating conditions associated with symptoms of unspecified retarded maturation Compositions and method for treating conditions in humans associated with symptoms of unspecified retarded maturation due to chromosomal abnormalities cerebral atrophy, Huntington's Chorea,...
16	5663167	Antipsychotic composition and method of treatment A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an α 2 -adrenergic receptor antagonist and...
17	5607955	Tricyclic compounds on angiotensin II receptor antagonists A tricyclic compound represented by the following formula (I): ##STR1## exhibits antagonism to angiotensin II receptors.
18	5602105	Cardiotropic formulation The invention provides a cardiotropic formulation comprising a cardiac glycoside, a beta-adrenergic receptor stimulant nicotinamide adenine dinucleotide, cytochrome C and inosine for use in...
19	5569678	Control of wound scar production This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The...
20	5552162	Method for improvement of scar size and appearance A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar....
21	5496818	Stable emulsion suitable for pharmaceutical administration, the production thereof and emulsion for pharmaceutical use A stable active substance emulsion of the oil-in-water type with a phospholipid as emulsifier is described, where the active substance dissolved in the lipid phase has one or more basic groups, is...
22	5432168	Method of treatment of hormone-unresponsive metastatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
23	5254546	Fused aryl substituted imidazole angiotensin II receptor inhibitors Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
24	5238936	Trisubstituted triazines The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to...
25	5086052	Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity Pyridazinone, triazinone and oxapyridazinone compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.
26	5084459	Tetrahydropyrimidines, their production and use There is provided a pest control composition containing a compound represented by the formula, ##STR1## wherein R 1 , R 2 , R 3 and R 4 are the same or different and independently mean a hydrogen...
27	4977145	Method for preventing or treating depression employing an ace inhibitor A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1- oxohexyl]-L-pr oline,...
28	4910197	Method and composition for the therapeutic and prophylactic treatment of trauma to the skin A novel method and composition is disclosed for the therapeutic and prophylactic treatment of trauma to the skin. In particular, burns, sunburn and frostbite are treated with compounds that have...
29	4892878	Oleic acid esters and pharmaceutical compositions The present invention relates to pharmaceutical compositions of novel oleic acid esters of wellknown neuroleptics and tranquillizers of the phenothiazine, thioxanthene and butyrophenone type...
30	4845083	Method of inhibiting mammalian leukotriene biosynthesis Phenothiazine derivatives and analogs thereof having the Formula I are useful as inhibitors of the biosynthesis of mammalian leukotrienes. As such, these compounds are useful therapeutic agents for...
31	4833138	Phenothiazinealkaneamines for treatment of neurotoxic injury Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or...
32	4758562	Method for inducing hypothermia and/or poikilothermia A combination of drugs including a kappa opioid receptor agonist and a dopamine receptor blocker or dopamine receptor agonist provides a synergistic effect in inducing hypothermia and/or...
33	4731359	Prolonged action drug formulation The time during which a drug is pharmacologically active is prolonged by coating the drug with at least one chemical derivative of the drug having minor relative pharmacological activity.
34	4717723	Pharmaceutical compositions Pharmaceutical compositions in the form of a buccal tablet comprise a phenothiazine derivative, at least one monosaccharide or disaccharide or a mixture thereof, and a mixture of xanthan gum and...
35	4668671	Tricyclic derivatives and pharmaceutical use This invention describes tricyclic derivatives which are useful as histamine H 1 -antagonists. A particular compound of this invention is...
36	4478822	Drug delivery system utilizing thermosetting gels This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
37	4443446	Use of psychoactive drugs as vaginal contraceptives The use of psychoactive drugs as vaginal contraceptives is disclosed. The invention may be implemented by incorporating a psychoactive drug in a known method such as jelly, foam, or suppository...
38	4407800	Protozoacidal activity of phenothiazines A method of treating or protecting against parasitic diseases caused by members of the protozoan family Trypanosomatidae comprising administering to a mammal a phenothiazine drug. This represents a...
39	4377577	Use of psychoactive drugs in uterus to prevent pregnancy The use of psychoactive drugs by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of...
40	4315909	Process for the preparation of solid drug formulations In order to allow for the greatest possible range of variation in the rate of liberation of active agents within an organism and to allow for the use of a wide variety of active agents in solid...
41	4297353	Non-irritating injectable dosage forms A non-irritating injectable dosage form of a tissue irritating medicament, comprising the medicament and a pharmaceutically acceptable glyceride vehicle comprising a glycerol ester of a saturated...
42	4289768	Phenothiazine derivatives and a process for their preparation Phenothiazine derivatives of the formula ##STR1## wherein R is H, F, Cl, Br, I, CH 3 , CF 3 , CN, CH 3 O or CH 3 CO; Y is S, SO, or SO 2 ; Z is imidazol-1-yl, 2-methyl-imidazol-1-yl,...
43	4183926	Phenothiazine derivatives, their preparation and therapeutic use New phenothiazine derivatives having pharmaceutical activity are disclosed. The compounds are of particular interest because of their neuroleptic activity. The compounds are suitably prepared by...
44	4155874	Phenothiazinyl sulfides A new group of compounds, generically classed as phenothiazinyl sulfides, are described having the formula: ##STR1## wherein n is 1 or 2, x and/or y and/or z represent 0, 1 or 2; R 1 may be H,...
45	4153694	Behenic acid esters, compositions thereof and a method of preparation thereof The present invention relates to novel behenic acid esters of the following general formula: ##STR1## wherein X is "N" or "CH," the non-toxic acid addition salts thereof, a method for the...
46	4147789	6-Methyl-8-thiomethyl-ergolene derivatives This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring...
47	3966930	Phenothiazine derivatives, compositions thereof and methods of preparation thereof Fluoro-substituted phenothiazine derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of...
48	3896221	Anesthetic composition There is disclosed a novel anesthetic compound, which upon intramuscular injection in cats, produces the advantageous anesthetic effects of ketamine but which does not result in many of the...
49	3885034	Phenothiazine derivatives in the treatment of psychotic persons This invention relates to and has as its object a novel phenothiazine derivative and its pharmacologically acceptable salts which have important therapeutic properties.
50	3621097	METHOD AND COMPOSITIONS FOR TREATMENT OF MENTAL ILLNESS A process for the treatment of mental illness comprising the administration of dimethyl biguanide of the formula ##SPC1## To an animal receiving an ataractic. A pharmaceutical composition...

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