|
Match
|
Document |
Document Title |
|
|
7579343 |
Pyrrolo-thiazines and processes for the preparation and use thereof
1H-Pyrrolo-1,4-thiazines and a process for the preparation thereof are described. These compounds are useful as enzyme inhibitors in cells, particularly for medical uses.
|
|
|
7514427 |
1,5,6,-substituted-2-oxo-3-cyano-1,6a-diaza-tetrahydro-fluoranthenes as anti-inflective agents
HIV inhibitory compounds of formula:
salts and stereoisomers thereof, wherein
R 1 and R 2 are hydrogen or optionally substituted C 1-10 alkyl; R 3 is
n is 1, 2 or 3;
...
|
|
|
7488726 |
Rifamycin analogs and uses thereof
The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the...
|
|
|
7141566 |
Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments.
|
|
|
7135468 |
Antibacterial compounds
Bacterial protein synthesis-inhibiting compounds having formula (I)
and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the...
|
|
|
RE39300 |
Inhibiting the development of tolerance to and/or dependence on an addictive substance
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor...
|
|
|
7018999 |
Methods for the treatment and prevention of pain
Novel methods for the treatment and/or prevention of pain are presented. The methods may comprise administering to a subject in need thereof an effective amount of a stress-activated protein kinase...
|
|
|
6800623 |
Method of treating schizophrenia
A method for treating schizophrenia which comprises administering a compound of general formula (I)
|
|
|
6720316 |
Therapeutic 5-HT ligand compounds
The present invention provides compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and Z have any of the values defined in the specification, as well as...
|
|
|
6713468 |
Methods of using thiazolobenzoheterocycles
Methods of using compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof.
|
|
|
6703401 |
Compounds, their preparation and use
The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the...
|
|
|
6638934 |
Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands
The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 4a , R 4b , R 5 , R 6 , R 7...
|
|
|
6624159 |
Heterocycle carboxamides as antiviral agents
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
|
|
|
6608048 |
Tricyclic protein kinase inhibitors
This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the...
|
|
|
6541469 |
CRF receptor antagonists and methods relating thereto
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded...
|
|
|
6528517 |
Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents
The present invention discloses a novel quinobenzoxazine self-assembly complex on DNA and on the topoisomerase II-DNA complex. The related model is used to design a new series of quinobenzoxazines,...
|
|
|
6525045 |
Positive allosteric AMPA receptor modulators
The present invention relates to new positive allosteric AMPA receptor modulators of general formula (I) wherein R 1 , R 2 R 3 , R 4 , R 5 and R 6 may have the meanings indicated in the...
|
|
|
6514984 |
Treatment for alzheimer's disease
A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA 2 inhibitor.
|
|
|
6476021 |
Compounds having cGMP-PDE inhibitory effect
Novel fused tetracyclic heterocyclic compounds having a potent and highly selective effect of inhibiting cyclic GMP phosphodiesterase (cGMP-PDE) and a high safety; a process for producing the same;...
|
|
|
6462038 |
Androgen receptor modulator compounds and methods
Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions...
|
|
|
6448241 |
Thiazolobenzoheterocycles, their preparation and medicaments containing them
Compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them...
|
|
|
6399593 |
Cyclic regimens using cyclic urea and cyclic amide derivatives
This invention concerns cyclic combination therapies using progestational agents and indoline derivatives which are progesterone receptor antagonists of the general structure: wherein: A, B and...
|
|
|
6387893 |
Spirotricyclic substituted azacycloalkane derivatives and uses thereof
Spirotricyclic azacycloalkyl compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds is also described. One application of these compounds, which are...
|
|
|
6384045 |
Tricyclic and tetracyclic pyrones
This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone...
|
|
|
6380235 |
Benzimidazolones and analogues
The present invention provides compounds and pharmaceutical formulations useful as progesterone receptor agonists and antagonists and having the general formula: wherein: A is O, S, or NR 4 ; B...
|
|
|
6352960 |
Controlling agent for agricultural or horticultural bacterial disease
A controlling agent for agricultural or horticultural, which is less phytotoxic and which has considerable controlling effect against bacterial plant diseases, is provided by using...
|
|
|
6350743 |
Cytotoxic pyridoacridine alkaloids
Shermilamine D, a novel cytotoxic pyridoacridine alkaloid of Formula 1, has been isolated from the tunicate Cystodytes violatinctus. The structure of the compound has been established on the...
|
|
|
6348460 |
1,2,3-thiadiazole derivatives, plant disease controller and method for using the same
A 1,2,3-thiadiazole derivative represented by general formula (I): [wherein R 1 is hydrogen atom, halogen atom, (C 1 -C 6 ) alkyl, phenyl, etc., R 2 is the following group (A) or group (B): ...
|
|
|
6306437 |
Apomorphine-containing dosage forms for ameliorating male erectile dysfunction
Psychogenic impotence can be ameliorated without substantial undesirable side effects by administration of apomorphine and an antiemetic agent in an amount sufficient to substantially reduce nausea...
|
|
|
6235731 |
Fused imidazopyridine derivatives as antihyperlipidemic agents
A novel compound of the formula: ##STR1## wherein ring Q is an optionally substituted pyridine ring; One of R 0 , R 1 and R 2 is --Y 0 --Z 0 , and the other tow groups are a hydrogen, a halogen,...
|
|
|
6225306 |
Biphenyl derivatives and drug composition
A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## [In the formula (1), A represents a single bond, --CH 2 --, --CO--,...
|
|
|
6218373 |
Formulations containing hyaluronic acid
A method of treating a disease of condition administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage comprising a...
|
|
|
6187786 |
Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
This invention concerns compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an...
|
|
|
6121278 |
Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
A compound of formula I: ##STR1## or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: Y represents the atoms necessary...
|
|
|
6071905 |
Biologically active substance on the basis of tetracyclic nitrogen heterocycles of pyrimidine row
Biologically active substance on the basis of tetracyclicnitrogen heterocycles of pyrimidine row for treating tuberculosis, mycobacteriousis, viral diseases, infections caused by chlamydias, and...
|
|
|
6057315 |
Antibacterial agents
Described are antibacterial agents of formula (I): X is O, S or N--R 8 ; R 1 , R 2 , R 3 and R 8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons,...
|
|
|
6030973 |
Heterocyclic compounds having antidiabetic hypolipidemia and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable...
|
|
|
6017900 |
Topical composition containing hyaluronic acid and nsaids
A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology or trauma of skin or exposed tissue of...
|
|
|
6001866 |
Method for treating and preventing inflammation and atherosclerosis
This invention provides a method for treating or preventing inflammation or atherosclerosis in mammals comprising administering an effective amount of a 15-LO inhibitor of Formula I: ##STR1##...
|
|
|
5998409 |
Condensed indole derivatives as 5HT.sub.4 -receptor antagonists
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS...
|
|
|
5990122 |
Quinolone- and naphthyridonecarboxylic acid derivatives
The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their...
|
|
|
5981522 |
Treatment of disease caused by infection of Helicobacter
A method for treating a digestive organ disease caused by the infection of Helicobacter, comprising administering a rifamycin derivative expressed by the formula (I), or a physiologically...
|
|
|
5962449 |
Tricyclic compounds in treating hyperalgesic conditions and NIDDM
The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their...
|
|
|
5955460 |
Oxazolidinone antibacterial agent with tricyclic substituents
This invention provides novel oxazolidinone derivatives represented by chemical Formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein X is NR 1 , CR 2 R 3 , O, S, SO, or SO 2...
|
|
|
5952329 |
Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors
A method of ablating the growth of or eradicating neoplasms in mammals by (a) contacting the cells of the neoplasm with an effective amount of a combination of photoactive chromophores, and ...
|
|
|
5952335 |
Fused polycyclic heterocycle derivatives
Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or...
|
|
|
5935952 |
Quinolone- or naphthylidone-carboxylic acid derivates or their salts
This invention relates to a novel quinolone- or naphthyridone-carboxylic acid derivative or its salt useful as an antibacterial agent, said derivative has a substituent represented by the following...
|
|
|
5885988 |
Benzo g!quinoline derivatives
The invention provides compounds of formula I ##STR1## wherein X, Y, R 1 , R 2 , R 3 and R 4 are as defined in the description, and a process for preparing them. The compounds of formula I are...
|
|
|
5849731 |
Indole derivatives and medical application thereof
The present invention relates to indole derivatives represented by the following compound 1 and the pharmacologically acceptable acid addition salt thereof. ##STR1## The compounds of the present...
|
|
|
5824677 |
Substituted amino alcohol compounds
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
|