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8871208 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof  
A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteoporosis, comprising administering an effective amount of...
8815934 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations  
The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as...
8802665 Pyrrolidine derivatives  
The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
8765738 Carbazole compounds and therapeutic uses of the compounds  
Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include...
8754107 Aminopyrrolidines as chemokine receptor antagonists  
The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs...
8735388 Heterocyclic compounds with affinity to muscarinic receptors  
The present invention relates to heterocyclic compounds of formula (I) having affinity to muscarinic receptors, a pharmaceutical composition containing the compounds, as well as the use of the...
8394788 Phenylsulfoxyoxazole compound inhibitors of urea transporters  
Provided herein are small molecule compounds that alter the transport activity of solute transporters, particularly urea transporters. The compounds described herein belong to the...
8318769 Substituted sulfonamide compounds  
Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted...
8153625 Nitrogen-containing heterocyclic compounds and medicinal use thereof  
The compound represented by formulae (I) and (II), the salt thereof, the N-oxide thereof or the solvate thereof, or the prodrug thereof and the pharmaceutical composition comprising thereof have a...
8071584 Indole carboxamides as IKK2 inhibitors  
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined...
8063041 Polymorphic Form D of bazedoxifene acetate and methods of preparing same  
The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.
8034807 Salts of bazedoxifene  
The invention deals with new crystalline salts of bazedoxifene, by means of which a high API quality can be achieved in a high yield.
8022063 CRTH2 receptor ligands for medicinal uses  
Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic...
7989447 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity  
The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The...
7968591 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments  
1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin...
7943605 Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses  
The present invention relates to compounds of formula (I) comprising a lactam or a lactam derivative moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and...
7910576 Pyrrole derivatives as P2Y12 antagonists  
The present invention relates to compounds of the formula I, in which R1; R2; R3; R4; R5; R6; R7; R8; R9; R10; R11; R12; R13; A; B, D and E have the meanings indicated in the claims. The compounds...
7771744 Bazedoxifene acetate formulations  
Bazedoxifene acetate formulations and compositions thereof having improved properties relating to reduction, elimination, or prevention of polymorphic conversion of bazedoxifene acetate, and...
7754710 Noribogaine in the treatment of pain and drug addiction  
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
7750039 Indoles are cannabinoid receptor ligands  
The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
7737137 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme  
Methods for treating a mammal suffering from glucocorticoid-related diseases and conditions, comprising administering to the mammal an effective amount of a selective inhibitor of...
7700583 11β-hydroxysteroid dehydrogenase type 1 active compounds  
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are...
7683051 Crystalline polymorph of bazedoxifene acetate  
The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
7683052 Crystalline polymorph of bazedoxifene acetate  
The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
7666862 Mitotic Kinesin Inhibitors  
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
7645752 Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors  
The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine...
7612060 Triazoles and methods of use  
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
7560481 Indoles are cannabinoid receptor ligands  
The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
7504394 Bazedoxifene ascorbate  
The present invention is directed to bazedoxifene ascorbate, compositions containing the same, dispersions thereof, preparations thereof, and uses thereof.
7468363 Methods for treatment of cancers using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione  
Methods of treating a specific cancer or amyloidosis are disclosed. Specific methods encompass the administration of 3-(4-amino-1 oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione alone or in...
7407950 N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands  
The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. Said compounds are ligands of the TRPV1 vanilloid receptor, and...
7405209 Protease inhibitors  
The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K,...
7393842 Pyrazole analogs acting on cannabinoid receptors  
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or...
7304048 Indole-type derivatives as inhibitors of p38 kinase  
The invention is directed to methods to inhibit p38-α kinase using compounds containing an aromatic system coupled through a 7-membered heterocycle to an indole-type system.
7202237 Pyridylether derivatives, their preparation and use  
The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions,...
7179835 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors  
The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by...
7173024 Compounds having prolyl oligopeptidase inhibitory activity, methods for their preparation and their use  
Compounds of the formula (I), wherein the symbol aa means a residue of an α-amino acid. The invention is also directed to a method for the preparation of the compounds of formula (I), as well as...
7160877 Aliphatic nitrogen-containing 5-membered ring compound  
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—,R1 represents hydrogen atom, a lower...
7148249 Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments  
The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers,...
7138392 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents  
The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: or which are useful in treating or preventing bone loss.
7071184 Protease inhibitors  
The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin...
6906090 Compositions and methods for treating mycobacterial diseases  
The invention provides the use of certain isatin and oxindole derivatives in the preparation of a medicament for use in the treatment of mycobacterial disease.
6887865 N-heterocyclic derivatives as NOS inhibitors  
N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these...
6887864 Azepane derivatives  
This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as well...
6861432 Piperazine derivatives that destabilize androgen receptors  
This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds according to...
6849622 Aliphatic nitrogenous five-membered ring compounds  
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—,R1 represents hydrogen atom, a lower...
6713473 Tricyclic compounds  
A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR3—CO—, —CO—NR3— and the like (R3 represents a hydrogen atom, a lower alkyl group,...
6699864 Substituted phenyl-piperazine derivatives, their preparation and use  
The present invention provides compounds of the formula: wherein R1-R8, X, Y, Z, n and m are defined in the application.The compounds of the invention have affinity for the 5-HT1A receptor.
6693096 Treatment of inflammation-associated disorders using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors  
The present invention provides methods and compositions for preventing and treating inflammation-associated disorders or ameliorating symptoms thereof by the suppression of the activity of a...
6673790 Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands  
The present invention relates to novel indolin-2-one derivatives of formula: to the preparation and to the pharmaceutical compositions comprising them.These compounds have an affinity for oxytocin...

Matches 1 - 50 out of 209 1 2 3 4 5 >