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7384936 |
Carboxamidine derivatives and their use in the treatment of vascular diseases
The invention relates to carboxamidine derivatives to pharmaceutical compositions containing the same and the use thereof in the preparation of pharmaceutical compositions for the treatment of...
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7371743 |
Carboxylic acid amides, the preparation thereof and their use as medicaments
The present invention relates to new substituted carboxylic acid amides of general formula
wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the...
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7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
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7323460 |
N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I):
wherein R...
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7273862 |
Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
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7253160 |
Depeptidized inhibitors of hepatitis C virus NS3 protease
The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7186730 |
Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
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7151099 |
Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases
Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer.
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7141562 |
Substituted benzoxazinones and uses thereof
Compound of the Formula:
and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO 2 — or —(CR a R b ) r —, n is 1 or 2, R 2 is aryl or...
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7122541 |
Methods of inhibiting metastases
The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue...
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7064136 |
Compounds
A compound having the general formula
and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
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7015216 |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
Disclosed are a series of heteroaryl-β-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.
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6995164 |
Methods of treating tumors
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
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6964959 |
Use of a methylol-containing compound to treat tumors
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing methylol-containing compound. The composition is administered to...
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6927215 |
Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I)
The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I)
in which
X represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n...
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6921759 |
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
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6900222 |
Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
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6878702 |
Anti-inflammatory agents
The use of mitochondrial K ATP channel openers, particularly compounds of general formula (I), for the treatment or prevention of inflammation by inducing apoptosis of inflammatory cells.
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6849623 |
Xanthine and phenazone-acesulfame-H complexes having improved taste, process for their preparation and their use
Complex compounds or adducts of xanthine derivatives, for example propentofylline or pentoxyfylline, or phenazone derivatives, for example phenazone, propylphenazone and aminophenazone, and...
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6828317 |
Antimicrobial thiadiazinone derivatives and their application for treatment of bacterial infections
The present invention provides certain thiadiazinone derivatives of oxazolidinones of the following formula I: or pharmaceutically acceptable salts thereof that are antibacterial agents,...
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6825192 |
Heterodiazinone derivatives
The present invention provides a hetrodiazinon compound having 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonistic action, which is represented by the following...
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6821968 |
Stable taurolidine electrolyte solutions
A taurolidine composition includes an aqueous solution containing about 1.5-3% by weight taurolidine, the solution containing a stability-enhancing effective amount of at least one physiologically...
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6815441 |
Reaction products of taurultam and glucose
Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30...
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6803363 |
Peritoneal dialysis solution with taurolidine
The present invention contemplates the addition of 0.5% to 4% taurolidine into solutions used peritoneal dialysis. The taurolidine is intended to prevent or reduce the incidence of infection within...
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6753328 |
Methods of inhibiting metastases
The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue...
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6699857 |
Tetrahydroquinolinyl 6-methyldihydrothiadiazinone derivatives and use thereof
The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for treating anaemia. The invention...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6683028 |
Cyclic guanidine derivatives and their use as pesticides
The invention relates to novel guanidine derivatives of the formula (I) in which A, R 1 , R 2 , R 3 and Z are as defined in the description, to a process for their preparation and to their use...
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6630464 |
Cyclin dependent kinase (CDK)4 inhibitors and their use for treating cancer
Certain derivatives of acridones and benzothiadiazines have been found to have anti-cancer properties by virtue of their specific inhibition of the cyclin D dependant kinase CDK4. These molecules...
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6608051 |
Compositions and methods for treating blood
A blood collection system and method are disclosed in which taurolidine, a neutralizing agent for pathogens is added to the blood collected in standard blood bags. The taurolidine agent may be...
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6569852 |
Coatings and soaks for medical prosthetic devices comprising taurinamide derivatives and carboxylic acids and/or salts thereof
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after the device has been inserted in a patient by...
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6555534 |
Method and compositions for the control or eradication of Helicobacter pylori
The use of 4,4-methylenebis (tetrahydro-1,2-4-thiadiazine-1,1 -dioxide) in the eradication and control of the microorganism Helicobacter pylori in humans is disclosed.
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6521616 |
Methods of treating tumors with taurolidine
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
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6500818 |
Naphthalenecarboxamides as tachykinin receptor antagonists
Compounds having the following formula wherein L, M, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 are as defined in the specification, pharmaceutically-acceptable salt thereof, useful for...
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6479481 |
Methods and compositions for treating primary and secondary tumors of the central nervous system (CNS)
Methods and compositions for the treatment and/or prophylaxis and/or suppression of primary and/or secondary tumors of the central nervous system (brain and spinal cord, eyes) in mammalian subjects...
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6461646 |
Pharmaceutical composition for preventing and/or curing digestive disorders
The invention provides a pharmaceutical composition for preventing and/or curing digestive disorders such as digestive ulcers, gastritis, etc. The pharmaceutical composition contains, as the active...
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6436926 |
Compositions and methods for treating superficial fungal infections
Compositions comprising 4,4′-methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1′,1′,-tetraoxide and their use in treating dermatologic disorders are disclosed.
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6423718 |
4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms...
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6423706 |
Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after said device has been inserted in a patient...
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6407098 |
Fungicidal aza-heterocycloalkenes
The application relates to novel heterocycloalkenes, to a number of processes for their preparation and to their use as fungicide.
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6407097 |
Methoximinomethyloxathiazines
The invention relates to novel methoximinomethyloxathiazines, to two processes for their preparation and to their use as pesticides.
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6384056 |
Heterocyclic thioesters or ketones for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic...
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6362134 |
Herbicidal 1,2,4,6-thiatriazines
Compounds of formula (I), in which R 1 , R 2 and R 3 are as defined in claim 1, are particularly suitable as herbicides.
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6350251 |
Biocidal locks
Disclosed herein is an internal prosthetic device comprising: (a) device for providing a continuous flowpath, crossing a patient's skin, between an external-to-patient site and an...
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6337340 |
Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
This invention relates to novel compositions and uses of carboxylic acid or isostere of a heterocyclic ring compound having two or more heteroatoms within the heterocyclic ring and wherein the...
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6319912 |
Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
This invention relates to cyclic combination therapies utilizing, in combination with a progestin, an estrogen, or both, progesterone receptor antagonists of the general structure: ##STR1## wherein...
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6313111 |
Substituted 6H-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and pharmaceutical composition containing them
Substitued 6H-1,3,4-thiadiazin-2-amines of the following general formula: ##STR1## wherein Ar is phenyl optionally substituted with one or more chloro, bromo atoms, C 1 -C 4 alkoxy, or C 1 -C 4 ...
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6303596 |
Use of taurolidine for treatment of leukemias
The invention relates to selective induction of cell death by apoptosis and applicability to treatment of leukemias.
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6265398 |
Substituted pyridines/pyrimidines, their preparation and their use as pesticides
The present invention relates to novel substituted pyridines/pyrimidines of the formula I ##STR1## where A is CH or N; X is NH, O or S(O) q where q is 0, 1 or 2; Y 1 , Y 2 and Y 3 ...
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