|
Match
|
Document |
Document Title |
|
|
7384937 |
Fused heterocyclic compounds and use thereof
Fused heterocylic compounds of the following Formula
wherein R 1 , R 2 , R 5 , Z, J 1 and J 2 are described herein, and analogs thereof are provided which are useful in treating leukocyte...
|
|
|
7354915 |
6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators
Compounds having the structure of formula I are provided. In formula I, R 1 is H, OH, substituted or unsubstituted C 1 to C 3 alkyl, C 1 to C 3 perfluoroalkyl, or COR 6 ; R 6 is H,...
|
|
|
7342010 |
2-thiaquinolizidines and process for the preparation thereof
A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula:
where x is 0 to 3.
|
|
|
7342009 |
Cyclic sulfonamides for inhibition of gamma-secretase
Compounds of formula I:
inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
|
|
|
7312211 |
Pryanone compounds useful as reversible inhibitors of cysteine proteases
Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 2 , R 3 , R 4 , R 6 , R 8 and Y are defined herein. The compounds are useful for...
|
|
|
7244727 |
Fused bicyclic nitrogen-containing heterocycles
Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the...
|
|
|
7186730 |
Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
|
|
|
7160874 |
Phenylalanine derivatives
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
|
|
|
7141564 |
Nitrogen-containing bicyclic heterocycles for use as antibacterials
Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
|
|
|
7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
|
|
|
7067513 |
Phenylpiperazines
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D 2 receptor and/or the serotonin reuptake site,...
|
|
|
7049312 |
Benzothiazinone and benzoxazinone compounds
Q is —N=or CR 2 X is S, O or NOR 3 Y is —O—, —S—, —SO— or —SO 2 — R and R 1 are each, independently, H, a substituted or unsubstituted aliphatic, aromatic, heteroaromatic or...
|
|
|
7008941 |
Reverse-turn mimetics and methods relating thereto
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed:
...
|
|
|
7008798 |
Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
The present invention pertains to luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by...
|
|
|
6982261 |
Cyanopyrroles
This invention provides a progesterone receptor antagonist of formula 1 having the structure
wherein T is O, S, or absent; R 1 , and R 2 are each, independently, hydrogen, alkyl, substituted...
|
|
|
6933304 |
Heteroarylalkanoic acids as integrin receptor antagonists
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
|
|
|
6919332 |
N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula
wherein X, A, Y, B, G, and R 1 are as defined in the...
|
|
|
6867211 |
4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy
The present invention relates to 4-pyridyl- and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1:
in which the variables have the meanings indicated...
|
|
|
6841559 |
Pyridinones to treat and prevent bacterial infections
Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods...
|
|
|
6825184 |
1,4-Disubstituted benzo-fused urea compounds
Disclosed are compounds of the formulas (I) & (II) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein G, X, A and Q...
|
|
|
6794383 |
Heart muscular cell apoptosis inhibitors and remedies/preventives for heart diseases
The present invention is intended to provide excellent preventives and/or remedies for heart diseases. Specifically, the present invention provides heart muscle cell apoptosis inhibitors,...
|
|
|
6794373 |
Contraceptive methods using benzimidazolones
This invention relates to cyclic combination therapies and regimens utilizing indoline compounds which are antagonists of the progesterone receptor and having the general structure: A is O, S,...
|
|
|
6747039 |
Aza-benzothiopyranoindazoles with antitumor activity
The present invention relates to a group of aza-anthrapyrazole compounds having antitumor activity, and processes for their preparation. Compositions containing the aza-anthrapyrazole compounds and...
|
|
|
6747023 |
Sulfonyl derivatives
Described in the present invention are a sulfonyl derivative represented by the following formula (I): Q 1 —Q 2 —T 1 —Q 3 —SO 2 —Q A (I) [wherein Q 1 represents a saturated or...
|
|
|
6740649 |
Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from...
|
|
|
6730681 |
Triazolo-pyrimidine derivatives as ligands for gaba receptors
A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-α]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an...
|
|
|
6727258 |
Allosteric adenosine receptor modulators
The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators...
|
|
|
6727243 |
Compositions comprising cefuroxime axetil
Cefuroxime axetil in a non-gelatinous form on contact with an aqueous liquid, e.g., in the form of a solid dispersion on a carrier, e.g., useful for the production of pharmaceutical compositions...
|
|
|
6713477 |
Hydroxamic acid derivatives
A hydroxamic acid derivative represented by formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which has a matrix metalo-proteinase inhibitor.
|
|
|
6706713 |
Conjugate for treating inflammatory infectious and/or skin diseases
This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation...
|
|
|
6602868 |
Treatments for restless legs syndrome
The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).
|
|
|
6531484 |
Pyrrolidine modulators of CCR5 chemokine receptor activity
Pyrrolidine compounds of Formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8a , R 8b , j, k, 1, m, and n are defined herein) are described. The compounds are modulators of CCR5...
|
|
|
6531469 |
Substituted 1-(4-piperidyl)-3-(aryl) isothioureas their preparation and their therapeutic application
The invention concerns novel substituted N-benzo(thia/oxa)zines-2-yl-1-arylalkyloxyalkyl-4-piperidina
mine, their preparation and their therapeutic use. The invention concerns compounds of formula...
|
|
|
6509335 |
Benzoxazinoes/benzothiazinones as serine protease inhibitors
This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also...
|
|
|
6468996 |
Substituted hetero-polycyclic compounds as PPARα and PPAR&ggr activators
The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
|
|
|
6448246 |
Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands
Disclosed are 4H-1,4-Benzothiazine-2-carboxamides. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or...
|
|
|
6448008 |
Fluorescent cyanine labels containing a sulfamido linker arm
A fluorescent cyanine dye of the following general formula is disclosed: wherein: X 1 and X 2 are independently selected from the group consisting of —O—, —S—, —C(CH 3 ) 2 or...
|
|
|
6432946 |
3-aminoalkylamino-2H-1,4-benzoxazines and 3-aminoalkylamino-2H-1,4-benzothiazines: dopamine receptor subtype specific ligands
Disclosed are compounds of the formula: or the pharmaceutically acceptable acid addition salts thereof, wherein: Ar represents aryl or heteroaryl; R 1 and R 2 are the same or different and...
|
|
|
6423699 |
Combination therapies using benzimidazolones
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general...
|
|
|
6387896 |
Bicyclic oxazolidinones as antibacterial agents
The present invention provides compounds of formula I useful as antimicrobial agents wherein W, X, Y, R 1 , R 2 and n are as defined in thereof.
|
|
|
6380235 |
Benzimidazolones and analogues
The present invention provides compounds and pharmaceutical formulations useful as progesterone receptor agonists and antagonists and having the general formula: wherein: A is O, S, or NR 4 ; B...
|
|
|
6348460 |
1,2,3-thiadiazole derivatives, plant disease controller and method for using the same
A 1,2,3-thiadiazole derivative represented by general formula (I): [wherein R 1 is hydrogen atom, halogen atom, (C 1 -C 6 ) alkyl, phenyl, etc., R 2 is the following group (A) or group (B): ...
|
|
|
6348457 |
4-&lsqb 3-benzofuranyl&rsqb piperidinyl and 4-&lsqb 3-benzothienyl&rsqb piperidinyl derivatives
The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein X is oxygen or...
|
|
|
6346529 |
Antiviral therapy using thiazine dyes
A method for using thiazine dyes, especially methylene blue, alone or in combination with low levels of light, to selectively inactivate or inhibit intracellular replication of specific viruses,...
|
|
|
6339084 |
Process for the production of thiazine-indigo pigments
A process of forming the cis- or the trans-isomers of thiazine-indigo compounds comprising the step of reacting o-aminomercapto-carbocyclic or -heterocyclic compounds with a maleic acid or fumaric...
|
|
|
6313113 |
Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable...
|
|
|
6306437 |
Apomorphine-containing dosage forms for ameliorating male erectile dysfunction
Psychogenic impotence can be ameliorated without substantial undesirable side effects by administration of apomorphine and an antiemetic agent in an amount sufficient to substantially reduce nausea...
|
|
|
6300342 |
Antithrombotic phenylalkyl derivatives
Antithrombotic phenylalkyl derivatives of the formula ##STR1## Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphona
mido)-1,2,3,4- tetrahydro-quinoline, ...
|
|
|
6281208 |
Therapeutic agent for glaucoma
A therapeutic agent for glaucoma comprises (+)-(R)-3,4-Dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3,4-m
ethylenedioxy) phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1,4-be
nzothiazine or...
|
|
|
6274619 |
Amidino substituted tetrahydrobenzo thiophene or furan derivatives and their use as urokinase inhibitors
A compound of the formula: ##STR1## in which R 1 is hydrogen, optionally substituted lower alkylcarbamoyl(lower)alkylidene, lower alkylidene, lower alkyl, optionally substituted ar(lower)alkyl,...
|