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7314870 |
Compounds, their preparation and use
The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due...
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7220737 |
Noribogaine in the treatment of pain and drug addiction
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
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7176198 |
1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or...
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7160876 |
Fused bicycloheterocycle substituted quinuclidine derivatives
Compounds of formula (I)
wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar 1 is a 6-membered aromatic ring; and Ar 2 is a fused bicycloheterocycle. The compounds are useful in...
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7049308 |
C-nitroso compounds and use thereof
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon,...
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7001900 |
Azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
W is a six-membered heterocyclic ring system having 1–2 nitrogen atoms or a 10-membered bicyclic-six-six-fused-ring...
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6977253 |
Methods for the treatment of bipolar disorder using carbamazepine
Carbamazepine, in extended release form, is useful in the treatment of patients suffering from bipolar disorder. In order to minimize the time it takes to reach efficacy, carbamazepine, in extended...
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6908927 |
Pyridopyranoazepine derivatives, their preparation and their therapeutic application
The invention relates to pyridopyranoazepine derivatives, to pharmaceutical compositions containing them, to process for preparing them, and to the method of use thereof in the treatment or...
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6867198 |
Agents and methods for the treatment of proliferative diseases
The present invention provides selective kinase inhibitors of formula (I)
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6852716 |
Substituted-aryl compounds for treatment of disease
The invention provides compounds of Formula I:
These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of...
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6849619 |
Substituted pyridoindoles as serotonin agonists and antagonists
The present invention is directed to certain novel compounds represented by structural Formula (I)
or pharmaceutically acceptable salt forms thereof, wherein R 1 , R 5 , R 6 , R 7 , R 8 , R 9...
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6806291 |
Analgesic compounds, their synthesis and pharmaceutical compositions containing them
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
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6780871 |
Methods and compositions for treating addiction disorders
A method for treating an addiction disorder (such as an addiction to or dependency on stimulants, nicotine, morphine, heroin, other opiates, amphetamines, cocaine, and/or alcohol) in a patient is...
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6552015 |
Azabicycloalkane derivatives and therapeutic uses thereof
The present invention is directed to a compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , Y, U, W, k, A, E, V, R 4 and R 5 are as defined herein,...
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6531468 |
Diazabicyclooctane derivatives and therapeutic uses thereof
The present invention provides diazabicyclooctane derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein the group represents R 1 and R 2 are selected...
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6468998 |
Pyrrolidine compounds and medicinal utilization thereof
The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically...
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6348456 |
Method of treating chemical dependency in mammals and a composition therefor
An essentially pure noribogaine compound having the formula: wherein R is hydrogen or a hydrolyzable group of the formula: wherein X is an unsubstituted C 1 -C 12 group or a C 1 -C 12 group...
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6284771 |
Method for treating schizophrenia
The present invention provides a method for treating a condition selected from the group consisting of schizophrenia, schizoaffective disorder, and schizophreniform disorder in a patient using a...
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6221878 |
Method for treatment of depression
The invention relates to the use of compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT 3 receptors for the treatment of depression.
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6203813 |
Pharmaceutical delivery device and method of preparation therefor
The present invention provides an opiate antagonist implant which is an admixture of an opiate antagonist, in either acid or base form, and a pharmaceutically acceptable carrier. The admixture is...
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6113877 |
σ-2 receptors as biomarkers of tumor cell proliferation
The invention provides detectably-labeled compounds of formula (I): ##STR1## wherein A, B, C, D, E, F, R, X, Y and Z have any of the meanings given in the specification, and their pharmaceutically...
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6030966 |
Heterocyclic compound and their use
The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
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6017910 |
PCP receptor ligands and the use thereof
The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention...
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5998434 |
Composition for treating pain
The present invention provides a composition and method for treating pain using Selected Muscarinic Compounds and one or more compounds selected from the group consisting of Nonsteroidal...
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5998405 |
Fused tropane-derivatives as neurotransmitter reuptake inhibitors
The present invention discloses compounds of the formula, or any of its enantiomers or any mixture thereof, a pharmaceutically acceptable addition salt thereof or the N-oxide thereof wherein X...
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5990104 |
Polycyclic alcaloid-derivatives as NMDA-receptor antagonists
Polycyclic alkaloids of formula (I), wherein R 1 is H, C 1 -6 alkyl, or C 6 -12 aryl optionally substituted with polar groups; R 2 and R 3 are independently H, OH, C 1 -6 alkyl, --C(NH)--NH 2 ,...
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5985866 |
Use of serotonin antagonists for treating fibromyalgia
5-HT 3 antagonists are useful in the treatment of fibromyalgia.
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5958919 |
Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration
Methods for treating the very early (presymptomatic) stages of Alzheimer's disease are disclosed, wherein NMDA antagonist drugs are administered to protect NMDA receptors against neuronal damage....
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5952324 |
Bicyclic oxazine and thiazine oxazolidinone antibacterials
Phenyloxazolidinone compound of formula (I)or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents,...
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5925634 |
Use of ibogaine for treating neuropathic pain
This invention discloses that ibogaine, a plant derivative, can be used safely to treat neuropathic pain (i.e, pain which does not respond conventionally to opiate drugs such as morphine). Ibogaine...
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5859004 |
Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system
This invention relates to the use of azabicyclic compounds for the treatment of diseases caused by malfunctioning of the nicotinic cholinergic system. These diseases treated include obesity,...
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5798363 |
Use for tachykinin antagonists to treat emesis
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel...
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5712287 |
Method of treating urinary bladder dysfunctions
The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.
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5712270 |
2-arylamidothiazole derivatives with CNS activity
This invention relates to methods of treating neurological illnesses related to acetylcholine deficiency in the CNS including memory loss attending senility, Parkinson's disease, Down's syndrome or...
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5707985 |
Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators
There are disclosed novel substituted naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives that are useful in a method of treating immuno-inflammatory diseases in a mammalian patient...
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5629307 |
Use of ibogaine in reducing excitotoxic brain damage
This invention discloses that ibogaine, a plant derivative, can be used as a safe NMDA antagonist at relatively high dosages (including dosages high enough to cause hallucinations), to reduce or...
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5556851 |
Cinnoline-3-carboxylic acid derivatives
A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT 3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and...
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5541194 |
Certain 1-azabicyclo[2.2.1]heptanes and 1-azabicyclo[2.2.2]octanes
Novel compounds of formula (I), processes for their preparation, and their use as pharmaceutical agents are described: ##STR1## in which p represents an integer of 2 to 4; r represents an integer...
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5538985 |
Pyrrolidinone derivatives
Antipsychotics and ischemic cerebral disease therapeutics comprising as an effective ingredient a compound represented by the following formula (1) or (2): ##STR1## or a salt thereof. These drugs...
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RE35218 |
Azatetracycle compounds
An azatetracycle compound useful as 5HT 3 antagonists of the general formula ##STR1## wherein D is a tetracycle of the structure ##STR2## wherein Ar is an aromatic moiety and B is either NH or O.
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5500422 |
Benzamide derivative
A benzamide derivative represented by the following formula: ##STR1## wherein R 1 represents a hydrogen atom or a lower alkanoyl group; R 2 represents a hydrogen atom or a halogen atom; R 3 ...
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5436251 |
Treatment of anxiety and gastrointestinal disorders with azabicyclo carbonyl-2-(cyclopropylmethyloxy)benzamide
(Endo)-N-[[[8-azabicyclo[3.2.1]octan-3-yl]amino]carbonyl]-2-
(cyclopropylmet hyloxy)benzamide and pharmaceutically acceptable salts thereof possess 5-HT 3 antagonistic activity and are useful in...
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5414009 |
Azabicyclo substituted oxa- or thia-diazole compounds
The present invention relates to compounds ##STR1## where G is ##STR2## and Z is oxygen or sulfur and the remaining variables are as defined in the Specification. The compounds are useful as...
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5399562 |
Indolones useful as serotonergic agents
This invention relates to compounds of the formula: ##STR1## which are useful as 5-HT 4 agonists or antagonists and 5-HT 3 antagonists.
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5399553 |
Tricyclic compound or salts thereof, method for producing the same and anti-microbial agent containing the same
A tricyclic compound represented by the general formula (1) and salts thereof are disclosed. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent...
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5395832 |
Benzamide derivatives
A benzamide derivative represented by the following formula: ##STR1## wherein R 1 represents a hydrogen atom or a lower alkanoyl group; R 2 represents a hydrogen atom or a halogen atom; R 3 ...
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5352685 |
Thieno[3,2-b]pyridine derivatives
The thieno[3.2-b]pyridine derivative of the present invention promote the gastric emptying in male ddy mice and the gastric contraction in dogs sutured with a strain-gauge transducer. It is...
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5330982 |
Pharmaceutical composition containing a 5-HT receptor antagonist and an H.sup.+ K.sup.+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith
The invention relates to the use of a compound which is an antagonist of 5-HT at 5-HT 3 receptors and promotes gastric emptying in conjunction with an H + K + ATPase inhibitor in the treatment...
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5324724 |
Compounds for the treatment of senile dementia
Azabicyclic compounds, processes for their preparation and their use in the treatment and/or prophylaxis of dementia in animals.
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5324723 |
Oxazoles and thiazoles for the treatment of senile dementia
1,3-Oxazole and 1,3-thiazole compounds of formula I, and their pharmaceutically acceptable salts and prodrugs: ##STR1## wherein X represents oxygen or sulphur; R 1 represents a non-aromatic...
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