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7307074 Diazepan derivatives or salts thereof  
To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of...
7271161 Platinum complexes as antitumor agents in combination with biochemical modulation  
The present invention concerns the use of methods and compositions for the treatment of cancer and other hyperproliferative diseases. In certain embodiments, methods are described for the treatment...
7238685 Benzo-fused heterocycles as endothelin antagonists  
The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including...
7226917 Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia  
Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form)...
7214714 20-hydroxyeicosatetraenoic acid production inhibitors  
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R 1 represents a substituted morpholino group, a substituted...
7199158 Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors  
Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R 1 –R 6 , R 7 , R 7′ , R 8 , R 30 –R 34 , X′, Y, Y′, t, x, and n are as defined herein, are...
7141560 Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics  
The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I The invention also relates to pharmaceutical compositions comprising said derivatives,...
6967196 Sulfonamide compounds and uses thereof  
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
6953789 Thiol compounds, their production and use  
The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and...
6906059 Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances  
The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a...
6821965 Amidobenzamide derivatives which are useful as cytokine inhibitors  
The invention concerns amide derivatives of the Formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy,...
6534499 N-substituted-N′-substituted urea derivatives and the use thereof as TNF-α production inhibitory agents  
N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-α...
6525099 N-substituted sulfonamide derivatives  
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
6498150 Low molecular weight cell, bone marrow and immune stimulants  
The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other...
6436925 Substituted benzamides, their production and their use as cysteine protease inhibitors  
Benzamides of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the...
6429317 Indane derivatives for antipsychotic compositions  
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention...
6376468 Protein:prenyl transferase inhibitors  
The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell...
6352981 Substituted AZA- and diazacycloheptane and -cyclooctane  
Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar 1 —A—B—Ar 2 (I) where Ar 1 , A, B and Ar 2 have the meanings stated in the description have a high...
6235791 Use of amines to produce drugs for preventing tumor cell proliferation  
The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of...
6197773 N-acyl and N-aroyl aralkyl amides as serotonergic agents  
A compound of the formula ##STR1## wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined above, useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 ...
6174879 Aminocyclohexylesters and uses thereof  
Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a...
6172117 Biocidal preservatives  
Biocidal preservatives for use especially in preventing rotting and deterioration of wood include quaternary ammonium compounds which preferably have a fatty aliphatic substituent on the quaternary...
6124280 Substituted phenols as novel calcium channel blockers  
The present invention relates to novel substituted phenols and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the...
6114329 5-HT.sub.4 receptor antagonists useful in the treatment of gastroinstestinal, cardiovascular and CNS disorders  
Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--CH 2 --Z ...
6057322 Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them  
Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are also...
5985926 Method for inhibiting intracellular viral replication  
There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an...
5849732 Phenol compound having antioxidative activity and the process for preparing the same  
Disclosed are a phenol compound represented by the formula (1): ##STR1## wherein R 0 represents H, alkyl or alkyloxy; R 1 represents alkyl; R 2 represents alkyl or alkyloxy; OR 3 represents OH;...
5837717 Hydroxamic acid anesthetic compounds  
A compound of the following formula: ##STR1## and its pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are independently hydrogen, C 1 -4 alkyl, C 3 -7 cycloalkyl, C 2 -4 alkenyl, C...
5719141 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amide derivatives  
Compounds of the formula I ##STR1## in which R 1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a...
5665756 Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders  
Novel aminoalkyloximes of the formula ##STR1## wherein: a. X is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, or a group of the formula ##STR2## wherein Y is hydrogen or loweralkyl,...
5602119 Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors  
Succinoylamino hydroxyethylamino sulfamic acid derivative compounds which are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
5491149 Dihydroxypropylamine containing retroviral protease inhibitors  
This invention relates to substituted dihydroxypropylamines, a process to prepare intermediates useful for the synthesis of these compounds, compositions comprising such compounds, and a method of...
5470849 γ-turn peptidomimetics as fibrinogen antagonists  
This invention relates to a method of inhibiting platelet aggregation, and compounds which are mimics of the peptide sequence Arg-Gly-Asp.
5439940 Benz[e]indene derivatives  
The invention relates to novel, pharmaceutically active benz[e]indene derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, further to the use of the...
5310736 Fungicidal N-(2-cyano-2-alkoxyimino acetamido)cyclohexamethyleneimine derivatives  
Fungicidal N-(2-cyano-2-alkoxyimino acetamido) cyclohexamethyleneimine derivatives of the formula ##STR1## wherein R 1 and R 2 have the meanings given in the specification.
5308840 Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof  
Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen...
5304552 Aza-bicyclo-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension  
Compounds characterized generally as piperidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of...
5302602 Tricyclic thromboxane A.sub.2 antagonists  
Novel tricyclic compounds having a TXA 2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A 2 and also an antiallergic and/or...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
5250546 Amino-alcohol derivatives and processes for their preparation  
Amino-alcohol derivatives of the formula, ##STR1## where R 1 is a straight or branched alkyl group having 3 to 8 carbon atoms, R 2 and R 3 are each a lower alkyl group, or R 2 and R 3 form a...
5236922 Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives  
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH 2 , Y is H or a halogen atom, Z is H or a...
5231092 Hexahydroazepine derivatives and pharmaceutical compositions containing them  
The present invention relates to hexahydroazepine derivatives of formula ##STR1## in which: A=--CO--CH 2 --, --CH(OH--CH 2 --; --CH 2 --CH 2 --CH 2 --;--CHCH--; --C.tbd.C--; X=H or a...
5200405 Use of N-(1-hexahydroazepinylalkyl) acetamides for the treatment of cholinergic transmission disorders  
The invention relates to the use of a compound selected from those of formula (I): ##STR1## in which R, R 1 , R 2 and n are as defined in the description, for the treatment of cholinergic...
5122523 N-acylamino acid derivatives and their pharmaceutical compositions  
An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.
5104872 N-(substituted benzyloxy) imine derivatives and method of use thereof  
Compound of the general formula (I), which is useful as an agricultural and horticultural fungicide, an agricultural and horticultural fungicidal composition containing said compound, use of said...
5098916 Propanobicyclic amine derivatives for CNS disorders  
Certain propanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are...
5089251 Aromatic derivatives and their use as antimicrobial agents  
The present invention relates to aromatic derivatives of the formula: ##STR1## in which: n represents an integer between 2 and 10; R 1 and R 2 are identical or different and represent a...
5059620 Aryl substituted aminomethyl benzene derivatives  
The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R 1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole,...
5006523 Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers  
Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.
4996201 4-(N-substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof as centrally acting muscarinic agents  
4-(N-Substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are...
Matches 1 - 50 out of 101 1 2 3 >