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RE40000 Method of treatment for decreasing mortality resulting from congestive heart failure  
A method of treatment using a compound of Formula I: wherein: R 1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R 2 is hydrogen,...
RE39300 Inhibiting the development of tolerance to and/or dependence on an addictive substance  
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor...
6878703 Pharmaceutical composition  
A pharmaceutical composition comprises an angiotensin II receptor antagonist selected from among compounds having the following formula (I), a pharmacologically acceptable salt thereof, a...
6858228 Solid oral dosage forms of valsartan  
The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ, and b) Pharmaceutically acceptable additives...
6818647 Method and composition for restoring diuretic and renal function  
Methods and compositions for restoring diuretic and renal function.
6485745 Solid oral dosage forms of valsartan  
The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ , and b) Pharmaceutically acceptable additives suitable...
6436437 Covalent polar lipid conjugates with neurologically active compounds for targeting  
This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of...
6403579 Pharmaceutical compositions containing carvedilol and hydrochlorothiazide  
A pharmaceutical combination preparation for the treatment of cardiac and cardiovascular disorders, such as hypertension, angina pectoris, cardiac insufficiency and illnesses associated therewith,...
6342247 Pharmaceutical compositions containing irbesartan  
Pharmaceutical compositions containing irbesartan, alone or in combination with a diuretic, providing tablets with a high relative amount of active agent and excellent wetting and disintegration...
6313112 Methods of protecting neuronal function  
The present invention is generally directed to potassium adenosine triphosphate ("K ATP ") channel opening compositions. The present invention also relates to the use of K ATP channel openers in...
6245787 Composition containing amlodipine or a pharmaceutically acceptable salt thereof, and an ACE inhibitor  
Methods of treating congestive heart failure in a mammal, especially a human, by co-administration of (1) amlodipine, a pharmaceutically acceptable salt of amlodipine; (2) an ACE inhibitor; and...
6242440 Synergistic compositions comprising an oxathiazine and a benzothiophene-2-carboxamide-S,S-dioxide  
This invention relates to synergistic compositions of oxathiazines and benzothiophene-2-carboxamide-S,S-dioxides for use as fungicidal preservatives in the protection of materials, such as...
6093731 Isoquinolines  
Isoquinolinylguanidine compounds of formula (I): ##STR1## wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.
5985897 Benzothiphene compounds, intermediates, compositions, and methods  
The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions,...
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5753651 Method of modifying angiotensin receptor activity for mediation of pain  
The present invention relates to a method of modifying Angiotensin II subtype 1 (AT 1 ) receptor activity for the treatment of premenstrual syndrome (PMS) and the symptoms associated therewith, and...
5688809 5-heteroarylindole derivatives  
The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical compositions...
5686451 Combination of an ace inhibitor and a diuretic  
Pharmaceutical formulations comprising as active ingredients an angiotensin converting enzyme (ACE) inhibitor at a dose level normally found effective as an antihypertensive and a diuretic at a...
5464854 Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.  
The method of treatment moderating, blocking and/or eliminating premenstrual syndrome embodies the intermittent administering of an AT1 antagonist to a female having menstrual cycles characterized...
5321012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance  
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor...
5321024 Antiviral pharmaceutical composition for treating lymphocytes  
The present invention provides a pharmaceutical composition containing 3,4-dihydro-1-phenyl-1-thio -1,2,4-benzothiadiazine 1-oxide useful for protecting lymphocytes.
5256647 Compositions comprising 1-substituted azacycloalkanes  
This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or...
5234922 Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea  
Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are...
5231083 Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia  
The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds...
5214041 Hair revitalizing tonic composition  
A hair revitalizing tonic composition comprising (i) an amine oxide and (ii) a compound having a calmodulin inhibitory activity and/or a compound having an activity as a calcium antagonist.
5155105 Pharmaceutical methods for relief of dysmenorrhea and/or premenstrual syndrome and process  
A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of ibuprofen and hydrochlorothiazide.
5140012 Method for preventing onset of restenosis after angioplasty employing pravastatin  
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering pravastatin alone or in combination with an ACE inhibitor such as captopril or...
5132106 Halogenated pyrimidine 3-oxide derivatives, their use for the treatment and prevention of hair loss and for stimulating its regrowth  
The invention relates to compounds of formula: ##STR1## in which: R 1 and R 2 denote, independently of one another, a hydrogen atom or alternatively a carbamoyl group of formula: ##STR2## with R'...
5098889 Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors  
A method is provided for imhibiting loss of cognitive functon, including memory, which may or may not be associated with Alzheimer's disease, by administering an ACE inhibitor, such as captopril,...
5047235 Pharmaceutical preparations having an antihypertensive and cardioprotective effect  
A pharmaceutical preparation, which has an anti-hypertensive and cardio-protective effect, which coprises a pharmaceutically effective amount of a combination of...
5032578 Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors  
A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a drug that acts...
5015641 Antiglaucoma agents  
Pharmaceutical compositions and a method for reducing intraocular pressure by topically applying a carboxyalkyl dipeptide are disclosed.
4981852 Chemical compounds triamterene and hydrochlorothiazide  
A diuretic pharmaceutically acceptable solution of triamterene and solutions of triamterene and hydrochlorothiazide to provide an antihypertensive and diuretic effect for those in need thereof....
4973474 2,4-diaminopyrimidine 3-oxide derivatives and their use for the treatment and prevention of hair loss  
New 2,4-diaminopyrimidine 3-oxide derivatives and their use for the treatment and the prevention of hair loss. The compounds correspond to the formula: ##STR1## in which: R 1 and R 2 denote...
4898729 Treatment of hypertension, compounds and compositions for antihypertension and diuresis  
Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve antihypertension is insufficient to achieve...
4855289 Combination of two active substances  
The invention concerns the use of a compound with diuretic properties and of a magnesium supplementation in the form of magnesium monoaspartate hydrochloride, magnesium oxide, magnesium hydroxide...
4793999 Method of manufacturing an antihypertensive, diuretic and antihypokalemic pharmaceutical composition with polyethylene glycol  
A novel method of manufacturing a novel effective antihypertensive, diuretic and antihypokalemic pharmaceutical composition in which a triamterene active pteridine, a hydrochlorothiazide active...
4670422 α-acyloxy phosphonate angiotensin converting enzyme inhibitors  
Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting...
4663322 Antihypertensive hyperuretic and saluretic agent combinations  
Hyperuretic agents of the formula: ##STR1## wherein Y is O or NH; R is OH; NHCONR 4 R 5 ; or NC(NR 4 R 5 ) 2 ; R 1 and R 2 are hydrogen, amino, or mono- or disubstituted amino,...
4594341 Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives as antihypertensives  
There are disclosed perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives and related compounds which are useful as angiotensin converting enzyme inhibitors and as...
4557934 Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one  
Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at...
4547498 Pharmaceutical combination composition and associated method  
A novel combination pharmaceutical composition is described, together with a method for making the same, wherein the pharmaceutcially active ingredients are separately milled and then formed into...
4505910 Amino-pyrimidine derivatives, compositions and use  
Herein is disclosed amino-pyrimidine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical...
4444769 Antihypertensive diuretic combination composition and associated method  
A novel combination pharmaceutical composition is described, together with a method for making the same, wherein the pharmaceutically active ingredients are separately milled and then formed into...
4409222 Pinacidil-diuretic preparation for treating hypertension or congestive heart failure  
The present invention relates to a pharmaceutical preparation containing as the vasodilator N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine and as the diuretic active component a compound...
4362724 Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic  
Novel pyrazinyl -1,2,4-oxadiazoles of the formulas: ##STR1## are useful in treating edema and hypertension, and particularly may be combined with kaliuretic diuretics such as hydrochlorothiazide...
4351832 2-(Piperazinyl)-4-pyrimidinamines  
Herein is disclosed 2-(1-piperazinyl)-4-pyrimidinamine derivatives, acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of...
4327080 Novel Bendroflumethiazide formulations and method  
New bendroflumethiazide formulations in solid form are provided which are characterized by excellent disintegration and dissolution capabilities even after long periods of storage. The new...
4311697 Derivatives of mercaptoacyl prolines and pipecolic acids  
This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity.
4285947 Aldehyde adducts of triamterene  
The invention provides novel aldehyde adducts of triamterene having improved solubility and bioavailability as compared to triamterene. Pharmaceutical compositions containing the novel adducts and...
Matches 1 - 50 out of 79 1 2 >