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4550107 |
Condensed diazepinones, their compositions and methods of use as pharmaceuticals
Disclosed are novel condensed diazepinones of formula I ##STR1## wherein B is a fused ring selected from ##STR2## X is --CH-- or, when B is ortho-phenylene, X can also be nitrogen; A 1 is C 1 -C...
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4542131 |
Substituted diazolo[b][1,5]benzodiazepines and their use as CNS agents
Compounds are described of the formula ##STR1## or an acid addition salt thereof; in which R 1 , R 2 , R 3 and R 4 independently represent hydrogen, C 1 -4 alkyl, C 2 -4 alkenyl, C 3 -7...
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4518603 |
[2-[(Nitropyridinyl)amino]phenyl]arylmethanones in a process for preparing pyrido[1,4]benzodiazepines
[2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: ##STR1## wherein; B is carbonyl, thioxomethyl, ketal or...
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4514407 |
1-Ethanamine-triazolo-benzodiazepines as diuretics
Triazolo-benzodiazepine-1-ethanamines of the formulas ##STR1## where R, R 1 , R 2 , R 3 , R 4 and Ring A are as defined in the specification, e.g.,...
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4510153 |
Treatment of panic disorders with adinazolam
Therapeutic process for treating panic disorders in humans comprising, the systemic administration of a 8-chloro-1-[(dimethylamino)-methyl]-6-phenyl-4H-s-triazolo[4
,3-a][1,4]benz odiazepine...
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4508716 |
[1,2]-Fused 1,4-benzodiazepine compounds, process for their preparation and compositions containing them
[1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I ##STR1## wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R 1 is a...
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4508726 |
Treatment of panic disorders with alprazolam
Therapeutic process for treating panic disorders in humans comprising, the systemic administration of a 1-methyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodia
zepine including the N-oxides...
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4507313 |
Oxadiazolyl-imidazo-[1,4]benzodiazepines and their use in treatment of diseases of the central nervous system
New oxadiazolyl-imidazo-[1,4]benzodiazepine derivatives having benzodiazepine receptor activity have the formula ##STR1## R' is hydrogen, chlorine, fluorine or nitro in the 7- or 8-position, R 1 ...
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4492699 |
Triazolobenzodiazepine derivatives
These are described compounds of formula (I) ##STR1## or an acid addition salt thereof; in which R 1 , R 2 , R 3 and R 4 independently represent hydrogen, C 1 -4 alkyl, C 2 -4 alkenyl, halogen, C...
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4481208 |
Treatment of panic disorders with estazolam
Therapeutic process for treating panic disorders in humans comprising, the systemic administration of a 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine including the N-oxides and...
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4479959 |
Process for inducing hypnosis
Therapeutic compositions for treating humans and animals comprising, in dosage unit form, a 8-Chloro-1-hydroxymethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]b
enzodiazepine compound of the formula...
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4476134 |
Process for treating panic disorders
Therapeutic process for treating panic disorders in humans comprising the systemic administration of a 8-chloro-1-R-oxymethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]ben
zodiazepine of the formula...
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4472397 |
Use of certain 1-substituted-triazolo-benzodiazepines to treat psychoses
Certain 1-(Nitrogen-containing group)-triazolo-benzodiazepines, e.g., adinazolam, are useful for treating psychotic, including schizophrenic, conditions in human patients.
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4460587 |
5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines
5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines, for example compounds of the formula ##STR1## in which e.g., R 1 , R 2 and R 4 are hydrogen, R 3 is methyl and C n H 2n is CH 2 CH 2 ,...
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4455307 |
Antihypertensive use of triazolobenzodiazepines
This specification concerns the use to treat hypertension in mammals of novel and known 4H-s-triazolo[4,3-a][1,4]benzodiazepines, known 4H-s-triazolo[4,3-a][1,3,4]benzotriazepines and...
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4447434 |
Substituted dibenzodiazepinones
The specification describes new substituted dibenzodiazepinones of formula ##STR1## wherein R 1 is hydrogen or chlorine atom and R is (1-methyl-4-piperidinyl)methyl,...
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4443452 |
Dibenzodiazepinones, pharmaceutical compositions thereof and method of use thereof
This invention relates to compounds of the formula ##STR1## wherein X is oxygen, --NH--, or--NCH 3 --and R is 1-methyl-4-piperidinyl, 4-methyl-1-piperazinyl,...
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4443446 |
Use of psychoactive drugs as vaginal contraceptives
The use of psychoactive drugs as vaginal contraceptives is disclosed. The invention may be implemented by incorporating a psychoactive drug in a known method such as jelly, foam, or suppository...
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4424225 |
Thienobenzodiazepinones, pharmaceutical compositions thereof and method of use thereof
This invention relates to novel compounds of the formula ##STR1## wherein R 1 is hydrogen or alkyl having from 1 to 4 carbon atoms; R 2 is halogen, hydrogen, or alkyl having from 1 to 4 carbon...
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4424222 |
Pyridobenzodiazepinones, pharmaceutical compositions and method of use thereof
New pyridobenzodiazepinones of the formula ##STR1## are described wherein X represents oxygen, --NH-- or --NCH 3 -- and R represents 1-methyl-4-piperidinyl or 4-methyl-1-piperazinyl group...
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4424226 |
Pyridobenzodiazepinones, pharmaceutical compositions thereof and method of use thereof
This invention relates to compounds of the formula ##STR1## wherein R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl, 1-methyl-1,2,5,6-tetrahydro-4-pyridinyl,...
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4410527 |
Substituted thienobenzodiazepinones and salts thereof
Compounds of the formula ##STR1## wherein R is 1-methyl-4-piperididinyl, 4-methyl-1-piperazinyl, or 3 - or 3 -tropanyl, each of which may optionally have another methyl substituent attached to the...
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4381303 |
1,4,9,10-Tetrahydro-pyrazolo [4,3-]pyrido[-3,2-b][1,4]diazepin-10-ones
This invention is directed to the compounds of the formula ##STR1## wherein R 1 is hydrogen or an alkyl of from 1 to 6 carbon atoms; R 2 is an alkyl of from 1 to 3 carbon atoms; R 3 is...
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4381301 |
Substituted tricyclic thieno compounds, their synthesis, their use, their compositions and their medicaments
Substituted thienobenzodiazepinones of the general formula I ##STR1## [wherein R 1 denotes a hydrogen atom (--H) or an alkyl radical with 1 to 4 carbon atoms; R 2 represents a halogen atom (halo)...
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4377576 |
5-(Heterocyclic amino-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones
Compounds of the formula ##STR1## wherein R 1 is hydrogen, methyl or ethyl; R 2 is hydrogen or chlorine; R 3 is hydrogen or chlorine; and R 4 is pyrrolidino, piperidino,...
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4377577 |
Use of psychoactive drugs in uterus to prevent pregnancy
The use of psychoactive drugs by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of...
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4375473 |
Method
This specification concerns the use to treat hypertension in mammals of certain known 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines.
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4363816 |
Tricyclic pyrroles, their compositions and their use
1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-ones have been found o provide excellent protection for the stomach and intestines of warm-blooded animals. They are useful for the treatment...
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4360525 |
Dibenzazepine derivatives, pharmaceutical compositions containing them, and methods of use
Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging...
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4352815 |
Imidazo-benzodiazepines and their use
There is provided imidazodiazepines of the formula ##STR1## wherein R 1 is methyl, ethyl or isopropyl, one of R 4 and R 5 is hydrogen and the other is nitro or cyano, and either R 2 is hydrogen...
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4352817 |
Imidazo-diazepines and their use
There is provided imidazodiazepines of the formula ##STR1## wherein A together with the two carbon atoms denoted as α and β is the group ##STR2## X is an oxygen or sulphur atom and R 1 is...
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4338314 |
[1,2]Anellated-7-phenyl-1,4-benzodiazepine and pharmaceutical compositions thereof and use for treatment of ulcers
Compounds of [1,2]anellated-7-phenyl-1,4-benzodiazepines having the formula I ##STR1## wherein X is oxygen, sulfur or NR; R is H, C 1 -C 5 alkyl, C 1 -C 5 alkyl, substituted with a...
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4333944 |
8-Halo-6-phenyl-4H-s-triazolo (3,4-c) thieno 1,4-diazepin-1-ones
Compounds of the formula ##STR1## wherein R 1 is chlorine, bromine or iodine, R 2 is hydrogen or halogen, and R 3 is hydrogen, lower alkyl or hydroxy-lower alkyl, or when R 3 is hydrogen,...
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4317823 |
Pyrazolobenzodiazepinones, their intermediates, their compositions and their use
1-(Lower)alkyl-4-(substituted)aminoalkylcarbonyl-1,4,9,10-te
trahydropyrazol o[4,3-b][1,5]benzodiazepin-10-ones are useful, e.g., to protect warm blooded animals against the formation of gastric...
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4316900 |
Piperazinopyrrolobenzodiazepines
1,3,4,14b-Tetrahydro-2H,10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,
4]benzodiazepin es, e.g. those of the formula ##STR1## R 6 =H, alkyl, alkenyl, alkynyl, (cycloalkyl or HO)-alkyl R 7 =H, halo or CF 3...
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4311700 |
Pyrimidobenzodiazepinones, their use and medicaments containing them
11-Acyl-2-phenyl- and 11-acyl-5,6-dihydropyrimido[4,5-b][1,5]benzodiazepin-5-ones,
their acid-addition salts and their N-oxides provide protective action for the stomach and intestines of...
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4310524 |
TCA Composition and method for rapid onset antidepressant therapy
A method is provided for treating depression in a patient therefrom and requiring rapid symptomatic relief, which comprises administering to said patient concurrently (a) an effective...
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4309437 |
Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof
Novel 5,10,11,11a-tetrahydro-8-methyl-11-sulfo or sulfino-1H-pyrrolo[2,1-c][1,4]-benzodiazepin-2-acrylamides which have antitumor activity and low toxicity are prepared by reacting corresponding...
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4292319 |
Antiphlogistic pharmaceutical compositions and method of use
Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[
2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic...
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4287196 |
Method of inhibiting prolactin secretion
Certain known pyrimido[2,1-a]isoindoles and diazepino[2,1-a]isoindoles, e.g., 7-(p-chlorophenyl)-7-hydroxy-2,3,4,5-tetrahydro-7H-[1,3]-dia
zepino[2,1-a]i soindoles, are useful for inhibiting...
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4264615 |
Compositions and process
Pharmaceutical compositions comprising, in unit dosage form, from about 0.5 mg. to about 100 mg. of a compound of the formula: ##STR1## wherein R 1 and R 2 are hydrogen, methyl or ethyl, and R 3 ...
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4263310 |
8-Bromo-6-(o-chloro- phenyl)-4H-S-triazolo-[3,4,-c]-thieno-[2,3-e]-1,4-diazepines and salts thereof
Compounds of the formula ##STR1## wherein R 1 is chlorine, bromine, cyclopropyl or cyclohexyl and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as...
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4252816 |
Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
Substituted tetrahydro-1H-1,4-diazepino[1,7-a]benzimidazoles of the formula: ##STR1## and pharmaceutically acceptable salts thereof having thereapeutic activity as analgesic agents.
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4215117 |
Stable pharmaceutical formulations
Stable formulations of ketazolam containing 15 to 100 mg of ketazolam are prepared by admixing the ketazolam with either calcium lactate and a powdered edible vegetable fat or fatty oil,...
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4213985 |
Novel 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-ones
Novel 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-ones of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, straight and...
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4213984 |
11-(Piperazino-acetyl)-5,11-di hydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones and salts thereof
Compounds of the formula ##STR1## wherein R 1 is alkyl of 3 to 12 carbon atoms; unsaturated aliphatic hydrocarbyl of 3 to 20 carbon atoms comprising 1 to 3 double bonds and/or one triple bond;...
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4210648 |
II-Aminoacyl-5,11-dihydro-6H-pyrido(2,3-B) (1,4)benzodiazepin-6-ones and salts thereof
Compounds of the formula ##STR1## wherein A is alkylene of 1 to 5 carbon atoms; R 1 is amino, tert.butylamino, N-cyclohexyl-N-methyl-amino, dibenzylamino, benzylamino, trimethoxybenzyl-amino,...
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4207322 |
6-Aryl-s-triazolo-(4,3-alpha)-pyrido-(2,3-f)-(1,4)-diazepines
There are produced 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepines of the formula: ##STR1## wherein R 1 is hydrogen, a halogen atom, an alkyl mercapto group having 1 to 6 carbon atoms, R...
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4199588 |
6-Phenyl-4H-s-triazolo-[3,4c]-thieno-[2,3e]-1,4-diazepines and salts thereof
Compounds of the formula ##STR1## wherein R 1 is hydrogen, chlorine, bromine or alkyl of 1 to 4 carbon atoms; R 2 is hydrogen, fluorine, chlorine, bromine, nitro or trifluoromethyl; and R 3...
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4191760 |
Dibenzodiazepines
This invention provides dibenzodiazepines represented by the formula ##STR1## The compounds of this invention are useful as antischizophrenics.
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