Matches 51 - 100 out of 209 < 1 2 3 4 5 >


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6667303 Aryl substituted 1,4-diazepanes and method of use thereof  
Aryl substituted 1,4-diazepanes are provided such as derivatives of 6-(1,4-diazepan-1-yl)benzo[cd]indol-2(1H)-one, 6-(1,4-diazepan-1-yl)acenaphthylen-1(2H)-one and...
6620806 Methods and kits for improving vascular health  
The present invention provides methods and kits for improving or maintaining vascular health, including preventing myocardial infarction or stroke; maintaining or improving vascular reactivity;...
6613781 Heterocyclylaklylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands  
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor
6608070 2,3-substituted indole compounds as anti-inflammatory and analgesic agents  
This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the following:...
6599926 Heteroaryl-phenyl substituted factor Xa inhibitors  
The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of...
6511986 Method of treating estrogen receptor positive carcinoma  
This invention provides a method of treating or inhibiting an estrogen receptor positive carcinoma in a mammal in need thereof, which comprises providing said mammal with an effective amount of a...
6500821 4-amino-1-aryl-1,5-dihydropyrrol-2-ones and process for making  
The invention relates to 1,5-dihydropyrrol-2-ones of Formula 1 which contain an aryl radical in the 1-position and a secondary amine radical in the 4-position, to a process for making and for a...
6495568 Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors  
Compounds of formula (I): or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line represents...
6492421 Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
6489354 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor...
6486153 Phenylindole derivatives as 5-HT2A receptor ligands  
A class of tryptamine analogues bearing an optionally substituted phenyl nucleus at the 2-position are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical...
6479480 Phenylindole derivatives as 5-ht2a receptor ligands  
Compounds according to Formula (I) or a salt thereof are selective antagonists of the human 5-HT2A receptor useful for treatment of adverse conditions of the central nervous system:
6479535 2-phenyl-1-&lsqb 4-(2-aminoethoxy)-benzyl&rsqb -indole and estrogen formulations  
The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as...
6476054 Cyclic amine modulators of chemokine receptor activity  
The present invention is directed to cyclic amines of the formula I: (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular,...
6465453 Azepine derivatives having effects on serotonin related systems  
The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises...
6465454 Combinations of statins and estrogenic agents  
This invention comprises methods of treating cardiovascular disorders and lowering blood LDL levels comprising administration of a statin and compound of the formulae I or II: wherein Z is a...
6451817 Alpha-substituted-1-benzyl-napthyls  
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether, amino, hydrazino, cyano or halo...
6448243 1,4-substituted cyclic amine derivatives  
A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or...
6436980 Peptidomimetic efflux pump inhibitors  
Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such...
6420395 Azacyclooctane and heptane derivatives, their preparation and use in therapy  
The present invention discloses compounds of formula (1) or (2), any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1; R is hydrogen,...
6403577 Hexamethyleneiminyl tachykinin receptor antagonists  
This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This...
6380185 N-substituted benzoyl indoles as estrogenic agents  
The present invention provides compounds of the formula: wherein R1, R2, R3, R4, X, n Y and Z, are as defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
6372764 Pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor...
6369051 Combinations of SSRI and estrogenic agents  
This invention comprises methods of depression, anxiety, generalized anxiety disorder (GAD), hot flush, post partum depression, premenstrual syndrome, obesity, obsessive compulsive disorder,...
6362201 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor...
6358943 N-substituted indolines as estrogenic agents  
This invention provides compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, X, n and Y, are as defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
6352981 Substituted AZA- and diazacycloheptane and -cyclooctane  
Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2 (I)where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the...
6303593 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine...
6255306 4-indole derivatives as serotonin agonists and antagonists  
The present invention relates to compounds of the formula ##STR1##
6251921 Antithrombotic diamines  
This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds...
6232307 Tissue selective compounds in the treatment of ovarian cancer  
The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment...
6191145 Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders  
Orally-active nipecotamide glycolamide ester derivatives of formula (I): ##STR1##are disclosed as useful in treating platelet-mediated thrombotic disorders.
6166037 Pyrrolidine and piperidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine and piperidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4a, R4b, R4c, R4d, R4e, R4f, R4g, R4h, m, n, x and y are defined herein)...
6166040 Indole compounds  
Pharmaceutical compounds of the formula: ##STR1## in which n is 1 to 6, m is 1 or 2 and p is 1 or 2, R1 and R2 are each hydrogen, C1-4 alkyl, C1-4 alkoxy, HO--C1-4 alkyl, C1-4 alkoxy-C1-4 alkyl,...
6124311 Methods for treating resistant tumors  
The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran,...
6121292 Methods for reversing multidrug resistance  
The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran,...
6107291 Azepine or larger medium ring derivatives and methods of use  
Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel...
6057322 Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them  
Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are...
6022880 Substituted pyridylamino indoles  
There are disclosed various compounds of the formula below, ##STR1## where R, R1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions...
5972975 Substituted 2-aminopyridines as inhibitors of nitric oxide synthase  
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
5958918 Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N- (aminominomethyl)phenylalkyl!-azaheterocyclylamide compounds  
The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain...
5952326 Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases  
Compounds of the formula ##STR1## wherein R is an optionally substituted heteroaryl group such as 2-chromanyl, 2-pyridyl or 5-fluoro-2-benzothiazoyl; X is O, S or (CH2)m ; R1 is phenyl or pyridyl,...
5932567 Thrombin inhibitors  
Thrombin inhibitors of the formula ##STR1## where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described.The compounds I are...
5889022 Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity  
Novel indole, indoline and quinoline derivatives of formula (I) processes for their preparation, pharmaceutical compositions containing them, and their use in medicine is disclosed. A structurally...
5872134 5-HT4 receptor antagonists  
The use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the treatment of artrial arrhythmia, stroke or CNS disorders X--CO--CH2 --Z (I)wherein X is a monocyclic or...
5859002 HIV protease inhibitors  
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
5843959 Methods and bicyclic polyamine compositions for the treatment of inflammation  
Methods for treating inflammatory conditions wherein the active agent is a polyamine having the formula set forth below: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein:...
5827871 Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof  
Use of a compound of general formula (I): ##STR1## wherein R1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C1-6 alkyl, C1-6 alkoxy, arylC1-6 alkoxy, --CO2 R4, --(CH2)n CN,...
5817651 3-arylcarbonyl-1-(C-attached-N-heteryl)-1H-indoles  
2-R2 --R4 -substituted-3-R3 --CO-1- (C-attached-N-heteryl)-(Alk) n !-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.
5792760 Bisindoles as tachykinin receptor antagonists  
This invention provides a series of substituted bisindole propanamides which are useful as tachykinin receptor antagonists and as serotonin agonists. This invention also provides methods for the...

Matches 51 - 100 out of 209 < 1 2 3 4 5 >