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5958903 |
Galanthamine derivatives, and their pharmaceutical compositions
Novel galanthamine derivatives of general fonnulae (Ia) and (Ib), a method for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as...
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5952335 |
Fused polycyclic heterocycle derivatives
Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or...
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5952324 |
Bicyclic oxazine and thiazine oxazolidinone antibacterials
Phenyloxazolidinone compound of formula (I)or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents,...
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5945431 |
Cytomegalovirus inhibiting compounds
The present invention relates to heterocyclic compounds having antiviral activity. In particular, compounds of formula (I): wherein B, W, X, Y, R 1 , R 2 , R 3 , R 4 and n are as defined herein,...
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5932238 |
Galanthamine containing transdermal applicator for the treatment of alcoholism
Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which...
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5929114 |
Arylthio compounds
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
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5929068 |
Optically active benzothiazepine compounds and process for preparing the same
An optically active salt of 1,5-benzothiazepine compound of the formula (I) or (II): ##STR1## wherein each of Ring A and Ring B is a substituted or unsubstituted benzene ring, and R 1 and R 2 are...
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5929069 |
Compounds activating pharmacological effects of retinoids
A compound represented by the formula (I) or (II) or a salt thereof wherein R 1 represents hydrogen atom or a C 1 -6 alkyl group; R 2 and R 3 independently represent a hydrogen atom or a C 1 -6...
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5922748 |
Indole derivatives as 5-HT agonists
Compounds of formula (I) ##STR1## wherein R and R 1 are hydrogen, C 1 -4 alkyl or are linked to form a ring, A is a cycloalkyl or alkyl-cycloalkyl group, n is an integer from 0 to 3, W is...
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5919779 |
5,6-Heteroaryl-dipyrido(2,3-B:3', 2'-F) azepines and their use in the prevention or treatment of HIV infection
"There are disclosed compounds of the formula I, II or III ##STR1## wherein A and D are carbon or nitrogen and B is oxygen, sulfur or nitrogen which are useful in the prevention or treatment of HIV...
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5919778 |
Cyclic amide derivatives
The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an...
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5908841 |
5,11-dihydro-6H-dipyrido 3,2-b:2',3'-e!azepine-6-ones and their use in the prevention of treatment of HIV infection
There are disclosed compounds of the formula 1 ##STR1## wherein X is an oxygen atom or nothing and R1, R2 and R3 are as defined in the specification, useful in the prevention or treatment of HIV...
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5877172 |
Process for isolating galanthamine
The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of...
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5869483 |
Tricyclic benzazepine vasopressin antagonists
Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V 1 and/or V 2 receptors and exhibit in vivo vasopressin antagonist activity, methods...
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5869482 |
Dipyridio 2,3-b:3',2'-! azepines and their use in the prevention or treatment of HIV infection
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5859002 |
HIV protease inhibitors
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
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5843945 |
AMPA antagonists and a method of treatment
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen, alkyl or benzyl; X is O or NOR 2 , wherein R 2 is...
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5827849 |
Cyclic dericatives, pharmaceutical compositions containing these compounds and processes for preparing them
The invention relates to cyclic derivatives of general formula ##STR1## wherein R a , R b , X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and...
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5780493 |
AMPA antagonists and method of treatment therewith
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen, alkyl or benzyl; X is O or NOR 2 , wherein R 2 is...
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5756453 |
Use of angiogenic lipids for vascularizing tissue
There is disclosed a method for vascularizing tissue, a method for improving vascularization of ischemic tissue, and a method for improving the viability of grafted tissue or tissue survival in...
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5750556 |
2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
Compounds of Formula I are selective autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems: ##STR1## in which X is --(CH 2 ) n --; n is 1-3; R 1 is...
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5747486 |
Thienopyridine or thienopyrimidine derivatives and their use
This invention provides an anti-inflammatory agent, particularly an agent for treating arthritis, and a bone resorption inhibiting agent, containing a thienopyridine or thienopyrimidine derivative...
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5696112 |
Fused heterocyclic azepines as vasopressin antagonists
This invention relates to bicyclic non-peptide vasopressin antagonists useful in treating conditions where decreased vasopressin levels are desired, in conditions with excess renal water...
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5691330 |
Condensed thiophene compound and pharmaceutical use thereof
A condensed thiophene compound represented by general formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein ring S represents a thiophene ring; R 1 represents hydrogen, halogen,...
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5686442 |
Tricyclic benzazepine and benzothiazepine derivatives
The tricyclic benzazepine and benzothiazepine derivatives represented by the formula (I) and pharmacologically acceptable salts thereof are disclosed. ##STR1## wherein Z represents CO, --CR 6 R 7 ...
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5681833 |
Benzodiazepine derivatives
Compounds of Formula (I), and salts and prodrugs thereof, wherein said formula, R 1 represents certain optionally substituted alkyl or C 3 -7 cycloalkyl; R 2 represents (II) or (III), where m is...
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5679670 |
Sulfonamides useful as carbonic anhydrase inhibitors
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration...
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5679671 |
Amino acid derivative
The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase...
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5677298 |
Benzoxazepine-2-one compounds and their use
Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula (I) ##STR1## wherein R 1 stands for H or an optionally substituted hydrocarbon group; R 2 and...
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5674865 |
Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b III.sub.a
A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII b III a receptor and is...
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5674866 |
Antiallergic imidazoazepines
The present invention is concerned with novel imidazoazepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the...
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5670532 |
Pyrazolyl derivatives for the treatment of inflammation
A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1##...
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5663167 |
Antipsychotic composition and method of treatment
A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an α 2 -adrenergic receptor antagonist and...
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5654297 |
Tricyclic thieno-azepine vasopressin antagonists
This invention relates to new bicyclic non-peptide vasopressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart...
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5652235 |
Method of using spiro piperidines to promote the release of growth hormone
There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote...
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5643905 |
Pharmaceutical formulation for the treatment of nicotine dependence
The present invention relates to the use of galanthamine and the pharmaceutically acceptable acid addition salts thereof for the treatment of nicotine dependence. The active substances are released...
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5635502 |
Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to certain novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and of ACE. These mercaptoacetylamide bicyclic lactam...
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5633238 |
Method for the treatment of schizophrenia
The present invention relates to the use of cholinesterase inhibitors, such as galanthamine, for the preparation of a pharmaceutical composition for counteracting the sedative or hypnotic or...
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5616577 |
Protein Kinase C inhibitor
The present invention relates to treatment of conditions wherein protein Kinase C inhibition is indicated.
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5616575 |
Bioactive tricyclic ibogaine analogs
Ibogaine analogs are provided, which are phenyl-substituted-hexahydroazepino[4,5-b]indoles useful to treat cocaine addiction and the use of other addictive substances.
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5612368 |
O-arylmethyl-N-(thio)acylhydroxylamines
The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar, X, R 1 and R 2 are as defined in the description and a medicinal product containing the same in order...
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5591739 |
2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
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5591740 |
Use of debromohymenialdisine for treating osteoarthritis
Disclosed is a method of treating osteoarthritis. The method comprises administering a therapeutic amount of debromohymenialdisine to an individual or animal with osteoarthritis....
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5589475 |
Benzodiazepine treatment
The use of a pharmaceutically acceptable cholinesterase inhibitor or a prodrug therefor for counteracting the sedative, hypnotic or respiratory depressive effects of benzodiazepines, substantially...
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5585375 |
Method for alleviating jet lag
Jet lag and other upheavals of the body's internal clock may be alleviated by administering galanthamine to a person suffering such an upheavals prior to or just after such upheavals.
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5565448 |
Medicament
The present invention relates to the treatment and prevention of conditions wherein protein Kinase C inhibition is indicated.
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5519017 |
Pharmaceutic formulation for the treatment of alcoholism
Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which...
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5512562 |
Tricyclic 2,3,4,5-tetrahydro-1H-3-benzapines
Tricyclic benzazepines having the general formula ##STR1## wherein A together with the α- and β-marked carbon atoms is a cyclopentene, cyclohexene, furan, dihydrofuran, pyran, dihydropyran,...
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5498776 |
Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
This invention relates to pyrrolo-, pyrido-, azepino-, and azocinopyrimidines of the general formula I ##STR1## wherein R 1 , R 2 , R 3 , and R 4 are independently H, lower alkyl containing 1 to 6...
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5436251 |
Treatment of anxiety and gastrointestinal disorders with azabicyclo carbonyl-2-(cyclopropylmethyloxy)benzamide
(Endo)-N-[[[8-azabicyclo[3.2.1]octan-3-yl]amino]carbonyl]-2-
(cyclopropylmet hyloxy)benzamide and pharmaceutically acceptable salts thereof possess 5-HT 3 antagonistic activity and are useful in...
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