Matches 101 - 150 out of 209 < 1 2 3 4 5 >


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5756496 Amide derivatives having 5HT1D-antagonist activity  
Compound of formula (1), processes for their preparation and their use as CNS agents are disclosed, in which A is CONR where R is hydrogen or C1-6 alkyl; Q is an optionally substituted 5 to...
5741789 Compounds having effects on serotonin-related systems  
A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds...
5721255 Substituted benzylamino nitrogen containing non-aromatic heterocycles  
The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R1, R2, R3 and A are...
5703070 Indole, indazole and benzisoxazole compounds  
Compound of formula (I): ##STR1## in which: R1 represents hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxyl, R2 represents hydrogen, alkyl or phenyl which is optionally substituted,...
5622917 Substituted 1H--3-aryl-pyrrolidine-2,4-dione derivatives  
The invention relates to new 1H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## in which A, B, X, Y and G have the meanings given in the description, to a plurality of...
5612331 Tetrahydrocarbazole derivatives as 5-HT1-like agonists  
Compounds of formula (I), wherein R1 represents halogen, C1-4 alkyl, C1-4 alkoxy, hydroxy, NO2, --NR4 R5, R4 R5 NCO(CH2)m --, R4 R5 NSO2 (CH2)m --, R6 CONH(CH2)-m or R7 SO2 NH(CH2)m --; R4 and R5...
5607960 Indole derivatives as 5-HT1-like agonists for use in migraine  
The present invention relates to 3,5-disubstituted indole compounds which are selective agonists which act on 5-hdroxytryptamine receptors useful in the treatment of migraine.
5585374 Amide derivatives  
Amide derivatives of formula (I) and their pharmaceutically acceptable salts (where a and b each represent 0, 1, 2 or 3 such that a+b=0, 1, 2 or 3, the dotted line represents an optional double...
5576313 Inhibitors of farnesyl-protein transferase  
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
5565447 Indole derivatives  
A compound of formula (I) ##STR1## wherein R1 and R2 each represents a hydrogen atom or an alkyl group, Z represents a ring selected from: ##STR2## in which n represents 4, 5 or 6; ##STR3## in...
5563166 Thienyl- and furylpyrrole fungicidal agents  
There are provided fungicidal thienyl- and furylpyrrole compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from...
5561146 Modified guanidino and amidino thrombin inhibitors  
Thrombin inhibitors are provided which have the formula ##STR1## wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; and R1 is cyano, hydroxyl,...
5538985 Pyrrolidinone derivatives  
Antipsychotics and ischemic cerebral disease therapeutics comprising as an effective ingredient a compound represented by the following formula (1) or (2): ##STR1## or a salt thereof. These drugs...
5527818 Sulfamoyltriazole derivatives of fungicidal composition containing same as effective component thereof  
The present invention relates to a sulfamoyl triazole derivative and a fungicide containing same as an effective component, the sulfamoyl triazole derivative being expressed by general formula...
5523299 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists  
Compounds of formula (I), ##STR1## wherein R1 represents C1-4 alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxyC1-4 alkyl, C1-4...
5514700 Substituted 1,2,3,4-tetrahydrocyclopent b!indoles, compositions and use  
There are disclosed various compounds of the formula below, ##STR1## where n, X and R1 through R4 are as defined in the specification, which are useful for alleviating various memory dysfunctions...
5512560 Conformationally restricted HIV-1 protease inhibitors  
HIV protease inhibitors containing hydroxypyrrolidine or hydroxypiperidine with one or more basic amines are disclosed.
5506257 Aminocyclohexylamides for antiarrhythmic and anaesthetic uses  
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
5491149 Dihydroxypropylamine containing retroviral protease inhibitors  
This invention relates to substituted dihydroxypropylamines, a process to prepare intermediates useful for the synthesis of these compounds, compositions comprising such compounds, and a method of...
5478823 Composition for suppressing infiltration of eosinophils  
An agent for suppressing infiltration of eosinophils comprising as an effective ingredient a tricyclic triazolo derivative, which strongly suppresses infiltration of eosinophils into inflammatory...
5447929 Method of treating joint disorders using hydroxamic derivatives  
Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint...
5376659 Substituted guanidine and amidine compounds, and fungicidal use  
The present invention relates to novel substituted guanidine and amidine compounds, their preparation and their use in the kill and control of fungal organisms which infest plants.
5340801 Compounds having cholecystokinin and gastrin antagonistic properties  
This invention relates to N-arylcarbamoyl proline analogues which are useful as cholecystokinin and gastrin antagonists, to pharmaceutical compositions including such proline analogues, and to...
5332736 Anti-convulsant aroyl aminoacylpyrroles  
Aroyl aminoacyl pyrroles are pharmaceutically useful as anti-convulsants, which includes utility for the treatment of epilepsy.
5270331 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides  
Antiinflammatory and analgesic oxindole prodrugs of the formula ##STR1## wherein R10, R11, R12 and R13 are hydrogen, alkyl or halogen and R is methyleneoxyalkanoyl, methyleneoxyalkenoyl or alkenoyl.
5258383 DC-89 derivatives  
DC-89 derivatives represented by the formula: ##STR1## wherein X represents hydrogen or CO2 CH3 ; and ##STR2## wherein Z represents Cl or Br; R represents hydrogen, CONR1 R2 (in which R1 and R2...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH2 R1 has the R-configuration, the carbon atom bearing CH2 R2 has the...
5248692 DC-89 derivatives as anti-tumor agents  
Novel DC-89 derivatives as shown below have an excellent anti-tumor activity, and thus are useful as anti-tumor agent ##STR1## wherein L represents chlorine or bromine; R represents ##STR2##...
5231083 Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia  
The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of...
5204341 1-arylsulphonyl-2-pyrrolidone derivatives, their preparation process and the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them  
1-arylsulphonyl-2-pyrrolidone derivatives for treating spasmodic disorders in gastro-enterology, in gynaecology, in obstetrics, in urology; intermediates in the preparation of such products;...
5200405 Use of N-(1-hexahydroazepinylalkyl) acetamides for the treatment of cholinergic transmission disorders  
The invention relates to the use of a compound selected from those of formula (I): ##STR1## in which R, R1, R2 and n are as defined in the description, for the treatment of cholinergic...
5151424 Pharmacologically active (Bicyclic heterocyclyl)methyl and -hetero) substituted hexahydro-1H-azepines and pyrrolidines  
[(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines and their pharmaceutically acceptable acid addition salts having anti-histaminic properties,...
5124324 Indole derivatives  
Disclosed are compounds of formula I ##STR1## wherein R1 is a hydrogen atom, a C1 -C6 alkyl group, benzyl or an indolyl carbonyl group, R2 is a saturated or unsaturated 5- or 8-membered...
RE33906 Cyclic carboxamide derivatives and their use as analgesics  
A compound of formula (I): ##STR1## or a salt or solvate thereof in which R. CO is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, R1 and R2 are...
5102882 Pyroglutamide derivatives  
Pyroglutamide derivatives have been found to be useful as nootropic agents for administration to humans and animals.
5071853 Polycyclic amines useful as cerebrovascular agents  
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
5061312 Fungicidal N-vinyl-3-cyano-4-phenyl-pyrroles  
Fungicidal N-vinyl-3-cyano-4-phenyl-pyrroles of the formula ##STR1## in which R1 represents alkyl, R2 represents alkyl, or R1 and R2 together with the nitrogen atom to which they are bonded form a...
5059620 Aryl substituted aminomethyl benzene derivatives  
The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole,...
5047402 Cyclic amides as medicaments  
This invention provides a series of novel cyclic amides of formula I in which the group >Z--Y--X< is selected from >CCH--N<, >N-CHCH<, >CN--N< and >N--NC< and the other radicals have the...
5037822 1-arylsulphonyl-2-pyrrolidinethione or 1-arylsulphonyl-2-piperidinethione derivatives, process for the preparation thereof their application as medicinal products and compositions containing them  
The invention relates to the products of formula ##STR1## in which R represents the radical ##STR2## in which R1 at any position on the benzene ring represents a linear, branched or cyclic alkyl,...
5006520 Fused pyrazole compounds and pharmaceutical use thereof  
Novel fused pyrazole compounds of the general formula ##STR1## wherein all the symbols are as defined in the specification or its pharmaceutically acceptable salt which possesses a stimulating...
4994450 Azacyclic compounds and their use as analgesic agents  
A compound, or a solvate or salt thereof, of formula (I) ##STR1## in which: R1 and R2 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C4-12 cycloalkylalkyl groups, or...
4988711 HMG-CoA reductare-inhibiting N-substituted N-amino-pyrroles  
Inhibiting HMG-CoA reductase, as in treating hyperlipopproteinaemia, lipoproteinaemia and arteriosclerosis, with the new N-substituted N-amino-pyrroles of the formula ##STR1## in which R1 is an...
4980368 Tryptamine compounds, and methods of cerebrovascular treatment therewith  
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R1 is hydrogen, C1-6 alkyl, C1-6 alkoxy or halogen; R2 and R3 are both hydrogen or together represent a...
4973350 Fungicidal 1-aminomethyl-3-(2-fluoro-3-chlorophenyl)-4-cyanopyrrole derivatives  
Fungicidal 1-aminomethyl-3-(2-fluoro-3-chlorophenyl)-4-cyano-pyrrole derivatives of the formula ##STR1## in which R stands for a ##STR2## wherein R1 stands for optionally substituted alkyl, for...
4960798 Methods for the treatment of angina  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R1, R2 R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds...
4935416 1-aminomethyl-3-aryl-4-cyano-pyrroles  
Fungicidally active novel 1-aminomethyl-3-aryl-4-cyano-pyrroles of the formula ##STR1## in which AR represents optionally substituted phenyl.
4898889 Methods for the treatment of hypertension  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R1, R2, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds...
4895840 N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines  
Novel N-(Aryl-,aryloxy-,arylthio-,arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or N',N')alkylaminoalkyl ureas, thioureas and cyanoguanidines represented by the following formula: ##STR1## wherein Ar...
4874756 Benzodipyrroles, processes for the preparation thereof and pharmaceutical compositions containing them  
The present invention provides compounds of the general formula ##STR1## wherein the variables are as defined herein. The present invention also provides processes for the preparation thereof,...

Matches 101 - 150 out of 209 < 1 2 3 4 5 >