Matches 401 - 450 out of 484 < 1 2 3 4 5 6 7 8 9 10 >
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4329341 5-Phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-ones, and pharmaceutical compositions containing them  
The invention relates to new optically active or racemic 5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one derivatives of the general formula (I) ##STR1## wherein R 1 stands for hydrogen,...
4328222 Pharmaceutical compositions for parenteral or local administration  
Colloidal aqueous vehicles, useful for the solubilization of insoluble or slightly soluble medicaments and suitable for parenteral or local administration, are disclosed. The vehicles contain, in...
4322422 Oxalylated amidinohydrazones, method for preparing same and use as insect and fire ant control agents  
There are provided certain oxalylated amidinohydrazones, and methods of use of the compounds for the control of insects, especially Lepidopterous insects, and for the control of ants, family...
4320124 Composition for enhancing binding of a benzodiazepine to central benzodiazepine receptors and use thereof  
Pharmaceutical compositions comprising the combination of a benzodiazepine and certain 1,9-dihydroxyoctahydrophenanthridine and 1-hydroxyhexahydrophenanthridine-9(8H)-one analgesic agents to...
4316897 Method of lowering serum prolactin  
Benzodiazepine derivatives which have tranquillizing activity, especially 1,4-benzodiazepine derivatives, can lower the serum prolactin concentration. They can reduce, dosage-dependently, the...
4313943 7-Chloro-2,3-dihydro-5-phenyl-1-propargyl-1H-1,4-benzodiazepine-2-one, and a pharmaceutical composition thereof  
The invention relates to 1-propargyl-5-(halo) phenyl-1,4-benzodiazepines, and particularly to 7-chloro-2,3-dihydro-5-phenyl-1-propargyl-1H-1,4-benzodiazep ine-2-one endowed with psycho-sedative,...
4305952 8-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)(1,4)-diazepine-1H, 4H-5,7-diones, and medicaments containing these  
8-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-b)(1,4)diazepine-1H,4H -5,7-diones of the formula ##STR1## in which R 1 through R 5 are as defined in the specification, and medicaments containing these...
4302468 4-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)-(1,5)diazepine-1H,4H-5,7-diones and medicaments containing same  
Compound of the general formula ##STR1## in which R 1 and R 2 are identical or different and represent hydrogen atoms or alkyl groups with 1-6 C atoms, it also being possible for one of the...
4261987 3-Di-n-propyl-acetoxy-benzodiazepine-2-ones and pharmaceutical compositions thereof  
Novel 3-Di-n-Propyl-Acetoxy-Benzodiazepine-2-Ones and use thereof as anti-convulsant compounds.
4246270 3-Fluorobenzodiazepines and compositions and uses thereof  
3-Fluorobenzodiazepines, such as 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzo diazepin-2-one , useful as tranquilizers, muscle relaxants, and sedatives.
4239684 1,5'-Benzodiazepine-2-ones, pharmaceutical compositions thereof and method of use thereof  
1-Aryl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones of the general formula ##STR1## wherein: R 1 is hydrogen, lower alkyl, preferably of 1-3 carbons, or unsaturated lower alkyl preferably of 2-3...
4235897 Benzodiazepine derivatives and pharmaceutical compositions thereof  
The invention relates to benzodiazepine compounds of the formula: ##STR1## wherein R 5 is C 1 -C 4 alkyl, R 3 is C 1 -C 4 alkyl, and R 4 is selected from Cl and F, and medicaments containing...
4235905 1H-Pyrimido[4,5-c]-1,2-diazepines  
Compounds of the general formula (I) ##STR1## wherein R 1 and R 2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a...
4232016 3-Fluorobenzodiazepines  
3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R 1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8...
4229447 Intraoral methods of using benzodiazepines  
A method of therapeutically administering benzodiazepines by the intraoral, i.e. sublingual or buccal route is disclosed.
4213983 Treating gastro-intestinal disorders and emesis with n-(heterocyclic substituted) benzamides  
Compounds of the formula (I), and their pharmaceutically acceptable salts: ##STR1## wherein: R 1 is a C 1 -6 alkoxy group; R 2 and R 3 are the same or different and are hydrogen, halogen, CF...
4213982 Novel 4H-S-triazolo[4,3-A] [1,5]benzodiazepin-5-ones  
Compounds of the following formula ##STR1## are useful as central nervous system depressants, tranquilizers, sedatives, growth promotors, anti-convulsants and muscle relaxants in mammalian species.
4190654 Pharmaceutical composition comprising anxiolytic drugs and beta-adrenergic receptor blocking agents  
A pharmaceutical composition for the therapeutical treatment of anxiety and neurodystonic states characterized by combining an anxiolytic belonging to the class of the benzodiazepines and a...
4189478 Medicinal composition and its use as antidepressive agent  
What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R 1 , R 3 and R 4 , which may be identical or different, and...
4182760 Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents  
N-Fluorohaloacetyl-N-methylaminobenzophenone anti-oxime, the corresponding diazepin-N-oxides, their use as tranquilizers, muscle relaxants and sedatives, and their use as intermediates in the...
4170649 1,4-Benzodiazepine derivatives, pharmaceutical compositions thereof, and process for their preparation  
New 1,4-benzodiazepine derivatives are disclosed which are substituted in 2-position by cyanomethylene or carbamoylmethylene and have the formula ##STR1## wherein R 1 represents hydrogen, halogen,...
4158707 Parenteral preparations  
Aqueous vehicles for insoluble or sparingly soluble medicaments suitable for parenteral administration are disclosed. The subject vehicles contain, in addition to pharmaceutical adjunct materials...
4156009 Diazepine derivatives  
The invention relates to 6-cyclopropyl-1,3-dihydro-1-methyl-5-phenyl-2-oxo-2H-thieno [2,3-e] diazepine and pharmaceutically acceptable non-toxic acid addition salts, these compounds being useful as...
4151285 1,5-Disubstituted-1,2-dihydro-2H-1,4-benzodiazepin-2-ones  
1,5-Disubstituted-1,2-dihydro-2H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R is hydrogen or fluoro, R 1 is hydrogen, fluoro chloro, bromo or trifluoromethyl, and n is 2 to 4, having...
4147789 6-Methyl-8-thiomethyl-ergolene derivatives  
This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring...
4145417 Benzodiazepines  
Novel aldehyde adducts of 1,4-benzodiazepine-4-oxides, novel azeto- 1,4!-benzodiazepine derivatives derived therefrom, acid addition salts thereof and methods for their preparation. The aldehyde...
4088756 Pharmaceutical composition and process of treatment  
A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans, or domesticated animals,...
4076817 Certain thiazolo compounds as acaricidal agents  
Quaternary 5,6-dihydroimidazo[2,1-b]thiazolium salts and novel quaternary 6,7-dihydro-[5H]thiazolo[3,2-a]pyrimidinium and 5,6,7,8-tetrahydrothiazolo[3,2-a][1,3]diazepinium salts, their preparation...
4061745 Azeto [2,3-b][1,4] benzo diazepines  
Novel aldehyde adducts of 1,4-benzodiazepines-4-oxides, novel azeto-[1,4]-benzodiazepine derivatives derived therefrom, acid addition salts thereof and methods for their preparation. The aldehyde...
4060608 Substituted hydroxymethyl benzodiazepines  
Novel 2-disubstituted amino 3H-1,4-benzodiazepines and their 4-oxides, acid addition salts thereof and a method for their preparation from 2-monosubstituted amino benzodiazepines and their 4-oxides.
4046890 Benzodiazepine derivatives  
This invention is directed to pharmacologically active compounds of the formula ##STR1## wherein R 1 represents a hydrogen atom or lower alkyl group and R 2 represents a halogen atom. The...
4045569 Optically active 1,4-benzodiazepines and process for use as a tranquilizer  
Compositions, useful as tranquilizers containing, as active ingredient, an optically active compound having the formula: ##STR1## having an asymmetric carbon atom in position 3 having the S...
4028466 Analgesic compositions comprising dextro-propoxyphene and benzodiazepine and process  
Analgesic compositions having a remarkably high analgesic activity and a process for obtaining an analgesic effect are provided, in which the active components are dextro-propoxyphene and at least...
4028467 Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process  
Analgesic compositions having a remarkably high analgesic activity and a process for obtaining an analgesic effect are provided, in which the active components are levopropoxyphene and a...
4017616 Parenteral benzodiazepine compositions  
Stable, non-aqueous parenteral dosage forms of benzodiazepine compounds comprise from about 10% to about 65% polyethylene glycol, from about 35% to about 90% propylene glycol, from 0% to about 10%...
4017619 Anesthetic and sedative composition  
An anesthetic and sedative composition comprising a mixture of ketamine hydrochloride and diazepam is disclosed. The ratio of ketamine hydrochloride to diazepam is 10:1. As administered in...
4009271 6-Aza-3H-1,4-benzodiazepines  
There are produced 6-aza-3H-1,4-benzodiazepines and 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula: ##STR1## wherein R 1 is the group --NR a R b or --NR a R b R c halide and R a and...
4001408 Substituted heterocyclic compounds, processes and composition including those  
This invention relates to substituted 1,5-benzodiazepines having the formula ##STR1## wherein R 1 and R 2 are hydrogen or substituents R 3 is hydrogen or substituents R 4 is methyl or aryl...
3989829 1,4-Benzodiazepines  
Benzodiazepine derivatives of the formula, ##SPC1## Wherein R 1 is a C 2 -4 alkenyl group, R 2 is a halogen atom and R 3 is a hydrogen or halogen atom, which are useful as minor tranquilizer and...
3984545 Novel method and compositions for treating paralysis agitans  
An improvement in the method of treating paralysis agitans by administration of 3,4-dihydroxy-phenyl-1-alanine, its hydrates and salts thereof is disclosed, which comprises administering it...
3978227 5-Furoyl-2,2,4-trimethyl-1,4-dihydro-1H-1,5-benzodiazepine as an anti-inflammatory agent  
5-furoyl-2,2,4-trimethyl-1,4-dihydro-1H-1,5-benzodiazepine as an anti-inflammatory agent.
3960757 Process for encapsulation of medicaments  
Encapsulated medicaments are prepared by dissolving a wall material for capsules in at least one organic solvent poorly miscible with water which has a boiling point of less than 100°C., a vapor...
3956492 Pharmaceutical compositions containing a 3-(amino-methylene)-5-phenyl-1,4-benzodiazepin-2-one and method of use  
Pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##SPC1## Wherein R 1 and R 2 , which may be identical to or different from each other, are...
3952108 Scopolamine derivatives for treating ulcers and spasms  
The specification describes quaternary bromides of scopolamine in which the substituent on the nitrogen atom has the formula --(CH 2 ) n -R in which R represents a cycloalkyl group containing up...
3934018 4,6-Dihydro-1,3-dimethyl-8-phenylpyrazolo[4,3-e] [1,4]diazepin-5-(1H)-one and derivatives as anti-inflammatory agents  
A method of relieving inflammation and its concomitant swelling, tenderness and pain by administering therapeutically effective amounts of 4,6,-dihydro-1,3-dimethyl-8-phenylpyrazolo[4,3-e]...
3932637 Methods and compositions for improving the feed intake of meat producing animals  
Compositions and methods for inducing polyphagia in immature meat producing animals comprise administering orally or by injection an effective but nontoxic subpharmacodynamic quantity of a...
3928589 Novel method and compositions  
An improvement in the method of treating paralysis agitans by administration of 3,4-dihydroxy-phenyl-1-alanine, its hydrates and salts thereof is disclosed, which comprises administering it...
3920818 1-Polyfluoroalkyl-1,4-benzodiazepin-2-thiones for effecting tranquilization, sedation and treating colvulsions  
Disclosed herein are 1-polyfluoroalkyl-1,4-benzodiazepin-2-thiones, a new class of chemical compounds particularly useful as sedatives, anti-anxiety agents and anti-convulsants.
3903276 N-carboxymethyl-N-substituted glycinate esters of 3-hydroxy-1,4-benzodiazepin-2-ones for inducing a calming effect  
This invention is directed toward novel central nervous system depressants of the formula: ##EQU1## wherein R 1 is a member selected from the group consisting of the hydrogen, lower alkyl, benzyl...
3886276 1,3-Dihydro-3 -hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts in compositions and methods for inducing a calming effect  
This invention is directed to novel central nervous system depressants of Formula I: ##SPC1## wherein R 1 is selected from the group consisting of (lower)alkyl and ar(lower)alkyl; R 2 is selected...
Matches 401 - 450 out of 484 < 1 2 3 4 5 6 7 8 9 10 >