|
Match
|
Document |
Document Title |
|
|
5674866 |
Antiallergic imidazoazepines
The present invention is concerned with novel imidazoazepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the...
|
|
|
5674879 |
Compositions including and methods of using conformationally restricted angiotensin II antagonist
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders.
|
|
|
5629308 |
Imidazo [1,2-A] (pyrrolo, thieno or furano) [2,3-D] azepine derivatives
Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of...
|
|
|
5622950 |
Pyrrolo-pyridine derivatives
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a...
|
|
|
5597816 |
Pyrazoloazepino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents
Pyrazoloazepino-substituted oximes, having the formula ##STR1## wherein R is ##STR2## where R 5 is --(CH 2 ) c -- and c is 3-6 are disclosed. These compounds are useful for the treatment of...
|
|
|
5595988 |
Triazolo(pyrrolo, thieno or furano)azepine derivatives
Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the...
|
|
|
5591738 |
Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof
A method of treating a chemical dependency disorder, an abuse syndrome or a combination thereof in a mammal in need thereof, which entails administering, to a mammal in need thereof, an amount of a...
|
|
|
5552399 |
Substituted tetracyclic azepine derivatives
This invention concerns the compounds of formula (I), the pharmaceutically acceptable salts and stereoisomeric forms thereof, and also the N-oxide forms thereof. ##STR1## wherein: R 1 and R 2 ...
|
|
|
5536715 |
Combinations of anthelmintically active agents
Pharmaceutical compositions comprising a compound of formula (I) and at least one other anthelmintically active compound, being an avermectin or a milbemycin, are useful in the treatment of...
|
|
|
5486512 |
Quinazoline derivatives as acetylcholinesterase inhibitors
A method of treating cognitive deficiencies is described by administering a quinazoline derivative of the general formula ##STR1## wherein A represents ##STR2## in which n is 1-10, P is a bond or...
|
|
|
5482936 |
Imidazo[4,5-C]quinoline amines
Compounds and pharmaceutically acceptable salts thereof formally derived by bridging the 1- and 2-positions of 1H-imidazo[4,5-c]quinolin-4-amines. Also, methods of using such compounds and...
|
|
|
5476848 |
14B(R) isomers of novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, and their use
An optically active compound of formula (I): ##STR1## in which R 3 represents groups of formula --A--COOR 4 , wherein A represents alkylene groups having 3 or 5 carbon atoms and R 4 ...
|
|
|
5470851 |
Thiazolidinecarboxylic acid amide derivatives and their therapeutic uses
Thiazolidinecarboxylic acid amides having combined antiallergic and antiasthmatic activities with an antagonist activity against platelet Activating Factor and having the following general formula...
|
|
|
5468743 |
Imidazo[2,1-b]benzazepine derivatives, compositions and method of use
The present invention is concerned with novel imidazo[2, 1-b][3]benzazepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein...
|
|
|
5461051 |
Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use
Compounds of formula (I): ##STR1## in which: Q is nitrogen or CH--; R 1 and R 2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R 3 is a substituted alkyl groups, or a...
|
|
|
5426105 |
Conformationally restricted angiotensin II antagonists
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest...
|
|
|
5393753 |
Substituted imidazobenzazepines
Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl, CF 3 , aryl, substituted aryl, heteroaryl, -O-C 1 -C 7 alkyl, or -O-C 3 -C 7 cycloalkyl; R 2 and R...
|
|
|
5366969 |
Amidine group containing monocycloheteracyclic or bicycloheterocyclic diphosphonic acid derivatives and medicaments containing these compounds
Compounds of the formula I ##STR1## in which R can be hydrogen or C 1 -C 4 -alkyl, R 1 hydrogen, C 1 -C 6 -alkyl, aryl, aryl-C 1 -C 4 -alkyl, amino-C 1 -C 6 -alkyl, C 1 -C 6 ...
|
|
|
5328905 |
8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives
New 8,9-annelated-1,2,3,4-tetrahydro-β-carboline derivatives of the formula ##STR1## wherein R 1 -R 7 are as defined herein; and pharmaceutically acceptable salts and prodrugs thereof. A method...
|
|
|
5152994 |
Rapid method for interrupting or attenuating poly-drug dependency syndromes
The administration to a poly-drug addict of ibogaine, ibogaine, tabernanthine, alkaloids in the family of apocynaceae, or their non-toxic salts have been discovered to interrupt the physiological...
|
|
|
5057521 |
Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
The invention relates to specific bicyclic imidazole compounds such as 5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine, or pharmaceutically acceptable non-toxic salts thereof, for the...
|
|
|
4997831 |
Lactam derivatives
The invention provides lactam derivatives of the general formula (I) ##STR1## wherein n represents 2 or 3; Im represents an imidazolyl group of the formula: ##STR2## wherein one of the groups...
|
|
|
4939137 |
Ring-fused thienopyrimidinedione derivatives
The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and...
|
|
|
4866056 |
Benzazepines and methods therefor
A compound of formula (I): ##STR1## in which R is optionally substituted phenyl; C 3 -8 cycloalkyl; C 5 -8 cycloalkenyl; C 1 -8 alkyl which may be straight or branched; C 2 -8 alkenyl which may be...
|
|
|
4703044 |
Imidazoquinolines containing other heterocyclic groups, useful as anti-ulcer or anti-secretory agents
The invention provides novel imidazoquinolines, processes for their preparation and pharmaceutical compositions containing them. The compounds have Formula I ##STR1## wherein A is a C 1 -C 4 ...
|
|
|
4661489 |
Benzazepines, and their use as anthelminthics
A compound of formula (I): ##STR1## in which R is optionally substituted phenyl; C 3 -8 cycloalkyl; C 5 -8 cycloalkenyl; C 1 -8 alkyl which may be straight or branched; C 2 -8 alkenyl which may be...
|
|
|
4634701 |
Furan derivatives having anti-ulcer activity
Compounds of formula (I): ##STR1## wherein: A represents a CH-NO 2 group or a N-CN group; B represents CH 2 , O, S or a direct bond; R represents a bicyclic or polycyclic residue, variously...
|
|
|
4609655 |
Anti-ulcer imidazo-quinoline, indole and benzazepine derivatives
The invention provides a compound of formula I ##STR1## wherein A is a C 1 -C 4 straight or branched alkylene chain which may be saturated or unsaturated, B is a C 2 -C 4 straight or...
|
|
|
4585588 |
Pentacyclic compounds
Compounds of formula (I), ##STR1## or an N-oxide or pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, C 1 -7 alkyl, C 3 -7 cycloalkyl, C 4 -7 cycloalkenyl or C 1 -4 alkyl...
|
|
|
4585770 |
Novel 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-j-k][1]-benzazepin-2- (1H)-one
Novel 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,l-j-k][1]-b
enzazepin-2-(1 H)-one derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1...
|
|
|
4581171 |
[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
|
|
|
4581172 |
Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension
Pyrimidone derivatives of the formula ##STR1## wherein n is the integer 1 or 0; A 1 and A 2 are independently methylene or mono-lower alkyl or di-lower alkyl methylene; X is methylene, mono-lower...
|
|
|
4515792 |
Tetracyclic heterocycles and antidepressant compositions thereof
Tetracyclic heterocycles of the formula ##STR1## wherein Th is the residue completing a fused thiophen ring, X represents oxo, hydroxyl together with hydrogen, or preferably two hydrogens, R 1 ...
|
|
|
4503060 |
3-Imino-3H-dibenzo-[c,f]-imidazo-[1,5-a]azepine pharmaceuticals
Compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are each hydrogen, halogen, alkyl of 1 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms; R 5 is hydrogen, alkyl of 1 to 6...
|
|
|
4503058 |
Therapeutically useful 3,7a-diazacyclohepta[j,k]fluorene derivatives
Compounds of the formula: ##STR1## wherein R 1 represents hydrogen, chlorine or methoxy, R 2 represents hydrogen, methyl or benzyl, and R 3 and R 4 represent hydrogen, or R 3 represents methyl...
|
|
|
4442098 |
Pentacyclic derivatives of piperazine
Compounds of formula (I): ##STR1## wherein: X is CH 2 , O, S or NR wherein R is hydrogen or C 1 -4 alkyl; Y and Z are independently selected from hydrogen, C 1 -4 alkyl, C 1 -4 alkoxy, halogen...
|
|
|
4404205 |
2-Oxo-2,6,7,8,9,10 hexahydro-pyrimido[1,2-a]azepines and antianginal method of use thereof and of 4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepines
3 Substituted hexahydro-pyrimido[1, 2 a]azepines and quaternary derivatives, useful as antianginals are prepared. Specifically tested are 3 carboxylates and carbo hydrazides. 3 Cyano Carbamonyl and...
|
|
|
4313931 |
Fused dibenzo imidazolo compounds, compositions and use
This invention relates to a compound of the formula ##STR1## wherein R 1 , R 2 , R 3 , and R 4 , which may be the same or different, each represent a hydrogen or halogen atom or an alkyl or alkoxy...
|
|
|
4307096 |
Method of treating glaucoma with cycloalkyltriazoles
Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals: aliphatic alkyl chains; and R and R' represent the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF 3...
|
|
|
4307095 |
Method of treating schizophrenia with cycloalkltriazoles
Compounds of the general formula: ##STR1## in which alk and alk' represent the bivalent radicals aliphatic alkyl chains; and R and R' represents the alkyl, halogen, hydrogen, alkyloxy, --OH, --CF 3...
|
|
|
4213983 |
Treating gastro-intestinal disorders and emesis with n-(heterocyclic substituted) benzamides
Compounds of the formula (I), and their pharmaceutically acceptable salts: ##STR1## wherein: R 1 is a C 1 -6 alkoxy group; R 2 and R 3 are the same or different and are hydrogen, halogen, CF...
|
|
|
4150139 |
Triazolobenzazepine derivatives
Novel triazolobenzazepine derivatives of the formula ##STR1## (wherein R 1 and R 2 are hydrogen or alkyl, X is ##STR2## wherein R 3 and R 4 are hydrogen, alkyl, aryl or aralkyl, and R 5 is...
|
|
|
4148898 |
N-oxy-ajmaline and the use thereof in treating cardiovascular disorders
N-oxy-ajmaline of the formula ##STR1## useful for treating myocardium infarct and ventricular and supraventricular tachycardia.
|
|
|
4070467 |
Trans-octahydro-pyrido-indolo-benzazepine-3-alkanols, -alkanonitriles,-alkanoic acid and ester as tranquilizers
Certain 3-substituted trans-octahydro-pyrido-pyrrolo-benzazepines are useful as major tranquilizers in warm-blooded animals or are useful as intermediates for producing such major tranquilizers.
|
|
|
4018930 |
Substituted indolobenzazepines
Certain trans-1,2,3,4,4a,8,9,14a-octahydropyrido-[4',3':2,3]indolo[1
,7-ab][1]benza zepines substituted at the 3-position with (a) certain unsaturated organic radicals, prepared by alkylation or...
|
|
|
3932650 |
Trans-octahydropyridoindolobenzazepines as central nervous system depressants
Certain 3-substituted octahydropyridoindolobenzazepines and their addition salts with pharmaceutically acceptable acids produce a marked central nervous system depressant activity in warm-blooded...
|
|
|
3764684 |
NOVEL INDOLOBENZAZEPINE DERIVATIVES, USEFUL AS TRANQUILIZERS
Certain novel 1,2,3,4,8,9-hexahydro-3-(substituted)pyrido[4',3':2,3]indolo
[1,7-ab][1]-be nzazepines are useful as minor tranquilizers (anxiolytics) and/or major tranquilizers (antipsychotics). The...
|
|
|
3754089 |
Title is not available
|
|
|
3749781 |
Title is not available
|
|
|
3790675 |
Title is not available
|