|
Match
|
Document |
Document Title |
|
|
7615554 |
Erastin and erastin binding proteins, and uses thereof
The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also...
|
|
|
7612061 |
Piperazine compounds
A compound selected from those of formula (I):
wherein:
R 1 , R 2 , R 3 and R 4 , which may be the same or different, each represent an atom or group selected from hydrogen, halogen,...
|
|
|
7605155 |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds,...
|
|
|
7601713 |
Kinase inhibitors and their uses
The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein...
|
|
|
7601711 |
5-amido-indole-2-carboxamide derivatives
The present invention relates to compounds of formula I
wherein G and R 1 to R 5 and R 12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The...
|
|
|
7589087 |
Benzoimidazol-2-yl pyridines as modulators of the histamine H4receptor
Benzoimidazol-2-yl pyridines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, including allergy, asthma,...
|
|
|
7585856 |
Resolvins: Biotemplates for novel therapeutic interventions
The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as...
|
|
|
7576088 |
Benzodioxole derivatives
The present invention relates to compounds of the general formula
and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such...
|
|
|
7576076 |
Modified pyrimidine glucocorticoid receptor modulators
The present invention provides a compound having the formula:
wherein, n and m are 1 ; X 1 and X 2 are O; R 1 is a member selected from unsubstituted phenyl and substituted phenyl; R 2 is...
|
|
|
7572787 |
Substituted naphthalene sulfonamides
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
|
|
|
7572786 |
Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists
This invention concerns substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK 1 antagonistic activity, a combined NK 1 /NK...
|
|
|
7569574 |
Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
The invention relates to new purine derivatives of general formula
wherein R 1 to R 4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and...
|
|
|
7569563 |
Substituted quinolones II
The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of...
|
|
|
7560546 |
Tyrosine kinase inhibitors
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The...
|
|
|
7557112 |
Aromatic-ring-fused pyrimidine derivative
There are provided novel pyrimidine derivatives which has been fused with an aromatic heterocycle selected from thiophene, thiazole and pyridine or pharmaceutically acceptable salts thereof; and a...
|
|
|
7557098 |
1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
|
|
|
7550456 |
Substituted aryl cycloalkanoyl derivatives and methods of their use
The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
|
|
|
7550455 |
8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition
The present invention relates to substituted xanthines of the general formula
in which R 1 to R 3 and n are as defined in claims 1 to 8, their tautomers, their enantiomers, their...
|
|
|
7550453 |
2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof
The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.
|
|
|
7547691 |
[4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases
The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
|
|
|
7538114 |
Glycine transporter-1 inhibitors
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition...
|
|
|
7531532 |
Pyridine derivative and pyrimidine derivative
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor...
|
|
|
7524839 |
Compounds, their use and preparation
The invention-provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I):
in which Ar, R 2 , R 3 , R 4 and R 5 are as defined in...
|
|
|
7501407 |
Pyrimidine A2B selective antagonist compounds, their synthesis and use
The subject invention provides compounds having the structure:
wherein R 1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5...
|
|
|
7482439 |
Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof
Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II)
and a caprazene-1′″-ester...
|
|
|
7476663 |
Substituted thiophene carboxamides
The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula
wherein A, and R 1 to R 8c are defined as in claim 1, the tautomers, the enantiomers,...
|
|
|
7465733 |
Piperazine compounds
A compound selected from those of formula (I):
wherein:
R 1 , R 2 , R 3 and R 4 , which may be the same or different, each represent an atom or group selected from hydrogen, halogen,...
|
|
|
7465726 |
Substituted pyrrolo[2.3-B]pyridines
Compounds represented by Formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3,...
|
|
|
7456168 |
2-(pyridin-2-ylamino)-pyrido[2,3, d]pyrimidin-7-ones
The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent...
|
|
|
7452877 |
Methods for treating digestive functional pathologies
Methods are disclosed for treating hyperalgesia associated with irritable bowel syndrome comprising administering a direct and selective inhibitor of MLCK.
|
|
|
7449477 |
7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B)
The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
|
|
|
7449456 |
Diaminopyrimidinecarboxamide derivative
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is...
|
|
|
7442693 |
Diazepine compounds as ligands of the melanocortin 1 and/or 4 receptors
There is provided novel diazepines that function as agonists at the melanocortin 4 receptor and as agonists at the melanocortin 1 receptor, pharmaceutical compositions containing them, methods for...
|
|
|
7442692 |
Indanyl-piperazine compounds
A compound selected from those of formula (I):
wherein:
R 3 represents a hydrogen atom, and R 1 and R 2 together with the carbon atoms carrying them form a benzene, naphthalene or...
|
|
|
7439245 |
Compounds
Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of anxiety.
|
|
|
7439244 |
Quinoline compounds and pharmeceutical compositions containing them
Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other...
|
|
|
7439243 |
Piperazinyl-quinoline derivatives useful for the treatment of CNS disorders
Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other...
|
|
|
7429580 |
Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a psychotherapeutic agent and the second compound is a...
|
|
|
7423048 |
Compounds for treating fundic disaccomodation
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -a...
|
|
|
7419976 |
Diazepanes derivatives useful as IFA inhibitors
Pharmaceutically active diazepanes, e.g. useful for treating disorders or diseases mediated by LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/ICAM-3 or LFA-1/JAM-1 interactions.
|
|
|
7407971 |
Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
A new class of pyrazolo derivative compounds having the formula
where R and R 1 have the meanings given herein. The pyrazolo derivative compounds are useful in treating cell proliferative...
|
|
|
7390800 |
Adenosine deaminase inhibitor and novel Bacillus sp. Iada-7 strain which produces it
The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase...
|
|
|
7378413 |
2-amino-3-(alkyl)-pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof:
Wherein:
R1 represents a hydrogen atom or a C 1-6 alkyl group which may be substituted by a C 6,10 aryl group; R2...
|
|
|
7378411 |
Substituted thienopyrimidinones as a mitotic kinesin inhibitor
The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7371753 |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
Disclosed are new dihydropteridinones of general formula (I)
wherein the groups R 1 to R 5 , R a to R c , W, Q 1 and Q 2 have the meanings given in the claims and specification, the isomers...
|
|
|
7365063 |
Quinazolinone and benzoxazinone derivatives and uses thereof
Compounds of the formula I:
and pharmaceutically acceptable salts thereof wherein X is N, Y is S, Z is —(CR a R b ) r —, A is —NR 3 , m is 2, n is 1, q is 2, R 2 is optioinally...
|
|
|
7361648 |
Heterocyclylakylamines as muscarinic receptor antagonists
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I:
wherein X, Y, and Z are O, S or NR 5 , and the other...
|
|
|
7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
|
|
|
7351700 |
Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors
The present invention relates to compounds of formula
wherein
X is —S— or —NH—; R 3 /R 4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7...
|
|
|
7348347 |
Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds
Substituted 4,5,6,7-tetrahydrobenzothiazol-2-ylamine compounds, a method for their production; pharmaceutical compositions comprising them, and methods of use for modulating biological functions...
|