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8178524 |
Noribogaine in the treatment of pain and drug addiction
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
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7989438 |
Therapeutic compounds
A class of macrocyclic compounds of formula (I), wherein R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the...
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7754710 |
Noribogaine in the treatment of pain and drug addiction
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
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7683050 |
Formulations and methods of administration of cephalotaxines, including homoharringtonine
The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is also directed to improvements in...
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7678363 |
Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes...
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7652010 |
Azabicyclic aryl derivatives and their medical use
Azabicyclo pyridazinyl compounds including azabicyclooctyl-pyridazinyl-oxy compounds, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the...
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7476402 |
Methods and compositions for deterring abuse of opioid containing dosage forms
This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
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7314870 |
Compounds, their preparation and use
The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to...
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7220737 |
Noribogaine in the treatment of pain and drug addiction
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
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7176198 |
1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or...
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7160876 |
Fused bicycloheterocycle substituted quinuclidine derivatives
Compounds of formula (I) wherein n is 0, 1, or 2; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treat...
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7001900 |
Azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I: wherein Azabicyclo is W is a six-membered heterocyclic ring system having 1–2 nitrogen atoms or a 10-membered bicyclic-six-six-fused-ring system h...
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6977253 |
Methods for the treatment of bipolar disorder using carbamazepine
Carbamazepine, in extended release form, is useful in the treatment of patients suffering from bipolar disorder. In order to minimize the time it takes to reach efficacy, carbamazepine, in extended...
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6908927 |
Pyridopyranoazepine derivatives, their preparation and their therapeutic application
The invention relates to pyridopyranoazepine derivatives, to pharmaceutical compositions containing them, to process for preparing them, and to the method of use thereof in the treatment or...
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6867198 |
Agents and methods for the treatment of proliferative diseases
The present invention provides selective kinase inhibitors of formula (I)
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6852716 |
Substituted-aryl compounds for treatment of disease
The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I...
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6849619 |
Substituted pyridoindoles as serotonin agonists and antagonists
The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9, X, b, k, and n,...
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6806291 |
Analgesic compounds, their synthesis and pharmaceutical compositions containing them
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These...
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6780871 |
Methods and compositions for treating addiction disorders
A method for treating an addiction disorder (such as an addiction to or dependency on stimulants, nicotine, morphine, heroin, other opiates, amphetamines, cocaine, and/or alcohol) in a patient is...
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6552015 |
Azabicycloalkane derivatives and therapeutic uses thereof
The present invention is directed to a compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, Y, U, W, k, A, E, V, R4 and R5 are as defined herein,...
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6531468 |
Diazabicyclooctane derivatives and therapeutic uses thereof
The present invention provides diazabicyclooctane derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein the group represents R1 and R2 are selected independently from...
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6468998 |
Pyrrolidine compounds and medicinal utilization thereof
The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically...
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6348456 |
Method of treating chemical dependency in mammals and a composition therefor
An essentially pure noribogaine compound having the formula: wherein R is hydrogen or a hydrolyzable group of the formula: wherein X is an unsubstituted C1-C12 group or a C1-C12 group substituted...
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6284771 |
Method for treating schizophrenia
The present invention provides a method for treating a condition selected from the group consisting of schizophrenia, schizoaffective disorder, and schizophreniform disorder in a patient using a...
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6221878 |
Method for treatment of depression
The invention relates to the use of compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT3 receptors for the treatment of depression.
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6203813 |
Pharmaceutical delivery device and method of preparation therefor
The present invention provides an opiate antagonist implant which is an admixture of an opiate antagonist, in either acid or base form, and a pharmaceutically acceptable carrier. The admixture is...
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6113877 |
σ-2 receptors as biomarkers of tumor cell proliferation
The invention provides detectably-labeled compounds of formula (I): ##STR1## wherein A, B, C, D, E, F, R, X, Y and Z have any of the meanings given in the specification, and their pharmaceutically...
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6030966 |
Heterocyclic compound and their use
The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
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6017910 |
PCP receptor ligands and the use thereof
The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention...
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5998405 |
Fused tropane-derivatives as neurotransmitter reuptake inhibitors
The present invention discloses compounds of the formula, or any of its enantiomers or any mixture thereof, a pharmaceutically acceptable addition salt thereof or the N-oxide thereofwherein X and Y...
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5998434 |
Composition for treating pain
The present invention provides a composition and method for treating pain using Selected Muscarinic Compounds and one or more compounds selected from the group consisting of Nonsteroidal...
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5990104 |
Polycyclic alcaloid-derivatives as NMDA-receptor antagonists
Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH)--NH2, a positively...
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5985866 |
Use of serotonin antagonists for treating fibromyalgia
5-HT3 antagonists are useful in the treatment of fibromyalgia.
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5958919 |
Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration
Methods for treating the very early (presymptomatic) stages of Alzheimer's disease are disclosed, wherein NMDA antagonist drugs are administered to protect NMDA receptors against neuronal damage....
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5952324 |
Bicyclic oxazine and thiazine oxazolidinone antibacterials
Phenyloxazolidinone compound of formula (I)or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents,...
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5925634 |
Use of ibogaine for treating neuropathic pain
This invention discloses that ibogaine, a plant derivative, can be used safely to treat neuropathic pain (i.e, pain which does not respond conventionally to opiate drugs such as morphine). Ibogaine...
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5859004 |
Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system
This invention relates to the use of azabicyclic compounds for the treatment of diseases caused by malfunctioning of the nicotinic cholinergic system. These diseases treated include obesity,...
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5798363 |
Use for tachykinin antagonists to treat emesis
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel...
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5712270 |
2-arylamidothiazole derivatives with CNS activity
This invention relates to methods of treating neurological illnesses related to acetylcholine deficiency in the CNS including memory loss attending senility, Parkinson's disease, Down's syndrome or...
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5712287 |
Method of treating urinary bladder dysfunctions
The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.
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5707985 |
Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators
There are disclosed novel substituted naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives that are useful in a method of treating immuno-inflammatory diseases in a mammalian patient...
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5629307 |
Use of ibogaine in reducing excitotoxic brain damage
This invention discloses that ibogaine, a plant derivative, can be used as a safe NMDA antagonist at relatively high dosages (including dosages high enough to cause hallucinations), to reduce or...
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5556851 |
Cinnoline-3-carboxylic acid derivatives
A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical...
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5541194 |
Certain 1-azabicyclo[2.2.1]heptanes and 1-azabicyclo[2.2.2]octanes
Novel compounds of formula (I), processes for their preparation, and their use as pharmaceutical agents are described: ##STR1## in which p represents an integer of 2 to 4; r represents an integer...
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5538985 |
Pyrrolidinone derivatives
Antipsychotics and ischemic cerebral disease therapeutics comprising as an effective ingredient a compound represented by the following formula (1) or (2): ##STR1## or a salt thereof. These drugs...
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RE35218 |
Azatetracycle compounds
An azatetracycle compound useful as 5HT3 antagonists of the general formula ##STR1## wherein D is a tetracycle of the structure ##STR2## wherein Ar is an aromatic moiety and B is either NH or O.
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5500422 |
Benzamide derivative
A benzamide derivative represented by the following formula: ##STR1## wherein R1 represents a hydrogen atom or a lower alkanoyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents...
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5436251 |
Treatment of anxiety and gastrointestinal disorders with azabicyclo carbonyl-2-(cyclopropylmethyloxy)benzamide
(Endo)-N-[[[8-azabicyclo[3.2.1]octan-3-yl]amino]carbonyl]-2-
(cyclopropylmet hyloxy)benzamide and pharmaceutically acceptable salts thereof possess 5-HT3 antagonistic activity and are useful in the...
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5414009 |
Azabicyclo substituted oxa- or thia-diazole compounds
The present invention relates to compounds ##STR1## where G is ##STR2## and Z is oxygen or sulfur and the remaining variables are as defined in the Specification. The compounds are useful as...
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5399553 |
Tricyclic compound or salts thereof, method for producing the same and anti-microbial agent containing the same
A tricyclic compound represented by the general formula (1) and salts thereof are disclosed. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent...
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