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7384936 Carboxamidine derivatives and their use in the treatment of vascular diseases  
The invention relates to carboxamidine derivatives to pharmaceutical compositions containing the same and the use thereof in the preparation of pharmaceutical compositions for the treatment of...
7371743 Carboxylic acid amides, the preparation thereof and their use as medicaments  
The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the...
7358239 Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives  
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
7323460 N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors  
N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R...
7273862 Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives  
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
7253160 Depeptidized inhibitors of hepatitis C virus NS3 protease  
The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them...
7217706 Propanolamine derivatives  
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which...
7186730 Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials  
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
7151099 Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases  
Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer.
7141562 Substituted benzoxazinones and uses thereof  
Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO 2 — or —(CR a R b ) r —, n is 1 or 2, R 2 is aryl or...
7122541 Methods of inhibiting metastases  
The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue...
7064136 Compounds  
A compound having the general formula and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
7015216 Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors  
Disclosed are a series of heteroaryl-β-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.
6995164 Methods of treating tumors  
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
6964959 Use of a methylol-containing compound to treat tumors  
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing methylol-containing compound. The composition is administered to...
6927215 Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I)  
The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which X represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n...
6921759 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors  
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
6900222 Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives  
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
6878702 Anti-inflammatory agents  
The use of mitochondrial K ATP channel openers, particularly compounds of general formula (I), for the treatment or prevention of inflammation by inducing apoptosis of inflammatory cells.
6849623 Xanthine and phenazone-acesulfame-H complexes having improved taste, process for their preparation and their use  
Complex compounds or adducts of xanthine derivatives, for example propentofylline or pentoxyfylline, or phenazone derivatives, for example phenazone, propylphenazone and aminophenazone, and...
6828317 Antimicrobial thiadiazinone derivatives and their application for treatment of bacterial infections  
The present invention provides certain thiadiazinone derivatives of oxazolidinones of the following formula I: or pharmaceutically acceptable salts thereof that are antibacterial agents,...
6825192 Heterodiazinone derivatives  
The present invention provides a hetrodiazinon compound having 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonistic action, which is represented by the following...
6821968 Stable taurolidine electrolyte solutions  
A taurolidine composition includes an aqueous solution containing about 1.5-3% by weight taurolidine, the solution containing a stability-enhancing effective amount of at least one physiologically...
6815441 Reaction products of taurultam and glucose  
Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30...
6803363 Peritoneal dialysis solution with taurolidine  
The present invention contemplates the addition of 0.5% to 4% taurolidine into solutions used peritoneal dialysis. The taurolidine is intended to prevent or reduce the incidence of infection within...
6753328 Methods of inhibiting metastases  
The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue...
6703413 Use of taurolidine to treat tumors  
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
6699857 Tetrahydroquinolinyl 6-methyldihydrothiadiazinone derivatives and use thereof  
The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for treating anaemia. The invention...
6686388 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
6683028 Cyclic guanidine derivatives and their use as pesticides  
The invention relates to novel guanidine derivatives of the formula (I) in which A, R 1 , R 2 , R 3 and Z are as defined in the description, to a process for their preparation and to their use...
6679870 Methods and kits for locking and disinfecting implanted catheters  
Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, most preferably isopropanol, and an additive, the additive comprising an...
6630464 Cyclin dependent kinase (CDK)4 inhibitors and their use for treating cancer  
Certain derivatives of acridones and benzothiadiazines have been found to have anti-cancer properties by virtue of their specific inhibition of the cyclin D dependant kinase CDK4. These molecules...
6608051 Compositions and methods for treating blood  
A blood collection system and method are disclosed in which taurolidine, a neutralizing agent for pathogens is added to the blood collected in standard blood bags. The taurolidine agent may be...
6569852 Coatings and soaks for medical prosthetic devices comprising taurinamide derivatives and carboxylic acids and/or salts thereof  
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after the device has been inserted in a patient by...
6562811 Pyridine derivatives  
Pyridine compounds of general formula: wherein —R 1 represents in which R 11 is hydrogen, C 1-6 alkyl, halogen, hydroxy, C 1-12 alkoxy, nitro, amino, C 1-6 alkylsulfonylamino, C 1-6 ...
6555534 Method and compositions for the control or eradication of Helicobacter pylori  
The use of 4,4-methylenebis (tetrahydro-1,2-4-thiadiazine-1,1 -dioxide) in the eradication and control of the microorganism Helicobacter pylori in humans is disclosed.
6521616 Methods of treating tumors with taurolidine  
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
6500818 Naphthalenecarboxamides as tachykinin receptor antagonists  
Compounds having the following formula wherein L, M, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 are as defined in the specification, pharmaceutically-acceptable salt thereof, useful for...
6498157 Coatings and soaks for medical prosthetic devices comprising taurinamide derivatives and carboxylic acids and/or salts thereof  
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after said device has been inserted in a patient...
6495546 Propanolamine derivatives  
Propanolamine derivatives represented by the following formula (I): These derivatives may be β 3 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and...
6479481 Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS)  
Methods and compositions for the treatment and/or prophylaxis and/or suppression of primary and/or secondary tumors of the central nervous system (brain and spinal cord, eyes) in mammalian subjects...
6461646 Pharmaceutical composition for preventing and/or curing digestive disorders  
The invention provides a pharmaceutical composition for preventing and/or curing digestive disorders such as digestive ulcers, gastritis, etc. The pharmaceutical composition contains, as the active...
6436926 Compositions and methods for treating superficial fungal infections  
Compositions comprising 4,4′-methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1′,1′,-tetraoxide and their use in treating dermatologic disorders are disclosed.
6429224 Use of taurolidine to treat tumors  
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
6423718 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors  
The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms...
6423706 Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof  
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after said device has been inserted in a patient...
6407098 Fungicidal aza-heterocycloalkenes  
The application relates to novel heterocycloalkenes, to a number of processes for their preparation and to their use as fungicide.
6407097 Methoximinomethyloxathiazines  
The invention relates to novel methoximinomethyloxathiazines, to two processes for their preparation and to their use as pesticides.
6384056 Heterocyclic thioesters or ketones for vision and memory disorders  
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic...
6362134 Herbicidal 1,2,4,6-thiatriazines  
Compounds of formula (I), in which R 1 , R 2 and R 3 are as defined in claim 1, are particularly suitable as herbicides.
Matches 1 - 50 out of 190 1 2 3 4 >