Match Document Document Title
9040524 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives  
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives...
9040523 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives  
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and...
9034867 Pharmaceutical compositions comprising sorbitan esters  
The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
9034868 Inhibitors of the shiga toxins trafficking through the retrograde pathway  
The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.
9023842 Benzodiazepine bromodomain inhibitor  
The present invention relates to a benzodiazepine compound of formula (I), processes for its preparation, pharmaceutical compositions containing such a compound and to its use in therapy.
9018202 Methods for treating diseases of the retina  
Disclosed herein is a method of treating disorders of the retina comprising administering to a patient in need of such treatment a compound selected from the group consisting of olanzapine,...
9017735 Modulation of KCNQ potassium channel activity for treatment of psychiatric disorders and the symptoms thereof  
Disclosed herein are compositions and methods for treating a psychiatric disorder or symptoms thereof in a patient. The compositions comprise a compound that modulates KCNQ (Kv7) potassium channel...
9011912 Extended-release oral dosage forms for poorly soluble amine drugs  
Oral dosage forms for poorly soluble amine drugs are provided. Such dosage forms include an ionizable compound such as an organic acid, an amphiphilic polymer and a release rate-controlling...
9006233 Gabaergic receptor subtype selective ligands and their uses  
Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety...
8980882 Pharmaceutical preparation comprising permethylated cyclodextrin  
The invention relates to a pharmaceutical preparation for applying a pharmaceutical agent. According to the invention, the preparation contains: a) a pharmaceutical agent which has an aromatic...
8969337 Prodrugs of secondary amine compounds  
The present invention relates to compounds of Formula I:
8969371 Compositions and methods for weight loss in at risk patient populations  
The present disclosure relates to compositions, kits, uses, systems and methods related to naltrexone plus bupropion for treating an overweight or obese subject at increased risk of adverse...
8962018 Oral formulation of anhydrous olanzapine form I  
The invention relates to a solid formulation for the oral administration of olanzapine that comprises a core of anhydrous olanzapine Form I or a pharmaceutically acceptable salt thereof and,...
8962613 P2X4 receptor antagonist  
A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8...
8946208 Non-aqueous pharmaceutical composition  
A composition for intranasal delivery of a drug comprising: includes: (i) the drug; and (ii) a non-aqueous vehicle containing (a) propylene glycol and at least one additional solvent selected from...
8940732 Diagnosis of autism spectrum disorders and its treatment with an antagonist or inhibitor of the 5-HT2c receptor signaling pathway  
The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and...
8940315 Benzodiazepine formulation in a polyorthoester carrier  
Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an...
8940733 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases  
The present invention is directed to novel pyrrolobenzodiazepine dimers and methods of using the dimers in the treatment of proliferative diseases.
8927538 Carbazole linked pyrrolo[2,1-c][1,4]benzodiazefine hybrids as potential anticancer agents and process for the preparation thereof  
The present invention provides a compound of general formulae A useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the...
8927537 Patches, formulations, and associated methods for transdermal delivery of alprazolam and other drugs  
The present invention is drawn to transdermal drug formulations, transdermal patches incorporating such formulations, as well as associated methods. The formulations can include about 0.3 wt % to...
8906867 Production method of solid preparation and the solid preparations produced by the method  
The production method prepares a solid preparation by dissolving water-insoluble and/or water indissolvable alkaline active pharmaceutical ingredient in an acidifier-containing acid solution to...
8901113 Methods and compositions for deterring abuse  
Effective methods and compositions to deter abuse of pharmaceutical products (e.g., orally administered pharmaceutical products) including but not limited to immediate release, sustained or...
8895545 Acrylamide derivatives as Fab I inhibitors  
In part, the present invention is directed to antibacterial compounds.
8883214 Implantable delivery vehicle for ocular delivery of muscarinic antagonists  
The present invention provides compositions and methods for treating ocular disorders such as myopia.
8883777 Compositions controlling pH range of release and/or release rate  
The present invention provides a composition controlling a pH range of release and/or a release rate, which contains (i) a thienotriazolodiazepine compound of the formula (I) and (ii) at least one...
8877746 Compositions for delivery of insoluble agents  
Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble...
8865641 Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways  
A method of treating a fatty liver disease in a subject. The method comprises administering to the subject an effective amount of a cholinergic pathway stimulating agent, wherein the fatty liver...
8853203 Diazepinone derivatives  
The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments...
8846662 Benzodiazepine and/or pharmaceutical composition comprising benzodiazepine derivatives  
The invention relates to a pharmaceutical composition characterized in that it comprises a benzodiazapine and/or benzodiazapine derivative, and a non-ionic solubilizer, and induces in said...
8846663 Modulators of 5-HT receptors and methods of use thereof  
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine , 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine ,...
8846661 Diazahomoadamantane derivatives and methods of use thereof  
The invention relates to compounds that are diazahomoadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
8835424 Selective agents for pain suppression  
In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of the often chronic, severe and...
8828993 Psychotropic agents having glutamate NMDA activity  
The invention provides novel compounds and pharmaceutical compositions for the treatment of psychological and/or psychiatric diseases or disorders.
8822453 Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation  
The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a...
8809321 Diaryl ether linked pyrrolo [2,1-c][1,4] benzodiazepine hybrids and process for the preparation thereof  
The present invention provides a compound of general formula A, useful as potential anticancer agents against eleven human cancer cell lines. The present invention further provides a process for...
8809322 Methods and compositions for the delivery of a therapeutic agent  
The present invention provides a liquid pharmaceutical composition comprising a therapeutic agent and an alkoxy-polyethylene glycol, for example, methoxy-polyethylene glycol, for administration of...
8802668 Hematopoietic neoplasm chemotherapy  
A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage...
8778933 Diazepinedione derivative  
A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein R1 represents a hydrogen atom, an alkyl...
8778932 Dihydro-oxazolobenzodiazepinone compounds, a process for there preparation and pharmaceutical compositions containing them  
Compounds of formula (I): wherein: R1 represents a hydrogen atom or an alkyl group;R2 represents an alkyl group;R3 represents an aryl or heteroaryl group. Medicinal products containing the same...
8772301 Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof  
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as...
8772281 Remedy for diabetes  
A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function...
8748419 Treating obesity with muscarinic receptor M1 antagonists  
Provided are methods of treating obesity and effecting desired weight loss or preventing undesired weight gain by administration of a preferential muscarinic acetylcholine receptor M1 antagonist,...
8735389 Treating psychological conditions using muscarinic receptor M1 antagonists  
Provided are methods of treating psychological diseases and conditions by administration of a preferential muscarinic acetylcholine receptor M1 antagonist, optionally with at least one...
8729070 CNS pharmaceutical compositions and methods of use  
The present invention is directed to CNS pharmaceutical compositions and methods of use. The pharmaceutical compositions comprise a CNS active agent and preferably at least two vagal...
8722085 Methods for administering weight loss medications  
Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the...
8722666 Sedative for use during eye surgery  
A drug for sedating a patient, and especially a smoker, during eye surgery. The drug includes a sedative such as midazolam in a mix with nicotine. The mixture is injected into the patient prior to...
8722665 Cinnamido-pyrrolo[2,1-C][1,4]benzodiazepines as potential anticancer agents and process for the preparation thereof  
The present invention provides a compound of general formulae (8a-i), (11a-i), (14a-i), and (17a-i), useful as potential antitumour agents against human cancer cell lines. The present invention...
8716279 Pharmaceutical compositions of clonazepam and method of use thereof  
The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is...
8710046 5-HT3 receptor modulators, methods of making, and use thereof  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
8703764 Combination therapy for dementia, depression and apathy  
The invention provides, in part, methods and compositions for treating psychiatric disorders, for example, apathy, dementia, or depression, using combination therapies such a monoamine oxidase...