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Document Title |
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7358226 |
Ultrasonic concentration of drug delivery capsules
Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation...
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7148216 |
Combinations of drugs for the treatment of neoplastic disorders
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts...
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7119089 |
Phenothiazine kinesin inhibitors
Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer,...
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RE39300 |
Inhibiting the development of tolerance to and/or dependence on an addictive substance
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor...
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7008934 |
Composition and method for reducing adverse interactions between phenothiazine derivatives and plasma using cyclodextrins
Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine hydrochloride. The active...
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6992082 |
Phenothiazine kinesin inhibitors
Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer,...
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6846816 |
Combinations of drugs for the treatment of neoplastic disorders
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts...
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6756370 |
Piperidine alcohols
The invention relates to compounds of formula (I), wherein R 1 , R 2 and A have the meanings given in claim 1, are potent 5-HT 2A antagonists and are suitable for treating psychoses,...
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6583138 |
Heterocyclic-ring condensed benzothiazine compound
The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate....
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6566389 |
Therapeutic uses of melatonin
A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an...
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6525100 |
Composition and method for treating peyronie's disease and related fibrotic tissue disorders
The invention is of a topical medicament and associated methodology for use thereof, through the use of which Peyronie's disease may be effectively, cost effectively, and painlessly treated. The...
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6509335 |
Benzoxazinoes/benzothiazinones as serine protease inhibitors
This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also...
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6468971 |
Maintaining kidney function during surgery or trauma
Kappa-opioid agonists prevent the impairment of renal function otherwise caused by the combination of gaseous anesthesia and surgery or severe trauma. Not only do these agents preserve renal...
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6159966 |
Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R 3 , R 4 , R...
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5861394 |
Use of N-substituted phenothiazines
The invention relates to the use of N-substituted phenothiazines for the production of medicaments for the treatment of cerebral disorders. The invention likewise relates to novel active compounds...
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5795888 |
N-substituted azaheterocyclic carboxlic acids and esters thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for...
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5663167 |
Antipsychotic composition and method of treatment
A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an α 2 -adrenergic receptor antagonist and...
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5597819 |
Phenothiazine cytokine inhibitors
New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen, n represents 0, 1, or 2, B represents the following formula: ##STR2## in which:...
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5502049 |
Use of phenothiazine derivatives in the treatment of ischaemia and/or hypoxia
This invention relates to a novel therapeutical use of phenzothiazine derivatives of general formula (I), ##STR1## wherein R is a straight or branched chain C 1 -5 alkyl radical, and R 1 and R 2 ,...
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5321026 |
Phenothiazine derivatives, their preparation and pharmaceutical compositions containing them
New phenothiazine derivatives of general formula (I) in which R represents 4- to 6-membered cycloalkyl, or represents --CH 2 R" in which R" is hydrogen, alkyl containing 1 to 5 carbon atoms,...
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5321012 |
Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor...
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5262413 |
Use of isoxazolin-3-one derivatives as antidepressants
A method of treating depression comprising administering to a patient an effective amount of a compound of the formula (Ib): ##STR1## wherein R 1b is hydrogen, halogen, C 1 -C 4 alkyl, C 2 -C 4...
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5084459 |
Tetrahydropyrimidines, their production and use
There is provided a pest control composition containing a compound represented by the formula, ##STR1## wherein R 1 , R 2 , R 3 and R 4 are the same or different and independently mean a hydrogen...
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4977151 |
Ethanone oximes and pharmaceutical compositions thereof
Ethanone oximes represented by the following general formula: ##STR1## wherein R 1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl...
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4912105 |
Derivatives of phenothiazine and the compositions which contain them
Phenothiazine derivatives of formula ##STR1## in which R represents --NR 1 R 2 in which R 1 and R 2 , which may be identical or different, are alkyl, hydroxyalkyl or acetyloxyalkyl radicals, or...
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4910197 |
Method and composition for the therapeutic and prophylactic treatment of trauma to the skin
A novel method and composition is disclosed for the therapeutic and prophylactic treatment of trauma to the skin. In particular, burns, sunburn and frostbite are treated with compounds that have...
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4845083 |
Method of inhibiting mammalian leukotriene biosynthesis
Phenothiazine derivatives and analogs thereof having the Formula I are useful as inhibitors of the biosynthesis of mammalian leukotrienes. As such, these compounds are useful therapeutic agents for...
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4833138 |
Phenothiazinealkaneamines for treatment of neurotoxic injury
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or...
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4822796 |
1-((Phenothiazin-10-yl)alkyl)-alpha-phenyl-4-piperidinemethanols and pharmaceutical use
1-[(phenothiazin-10-yl)alkyl]-α-phenyl-4-piperidinemethanol
s and methods for treating pain or psychosis utilizing compounds or compositions thereof are disclosed.
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4812456 |
1-(N-(2-alkylthio-10H-phenothiazin-10-yl)alkyl)-4-benzoylpiperidines and pharmaceutical use
This invention relates to 1-[n-(2-alkylthio-10H-phenothiazin-10-yl)alkyl]-4-benzoylpip
eridines and methods for treating pain or psychosis utilizing compounds or compositions thereof.
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4758562 |
Method for inducing hypothermia and/or poikilothermia
A combination of drugs including a kappa opioid receptor agonist and a dopamine receptor blocker or dopamine receptor agonist provides a synergistic effect in inducing hypothermia and/or...
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4500527 |
Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl phenyl]-1,4-dihydropyridines
Unsaturated heterocyclic dihydropyridines of the formula: ##STR1## wherein the substituents defined herein have been found to have useful antihypertensive activity.
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4443446 |
Use of psychoactive drugs as vaginal contraceptives
The use of psychoactive drugs as vaginal contraceptives is disclosed. The invention may be implemented by incorporating a psychoactive drug in a known method such as jelly, foam, or suppository...
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4407800 |
Protozoacidal activity of phenothiazines
A method of treating or protecting against parasitic diseases caused by members of the protozoan family Trypanosomatidae comprising administering to a mammal a phenothiazine drug. This represents a...
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4377577 |
Use of psychoactive drugs in uterus to prevent pregnancy
The use of psychoactive drugs by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of...
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4297353 |
Non-irritating injectable dosage forms
A non-irritating injectable dosage form of a tissue irritating medicament, comprising the medicament and a pharmaceutically acceptable glyceride vehicle comprising a glycerol ester of a saturated...
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4155874 |
Phenothiazinyl sulfides
A new group of compounds, generically classed as phenothiazinyl sulfides, are described having the formula: ##STR1## wherein n is 1 or 2, x and/or y and/or z represent 0, 1 or 2; R 1 may be H,...
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4153694 |
Behenic acid esters, compositions thereof and a method of preparation thereof
The present invention relates to novel behenic acid esters of the following general formula: ##STR1## wherein X is "N" or "CH," the non-toxic acid addition salts thereof, a method for the...
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4138484 |
Method for treating schizophrenia and method and composition for potentiating neuroleptic drugs
A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a...
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4129652 |
Method for potentiating neuroleptic drugs
A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a...
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4032637 |
Method of promoting sleep
The present invention concerns a novel therapeutic use as a sleep-promoting agent for the known pharmaceutical compound 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulphinylphenothi
azine of the...
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4021552 |
10-[ω-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES
10-[ω-(Benzoylpiperidinyl)alkyl]phenothiazines having the formula ##STR1## wherein R is hydrogen, chloro, bromo, trifluoromethyl, lower alkoxy, acetyl, sulfamoyl, or dimethylsulfamoyl, R 1 is...
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4018922 |
10-(Piperidin o-alkyl)-phenothiazines
Novel 10-(piperidino-alkyl)-phenothiazines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, --CF 3 , --OCH 3 and SCH 3 , B and R are individually...
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3988453 |
Novel phenothiazines as neuroleptics
Novel phenothiazines of the formula ##SPC1## Wherein X is selected from the group consisting of hydrogen, chlorine, trifluoromethyl, methylthio and methoxy, B is selected from the group consisting...
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3966930 |
Phenothiazine derivatives, compositions thereof and methods of preparation thereof
Fluoro-substituted phenothiazine derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of...
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3961055 |
Hydroxy and ether containing phenothiazine derivatives
Phenothiazine derivatives of the formula: ##SPC1## Wherein X represents methylthio, methylsulphonyl or dimethylsulphamoyl, R represents hydrogen, alkyl of 1 through 10 carbon atoms, phenylalkyl...
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3956493 |
Long acting tranquilizing agent
1-Adamantanecarboxylic acid ester of pipotiazine is a long acting derivative of the tranquilizing agent.
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3879552 |
Enhanced learning ability by use of thioridazine
Thioridazine is useful in enhancing the learning process of mammals.
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3879551 |
Phenthiazine derivatives in pharmaceutical compositions
Phenthiazine derivatives of the formula: ##SPC1## Wherein R represents an alkyl, alkenyl or alkynyl group containing 7-17 carbon atoms, are very active as long acting neuroleptics, anti-emetics and...
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