Patents in Class 514/214.020

Matches 1 - 50 out of 96

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Match	Document	Document Title
1	7390798	Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
2	7378082	Method for treating allergic rhinitis without adverse effects The present invention is directed to a method for treating allergic rhinitis without causing an adverse effect of bitter taste. The method comprises administering to a patient an aqueous...
3	7268127	Azaindoles having serotonin receptor affinity Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula I: Wherein A, B, D, E, R 1 to R 3 and n are described herein. Also described is the use...
4	7247623	Method of treating dry eye disease with non-drying antihistamines A method and preparation for reducing dry eye symptoms and promoting tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the eyes of the...
5	7220737	Noribogaine in the treatment of pain and drug addiction The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
6	7202238	Diazabicyclo alkane derivatives with NK1 antagonistic activity The present invention relates to a group of unique diazabicyclo alkane derivatives having interesting neurokinin-NK 1 receptor antagonistic activity represented by the general formula (1) wherein:...
7	7030108	Combating Parkinson's disease-related movement disorder A method of combating movement disorder is disclosed in a patient with Parkinson's disease comprising administering an effective amount of mirtazapine, a receptor antagonist for 5HT 2/3 and α 2 ...
8	6953791	Dipeptide derivatives This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone...
9	6933293	Use of mirtazapine for the treatment of sleep disorders The invention relates to the use of mirtazapine for the preparation of a medicine for a new method of treatment of a sleep disorder in a subject, which treatment comprises the administration of...
10	6849619	Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R 1 , R 5 , R 6 , R 7 , R 8 , R 9...
11	6835728	Drug combination for the treatment of depression and related disorders comprising mirtazapine The invention relates to a combination comprising an amount of mirtazapine, or a pharmaceutically acceptable salt or solvate thereof, and an amount of gepirone, or a pharmaceutically acceptable...
12	6699855	Inhibitors of hepatitis C virus NS3 protease The present invention relates to compounds of Formula (I): wherein A 1 is methylene, ethylene or propylene group and A 2 is N or CR 5 , or stereoisomeric forms, stereoisomeric mixtures, or...
13	6686352	Substituted imidazo &lsqb 1,5-a&rsqb pyrimido &lsqb 5,4-d&rsqb &lsqb 1&rsqb benzazepine derivatives The present invention is a compound of formula wherein R 1 is halogen or lower alkyl; R 2 is hydrogen, lower alkyl, cycloalkyl, —(CH 2 ) m -phenyl, wherein the phenyl ring may be substituted...
14	6660730	Anhydrous mirtazapine and process for preparing the same Methods for producing anhydrous mirtazapine crystals that are either (1) substantially free of lower alcohol insolubles or (2) substantially free of residual solvent and have an average particle...
15	6649604	Substituted pyridone compounds and methods of use Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other...
16	6638934	Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 4a , R 4b , R 5 , R 6 , R 7...
17	6583134	Aza- indolyl derivatives for treating obesity Novel compounds of formula (I): wherein X 1 , X 2 , X 3 and X 4 , n, R 1 , R 2 and R 3 are defined in the specification, and pharmaceutically acceptable salts and prodrugs of the compounds of...
18	6562809	3-bicycloindole compounds Described herein are compounds selective for a 5-HT1D receptor, which have the general formula:
19	6552014	Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet...
20	6544979	Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents This invention concerns the use of compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dotted line...
21	6476020	Imidazo-benzazepine compounds, their compositions and uses The subject invention involves compounds having the structure: wherein the C α —N β , C 5 -C 6 , and C 6 -C 7 bonds are each single or double bonds, except that both C 5 -C 6 , and C 6 -C 7...
22	6476018	Fused imidazole derivatives as multidrug resistance modulators This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dotted line is an...
23	6462065	Use of 5-HT3 receptor antagonists for treating musculoeskeletal diseases The present invention relates to a new use for compounds having 5-HT 3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for...
24	6448280	Angiotensin II antagonists against disorders associated with impaired neuronal conduction velocity, especially diabetic neuropathy This invention relates to the use of angiotensin II antagonists in treating or preventing the development of disease conditions associated with impaired neuronal conduction velocity, such as...
25	6403651	Mediation of circadian rhythms Method for mediating the effects of light on melatonin rhythmicity in mammals and a method of mediating circadian rhythms, effected by the administration of a compound or compounds effective at a...
26	6348457	4-&lsqb 3-benzofuranyl&rsqb piperidinyl and 4-&lsqb 3-benzothienyl&rsqb piperidinyl derivatives The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein X is oxygen or...
27	6281207	Treatment of movement disorders by administration of mirtazapine A method of combating movement disorder in a patient experiencing or susceptible to same, by administerinig to the patient an effective amount of mirtazapine.
28	6251894	1-(1,2-disubstituted piperidinyl)-4 (fused imidazole)-piperidine derivatives This invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 0, 1 or 2;...
29	6251893	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are independently selected from the group...
30	6248729	Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination A method is provided for preventing a cerebral infarction by administering to a patient a combination of an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with an...
31	6218384	3-Oxo-pyrido(1,2-a)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)benzimidazole-5-carboxyl derivatives useful in treating central nervous system disorders A compound of the general formula I; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
32	6214821	Methods and composition for the inhibition of cancer cells Pharmaceutical compositions comprising a topoisomerase I inhibitor, such as camptothecin or a camptothecin analog, and a staurosporine such as 7-hydroxystaurosporine, together with a...
33	6150353	Therapeutic combinations of mirtazapine and antipsychotic agents, for the treatment or prophylaxis of psychotic disorders This application relates to a combination of the antidepressant mirtazapine and an antipsychotic agent such as haloperidol for the treatment of psychotic disorders.
34	6133255	Tricyclic pyridone analogues as GABA-A receptor ligands Tricyclic pyridin-2-one analogues which are ligands for GABA A receptors, are useful in the therapy of deleterious mendtal states, and are represented by the formula: ##STR1##
35	6114329	5-HT.sub.4 receptor antagonists useful in the treatment of gastroinstestinal, cardiovascular and CNS disorders Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--CH 2 --Z ...
36	6110910	Carbocyclic heterocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such...
37	5977099	Pharmaceutical composition comprising mirtazapine and one or more selective serotonin reuptake inhibitors The invention relates to a pharmaceutical composition comprising mirtazapine, a selective serotonin reuptake inhibitor (SSRI) and pharmaceutically acceptable auxiliaries. In particular the SSRI is...
38	5972930	Pyridinylamino tricyclic compounds as substance P antagonists This invention provides a compound of the formula: ##STR1## and its pharmaceutically acceptable salts, wherein Ar 1 is selected from groups of the following formulae: ##STR2## wherein, R 1 and R...
39	5962447	Benzoxazines for enhancing synaptic response Compounds based on the benzoxazine ring system are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering...
40	5942503	Use of Epinastine for the treatment of pain Disclosed herein is the use of epinastine for the treatment of pain, including migraine, Bing-Horton syndrome, tension headaches, muscle pain, inflammatory pain, and neuralgias. Epinastine may also...
41	5932569	Triazolobenzazepine derivatives Antiallergic triazolobenzazepines of formula ##STR1## wherein each of the dotted lines independently represents an optional bond; R 1 represents hydrogen, halo, C 1 -4 alkyl, hydroxy or C 1 -4...
42	5849731	Indole derivatives and medical application thereof The present invention relates to indole derivatives represented by the following compound 1 and the pharmacologically acceptable acid addition salt thereof. ##STR1## The compounds of the present...
43	5795894	Piperazino derivatives as neurokinn antagonists The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.
44	5705498	Piperidine derivatives as 5-HT.sub.4 receptor antagonists Compounds of formula (I): ##STR1## wherein X g is O, S, SO, SO 2 , CH 2 , CH, N or NR wherein R is hydrogen or C 1 -6 alkyl; A is a saturated or unsaturated polymethylene chain of 2-4 carbon...
45	5696111	3-acylaminobenzazepines This invention is concerned with novel compounds represented by structural formula I and II. ##STR1## which are antiarrhythmic agents.
46	5674879	Compositions including and methods of using conformationally restricted angiotensin II antagonist Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders.
47	5674866	Antiallergic imidazoazepines The present invention is concerned with novel imidazoazepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the...
48	5629308	Imidazo [1,2-A] (pyrrolo, thieno or furano) [2,3-D] azepine derivatives Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of...
49	5622950	Pyrrolo-pyridine derivatives A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a...
50	5597816	Pyrazoloazepino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents Pyrazoloazepino-substituted oximes, having the formula ##STR1## wherein R is ##STR2## where R 5 is --(CH 2 ) c -- and c is 3-6 are disclosed. These compounds are useful for the treatment of...

Matches 1 - 50 out of 96

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