Patents in Class 514/217.070

Matches 1 - 50 out of 191

1 2 3 4 >

Match	Document	Document Title
1	7456195	Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein...
2	7405209	Protease inhibitors The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K,...
3	7345038	Pyridyloxymethyl and benzisoxazole azabicyclic derivatives An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic compound of formula I, pharmaceutical composition comprising same, and a method of treating one or more CNS or other disorders,...
4	7319097	Compounds The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
5	7304052	Substituted homopiperidinyl benzimidazole analogues as fundic relaxants The present invention relates to compounds of formula (I) their prodrugs, N-oxides, addition salts, quaternary amines and stereochemically isomeric forms, wherein the bivalent radical -{circle...
6	7285547	Amidinophenylalanine derivatives as thrombin inhibitors The compounds of the formula (formula 1) and pharmaceutically acceptable salts thereof and a process for preparing the same and pharmaceutical compositions containing the same are described wherein...
7	7241745	Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds...
8	7205309	Quinazoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 , R 2 , R 3 and A have the significance given in the specification are provided. The...
9	7186710	Phthalazinones The compounds of formula I in which R1, R2, R3, R4 and R5 have the meanings as given in the description are PDE4/7 inhibitors.
10	7176214	Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. The present invention...
11	7135466	Quinoline and quinazoline derivatives and drugs containing the same There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation...
12	7132417	2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating uterine leiomyoma.
13	7119084	Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the...
14	7071184	Protease inhibitors The present invention provides C 1-6 alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin...
15	7041675	Heterocyclic compounds and their use as PARP inhibitors The invention relates to compounds of the formula I and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.
16	7012073	Quinoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 , R 2 , R 3 , A 1 and A 2 have the significance given in claim 1 , can be used in the form...
17	6964957	Fused pyrazole compounds, pharmaceutical compositions, and methods for modulating or inhibiting ERAB or HADH2 activity Pyrazole compounds represented by the formula: are described. The pyrazole compounds and pharmaceutical compositions containing them may be used in inhibiting ERAB or HADH2 activity and in...
18	6962926	Antagonist of MCP-1 function, and compositions and methods of use thereof Compounds of formula A and formula B: and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The...
19	6924292	Furoisoquinoline derivatives, process for producing the same and use thereof A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic...
20	6887864	Azepane derivatives This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as...
21	6835729	2-phenyl-1-&lsqb 4(2-aminoethoxy)-benzyl&rsqb -indoles as estrogenic agents The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in lowering cholesterol levels.
22	6699492	Quinolone carboxylic acid compositions and related methods of treatment The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release...
23	6613781	Heterocyclylaklylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor
24	6602864	Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from...
25	6602867	Triazole compounds with dopamine-D3-receptor affinity Triazole compounds of the following formula where R 1 , R 2 , A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity...
26	6593338	3-substituted 2,7-naphthyridin-1-yl derivatives 3-Substituted 2,7-naphthyridine derivatives of formula (1) are described: wherein L 1 and L 1 is each a covalent bond or a linker atom or group; Alk 1 is an optionally substituted aliphatic...
27	6566362	Benzo&lsqb f&rsqb naphthyridine derivatives, their preparation and compositions containing them Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for...
28	6548506	Benzo&lsqb 1,8&rsqb naphthyridine derivatives, their preparation and pharmaceutical compositions which comprise them Novel 1,8-benzo-naphthyridine derivatives of general formula (I): which are useful as antimicrobial agents.
29	6545013	2,7-naphthyridine derivatives 2,7-Naphthyridine containing squaric acids of formula (1) are described: wherein Ar 1 is an optionally substituted 2,7-naphthridin-1-yl group; L 2 is a covalent bond or a linker atom or group;...
30	6506772	Substituted &lsqb 1,2,4&rsqb triazolo&lsqb 1,5a&rsqb pyridine derivatives with activity as adenosine receptor ligands Substituted [1,2,4]triazolo[1,5a]pyridine derivatives and pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are useful for treatment...
31	6495568	Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors Compounds of formula (I): or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line...
32	6476025	Phenylphennanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics
33	6476054	Cyclic amine modulators of chemokine receptor activity The present invention is directed to cyclic amines of the formula I: (wherein R 1 , R 2 , R 3 , m and n are defined herein) which are useful as modulators of chemokine receptor activity. In...
34	6448243	1,4-substituted cyclic amine derivatives A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or...
35	6420395	Azacyclooctane and heptane derivatives, their preparation and use in therapy The present invention discloses compounds of formula (1) or (2), any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1; R is hydrogen,...
36	6358976	Integrin receptor antagonists This invention relates to novel fused heterocycles which are useful as antagonists of the α v β 3 and related integrin receptors, to pharmaceutical compositions containing such compounds,...
37	6294551	N-linked sulfonamides of heterocyclic thioesters This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as...
38	6225308	Tissue selective compounds in the treatment of prostate cancer or benign prostate hypertrophy The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment...
39	6211195	CRF antagonistic thiophenopyridines This invention concerns compounds of formula ##STR1## including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein X is S or SO 2 ; R 1 is C 1 -6...
40	6191145	Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders Orally-active nipecotamide glycolamide ester derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
41	6093723	4-substituted beta-carbolines and analogs thereof This invention relates to 4-substituted β-carbolines and β-carboline analogs that inhibit Ca +2 influx and interleukin-2 (IL-2) production. The 4-substituted β-carbolines and β-carboline...
42	6093731	Isoquinolines Isoquinolinylguanidine compounds of formula (I): ##STR1## wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.
43	6080758	Benzenesulfonamide derivatives as bradykinin antagonists The present invention relates to compounds selected from the group consisting of the compounds of formula (I): ##STR1## X is a halogen atom, A is --CH 2 --, --CH(OH)--, --CH(NH--COCH 3 )-- or S, R...
44	6034102	Atherosclerosis treatment A method of treating atherosclerosis, independent of lipid lowering, in mammals, including humans, in need of treatment by inhibiting progression of an atherogenic lesion or by stabilizing plaque....
45	6030984	Pyridone compounds useful in treating Alzheimer's disease The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R 1 , R 3 , R 4 , and R 7 are described herein and of their pharmaceutically acceptable...
46	6008215	Benzonaphthyridines as bronchial therapeutics Compounds of formula (I) in which R1, R2, R3 and R4 have the meanings indicated in the description, are novel active bronchial therapeutics
47	5972975	Substituted 2-aminopyridines as inhibitors of nitric oxide synthase Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
48	5968926	Antipsychotic method The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases.
49	5952326	Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases Compounds of the formula ##STR1## wherein R is an optionally substituted heteroaryl group such as 2-chromanyl, 2-pyridyl or 5-fluoro-2-benzothiazoyl; X is O, S or (CH 2 ) m ; R 1 is phenyl...
50	5952354	Tris carbamic acid esters: inhibitors of cholesterol absorption Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...

Matches 1 - 50 out of 191

1 2 3 4 >