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6100256 |
Use of NK-1 receptors antagonists for treating schizophrenic disorders
The present invention provides a method for the treatment or prevention of schizophrenic disorders using an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical...
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6087356 |
Rapid narcotic detoxification
Methods for rapid detoxification of patients addicted to opioid narcotics are provided. The methods include administering nalmefene to induce acute withdrawal, and administering dextromethorphan...
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RE36744 |
Nasal administration of benzodiazepine hypnotics
Nasal administration of benzodiazepines is described as providing improved therapeutic effects as compared to conventional delivery techniques. The compositions comprise a benzodiazepine hypnotic...
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6077839 |
Method for reducing intraocular pressure in the mammalian eye by administration of gamma aminobutyric acid (GABA) agonists
Ophthalmic compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by topically administering to the mammalian eye the ophthalmic composition...
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6075018 |
1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine derivatives
The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new...
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6071902 |
Method for treating excessive aggression
The invention provides a method for treating extreme aggression in a mammal comprising administering an effective amount of olanzapine, or a pharmaceutically acceptable salt or solvate thereof, to...
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6063774 |
Tricyclic quinoxaline derivatives as neuroprotective agents
Neuroprotective agents have forumula I ##STR1## wherein a is a ring of 6 to 8 members; n and n' are 1 or 2, R 2 is hydrogen or oxygen of carbonyl, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 ...
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6034078 |
Thienobenzodiazepine compounds
Pharmaceutical compounds of the formula ##STR1## in which R 1 is hydrogen or halo, and R 2 is C 1 -10 alkyl, C 2 -10 alkenyl, C 2 -10 alkynyl, C 3 -6 cycloalkyl optionally substituted by 1 to 3 C...
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6028081 |
Substituted quinolone derivatives and pharmaceuticals containing the same
Substituted quinolone derivatives represented by the following formula: ##STR1## wherein R 1 represents a substituted or unsubstituted (hetero)aryl group, R 2 represents H or an alkoxycarbonyl,...
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6015810 |
Aqueous ophthalmic solution containing apafant as active ingredient
The present invention relates to an aqueous ophthalmic solution containing apafant and additives wherein apafant is stabilized by lowering ionic strength to 0.05 or below, and a method of...
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6015791 |
Serine protease inhibitors-cycloheptane derivatives
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors,...
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5985869 |
Benzoheterocyclic compounds
Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R 1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R 2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally...
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5985868 |
Methods and compositions for treating androgen-dependant diseases using optically pure R-(-) casodex
Methods and compositions are disclosed utilizing optically pure R-(-)-casodex for the treatment of androgen-dependent prostate cancer, while substantially reducing the concomitant liability of...
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5977101 |
Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and...
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5972932 |
Anesthetic method and composition
The present invention provides a method for providing anesthesia using a composition comprising olanzapine and one or more opioids.
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5962450 |
Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines and their use as medicaments
The invention is concerned with basically-substituted imidazodiazepines of general formula I. These compounds can be used as anxiolytic and/or anticonvulsant and/or muscle relaxant and/or...
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5958921 |
Method for treating depression with olanzapine
This invention relates to the use of the antipsychotic drug olanzapine for the treatment of depression, including depressive signs and symptoms and Major Depression.
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5958881 |
Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures
A method of inducing a temporary substantial paralysis of an area of interest in a patient undergoing a medical procedure is provided. The method involves administering a therapeutically effective...
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5955459 |
Fatty acid-antipsychotic compositions and uses thereof
The invention provides compositions that include conjugates of a fatty acid molecule, preferably cis-docosahexaenoic acid, and antipsychotic agents. The conjugates are usefull in treating psychotic...
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5945416 |
Method for treating pain
The present invention provides a method for treating pain using a composition comprising olanzapine and Drug Useful in the Treatment of Pain.
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5942506 |
1- 2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives
This invention relates to new 1- 2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the...
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5929070 |
Method for treating migraine pain with olanzapine
The present invention provides a method for treating migraine pain comprising administering an analgesic dosage of olanzapine.
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5929069 |
Compounds activating pharmacological effects of retinoids
A compound represented by the formula (I) or (II) or a salt thereof wherein R 1 represents hydrogen atom or a C 1 -6 alkyl group; R 2 and R 3 independently represent a hydrogen atom or a C 1 -6...
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5919780 |
Tricyclic inhibitors of protein farnesyltransferase
Compounds of formula I ##STR1## wherein X is N or C--R 9 , Y is N--R 10 , CH 2 , O, S, SO, SO 2 , CO or CH--OH, R is H or alkyl, R 1 is heteroaryl, n is 1-5, and R 2 -R 10 are H...
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5902807 |
Method for the treatment of mental illness in mammals and a composition therefor
The invention relates to a method for treating a mammal suffering from mental illness induced by propagation of stress, said method comprising the step of removing or diminishing the tone of the...
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5895785 |
Treatment and prevention of disorders mediated by LA-paf or endothelial cells
The invention refers to the composition of substances to prevent and treat endothelial cell-mediated disorders with pathological differentiation of endothelial cells, for example, in response to...
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5891872 |
Tricyclic compounds
Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a...
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5891871 |
Substituted 2,3-benzodiazepin-4-ones and the use thereof
The invention relates to substituted 2,3-benzodiazepin-4-ones which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal...
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5880122 |
3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
This invention relates to tricyclic non-peptide vasopressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure,...
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5869487 |
Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
A compound which inhibits human thrombin and where has the structure ##STR1##
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5869479 |
Treatment of upper airway allergic responses
Relief from the symptoms of rhinitis is obtained by treatment with: (a) an antihistaminic effective amount of a histamine H 1 receptor antagonist; together with (b) a sufficient amount of a...
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5866567 |
Diazepinones, their production and use
A compound of the general formula ##STR1## wherein A represents a benzene ring, B represents a 6-membered hydrocarbon ring; X represents a lower alkylene, carbonyl or sulfonyl; Y represents a bond,...
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5854238 |
Use of a thienotriazolodiazephine to increase apolipoprotein A-I levels
9-methyl-4-phenyl-6H-thieno 3,2-f!-s-triazolo 4,3-a! 1,4!diazepine for the treatment and prevention of illnesses which are caused by low plasma apolipoprotein A-I levels as coronary coronary disease.
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5837704 |
2-heteroaryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1,4!diazepines and their use in the prevention or treatment of HIV infection
Novel compounds for the treatment of HIV-1 infection. These are 2-heteroary-5,11-dihydro-6H-dipyrido 3,2-b:2',3'-e! 1,4!diazepines of the formula ##STR1## wherein Z is oxygen, sulfur, NCN or...
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5834463 |
Condensed heterocyclic compounds, their production and use
Compounds represented by the formula: ##STR1## wherein ring A is benzene; Ar is aromatic group; R 1 , R 2 and R 3 each stands for H, acyl, hydrocarbon or heterocyclic, or R 2 and R 3 , taken...
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5834459 |
Alkyl-substituted compounds having dopamine receptor affinity
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or...
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5834464 |
Imidazolinobenzodiazepines
Imidazolinobenzodiazepines are cholecystokinin B (CCK-B) antagonists useful as anxiolytic agents. The compounds have structures such as: ##STR1##
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5824676 |
5-HT2 receptor ligands
Described herein are 5-HT2 receptor-selective compounds of Formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo-...
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5817656 |
Mental disorders
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno- 2,3-b! 1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of mental disorders. The...
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5817657 |
Psychoactive substance disorders
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno- 2,3-b! 1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders relating to...
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5817655 |
Methods of treatment using a thieno-benzodiazepine
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno - 2,3-b! 1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the...
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5814628 |
Benzyl-substituted compounds having dopamine receptor affinity
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered,...
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5795886 |
Dihydro-2,3-benzodiazepine derivatives
Compounds having general formula (I) wherein R is hydrogen or C 1 -C 10 alkyl; X is an aromatic moiety selected from phenyl, thienyl, furyl, pyridyl, imidazolyl, benzimidazolyl, benzothiazolyl...
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5776928 |
Method for treating dyskinesias with olanzapine
The invention provides a method for treating a dyskinesias comprising administering an effective amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno 2,3-b! 1,5! benzodiazepine.
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5770590 |
Cyclic compounds, their prudiction and use
Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --NC<, --CO--N< or --CS--N< as the partial structure --X . . ....
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5760032 |
Thienylazole compound and thienotriazolodiazepine compound
Thienylazole compounds (I) and thienotriazolodiazepine compounds (II) of the formulas ##STR1## wherein R 1 and R 2 are hydrogen, halogen, C 1 -C 5 alkyl and the like; --AB-- is --NN-- and...
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5756495 |
3-substituted 3H-2, 3-benzodiazepine derivatives, the production and use as pharmaceutical agents
New 3-substituted 3H-2,3-benzodiazepine derivatives of general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and n have the meanings indicated in the description, their...
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5753649 |
Therapeutic agent for osteoporosis and diazepine compound
A therapeutic agent for osteoporosis, comprising an azepine compound of the formula ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof as...
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5750519 |
Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates
A process for the long term modification and regulation of lipid and glucose metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these being...
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5744470 |
Method for treating insomnia
The invention provides a method for treating insomnia comprising administering an effective amount of olanzapine to a patient in need thereof.
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