Matches 351 - 400 out of 484 < 1 2 3 4 5 6 7 8 9 10 >
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4826839 Azabicyclic benzamide derivatives  
Compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: j is 0 or 1; q is 0, 1 or 2; p is 0 and r is 2 or 3, or p is 1 and r is 2; X is O, S, SO or NR...
4808605 Tetrahydronaphthalene derivatives as calcium antagonists  
Compounds of the formula ##STR1## wherein R is lower-alkyl, R 1 is halogen, R 2 is C 1 -C 12 -alkyl, R 3 is hydroxy, lower-alkoxy, lower-alkyl-carbonyloxy,...
4798826 Benzodiazepine tranquilizer combinations and the use thereof  
Combinations comprising (i) a drowsiness-inducing benzodiazepine tranquilliser and (ii) a compound selected from m-chloro-α-t-butylaminopropiophenone, m-fluoro-α-t-butylaminopropiophenone and the...
4788189 Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking  
Administering divided dose of oral Clonidine potentiated by an intramuscular tricyclic antidepressant alleviates the abstinence syndrome resulting from withdrawal of nicotine by smoking cessation....
4777169 Benzodiazepine derivatives  
Benzodiazepine derivatives useful in immunoassays for benzodiazepines.
4764512 Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses  
This invention relates to substituted benzodiazinone-pyridone compounds and their use as cardiotonic agents including methods for increasing cardiac contractility, pharmaceutical compositions...
4755508 Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin  
Benzodiazepines of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
4734412 Medicament  
The invention concerns a medicament that contains a combination of cinnarizine and at least one benzodiazepine compound as active principle besides usual pharmaceutical adjuvants and/or carrier...
4724237 2-substituted-aminomethyl-1,4-benzodiazepines  
Novel 2-substituted-aminomethyl-1,4-benzodiazepines which have been found to be antagonists of the function of cholecystokinins (CCK), to the preparation of these compounds, and to the use of these...
4722941 Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof  
A readily absorbable pharmaceutical composition of pharmacologically active agents, which per se are poorly absorbable, is disclosed which comprises a pharmacologically effective amount of at least...
4721709 Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions  
Pharmaceutical compositions are disclosed which contain hydrophobic practically water-insoluble drugs adsorbed onto carriers such as starch and/or microcrystalline cellulose. The rate of...
4710497 Method for percutaneously administering physiologically active agents  
A method of percutaneously administering a physiologically active agent which comprises applying to the skin of a mammal a physiologically active agent in a carrier system which comprises at least...
4692438 Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity  
Compounds of the formula ##STR1## wherein R 1 is hydrogen, alkanoyl or aroyl; R 2 is hydrogen or alkyl; R 3 is hydrogen or aryl; R 4 and R 5 each are hydrogen or R 4 and R 5 taken together...
4684646 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists  
A method of antagonizing the function of cholecystokinins in a disease state in mammals, especially in humans, which comprises administering a pharmaceutically-effective amount of certain...
4666913 Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses  
A method for increasing cardiotonic contractility in humans or other animals using a class of hydroxy and aminothiazolyl-benzodiazinone compounds and pharmaceutical compositions including the same.
4658024 Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives  
Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R 1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl,...
4657905 Novel hypotensive imidazothiadiazolealkanecarboxamides  
Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R 1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S,...
4656188 Ace inhibitors in macular degeneration  
Angiotensin converting enzyme inhibitors are useful in the treatment of senile macular degeneration.
4650797 Substituted 1,5-benzodiazepine compounds  
Compounds of the formula ##STR1## wherein R 1 is alkyl, alkenyl, alkynyl, cycloalkyl, or substituted alkyl, and R 4 is aryl or heterocyclo are disclosed. These compounds are useful as...
4649137 2-acylaminomethyl-1,4-benzodiazepine compounds, the preparation thereof, and pharmaceutical compositions containing them  
New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I ##STR1## wherein R 1 is a hydrogen atom or a lower alkyl or alkenyl radical or the...
4647561 1,5-benzodiazepine compounds  
Compounds of formula ##STR1## wherein R 4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.
4647560 New benzodiazepines and their use  
The present invention relates to novel benzodiazepines, acid addition salts thereof, processes for their preparation and their use in combating diseases, in particular for the treatment of cerebral...
4616011 Novel indole derivatives and pharmaceutical compositions containing same  
This invention relates to novel indole derivatives of the formula ##STR1## wherein A represents a --CH 2 --CH 2 --, --CHCH--, ##STR2## group and B represents a methylene, carbonyl, or...
4614740 5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same  
The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new...
4604389 Benzazepine derivatives  
This invention relates to benzazepine derivatives of formula I ##STR1## wherein A is --CH 2 CH 2 -- or --CHCH--; R 1 is hydrogen, chlorine, bromine, C 1 -C 3 alkyl, amino, C 1 -C 3 ...
4595684 Method of suppressing benzodiazepine induced sedation with 2-(p-methoxypenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one or a salt thereof  
A method of suppressing benzodiazepine induced sedation normally associated in the treatment of anxiety in a mammal with an anxiolytically effective amount of a benzodiazepine anti-anxiety agent,...
4590191 Soporific containing lorazepam  
A soporific containing lorazepam for oral or rectal administration, containing lorazepam and diphenhydramine or a diphenhydramine acid addition salt in the weight ratio of from 1:10 to 1:75. The...
4587245 Method of treating neuropsychic disturbances by benzodiazepine derivatives and composition therefor  
Benzodiazepines of formula ##STR1## wherein R3 is methyl or ethyl and R4 is chlorine or fluorine are useful therapeutic agents for the treatment of neuropsychic disturbances.
4584293 Aminotetralin derivatives  
This invention related to new aminotetralin derivatives of formula I ##STR1## wherein ##STR2## B is methylene or, when A is --CH 2 --CH 2 --, --CHCH--, --NH--CO-- or --CH 2 --CO--, B can also...
4571395 Lorazepam and bupropion, compositions and methods  
Combinations comprising (i) a drowsiness - inducing benzodiazepine tranquillizer and (ii) a compound selected from m-chloro-α-t-butylaminopropiophenone, m-fluoro-α-t-butylaminopropiophenone and...
4560684 1,4-Benzodiazepine derivatives  
1,4-Benzodiazepine derivatives of the formula: ##STR1## (in which R 1 is pyrrolidinyl or piperidinyl each optionally substituted by C 1 -3 alkyl, phenyl-C 1 -3 alkyl, C 1 -5 alkanoyl, or C 2 -5...
4554273 2-Amino-5-phenyl-1,3-benzodiazepines  
Disclosed are 2-amino-5-phenyl-1,3-benzodiazepines of the formula ##STR1## wherein R 1 and R 2 are hydrogen, halogen, alkyl, or alkoxy; R 2 being able to occupy any of the possible positions on...
4552694 Fluorinated benzodiazepins  
New fluorinated benzodiazepins are described. They are expressed by the following general formula: ##STR1## wherein A 1 and A 2 are the same or different groups, each expressed by one of the...
4533662 2-Acylaminomethyl-1,4-benzodiazepine compounds and analgesic use  
Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4-benzo diazepine compounds of the following Formula I ##STR1## which have valuable pharmacological properties are provided. In said Formula I...
4514410 Substituted 8-phenylisoxazolo[4,3-e][1,4]diazepin-5-ones  
This invention relates to substituted 8-phenylisoxazolo[4,3-e][1,4]diazepin-5-ones of the formula ##STR1## wherein R is lower alkyl; R 1 is hydrogen, amino alkyl, propargyl and lower alkyl; X is...
4512924 Pyridazo[1,2-a][1,2]diazepines  
Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R 1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl,...
4505908 7-Bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepine pharmaceuticals  
Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I ##STR1## in which R 1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R 2 is a halogen...
4490369 Benzazepine derivatives, their pharmaceutical compositions and method of use  
Compounds of the formula ##STR1## wherein A is --CH 2 --CH 2 --, --CHCH--, --NH--CO--, --CH 2 --CO-- or ##STR2## where R 7 is alkyl of 1 to 3 carbon atoms, and B is methylene, carbonyl or...
4487771 C-3 Substituted 1,4-benzodiazepines and pharmaceutical utilization thereof  
New 3-substituted 1,4-benzodiazepine derivatives of general formula ##STR1## show useful and valuable pharmacological and therapeutic properties more specifically as anticonvulsants,...
4482548 Analgesic pharmaceutical compositions containing 5-phenyl-1,4-benzo diazepine compounds and a method of using same  
Highly effective analgesic pharmaceutical compositions and methods of using same are described. Said compositions contain, as analgesic agent, a 5-phenyl-1H-2,3-dihydro-1,4-benzodiazepine compound...
4478822 Drug delivery system utilizing thermosetting gels  
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
4477464 Hetero-benzazepine derivatives and their pharmaceutical use  
Disclosed are variously substituted 3-(carboxymethylamino)-(1,5-benzothiazepin-4-one, 1,5-benzoxazepin-4-one and 1,5-benzodiazepin-4-one)-5-alkanoic acids and derivatives as angiotensin-converting...
4474777 Benzodiazepine derivatives and their pharmaceutical use  
There are presented novel pharmaceutically active substances which inhibit the intestinal resorption of cholesterol and which accordingly can be used in the control or prevention of...
4468391 Combination of β-adrenoceptor antagonists and anxiolytic agents  
A β-adrenoceptor antagonist, which does not penetrate or penetrates poorly the brain, is combined with subtherapeutic doses of an anxiolytic agent, such as diazepam, to give a method, and...
4423044 3,4-Dihydro-5H-2,3-benzodiazepine derivatives and pharmaceutical use thereof  
The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R represents a phenyl...
4411894 Pharmaceutical preparations  
Pharmaceutical compositions useful for the parenteral administration of fat-soluble medicaments are disclosed. The compositions comprise, in addition to the medicaments, a sugar-containing liposome...
4395409 Carbamoyloxyamino-1,4-benzodiazepines and medicaments containing these compounds  
What are disclosed are 1,4-benzodiazepines, having a carbamoyloxyamino group, of the following formula I ##STR1## tautomers thereof of the following formula IA ##STR2## physiologically tolerated...
4391817 Pyrrolo-diazepine derivatives and their pharmaceutical compositions  
A new class of pyrrolo-diazepines with anticonvulsant and anti-anxiety activity of the general formula ##STR1## wherein R is (C 1 -C 4 )alkyl, R 1 is chloro, bromo or nitro, R 2 is hydrogen or...
4388313 Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof  
The disclosure is directed to new 3-hydroxy-1,4-benzodiazepine-2-ones and to the process for the preparation thereof. The compounds of the invention have the structural formula ##STR1## in which R...
4344954 2,3-Disubstituted-2,3,5,6,7,8-hex ahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols  
This disclosure describes certain novel 2,3-disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-][1,3]d iazepin-3-ols which are useful as diuretic agents.
Matches 351 - 400 out of 484 < 1 2 3 4 5 6 7 8 9 10 >