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8999971 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha  
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral...
8952004 CXCR3 receptor antagonists  
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R3, A, B, X, and n are as defined herein. The invention also relates to...
8889665 Chemical compounds  
The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by...
8883774 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha  
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral...
8841290 Substituted tetrahydronaphthalenes, method for the production thereof, and use thereof as drugs  
Disclosed is a tetrahydronapthalene compound having Formula I the variables of which are as described herein, methods of preparing same and their use.
8703763 Bridged piperidine derivatives  
The present invention relates to compounds of formula I hetaryl I, hetaryl II, R1, R2, R3, Y, m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I...
8658636 TRPV4 antagonists  
The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
8642623 Vanilloid receptor ligand compounds, pharmaceutical compositions containing them, a method of producing them and the use thereof to treat pain and various other conditions  
Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical compositions containing such compounds, a method for producing the compounds, and the use of such...
8604020 Fluoroquinolone carboxylic acid molecular crystals  
Disclosed herein is a molecular crystal form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin-1-yl)-1-c yclopropyl-8-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-ca rboxylic acid. The...
8598159 Therapeutic pyrazoloquinoline derivatives  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the...
8536165 Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors  
The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their...
8524743 Bis(difluoromethyl)pyrazoles as fungicides  
Bis(difluoromethyl)pyrazole derivatives of the formula (I) in which the symbols R1, X and G are each as defined in the description, and agrochemically active salts, metal complexes and N-oxides...
8513237 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase  
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity;...
8507471 Biphenylcarboxamide derivatives as hedgehod pathway modulators  
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from...
8497262 Therapeutic pyrazolonaphthyridine derivatives  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype...
8481524 c-MET protein kinase inhibitors  
The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the...
8377924 Protein kinase C inhibitors and uses thereof  
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained...
8362008 Amido-thiophene compounds and their use as 11-beta-HSD1 inhibitors  
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
8299063 Amido-thiophene compounds and their use  
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
8217032 Selective estrogen receptor modulators for the treatment of vasomotor symptoms  
The present invention relates to a selective estrogen receptor modulator of formula I or Ia: (I) (Ia); or a pharmaceutical acid addition salt thereof; useful for treating vasomotor symptoms, in...
RE43481 Diazepan derivatives or salts thereof  
To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment...
8163733 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase  
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity;...
8097610 Derivative having PPAR agonistic activity  
A compound of the formula (I): or a pharmaceutically acceptable salt thereof.
8063036 Benzamides and related inhibitors of factor Xa  
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described....
7872002 Therapeutic pyrazoloquinoline derivatives  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the...
7863266 Therapeutic pyrazoloquinoline urea derivatives  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the...
7858614 Therapeutic pyrazolonaphthyridine derivatives  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the α5 subtype...
7754710 Noribogaine in the treatment of pain and drug addiction  
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
7745479 1,5-substituted indol-2-yl amide derivatives  
The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful...
7727981 Benzamides and related inhibitors of factor Xa  
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described....
7723330 Heterobicyclic pyrazole compounds and methods of use  
Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine...
7700628 Aromatic ether derivatives useful as thrombin inhibitors  
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use...
7595312 Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions  
The present invention relates to CGRP antagonists of general formula wherein A, U, V, W, X and R1 to R3 are defined as in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures...
7589085 Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity  
The present invention is further directed to compounds of the formulas: (I) (II) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24 and R25 are as defined herein) which...
7494989 Pyridine compounds useful as N-type calcium channel antagonists  
Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
7465726 Substituted pyrrolo[2.3-B]pyridines  
Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3,...
7405209 Protease inhibitors  
The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K,...
7361682 Indole derivatives as H3 inverse agonists  
The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the...
7323456 Carboxylic acid derivatives compounds and agents comprising the compounds as active ingredient  
A compound of formula (I) (wherein all symbols are as defined in the specification) and a salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active...
7319097 Compounds  
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
7307074 Diazepan derivatives or salts thereof  
To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment...
7291613 Inhibitors of p38 kinase  
The invention is directed to methods to inhibit p38-α kinase using compounds comprising saturated heterocycles coupled to a fused ring system.
7241745 Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives  
The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds as...
7202237 Pyridylether derivatives, their preparation and use  
The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions,...
7115596 Thiazole compounds as integrin receptor antagonists derivatives  
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I,...
7115635 Benzylpiperidine compound  
The object of the present invention is to provide a compound having a treatment effect based on a chemokine inhibitory activity, which is satisfactory as a pharmaceutical product for oral...
7071184 Protease inhibitors  
The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin...
7041675 Heterocyclic compounds and their use as PARP inhibitors  
The invention relates to compounds of the formula I and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.
7022695 Thioether-substituted benzamides as inhibitors of Factor Xa  
Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.
6992092 Anti-diabetic agents  
The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein R1,...

Matches 1 - 50 out of 258 1 2 3 4 5 6 >