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7429580 Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss  
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a psychotherapeutic agent and the second compound is a...
7423048 Compounds for treating fundic disaccomodation  
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -a...
7419976 Diazepanes derivatives useful as IFA inhibitors  
Pharmaceutically active diazepanes, e.g. useful for treating disorders or diseases mediated by LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/ICAM-3 or LFA-1/JAM-1 interactions.
7407971 Substituted pyrrolo-pyrazole derivatives as kinase inhibitors  
A new class of pyrazolo derivative compounds having the formula where R and R 1 have the meanings given herein. The pyrazolo derivative compounds are useful in treating cell proliferative...
7390800 Adenosine deaminase inhibitor and novel Bacillus sp. Iada-7 strain which produces it  
The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase...
7378413 2-amino-3-(alkyl)-pyrimidone derivatives  
A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C 1-6 alkyl group which may be substituted by a C 6,10 aryl group; R2...
7378412 Pharmaceutical compounds  
Compounds or their salts having general formula: A-B—C—NO 2 wherein: A...
7378411 Substituted thienopyrimidinones as a mitotic kinesin inhibitor  
The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
7371753 Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions  
Disclosed are new dihydropteridinones of general formula (I) wherein the groups R 1 to R 5 , R a to R c , W, Q 1 and Q 2 have the meanings given in the claims and specification, the isomers...
7365063 Quinazolinone and benzoxazinone derivatives and uses thereof  
Compounds of the formula I: and pharmaceutically acceptable salts thereof wherein X is N, Y is S, Z is —(CR a R b ) r —, A is —NR 3 , m is 2, n is 1, q is 2, R 2 is optioinally...
7361648 Heterocyclylakylamines as muscarinic receptor antagonists  
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR 5 , and the other...
7358239 Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives  
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
7351700 Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors  
The present invention relates to compounds of formula wherein X is —S— or —NH—; R 3 /R 4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7...
7348347 Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds  
Substituted 4,5,6,7-tetrahydrobenzothiazol-2-ylamine compounds, a method for their production; pharmaceutical compositions comprising them, and methods of use for modulating biological functions...
7348321 Flumazenil for the treatment of alcohol dependency  
The invention relates to the use of flumazenil in developing a drug used for the sequential administration of small quantities of flumazenil at short intervals, until a therapeutically effective...
7329652 Diaminotriazole compounds useful as protein kinase inhibitors  
The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the...
7323457 Substituted sulfonamides and ureas useful for inhibiting kinase activity  
Sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said...
7314871 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension  
The application claims a method for treating hypertension by administering an effective amount of a compound of the formula (I) wherein the variable groups are as defined in the specification...
7312209 Acridone inhibitors of IMPDH enzyme  
Compounds having the formula (I), wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2...
7304053 Substituted heterocyclic compounds for treating multidrug resistance  
Substituted heterocyclic compounds for treating multidrug resistance are disclosed. Compositions and methods of use for the substituted heterocyclic compounds are disclosed. Suitable substituted...
7304048 Indole-type derivatives as inhibitors of p38 kinase  
The invention is directed to methods to inhibit p38-α kinase using compounds containing an aromatic system coupled through a 7-membered heterocycle to an indole-type system.
7300929 Mediators of hedgehog signaling pathways, compositions and uses related thereto  
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
7294629 Quinazoline derivatives  
A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer...
7291642 Bradykinin-B1 antagonists, process for their preparation and their use as medicaments  
The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
7282495 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands  
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor
7282494 Heteroaryl diazacycloalkanes, their preparation and use  
The present invention relates to novel heteroaryl diazacycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological...
7276491 Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors  
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
7268128 1,3,5-trisubstituted-5-phenyl and 5-pyridyl pyrazolopyrimidinone derivatives having PDE7 inhibiting action  
Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB): where the symbols are as disclosed in the specification, are provided as desired compounds. These...
7262188 Phenyl sulfone derivatives and their use in the treatment of CNS disorders  
This invention relates to novel phenyl sulfone compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS...
7262187 Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor  
The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
7262186 Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor  
The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
7259160 Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes  
The present invention is directed to hexahydrodiazepinone compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or...
7259159 Guanidino derivatives as inhibitors of cell adhesion  
The present invention relates to acylguanidino derivatives of formula (I), in which R 1 , R 2 , R 3 , A, B, X, Y and n have the meanings indicated in claim 1 , their physiologically tolerable...
7253169 Aza compounds, pharmaceutical compositions and methods of use  
The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
7244723 Substituted furopyrimidinones as a mitotic kinesin inhibitors  
The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
7241787 Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments  
The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and...
7238696 Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands  
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor
7238688 Piperidine compounds  
Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or...
7235546 Inhibitors of macrophage migration inhibitory factor and methods for identifying the same  
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF...
7235538 Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV  
The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I wherein each n is one or two independently and R 1 , R 2 , R 3 , R...
7223788 Substituted N-aryl heterocycles, process for their preparation and their use as medicaments  
The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the...
7223751 Sulfonamide derivatives, intermediate thereof, its preparation methods, and pharmaceutical composition comprising the same  
The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly,...
7220736 Pyrimidine compounds  
A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR 4 —, —S—, —O—, —CH═N—,...
7217711 Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions  
The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R 1 to R 3 and n are defined as in claims 1 to 8 , the tautomers, enantiomers,...
7214701 Active substance combinations having insecticidal and acaricdal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G...
7208497 Substituted piperazines and diazepanes  
A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor....
7208489 2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones  
The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent...
7205303 Substituted heterocyclic compounds  
Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, m particular cardiovascular diseases such as atrial and ventricular...
7205292 CGRP receptor antagonists  
The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP...
7199118 Benzothiazine derivatives, their preparation and use  
This invention relates to novel benzothiazine derivatives of Formula I useful as modulators of the AMPA sensitive glutamate receptors, pharmaceutical compositions comprising such compounds and...
Matches 1 - 50 out of 838 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >