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RE40000 |
Method of treatment for decreasing mortality resulting from congestive heart failure
A method of treatment using a compound of Formula I:
wherein:
R 1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R 2 is hydrogen,...
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7268130 |
Benzothiadiazine compounds
The invention relates to compounds of formula (I):
wherein:
R 1 represents alkyl substituted by one or more halogen atoms, R 2 represents hydrogen, halogen or hydroxy, R 3 represents...
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7268129 |
Fluorinated benzothiadiazine compounds
Compounds of formula (I):
wherein:
R F represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R 1 represents hydrogen or a group selected from...
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7250411 |
Benzothiazine and benzothiadiazine compounds
Compounds of formula (I):
wherein:
R 1 represents hydroxy or RCO—O—, R 2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent...
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7235548 |
Compounds and their use as positive AMPA receptor modulators
The invention provides novel compounds represented by the general formula compound represented by the formula:
wherein
the bond represented by the broken line may be a single, a double...
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7091200 |
Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I:
wherein Z is —C(O)— or —S(O) 2 —, X is carbon or...
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7026317 |
Pyrazolotriazines as CRF antagonists
The present invention relates to pyrazolotriazines according to formula (I)
and stereoisomers, isomers and salts thereof wherein R 1 -R 5 are selected from certain alkyl, aryl and heteroaryl...
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6995164 |
Methods of treating tumors
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
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6919331 |
Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides...
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6894043 |
Benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same
Compound selected from those of formula (I):
wherein:
X represents flourine, bromine, iodine or methyl, each of R 1 and R 2 , which may be identical or different, represents hydrogen...
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6858228 |
Solid oral dosage forms of valsartan
The present invention is concerned with solid oral dosage forms of comprising
a) an active agent selected from valsartan and optionally HCTZ, and b) Pharmaceutically acceptable additives...
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6730668 |
6,7-dihydro-5H-pyrazolo&lsqb 1,2-a&rsqb pyrazol-1-ones which control inflammatory cytokines
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
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6656932 |
Benzo thiadiazine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are benzo thiadiazines of the Formula or a pharmaceutically acceptable salt thereof, wherein R 2 is hydrogen or alkyl; R 1 and R 3 include hydrogen, alkyl, and...
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6620808 |
Endocrine modulation with positive modulators of AMPA type glutamate receptors
Methods for modulating the endocrine system of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA receptors of the hypothalamus are administered to the host. The...
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6608051 |
Compositions and methods for treating blood
A blood collection system and method are disclosed in which taurolidine, a neutralizing agent for pathogens is added to the blood collected in standard blood bags. The taurolidine agent may be...
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6605627 |
Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-γ)....
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6521617 |
Treatment of apoptotic cell death
New methods are provided for treating against apoptotic cell death, including apoptotic cardiac and neuronal cells. Therapies of the invention include administration of a mitochondrial oxidizer...
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6485745 |
Solid oral dosage forms of valsartan
The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ , and b) Pharmaceutically acceptable additives suitable...
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6436927 |
IL-8 receptor antagonists
The present invention involves certain 8-ureido and 8-thioureido, 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the...
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6423706 |
Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after said device has been inserted in a patient...
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6350742 |
Compositions and methods for treating infections of the ear
The use of 4,4-methylenebis(tetrahydro-1,2,4-thiadiazine-1,2-dioxide) in treating infections of the ear.
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6319912 |
Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
This invention relates to cyclic combination therapies utilizing, in combination with a progestin, an estrogen, or both, progesterone receptor antagonists of the general structure: ##STR1## wherein...
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6313112 |
Methods of protecting neuronal function
The present invention is generally directed to potassium adenosine triphosphate ("K ATP ") channel opening compositions. The present invention also relates to the use of K ATP channel openers in...
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6242443 |
1,2,4-benzothiadiazine derivatives, their preparation and use
1,2,4-Benzothiadiazine derivatives represented by formula ##STR1## wherein D, R 1 , R 2 , R 3 , R 4 , R 5 , R 12 , R 13 , R 14 , R 15 are defined in the description, composition thereof and...
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6242440 |
Synergistic compositions comprising an oxathiazine and a benzothiophene-2-carboxamide-S,S-dioxide
This invention relates to synergistic compositions of oxathiazines and benzothiophene-2-carboxamide-S,S-dioxides for use as fungicidal preservatives in the protection of materials, such as...
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6197765 |
Use of diazoxide for the treatment of metabolic syndrome and diabetes complications
The present invention discloses a treatment for syndrome-X, and resulting complications, that include hyperlipidemia, hypertension, central obesity, hyperinsulinemia and impaired glucose...
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6166008 |
Treatment of schizophrenia with ampakines and neuroleptics
This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order...
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6030968 |
Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
Methods for increasing the level of neurotrophic factors and neurotrophic factor receptors in the brain of a mammal afflicted with a pathology which produces neurodegeneration without significant...
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5977160 |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
The invention involves a method for treating a human survivor of a heart attack and provides further improvement in survival following the heart attack by the early initiation and long-term...
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5952328 |
Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.
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5939442 |
Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-γ)....
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5773434 |
Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
Psychotic symptoms are treated by the administration of drugs which amplify the ability of natural stimulators of AMPA receptors to enhance the mediation of excitatory synaptic response. What is...
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5585392 |
Substituted aminomethyltetralins and their heterocyclic analogues
The method of treating stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R 1 , E...
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5554610 |
Inhalational treatment of pulmonary hypertension and related conditions
A method for the treatment and/or prophylaxis of disorders associated with pulmonary hypertension and/or disorders associated with right heart failure, in mammals, such as humans, which method...
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5488049 |
Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
The present invention is directed to the use of benzothiadiazide derivatives as nootropic agents to treat memory and learning disorders.
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5401739 |
Benzothiadiazine derivatives
A benzothiadiazine derivative, hydrate thereof and acid addition salt thereof, the derivative being represented by the general formula (I) ##STR1## wherein X is methylene or a nitrogen atom...
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5378704 |
Non-peptidic angiotensin-II-receptor-antagonists
Novel compounds having the formula ##STR1## wherein R 1 , R 2 , X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as...
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5321024 |
Antiviral pharmaceutical composition for treating lymphocytes
The present invention provides a pharmaceutical composition containing 3,4-dihydro-1-phenyl-1-thio -1,2,4-benzothiadiazine 1-oxide useful for protecting lymphocytes.
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5308857 |
Furylthiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
The invention relates to compounds of the formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , A and Q are as described, useful in the treatment of ulcers.
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5284845 |
Use of oral diazoxide for the treatment of disorders in glucose metabolism
A method is disclosed for normalizing blood glucose and insulin levels as measured by an oral glucose tolerance test in an individual exhibiting normal fasting blood glucose and insulin levels and...
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5234922 |
Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are...
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5214041 |
Hair revitalizing tonic composition
A hair revitalizing tonic composition comprising (i) an amine oxide and (ii) a compound having a calmodulin inhibitory activity and/or a compound having an activity as a calcium antagonist.
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5047235 |
Pharmaceutical preparations having an antihypertensive and cardioprotective effect
A pharmaceutical preparation, which has an anti-hypertensive and cardio-protective effect, which coprises a pharmaceutically effective amount of a combination of...
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5015641 |
Antiglaucoma agents
Pharmaceutical compositions and a method for reducing intraocular pressure by topically applying a carboxyalkyl dipeptide are disclosed.
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4997833 |
Aryloxy-aminoalkanes, and antihypertensive use thereof
Aryloxy-aminoalkanes useful as antihypertensive agents are described and disclosed.
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4927824 |
Fungicidal trisubstituted 1,3,5-triazine-2,4,6-triones
Fungicidal trisubstituted 1,3,5-triazine-2,4,6-triones of the formula ##STR1## in which R 1 stands for an optionally substituted aliphatic, aromatic or cycloaliphatic radical, R 2 stands for...
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4898729 |
Treatment of hypertension, compounds and compositions for antihypertension and diuresis
Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve antihypertension is insufficient to achieve...
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4889851 |
Benzothiadiazine compounds, and pharmaceutical composition comprising the same
A compound of the formula: ##STR1## wherein R' is phenyl, phenyl which is substituted with halogen, lower alkyl, lower alkoxy, halo lower alkyl, lower alkylamino, lower alkylthio, phenoxy, carboxy,...
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4883800 |
Quinazoline derivatives and process for their production
The invention relates to compounds having aldose reductase-inhibitory activity of the formula: ##STR1## in which R 1 and R 2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R 3 ...
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4879290 |
Agents for the prevention of ranking fights in pigs
A method of suppressing ranking fights during assembly of groups of pigs which comprises administering to such pigs an amount effective therefor of a 2-pyrimidinyl-1-piperazine derivative of the...
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