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7618988 |
Use of substituted aminomethyl chromans
Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
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7579389 |
Antimicrobial acrylic polymer
An antimicrobial additive composition is provided which economically and efficiently imparts antimicrobial characteristics to acrylic polymers, and particularly thermoformable acrylic sheets made...
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7538101 |
1,1-dioxo-thiomorpholinyl indolyl methanone derivatives
The present invention relates to compounds of formula I
wherein R 1 , R 2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are...
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7507730 |
Substituted pyrazolo[1,5-a]pyrimidines as potassium channel activators
Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors...
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7435731 |
Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same
Compounds of the formula Ia or Ib:
wherein A, B, X, Y, Z, W, k, R 1 , R 2 , R 3 , R 4 and R 5 are those defined herein, and compositions comprising the same. The present invention also...
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7411093 |
Aminocycloalkanes as DPP-IV inhibitors
The present invention relates to compounds of formula (I)
wherein R 1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for...
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7388029 |
Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
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7371743 |
Carboxylic acid amides, the preparation thereof and their use as medicaments
The present invention relates to new substituted carboxylic acid amides of general formula
wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the...
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7323460 |
N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I):
wherein R...
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7259157 |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I):
or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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7250157 |
Dermatological compositions and methods
Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin...
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7244725 |
Acetyl 2-hydroxy-1, 3-diaminoalkanes
Disclosed are compounds of the formula:
where variables Z, X, R 15 , R 2 , R 3 , and R C are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
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7229644 |
Pharmaceutical formulations of modafinil
The present invention is related to compositions of modafinil, including compositions of modafinil and one or more diluents, disintegrants, binders and lubricants, and the processes for their...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7205289 |
Combinations of active ingredients with insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
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7192948 |
Bicyclic heterocycles as HIV integrase inhibitors
The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the...
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7176209 |
Fungicidal formulation
Adjuvants selectes from mon/ionic water/soluble mixed polyalkoxy-lated aliphatic alcohol surfactants, non ionic water soluble ethoxylated aliphatic alcohol surfactants, amine ethoxylates, and...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7135467 |
HIV integrase inhibitors
Compounds useful for treating HIV are disclosed having the general formula
wherein R 1 , R 2 , and B are as defined in the specification. Compositions containing the compounds and methods for...
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7115599 |
Sulfonamide-substituted pyrazolopyridine compounds
This invention relates to compounds of the formula
in which R 1 , R 2 , and R 3 are as defined in the claims, to a process for preparing such compounds, to pharmaceutical compositions...
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7064136 |
Compounds
A compound having the general formula
and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
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7053055 |
Compounds of unstable DP IV-inhibitors
Novel compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The compounds can be used...
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7037908 |
HIV integrase inhibitors
The present invention relates to a series of pyrimidine compounds of Formula I which inhibit HIV integrase and to pharmaceutical compositions and methods of treatment for AIDS or ARC using these...
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7008798 |
Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
The present invention pertains to luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by...
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7008903 |
Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I)
wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active...
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6927215 |
Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I)
The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I)
in which
X represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n...
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6927216 |
Cyclic sulfonyl compounds as inhibitors of metalloproteases
The present application describes novel cyclic sulfonyl derivatives of formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing...
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6924282 |
Sodium salt of an HIV integrase inhibitor
A sodium salt of Compound A is disclosed, wherein Compound A is of formula:
Compound A is an HIV integrase inhibitor useful for preventing or treating HIV infection, for delaying the onset of...
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6921759 |
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
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6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
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6844366 |
Sulfonamide hydroxamates
This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for...
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6835743 |
Pesticidal pyrazoles and derivatives
Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said...
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6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
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6723343 |
Pharmaceutical tramadol salts
Disclosed are a compound of tramadol and a sugar substitute, pharmaceutical compositions and sustained-release formulations comprising the compound, and methods of treatment using the compound. The...
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6683076 |
Methods for therapeutic use of glucosylceramide synthesis inhibitors and composition thereof
Methods for treatment of disorders associated with glycolipid accumulation, such as Niemann-Pick Type C (NPC) disease, comprising administering a therapeutically effective amount of an inhibitor of...
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6605627 |
Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-γ)....
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6596716 |
2-propane-sulphonamide derivatives
The present invention relates to the potentiation of glutamate receptor function using certain 2-propane-sulphonamide derivatives. It also relates to novel 2-propane-sulphonamide derivatives, to...
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6586426 |
β-sheet mimetics and use thereof as protease inhibitors
There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, the β-sheet mimetics...
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6569862 |
Methods for treatment of disorders of cardiac contractility
The present invention relates to methods for modulating calcium sensitivity of cardiac muscle. In preferred aspects, the invention provides methods for enhancing myocardial contractility and...
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6569852 |
Coatings and soaks for medical prosthetic devices comprising taurinamide derivatives and carboxylic acids and/or salts thereof
The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after the device has been inserted in a patient by...
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6525099 |
N-substituted sulfonamide derivatives
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
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6500818 |
Naphthalenecarboxamides as tachykinin receptor antagonists
Compounds having the following formula wherein L, M, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 are as defined in the specification, pharmaceutically-acceptable salt thereof, useful for...
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6448008 |
Fluorescent cyanine labels containing a sulfamido linker arm
A fluorescent cyanine dye of the following general formula is disclosed: wherein: X 1 and X 2 are independently selected from the group consisting of —O—, —S—, —C(CH 3 ) 2 or...
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6436437 |
Covalent polar lipid conjugates with neurologically active compounds for targeting
This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of...
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6420360 |
Sultam and sultone derived oxazolidinones
The present invention provides a compound of formula I These compounds are useful as antibiotic agents.
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6407096 |
Benzene fused heterocyclic derivatives having thromboxane A2 receptor antagonistic activity and prostaglandin I2 Agonistic activity and application thereof
Benzene fused derivatives represented by the following formula: having strong TXA 2 receptor antagonistic action and PGI 2 receptor agonistic action, and effective for treating or preventing...
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6365587 |
Substituted aryl hydroxamic acids as metalloproteinase inhibitors
The present application describes novel substituted aryl hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring A is a 5-8 membered ring containing from...
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6350742 |
Compositions and methods for treating infections of the ear
The use of 4,4-methylenebis(tetrahydro-1,2,4-thiadiazine-1,2-dioxide) in treating infections of the ear.
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6344485 |
Method for treating glaucoma
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
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