Patents in Class 514/217.110

Matches 1 - 50 out of 123

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Match	Document	Document Title
1	7514425	Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
2	7405209	Protease inhibitors The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K,...
3	7351702	Caspase inhibitors and uses thereof This invention provides compounds of formula I: wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; next to R 3 represents a single or double bond;...
4	7351703	Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators The present invention relates to compounds of the formula I in which A 1 , A 2 , R 2 and R 3 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds for...
5	7285547	Amidinophenylalanine derivatives as thrombin inhibitors The compounds of the formula (formula 1) and pharmaceutically acceptable salts thereof and a process for preparing the same and pharmaceutical compositions containing the same are described wherein...
6	7235647	Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 2 1 -deoxy-2 1 ,2 1 -D-ribofuranosyl difluoronucleosides...
7	7160874	Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
8	7132451	Inhibition of TNF-α-initiated neutrophil response The impact of lipoxin A 4 (LXA 4 ) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFα)-initiated neutrophil (PMN) responses in vitro and in vivo using...
9	7071184	Protease inhibitors The present invention provides C 1-6 alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin...
10	6953789	Thiol compounds, their production and use The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and...
11	6906059	Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a...
12	6887864	Azepane derivatives This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as...
13	6787560	Serotonin reuptake inhibitor A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active...
14	6579889	Substituted isonipecotyl derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
15	6534536	Alkylsulfonamido heterocyclic thrombin inhibitors Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure wherein G is wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl,...
16	6506802	Disulfide derivatives useful for treating allergic diseases Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of...
17	6495544	Homoiminopiperidinyl hexanoic acid inhibitors of inducible nitric oxide synthase Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.
18	6486151	N-oxides of heterocyclic esters, amides, thioesters, and ketones This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their...
19	6462073	N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases...
20	6455520	Benzamide derivatives and their use as cytokine inhibitors The invention concerns amide derivatives of formula (I) wherein R 3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R 1 and R 2 is a group such as hydroxy, halogeno,...
21	6451817	Alpha-substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether, amino, hydrazino, cyano or halo...
22	6403584	Substituted nipecotyl derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
23	6376468	Protein:prenyl transferase inhibitors The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell...
24	6362174	Reduced dipeptide analogues as calcium channel antagonitsts The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke,...
25	6346547	N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of the general...
26	6344466	Benzamide and sulfonamide substitued aminoguanidines and alkoxyguanidines as protease inhibitors The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: wherein X is O or NH, L is —O— or —SO 2 —, and R 1 -R 4 , R 9 -R 19 ,...
27	6251919	Heterocyclic substituted aniline calcium channel blockers
28	6251949	Oxime derivatives, hydrazone derivatives and use thereof Compounds having fungicidal activities and represented by general formula (I) and salts and hydrates thereof ##STR1## wherein R 1 represents an optionally substituted aryl, an optionally...
29	6191125	Small molecule pipecolic acid derivative hair growth compositions and uses This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pipecolic acid derivatives.
30	6191144	Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis The present invention is directed to the use of a group of ACE inhibitors to stimulate angiogenesis in mammals or in mammalian tissue in vitro. Specifically, the present invention is directed to...
31	6140338	Chemokine receptor antagonists The present invention relates to a compound of the general formula: ##STR1## wherein each of R 1 and R 2 which may be the same or different, is e.g. a hydrogen atom, a halogen atom or a lower...
32	6107291	Azepine or larger medium ring derivatives and methods of use Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel...
33	6046211	Amidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
34	6034067	Serine protease inhibitors The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can...
35	6030971	Methods and compositions for controlling biofouling using amides The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amide to...
36	5952354	Tris carbamic acid esters: inhibitors of cholesterol absorption Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...
37	5939437	CCK and gastrin receptor ligands Compounds of formula (I) and their pharmaceutically active salts are gastrin and CCK receptor ligands, where Ar is a monocyclic aromatic group, R 1 is halo, amino, nitro, cyano, sulphamoyl,...
38	5932196	Buffered emulsion compositions containing actives subject to acid or base hydrolysis The present invention are for emulsion compositions and the process for making such compositions containing biological and cosmetic actives subject to hydrolysis of actives during processing and...
39	5877203	Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of...
40	5858402	Methods for in vivo reduction of cyanide levels and compositions useful therefor In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in...
41	5859002	HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
42	5854234	Amidino dervatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
43	5849732	Phenol compound having antioxidative activity and the process for preparing the same Disclosed are a phenol compound represented by the formula (1): ##STR1## wherein R 0 represents H, alkyl or alkyloxy; R 1 represents alkyl; R 2 represents alkyl or alkyloxy; OR 3 represents OH;...
44	5776927	Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The...
45	5773434	Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia Psychotic symptoms are treated by the administration of drugs which amplify the ability of natural stimulators of AMPA receptors to enhance the mediation of excitatory synaptic response. What is...
46	5741799	Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R 1 , R 2 , R 3 , G, G x , R 6 ', Ra, Xa, R 6 , Rb, R 3 , p, Q, A and R 4 are as defined herein.
47	5691356	Disubstituted heterocyclic thrombin inhibitors Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q...
48	5677344	Method for treating Parkinson's disease employing an ATP-sensitive potassium channel blocker A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea,...
49	5674864	N-substituted derivatives of α-mercapto alkylamines, their preparation process and the intermediates obtained, their use as medicaments and the compositions containing them Novel α-mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula ##STR1## wherein the substituents are as defined in the specification.
50	5639746	Hydroxamic acid-containing inhibitors of matrix metalloproteases The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity...

Matches 1 - 50 out of 123

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