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5728693 |
Arthropodicidal oxadiazine-thiadiazine-or triazine-carboxanilides
Arthropodicidal compounds, compositions and use of compounds having the formula ##STR1##
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5698553 |
Benzylpiperidine derivatives
A benzylpiperidine compound of formula I ##STR1## in which R 1 is H, Hal or nitro, R 2 is a benzyl group, which is unsubstituted or substituted by Hal on the aromatic portion, in the 2-, 3- or...
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5646139 |
Antimicrobial carbapenem quinolones
Compounds of Structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzable esters, and hydrates thereof, are effective antiinfective agents, useful in treating and...
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5627179 |
Magnesium salt of 3-isopropyl-2, 1, 3-benzothiadiazin -4-one 2,2-dioxide, its preparation and its use for controlling undesirable plant growth
Solid, non-hygroscopic magnesium salt of 3-isopropyl-2,1,3-benzothiadiazin-4-ones 2,2-dioxide (I), processes for its preparation, solid formulations, in particular granules, which contain this...
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5620970 |
Topical ophthalmic carbonic anhydrase inhibitor formulations
The present invention is directed to topical ophthalmic formulations of carbonic anhydrase inhibitors and polyethoxylated derivatives of castor oil. Methods for using the formulations for treating...
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5589477 |
Pyrimidine derivatives and drugs
The object of the present invention is to obtain new class of compounds which have improving effect on learning and memory disorders with good selectivity in central nervous system and little side...
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5583101 |
Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease...
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5580889 |
Insecticidal nitromethyl or niteoimino-heteromethyl-heterocyclics
Novel insecticides of the formula ##STR1## in which n is 0 or 1, X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R 9 variously...
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5580869 |
1N substituted pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides
1N substituted pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides of formula I ##STR1## where: R 1 and R 2 , which may be the same or different, are members of the group formed by hydrogen, straight...
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5536719 |
Benzothiadiazine compound
A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the...
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5510347 |
Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
New thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors are disclosed. Methods for using the compounds to control IOP are also disclosed.
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5498610 |
Neuroprotective indolone and related derivatives
The present invention is directed to a method of blocking N-methyl-D-aspartic (NMDA) acid receptor sites in a mammal in need thereof with an effective NMDA blocking (neuroprotective and...
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5459138 |
Pyridothiadiazines
The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R 1 , R 2 and R 4 are as defined in the description, and medicinal products containing the same which...
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5411955 |
Thiadiazinecarboxamide derivatives, processes for their preparation and pharmaceuticals
The invention relates to thiadiazinecarboxamide derivatives of the general formula I ##STR1## to processes for their preparation, and to pharmaceuticals comprising them.
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5403837 |
1,2,4-thiadiazino[3,4-b]benzothiazole derivatives, and medicinal products containing them
This invention relates to compounds of formula (I): ##STR1## wherein R is a polyfluoroalkoxy, polyfluoroalkyl, alkoxy or alkyl radical and R 1 is a hydrogen atom or an alkyl radical; salts...
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5378704 |
Non-peptidic angiotensin-II-receptor-antagonists
Novel compounds having the formula ##STR1## wherein R 1 , R 2 , X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as...
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5223501 |
Substituted pyrimidinones bearing acidic functional groups as angiotensin II antagonists
Novel substituted fused pyrimidinones of formula (I) are useful as angiotensin II antagonists. ##STR1##
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5182275 |
Dihydro-4(hydroxyalkyeneamino)quinolines
There are disclosed novel compounds of the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, nitro or trifluoromethyl; R 1 is hydrogen or loweralkyl; R 2 is...
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5106840 |
Method of preparing n-oxo-tetrahydro-beta-carbolines
The invention relates to a method of preparing N-oxo-tetrahydro-β-carbolines having formula 1. ##STR1## wherein R 1 is lower alkyl or alkoxy, halogen, trifluoromethyl, lower alkylthio, hydroxy,...
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5102882 |
Pyroglutamide derivatives
Pyroglutamide derivatives have been found to be useful as nootropic agents for administration to humans and animals.
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5037823 |
Pharmaceutical compositions for relief of dysmenorrhea and/or premenstrual syndrome and process
A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of ibuprofen and hydrochlorothiazide, and, optionally, an antihistamine.
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5001115 |
Prodrugs of biologically active hydroxyaromatic compounds
Prodrugs of bio-active hydroxyaromatic drugs having the structural formula: A pharmaceutically acceptable prodrug of a biologically active, therapeutically effective hydroxyaromatic drug, said...
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4994476 |
Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
A series of compounds useful in treating cardiovascular disorders due to the combined expression of both β-block and calcium-block activity by these agents. This useful combination of actions is...
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4990505 |
Phenethanolamine compounds
The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The...
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4985425 |
Dissolved composition of [benzo-1,2,4-thiadiazine]-1,1-dioxide
A dissolved composition containing (A) one or more of [benzo-1,2,4-thiadiazine]-1,1-dioxide derivatives, (B) dimethyl sulfoxide, benzyl alcohol, or the mixture thereof; (C) water; and (D) one or...
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4968678 |
Tetrazole excitatory amino acid receptor antagonists
The present invention provides novel tetrazole derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.
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4950665 |
Phototherapy using methylene blue
The present invention is a method for using thiazin dyes, especially methylene blue, in combination with light to hydroxylate guanosine or deoxyguanosine at the C8 of the purine ring. The number of...
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4943570 |
Benzimidazolesulfonamides and imidazopyridinesulfonamides, and their application as drugs
Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula: ##STR1## and their pharmaceutically acceptable salts in which: Z 1 to Z 4 represent...
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4942143 |
Imidazothiadiazine derivatives, and their use as medicaments
The present invention relates to 1,3,6,7-Tetrahydro-7-oxoimidazo[4,5-c][1,2,6]-thiadiazine 2-oxide derivatives of the general formula (I): ##STR1## wherein R 1 , R 2 and R 4 are the same or...
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4891374 |
Imidazo- and triazolothiadiazines
Novel imidazo- and triazolothiadiazines of the general formula I ##STR1## in which R 1 =C 1 -C 4 -alkyl, R 2 =H or C 1 -C 3 -alkyl and the structural element --A--B--=--CH 2 --CH 2 ...
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4873237 |
2,3-dihydro- thiazolo- and thiazino- benzimidazoles as atni-hyper secretion agents
The invention relates to a method of treatment of ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof...
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4861773 |
Heterocyclic compounds
The invention relates to thiadiazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 7-(1H-imidazol-1-yl)-9,9a-dihydroindeno[1,2-e][1,3,4]-thiadi
azin-2(3H)-one .
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4737500 |
1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents
Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.
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4636499 |
Sulphenamides
Novel compounds of the formula IIIa ##STR1## wherein R 1a , R 2a , R 3a and R 4a are the same or different and are hydrogen, an alkyl, alkoxy optionally completely or predominantly substituted by...
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4616013 |
Fused thiadiazines
This invention relates to thiadiazinone derivatives which have inotropic and vasodilator activity. A specific compound of this invention is...
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4612311 |
1,2,4-benzothiadiazine oxide derivatives
1,2,4-Benzothiadiazine oxide derivatives of the general Formula I ##STR1## in which R 1 represents an unsubstituted or substituted aryl radical; R 2 and R 5 , which may be the same or...
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4578459 |
Heterocyclic alkylaminoheterocycles
Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is...
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4558044 |
1,2,4-Benzothiadiazines
Disclosed are compounds of the formula R 1 --Ar--(CH 2 ) a --X--(CH 2 ) b --NH--Het wherein R 1 is guanidino or substituted guanidino, Ar is furandiyl, thiophendiyl, phenylene, pyridinediyl,...
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4544655 |
Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methyl-n-(2-pyridyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2- thiazine-3-carboxamide 1,1-dioxide, corresponding compositions, and 3-carboxylic acid lower alkyl ester intermediates
4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-
2H-thieno[2,3-e ]-1,2-thiazine 1,1-dioxide of the formula ##STR1## and its pharmaceutically acceptable salts which possess valuable...
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4443445 |
Imidazo- and pyrimido-1,3,5-thiadiazin-4-ones
The invention relates to novel substituted imidazo- and pyrimido-1,3,5-thiadiazin-4-ones of the formula ##STR1## wherein each of R 1 , R 2 and R 3 independently of one another is hydrogen,...
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4390536 |
Piperidine derivatives
New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
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4221790 |
Substituted 2,2-dioxo-1,2,3-benzoxathiazines
The invention relates to novel 2,2-dioxo-1,2,3-benzoxathiazines substituted in the benzene nucleus, as well as the 3,4-dihydro analogs thereof, useful as anti-inflammatory, antipyretic, analgesic...
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4219541 |
Novel oral composition for the care of the mouth and teeth
An oral composition for the care of the mouth and teeth which contains as an active ingredient, a compound of the formula: ##STR1## wherein R 1 and R 2 , which may be the same or different, are...
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4171361 |
1-Substituted-3-amino-6,7-dialkoxy-1H-1,2,4-benzothiadiazine-1-oxides
1-Substituted-3-amino-6,7-dialkoxy-1H-1,2,4-benzothiadiazine
-1-oxides, useful as hypotensive agents.
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4100280 |
1,3-Dialkyl-6,7-methoxy-1H-1,2,4-benzothiadiazine-1-oxides
1,3-Dialkyl-6,7-methoxy-1H-1,2,4-benzothiadiazine-1-oxides, useful as hypotensive agents.
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4069325 |
3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives
3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives are disclosed as well as a process for their manufacture. The compounds are suitable for combatting helminths and especially gastrointestinal...
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4042693 |
Derivatives of 1,2,4-thiadiazine
This invention relates to new derivatives of 1,2,4-thiadiazine having anti-inflammatory properties. The new derivatives of 1,2,4-thiadiazine may be represented by the following general formula:...
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4018920 |
3-Halohydrocarbylthio-1,2,3-benzoxathiazin-4-(3H)-one 2-oxides
Compounds of the formula ##STR1## wherein R is an alkyl group or an alkenyl group, each substituted with 1 to 5 halogen atoms of atomic number 9 to 35, and X is halogen of atomic number 9 to 35,...
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3954984 |
Triazolocycloalkylthiadiazine derivatives
Novel triazolocycloalkylthiadiazines, their preparation, and use as antisecretory agents and central nervous system depressants.
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3954983 |
Triazolobenzocycloalkylthiadiazine derivatives
Novel triazolobenzocycloalkylthiadiazines, their preparation, and use as central nervous system antidepressants.
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