Matches 301 - 350 out of 485 < 1 2 3 4 5 6 7 8 9 10 >
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5541182 Benzodiazepine aryl urea derivatives  
This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, ##STR1## (wherein R 1 is an aryl group, or...
5521170 Benzamide derivatives and pharmaceutical composition comprising the same  
Compounds having the structure below ##STR1## and pharmaceutically acceptable salts thereof exhibit vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for...
5510346 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines  
Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety...
5486514 Carbamate derivatives  
The present invention relates to compound of formula (I) which are antagonists of gastrin and CCK-B receptors. The compounds of formula (I) are carbamate derivatives. ##STR1##
5453424 Furanodiazepines  
This invention is concerned with novel compounds represented by structural formulae I and II. ##STR1## which are useful in the treatment of cardiac arrhythmia.
5439905 Thienodiazepine compounds and their use  
Thienodiazepine compounds of the formula ##STR1## wherein each symbol is as defined in the specification, their pharmaceutically acceptable salts, and pharmaceutical compositions containing said...
5430030 Nerve gas antidote  
A prophylactic pretreatment for nerve gas and pesticide poisons which can be administered orally and which comprises the following agents, in combination: a. Pyridostigmine (pyridostigmine bromide)...
5430029 Pharmaceutical compositions active in the therapy of sleep disorders  
The present invention relates to new pharmaceutical compositions active in the therapy of sleep disorders comprising N-acetyl-5-methoxy-triptamine (melatonin) or one of its derivatives, preferably...
5427814 Process for protecting a fat against oxidation  
A fat is protected from oxidation by, in one process embodiment, forming a mixture of tocopherol and lecithin at a temperature not greater than 60° C., mixing ascorbic acid dissolved in a polar...
5416083 Benzodiazepinyl-terminated non-peptidyl α-succinamidoacyl aminodiols as anti-hypertensive agents  
Non-peptidyl compounds characterized generally as α-succinamidoacyl aminodiols having a benzodiazepinyl-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.
5391548 Transdermal flux enhancing compositions to treat hypertension, diabetes and angina pectoris  
A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of a pharmacologically active...
5366973 Mercaptoacetylamido pyridazo [1,2]pyridazine, pyrazolo[1,2]pyridazine pyrazolo[1,2]pyridazine, pyridazol[1,2-a][1,2]diazepine and pyrazolol[1,2-a][1,2]diazepine  
The present invention relates to certain novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2- a] [1,2]diazepine and pyrazolo[1,2- a ][1,2]diazepine derivatives...
5324726 Benzodiazepine analogs  
Benzodiazepine analogs of the formula: ##STR1## wherein: R 3 is ##STR2## --NH(CH 2 ) 2 -- 3 NHCOR 7 , ##STR3## or --X 11 NR 18 SO 2 (CH 2 ) q R 7 ; R 7 is O,S,HH, or NR 15 with the...
5317021 3-mercapto-glutamic acid derivatives  
Amino acid compounds of the formula: ##STR1## wherein the various symbols are as hereinafter described, which have inhibiting effect on enkephalinase.
5312625 Fused 7-membered cyclic compound and antipsychotic preparation containing the same  
A therapeutically effective antipsychotic preparation comprising a fused cyclic compound for the treatment of diseases involving the serotonergic pathway having the formula (I) or salts thereof:...
5302591 Benzodiazepine derivatives  
Compounds of formula (I), and salts and prodrugs thereof ##STR1## R 1 is H, certain optionally substituted alkyl or C 3 -7 cycloalkyl; R 2 represents (CH 2 ) m -tetrazolyl, (CH 2 ) m ...
5273974 Condensed heterocyclic compounds, their production and use  
A condensed heterocyclic derivative of the formula (I): ##STR1## wherein X is an oxygen atom, a sulfur atom or R 1 --N< wherein R 1 is a hydrogen atom, a hydrocarbon group which may be...
5248678 Methods for increasing arousal and alertness and for the amelioration of comatose states  
A method of treating comatose patients or near-comatose patients to increase their arousal and alertness as measured by the Glascow Coma Score by administering effective amounts of an adenosine...
5232950 Method for using ketamine for prevention or reduction of the effects of stroke in a subject having increased risk for stroke  
The present invention is a method of use for the prevention or reduction of the effects of stroke in a subject susceptible to or at risk of stroke with ketamine. The method also includes...
5206237 Benzodiazepine analogs  
Pharmaceutical compositions containing benzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
5204343 5H-benzodiazepin derivative  
The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benz odiazepine of formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof,...
5175159 3-substituted-1,4-benzodiazepines as oxytocin antagonists  
Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery. ##STR1##
5158947 Condensed heterocyclic compounds and psychopharmaceutical composition containing same  
A condensed heterocyclic compound having the formula (I): ##STR1## wherein A and B are both carbonyl groups of one thereof represents a methylene group and the other represents a carbonyl group; Z...
5141735 Substituted amino-benzodiazepines having anitviral activity  
Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections.
5140032 Drug therapy for alcohol abusers  
A novel composition and/or method for the treatment of alcoholism, wherein the composition comprises a therapeutically effective dosage of disulfiram and a drug that affects the neurological system...
5064825 Angiotensin II antagonists  
Novel substituted imidazo-fused 7-member ring heterocycles of the formulae (I) and (Ia), which are useful as angiotensin II antagonists, are disclosed. ##STR1##
5041438 Method for treating retroviral infections with benzodiazepine compounds  
A method for treating viral infections in a patient with a benzodiazepine derivative compound and compositions.
5010076 1,7-fused 1H-indole-2-carboxylic acid-N-(1,4-benzodiazepin-3-yl)amides  
Compounds corresponding to the formula I ##STR1## in which R 1 represents hydrogen, lower alkyl or cycloalkylalkyl with 4-7 carbon atoms, R 2 represents hydrogen, halogen, lower alkyl, lower...
5008263 Diazepine antiallergy agents  
Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or...
5006522 Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds  
Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X 1 , X 2 , A 1 , A 2 and R 1 to R 10 are as defined in...
5004741 Methods of antagonizing CCK or gastrin with benzodiazepine analogs  
Methods of antagonizing gastrin and/or cholecystokinin (CCK) with benzodiazepine analogs are disclosed, as well as related pharmaceutical compositions, which are useful in treating disorders of the...
5002944 Compounds having cardiotonic activity  
Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general...
4992437 Thienodiazepine compounds and their pharmaceutical use  
Thienodiazepine compounds of the general formula ##STR1## wherein R 1 and R 2 are the same or different and respectively stand for a hydrogen atom, a halogen, an alkyl or an aralkyl, or mean a...
4988692 2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepines  
A compound in all possible isomeric forms and mixtures thereof of the formula ##STR1## wherein X and X' are individually selected from the group consisting of hydrogen, halogen, cyano, --NO 2 ,...
4970209 Fat emulsions  
The invention concerns fat emulsion for intravenous adminstration for nutritive, diagnositic or therapeutic purposes, or for tissue culture and storage or organ transplants. According to the...
4959368 Therapeutic agent for neurological diseases  
A pharmaceutical composition comprising a pyrimidine represented by the following formula ##STR1## wherein R 1 represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an...
4957915 Benzodiazepine analogs  
BZDs of the general formula 1: ##STR1## where: R represents H, alkyl, alkenyl, cycloalkyl or cycloalkenyl each with up to 8 carbon atoms, phenylalkyl with an alkylene chain of 1 to 3 carbon atoms...
4937337 Substituted heterocyclic compounds and the pharmacologically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them  
The present invention provides compounds of the general formula: ##STR1## wherein R 1 is a straight-chained or branched C 1 -C 12 -alkyl radical which can be substituted by a phenyl, naphthyl or...
4935418 Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof  
The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower...
4908360 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetr ahydro-2H-1,3-benzodiazepine-2-ones  
This invention relates to 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1 ,3-benzodiazep ine-2-ones having the formula ##STR1## where R 1 and R 2 are each independently hydrogen,...
4906630 Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds  
A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including...
4898861 Method for inhibiting the proliferation of tumor cells  
A method of inhibiting the proliferation of tumor cells is disclosed which comprises the treatment of such tumor cells with a benzodiazepine having a selective affinity to bind peripheral binding...
4889850 Treatment of colic and teething  
Teething and colic are alleviated in infants and toddlers by the administration of a combination of an antihistamine and a benzodiazepine having sedative hypnotic activity. An exemplary...
4880800 Aminocyclopentyl ethers and pharmaceutical formulation  
Compounds are described of the formula ##STR1## where: R 1 is --H or --CH 3 , n is 1, m is 2-4 and X is --CHCH-- or --CH 2 CH 2 --; Y is a saturated heterocyclic amino group, R 2 is...
4873235 Benzofused lactams as antihypertensives  
Benzofused lactams of the formula: ##STR1## and their use as angiotensin converting enzyme inhibitors and antihypertensive agents are disclosed.
4873076 Method of safely providing anesthesia or conscious sedation  
A method of inducing anesthesia or conscious sedation while avoiding serious hypotensive episodes comprising the administration of a parenterally active benzodiazpine in conjunction with an opiate...
4859666 THAZ derivatives for enhancement of cerebral function  
Tetrahydro-isoxazolo[4,5-d]azepine derivatives possess antiamnesic properties and are cognition enhancers.
4859709 Pharmaceutical composition  
A pharmaceutical composition comprising a freely flowable powder, the powder comprising a porous, high absorption silica or silicate having absorbed therein at least 10% by volume of a liquid,...
4859665 Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine  
Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting...
4840948 1-(hydroxystyrl)-5H-2,3-benzodiazepine derivatives, and pharmaceutical compositions containing the same  
This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions...
Matches 301 - 350 out of 485 < 1 2 3 4 5 6 7 8 9 10 >