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9040508 Compositions of protein receptor tyrosine kinase inhibitors  
The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of...
9012445 Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors  
In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of...
8999976 Modulators of cystic fibrosis transmembrane conductance regulator  
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof,...
8987254 Tetrahydropyrrolothiazine compounds  
The present invention provides a compound of Formula I: wherein R is H or F; andA is: or a pharmaceutically acceptable salt thereof.
8980883 Arylpiperazine derivatives and methods of utilizing same  
The present invention provides arylpiperazine derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic...
8962616 Heterocyclic substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds  
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding...
8962618 Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof  
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohdroxy pridines or primidines as diacylglycerol O-acyltransferase 1 DGAT-1 inhibitors to treat hyperlipidiemias and...
8946211 Fused aminodihydrothiazine derivatives  
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like...
8946210 Fused aminodihydrothiazine derivatives  
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like...
8940734 Fused aminodihydrothiazine derivatives  
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine;A is CH or N;Y is methyl, ethyl, monofluoromethyl, difluoromethyl,...
8865706 Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds  
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the...
8853197 Nitrogen containing compounds  
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
8841293 Tetrahydropyrrolothiazine compounds  
The present invention provides a compound of Formula I: Formula I wherein R is H or F; andA is: or a pharmaceutically acceptable salt thereof.
8822455 Fused aminodihydrothiazine derivatives  
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein R is hydrogen or C1-6alkyl, optionally substituted by one to five halogen atoms;n is 0, 1, 2 or...
8822456 Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds  
The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure...
8822450 1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections  
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
8778628 Arylalkylamine compound and process for preparing the same  
An arylalkylamine compound is represented by the following formula [I-e] or a pharmaceutically acceptable salt thereof.
8772282 Tetrahydropyrrolothiazine compounds  
The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F;R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN;R4 is H, F; or CN; andR5 is...
8765741 5,6-dihydro-1H-pyridin-2-one compounds  
The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is CR3, andA is and pharmaceutical compositions containing such compounds that are useful in treating...
8716280 Bicyclic antibiotics  
The antibacterial compound of formula I whereinX1, X3; X4 and X6, each independently of the others, represents a nitrogen atom or CR2, with the proviso that at least one of X1, X3; X4 and X6...
8703721 Arylalkylamine compound and process for preparing the same  
The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the...
8685963 Compounds that inhibit NFκB and BACE1 activity  
The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's...
8658639 N-substituted-cyclic amino derivative  
The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is —N(R1b)—,...
8623818 Glucagon receptor antagonists, compositions, and methods for their use  
The present invention relates to compounds of general formula (I), wherein ring A, ring B, R1, R2, R3, Z, and L1 are selected independently of each other and are as defined herein, to compositions...
8618092 Tricyclic oxazolidinone antibiotic compounds  
The invention relates to antibacterial compounds of formula I wherein is a bond or is absent, V is CH, CR6 or N; R0 is H or, if is a bond, may also be alkoxy; R1 is notably H or halogen; U is CH...
8598161 Compounds for the reduction of beta-amyloid production  
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein R1, R2, R3, R4, R5, and R6 are independently hydrogen, C1-C6 alkyl or C1-C6 cycloalkyl;...
8592408 Fused aminodihydrothiazine derivatives  
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine;A is CH or N;Y is methyl, ethyl, monofluoromethyl, difluoromethyl,...
8524707 Bicyclic pyrazoles as protein kinase inhibitors  
3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions...
8507478 Oxazolidinyl antibiotics  
The invention relates to antibacterial compounds of formula I wherein R1 is alkoxy or halogen; U and V each independently are CH or N; is a bond or is absent; W is CH or N or, when is absent, W is...
8492111 Arylalkylamine compound and process for preparing the same  
The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the...
8461133 Inclusion complexes containing an active substance, a cyclodextrin and an agent for interaction  
The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or...
8461154 Methods of utilizing arylpiperazine derivatives  
The present invention provides arylpiperazine derivatives having Formula I which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder,...
8420634 Amidine, thiourea and guanidine derivatives of 2-aminobenzothiazoles and aminobenzothiazines for their use as pharmacological agents for the treatment of neurodegenerative pathologies  
Amidine, thiourea and guanidine derivatives of appropriately substituted 2-aminobenzothiazoles, 2-amino-3,1-4H-benzothiazines and 3-amino-1,4-3H-benzothiazines, as understood from formula (I), the...
8389511 Bicyclic heterocyclic derivative  
The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H,...
8349828 Azatricyclic antibiotic compounds  
The invention relates to antibacterial compounds of formula I wherein n is 0 or 1; R1 represents H or F; U represents CH2 or, provided n is 1, O or NH; “-----” is a bond or is absent; V represents...
8349829 [4-(1-amino-ethyl)-cyclohexyl]-methyl-amine and [6-(1-amino-ethyl)-tetrahydro-pyran-3-yl]-methyl-amine derivatives as antibacterials  
The invention relates to antibacterial compounds of formula I wherein R1 represents alkoxy or halogen;U, V and W each represent CH, or one of U, V and W represents N and the others each represent...
8338407 Fused aminodihydrothiazine derivatives  
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine;A is CH or N;Y is methyl, ethyl, monofluoromethyl, difluoromethyl,...
8217029 Oxazolidinone antibiotics  
The invention relates to compounds of formula (I) wherein U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m, and n are as defined in the description, to pharmaceutically acceptable salts of...
8198269 Fused aminodihydrothiazine derivative  
A compound represented by the general formula: wherein Ring A is a C6-14 aryl group or the like, L is —NRLCO— or the like (wherein RL is a hydrogen atom or the like), Ring B is a C6-14 aryl group...
8193179 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives  
Antibacterial compounds including 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives are provided, and methods of treatment or prevention of bacterial infection with such compounds are provided.
8188073 Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents  
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a...
8158620 Fused aminodihydrothiazine derivatives  
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like...
8129369 Antifungal compounds containing benzothiazinone, benzoxazinone or benzoxazolinone and process thereof  
The present invention discloses novel compounds of the Formula (1), comprising benzothiazinone, benzoxazinone or benzoxazolinone moieties having antifungal activity, method for preparing these...
8124602 Compounds for the treatment of multi-drug resistant bacterial infections  
The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active...
8114867 Oxazolidinone antibiotic derivatives  
The invention relates to antibacterial compounds of formula I wherein R1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent CH, one or two of U, V, W and X represent(s) N and...
8106043 Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity  
The present invention features benzothiazines that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS...
8097614 Transmucosal administration of meloxicam compositions for treating and preventing disorders in non-human domesticated animals  
The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is...
8093241 Acid amide derivatives, process for their production and pesticides containing them  
The present invention relates to an acid amid derivative of the formula (I) or a salt thereof: wherein A is phenyl which may be substituted by X, benzyl which may be substituted by X, naphthyl...
8076327 Condensed imidazole derivatives as aldosterone synthase inhibitors  
The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferable pharmaceutically acceptable salts, thereof, in which R, R1, R2, R3, Q, m and n have the...
8044044 4-(1-amino-ethyl)-cyclohexylamine derivatives  
The invention relates to compounds of formula (I) wherein R0 represents H or OH; R1 represents alkoxy; U and W represent N, V represents CH and R2 represents H or F, or U and V represent CH, W...

Matches 1 - 50 out of 287 1 2 3 4 5 6 >