|
Match
|
Document |
Document Title |
|
|
6737419 |
Benazepril hydrochloride tablet formulations
Stable tablets comprising benazepril hydrochloride are prepared by employing zinc stearate as the lubricant.
|
|
|
6730707 |
Method for reducing intraocular pressure using indole derivatives
The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this...
|
|
|
6727258 |
Allosteric adenosine receptor modulators
The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators...
|
|
|
6720316 |
Therapeutic 5-HT ligand compounds
The present invention provides compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and Z have any of the values defined in the specification, as well as...
|
|
|
6670356 |
Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
Analogs of galanthamine and lycoramine are useful in modulating nicotinic receptors in humans and other animals. Modulation of such receptors is useful in treatment and/or prevention of a number of...
|
|
|
6664249 |
Bicyclic vasopressin agonists
Compounds according to general formula (1), and pharmaceutically acceptable salts thereof, wherein V is a covalent bond or NH, X is selected from CH 2 , O and N-alkyl, Z is either S or...
|
|
|
6649605 |
Treatment of tension-type headaches with NMDA receptor antagonists
NMDA receptor antagonists, especially mirtazapine, can be used to treat tension-type headaches.
|
|
|
6645959 |
Method for treating postoperative ileus
This invention is a method for preventing or treating postoperative ileus comprising administering a vasopressin antagonist such as a compound of Formula (1), where R 1 , R 2 , and R 3 include...
|
|
|
6642222 |
Pyrano, piperidino, and thiopyrano compounds and methods of use
The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder...
|
|
|
6586422 |
Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno &lsqb d&rsqb azepine
The invention relates to compounds which are represented by the formula wherein R 1 , R 2 , R 3 , R 4 , X and Y are as defined in the specification, as well as pharmaceutically acceptable salts...
|
|
|
6583135 |
Substituted azepino&lsqb 4,5b&rsqb indole derivatives
Disclosed are compounds of Formula (I): wherein R 1 -R 4 , p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions...
|
|
|
6569848 |
Compounds for the treatment of alzheimer's disease
The present invention is directed to analogs of galanthamine of the structure wherein the R terms are herein defined, for use in treating Alzheimer's disease.
|
|
|
6503899 |
Azepino&lsqb 4,5-b&rsqb pyrano&lsqb 3,2-e&rsqb indoles
The invention provides a compound of formula (I): wherein: R 1 -R 5 , m, n, p, and the bonds a and b represented by - - - have any of the values, specific values, or preferred values described...
|
|
|
6489354 |
3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of chemokine...
|
|
|
6468999 |
1,2,3,4,5,6,-hexahydroazepino &lsqb 4,5-b&rsqb indoles containing arylsulfones at the 9-position
The present invention are substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the...
|
|
|
6465507 |
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to...
|
|
|
6444664 |
Method for controlling the plasma level of lipoproteins to treat alzheimeris disease
A compound which is an antagonist of platelet activating factor (PAF-antagonist) or a structurally related compound thereof not having PAF-antagonistic activity can be used for decreasing the...
|
|
|
6410527 |
Method of treating obsessive compulsive disorders, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism
A method for treating obsessive-compulsive disorders, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism is disclosed. These disorders are treated...
|
|
|
6403578 |
Bicyclic fibrinogen antagonists
This invention relates to compounds of the formulae: wherein A 1 is O, S, N—R 1 or CHR 1 ; A 4 is N—R 4 or CHR 4 ; R 2 is a sidechain containing an acid or ester group; R 1 , R 4 and R...
|
|
|
6399310 |
Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
This invention relates to methods for improving the therapeutic response of human patients with major depression by determining the apolipoprotein E genotype of a human patient and administering...
|
|
|
6369114 |
Administration of an α2-adrenergic receptor agonist to enhance cardiopulmonary resuscitation
Methods, formulations and kits are described for resuscitating a patient suffering from cardiac arrest, for enhancing the efficacy of cardiopulmonary resuscitation, for treating post-resuscitation...
|
|
|
6358941 |
Treatment of arthritis disorders, rheumatoid arthritis and manifestations associated with rheumatoid disorders
The present invention relates to the use of pharmaceutically acceptable cholinesterase inhibitors for the preparation of a pharmaceutical composition for the treatment or prophylaxis of arthritic...
|
|
|
6348485 |
Method for treating or preventing sleep disorders
The present invention provides a pharmaceutical composition for treating or preventing sleep disorders which comprises (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethy
l]propionamide in...
|
|
|
6331537 |
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and...
|
|
|
6323196 |
Galanthamine derivatives as acetylcholinesterase inhibitors
This application relates to compounds of the formula ##STR1## wherein R 1 is hydrogen, (C 1 -C 12 )alkylcarbonyl, (C 1 -C 12 )alkoxycarbonyl, mono(C 1 -C 12 )alkylaminocarbonyl, or di(C 1 -C...
|
|
|
6319919 |
Galanthamine derivatives for treatment of alzheimer's disease
Compounds of the formula ##STR1## wherein the broken line represents an optionally present double bond, and R 1 -R 3 , R 4 , R 6 and R 9 are as defined herein, and compositions containing these...
|
|
|
6303595 |
Use of mirtazapine for treating sleep apneas
The compound mirtazapine is found to be effective in treating sleep apneas. Optionally, mirtazapine is combined with an SSRI such as fluoxetin.
|
|
|
6288058 |
Substituted tetracyclic tetrahydrofuran derivatives
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
|
|
|
6277844 |
Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
The invention provides compounds of the formula (I): ##STR1## wherein R 1 is an amino or an alkyl group, optionally substituted with one or more groups selected from C 1 - C 6 alkyl group; R 2...
|
|
|
6268359 |
Preventives or remedies for vision disorders
A pharmaceutical composition for preventing or treating visual function disorders caused by ocular circulatory disorders (for example, ocular hypertension and glaucoma) and visual function...
|
|
|
6251894 |
1-(1,2-disubstituted piperidinyl)-4 (fused imidazole)-piperidine derivatives
This invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 0, 1 or 2;...
|
|
|
6218383 |
Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
A pharmaceutical composition incorporates a pharmaceutically effective amount of at least two components, one of those components being a nicotinic compound capable of interacting with nicotinic...
|
|
|
6218376 |
Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists
Compounds of formula I or salts thereof ##STR1## where for example Y is a group of the formula (i) ##STR2## and R 1 is a group of formula (ii) ##STR3## are provided along with compositions...
|
|
|
6194405 |
Method of using substituted tetracyclic tetrahydrofuran derivatives
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
|
|
|
6184004 |
Process for the preparation of galanthamine and its derivatives
The subject invention pertains to a process for preparing a compound having a formula (4) or (5), in either optically-enriched or racemic form, wherein R 1 , R 2 , R 3 and R 4 are independently...
|
|
|
6180640 |
Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical...
|
|
|
6150355 |
Phenylpiperidine derivative
A phenylpiperidine derivative or pharmaceutical acceptable salt thereof represented by formula (I): ##STR1## wherein X represents CH or N; Y--Z represents CH 2 --O, CH 2 --S, CH 2 --CH 2 ,...
|
|
|
6140322 |
Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
There are provided novel compounds of formula (I) ##STR1## wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification and optical isomers and racemates thereof and...
|
|
|
6133254 |
Use of aspirochlorine or derivatives thereof as immunosuppressive agents
Use of a compound of formula (I) wherein R represents hydrogen or chlorine, for preparing an immunosuppressive medicament.
|
|
|
6130229 |
Tricyclic compounds having activity as RAS-FPT inhibitors
Compounds of Formula I: ##STR1## wherein: X 1 is hydrogen, halogen, CF 3 , nitro, NH 2 or lower alkyl; each X 2 is independently selected from the group consisting of hydrogen, halogen, lower...
|
|
|
6124281 |
Azolobenzazepine derivatives as neurologically active agents
The invention relates to azolobenzazepine derivatives of formula (I), wherein: X is O or S; R 1 , R 2 , R 3 and R 4 are independently hydrogen, perfluorolower-alkyl, halogen, nitro or cyano; and...
|
|
|
6114324 |
Oral liquid antidepressant solution
For the oral administration of the anti-depressant mirtazapine an aqueous solution or suspension is found which is preferably stabilized by methionine, is thickened, and which has a pH of from 2.5...
|
|
|
6093714 |
Tricyclic benzazepine compounds
Tricyclic benzazepine compounds represented by the following formula (I) and pharmacologically acceptable salts thereof are disclosed. These compounds have antiallergic activity and are useful for...
|
|
|
6048854 |
2,3-diaminopropionic acid derivative
The present invention relates to a 2,3-diaminopropionic acid derivative of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof. The compounds of the present invention are useful...
|
|
|
6043238 |
2-Aminobenzazapine derivatives
A compound of the formula ##STR1## wherein a, V, X, Y, Z, R 1 , R 2 , R 3 and R 4 are as defined above, useful in (a) the treatment of myelosuppression including suppression associated with...
|
|
|
6034117 |
Methods of treating and diagnosing sleep disordered breathing and means for carrying out the method
This invention relates to a method for treating snoring, sleep apnea and other form of sleep-disordered breathing, which comprises administration of a therapeutically effective dose of an acetyl...
|
|
|
6030967 |
Naphtholactams and lactones as bone morphogenetic protein active agents
|
|
|
6008213 |
Integrin receptor antagonists
Compounds of formula (I) ##STR1## wherein A 1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R 3 or R 4 ; X 1 --X 2 is CHR 1 ...
|
|
|
5972951 |
Tetracyclic spiro compounds, process for their preparation and their use as 5HT.sub.1D receptor antagonists
Novel piperidine derivatives of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use as medicaments for the treatment of CNS disorders are disclosed.
|
|
|
5968928 |
Excitatory amino acid antagonists: fused-azacyclic quinoxalinediones and immunoassays thereof
The invention discloses novel fused-azacylic quinoxalinediones. These compounds may be employed as excitatory amino acid antagonists and as analogs for use in immunological assays. The invention is...
|