Patents in Class 514/225.200

Matches 1 - 50 out of 58

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Match	Document	Document Title
1	7384933	Derivatives of 2-hydroxytetrahydrofuran and their use as medicaments A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive...
2	7148216	Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts...
3	7119089	Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer,...
4	7008934	Composition and method for reducing adverse interactions between phenothiazine derivatives and plasma using cyclodextrins Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine hydrochloride. The active...
5	6992092	Anti-diabetic agents The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein...
6	6992082	Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer,...
7	6991806	Pharmaceutical compositions comprising ibuprofen and domperidone A stable pharmaceutical composition comprising a mixture of (i) an ibuprofen medicament; (ii) a domperidone medicament and (iii) a carrier material characterized in that the carrier material is...
8	6846816	Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts...
9	6800618	Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof A compound having the structural formula or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4, 5 or 6; Y is a...
10	6703401	Compounds, their preparation and use The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the...
11	6583138	Heterocyclic-ring condensed benzothiazine compound The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate....
12	6544986	Pyridones and their use as modulators of serine hydrolase enzymes This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof; in which preferably R 3 , R 4 and R 6 are each hydrogen; X is C═O or CH 2 ; and R 7 and R 8...
13	6509335	Benzoxazinoes/benzothiazinones as serine protease inhibitors This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also...
14	6485750	Phenothiazine in prill form and method for making the same Phenothiazine and its derivatives products are provided with a minimal level of fines or dust as a result of forming such products in prill form. The prills are generally spherical. Also provided...
15	6482822	N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use...
16	6468996	Substituted hetero-polycyclic compounds as PPARα and PPAR&ggr activators The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
17	6319514	Analgesic and anti-inflammatory compositions comprising domperidone and methods of using same The present invention provides a method for eliciting an onset hastened analgesic and anti-inflammatory response and combating nausea in acute migraine attacks. This method comprises administering...
18	6159966	Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R 3 , R 4 , R...
19	5861394	Use of N-substituted phenothiazines The invention relates to the use of N-substituted phenothiazines for the production of medicaments for the treatment of cerebral disorders. The invention likewise relates to novel active compounds...
20	5795888	N-substituted azaheterocyclic carboxlic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for...
21	5770596	Pharmaceutical compositions based on mequitazine The subject of this invention is a ready-for-use collyrium intended for the treatment of ocular allergies, comprising, in aqueous solution, mequitazine and a β- or a γ-cyclodextrin optionally...
22	5710152	Benzoazine derivative or salt thereof and pharmaceutical compostion comprising the same A benzoazine derivative represented by the following formula (1), ##STR1## wherein R 1 represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group,...
23	5654298	Amine derivatives This invention concerns novel aminopyridinium compounds of the formula I wherein R 1 , R 2 , R 3 , R 5 and R 6 are selected from the following combinations: ##STR1## (a) one of R 2 and R 6 is a...
24	5597819	Phenothiazine cytokine inhibitors New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen, n represents 0, 1, or 2, B represents the following formula: ##STR2## in which:...
25	5504081	Combating fish parasites The present invention relates to the use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for combating fish parasites.
26	5502049	Use of phenothiazine derivatives in the treatment of ischaemia and/or hypoxia This invention relates to a novel therapeutical use of phenzothiazine derivatives of general formula (I), ##STR1## wherein R is a straight or branched chain C 1 -5 alkyl radical, and R 1 and R 2 ,...
27	5340832	Prolinal derivatives useful for treating amnesia A novel prolinal derivative of the general formula: ##STR1## [wherein A represents alkylene or alkenylene group of from 1 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon...
28	5332734	Oxazinone derivative Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent...
29	5322847	Azabenzimidazoles in the treatment of asthma, arthritis and related diseases A series of imidazo[4,5-c]pyridines which inhibit platelet activating factor (PAF) and also block leukotriene D4 receptors are useful in treating asthma, arthritis, psoriasis, gastrointestinal...
30	5321026	Phenothiazine derivatives, their preparation and pharmaceutical compositions containing them New phenothiazine derivatives of general formula (I) in which R represents 4- to 6-membered cycloalkyl, or represents --CH 2 R" in which R" is hydrogen, alkyl containing 1 to 5 carbon atoms,...
31	5223497	Treating habit disorders A method for treating habit disorders in a human patient comprising administering to the patient an anti-habitual amount of a pharmaceutically active compound, which results in activation of a...
32	4912105	Derivatives of phenothiazine and the compositions which contain them Phenothiazine derivatives of formula ##STR1## in which R represents --NR 1 R 2 in which R 1 and R 2 , which may be identical or different, are alkyl, hydroxyalkyl or acetyloxyalkyl radicals, or...
33	4910195	Dihydropyridine derivatives Dihydropyridine derivatives represented by formula (I): ##STR1## wherein R 1 , R 2 , R 3 and R 6 , which may be the same or different, each represents an alkyl group, a cycloalkyl group or an...
34	4845083	Method of inhibiting mammalian leukotriene biosynthesis Phenothiazine derivatives and analogs thereof having the Formula I are useful as inhibitors of the biosynthesis of mammalian leukotrienes. As such, these compounds are useful therapeutic agents for...
35	4833138	Phenothiazinealkaneamines for treatment of neurotoxic injury Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or...
36	4749700	Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same Invention relates to nasal administration of physiologically active therapeutic agents and dosage forms useful for such administration.
37	4734411	Pyrrolizidine compounds, salts thereof, process for the preparation of same and pharmaceutical agents comprising same Novel pyrrolizidine compounds represented by the formula ##STR1## wherein R is a radical of ##STR2## R 1 is hydrogen, halogen, alkyl group, alkoxy group, alkanoyl group, trifluoromethyl radical,...
38	4603132	Phenothiazine compounds with anti-bronchospastic activity and pharmaceutical compositions containing them Quarternized derivatives of mequitazine, particularly 3-(10-H-phenothiazine-methyl)-1-methyl-1-azoniabicyclo [2.2.2]-octane iodide, show powerful anti-bronchospastic activity if administered by...
39	4578385	Use of phenothiazine 5-oxide drugs in uterus to prevent pregnancy The use of phenothiazine 5-oxide drugs by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means...
40	4578379	Use of phenothiazine 5-oxide drugs as vaginal contraceptives The use of phenothiazine 5-oxide drugs as vaginal contraceptives is disclosed. The invention may be implemented by incorporating an effective amount of a phenothiazine 5-oxide drug in a known...
41	4514395	Phenothiazine derivatives and anti-psychotic drugs containing the same New phenothiazine derivatives having the general formula: ##STR1## wherein R represents a straight or branched alkyl group or alkenyl group having 5-15 carbon atoms, their acid addition salts and...
42	4451461	10-(1-Aza-[2,2,2)-bicyclo-3-octyl]-10H-2-phenothiazinesulfonamide and derivatives thereof 10-[1-aza-(2,2,2)-bicyclo-3-octyl]-10H-2-phenothiazinesulfon amides of the formula: ##STR1## wherein R represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms are disclosed together...
43	4435393	Derivatives of 10-(1-azabicyclo[2.2.2]oct-3-yl)-N,N dimethyl-10H-phenothiazine-2-sulfonamide as medicaments Compounds of the general formula: ##STR1## in which either X represents an atom of sulfur and Y represents the N-oxide group or X represents the sulfinyl group or the sulfonyl group and Y...
44	4407800	Protozoacidal activity of phenothiazines A method of treating or protecting against parasitic diseases caused by members of the protozoan family Trypanosomatidae comprising administering to a mammal a phenothiazine drug. This represents a...
45	4366154	Tropyl derivatives Tropyl derivatives of the formula: ##STR1## in which R 1 is (a) phenyl linked through a direct bond, --O--, ##STR2## (in which m=2 or 3); (b) diphenylmethyl; or (c) 10H-phenothiazin-10-yl; (each...
46	4139632	Psychotropic 2-trifluoromethyl-10-[3-(3-hydroxy-pyrrolidino)-propyl]-phenothiazine compounds New phenothiazine derivatives having the general formula: ##STR1## wherein R represents hydrogen atom or a lower alkyl group, and A represents a lower alkylene group, and process for the production...
47	4115571	10-(Bis-pyrrolinyl) phenoxazines Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or...
48	4083976	10'-( ω-N)-1,4-Diazabicyclo(4,3,0)-alkanyl-lacyl) -phenothiazine compositions Novel compounds 10'-[ω-N/1,4-diazabicyclo(4,m,0)-alkanyl/-acyl] -phenothiazines having the formula: ##STR1## wherein X = H, Cl, CF 3 ; n = 1, 2, 3; m = 3, 5; and their salts of acidic addition...
49	3954982	Pharmaceutical compositions and method of inhibiting H-1 and H-2 histamine receptors Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in...
50	3864487	Antiarhythmic pharmaceutical preparation containing ethyl 10-α-morpholylpropionyl) phenthiazine-2-carbamate hydrochloride A method for preparing a novel composition of matter, ethyl 10-(β-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride, having the formula ##SPC1## Which comprises reacting ethyl...

Matches 1 - 50 out of 58

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