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7547690 Compounds for the treatment of Hepatitis C  
The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against...
7541352 Compounds for the treatment of hepatitis C  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7541351 Compounds for the treatment of hepatitis C  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7538103 Compounds for the treatment of hepatitis C  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7521443 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7521442 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7517872 Compounds for the treatment of hepatitis C  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7485633 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors  
The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus...
7473688 Indolobenzazepine HCV NS5B inhibitors  
The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV)...
7465721 2-hydroxytetrahydrofuran derivatives and use thereof as medicaments  
A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive...
7456165 HCV NS5B inhibitors  
The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7456167 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors  
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
7452876 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors  
The invention encompasses compounds as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected...
7384933 Derivatives of 2-hydroxytetrahydrofuran and their use as medicaments  
A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive...
7285546 Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents  
The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or...
7250409 Ningalin B analogs employable for reversing multidrug resistance  
Anlogs of ningalin B lacking inherent cytotoxic activity may be employed to reverse multi-drug resistant (MDR) phenotype and to resensitize transformed cells, including a human colon cancer cell...
7235547 Pharmaceutical composition comprising an AChE inhibitor and a mGluR2 antagonist  
The present invention relates to a pharmaceutical composition comprising an inhibitor of acetylcholinesterase (AChE inhibitor) and a metabotropic glutamate receptor 2 antagonist (mGluR2 antagonist)...
7232835 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists  
This invention relates to derivatives of 3,6-disubstituted azabicyclo compounds. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment...
7220737 Noribogaine in the treatment of pain and drug addiction  
The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
7169774 Cephalotaxane derivatives and their processes of preparation and purification  
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct...
7153848 Inhibitors of HCV replication  
Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions...
7141562 Substituted benzoxazinones and uses thereof  
Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO 2 — or —(CR a R b ) r —, n is 1 or 2, R 2 is aryl or...
6992078 Plant extracts and alkaloids having antitussive activity  
The present invention provides plant extracts, isolated alkaloids, synthetic alkaloids and compositions having antitussive activity. In some preferred embodiments, the plant extracts and the...
6987103 Treatment of chronic myelogenous leukmia, resistant or intolerant to ST1571, involving homoharringtonine alone or combined with other agents  
The present invention concerns a method of treating chronic myelogenous leukemia, a related myeloproliferative disorder or a Ph-positive acute lymphocytic leukemia in a subject animal, comprising: ...
6921771 Method of treating sexual disturbances  
The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually...
6861432 Piperazine derivatives that destabilize androgen receptors  
This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds...
6852741 Compositions and methods for treatment of neurological disorders  
The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by co-administration of metanicotine and...
6849620 N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease  
The invention provides compounds of Formula I: wherein Azabicyclo is W 0 is a bicyclic moiety and is These compounds may be in the form of pharmaceutical salts or...
6734178 Cephalotaxine alkaloid compositions and uses thereof  
A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a cephalotaxine and an antiproliferative agent, each in an amount sufficient to modulate...
6610685 Fused indole derivatives  
The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salt, solvate and ester thereof, wherein R 1 to R 4 and n are as defined in the specification. A...
6608079 Indole derivatives and their use as 5-HT1F agonists  
The present invention relates to a compound of formula (I), or a pharmaceutical acid addition salt thereof, which are useful for activating 5-HT 1F receptors and inhibiting neuronal protein...
6562809 3-bicycloindole compounds  
Described herein are compounds selective for a 5-HT1D receptor, which have the general formula:
6391871 Preventing neuronal degeneration in Alzheimer's disease  
A method of treating Alzheimer's disease is disclosed, not just with palliatives, but in a manner that prevents the progressive degeneration caused by Alzheimer's disease. Certain types of...
6271264 Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants  
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective...
6251893 Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity  
Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are independently selected from the group...
6218383 Pharmaceutical compositions for the prevention and treatment of central nervous system disorders  
A pharmaceutical composition incorporates a pharmaceutically effective amount of at least two components, one of those components being a nicotinic compound capable of interacting with nicotinic...
6156747 Isoxazolidine derivatives  
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero...
6133255 Tricyclic pyridone analogues as GABA-A receptor ligands  
Tricyclic pyridin-2-one analogues which are ligands for GABA A receptors, are useful in the therapy of deleterious mendtal states, and are represented by the formula: ##STR1##
6121257 Sulfamate containing macrocyclic immunomodulators  
The present invention relates to novel compounds of formula I: ##STR1## which are useful as immunomodulators, in particular, macrolide immunosuppressants. The invention also relates to the...
6114324 Oral liquid antidepressant solution  
For the oral administration of the anti-depressant mirtazapine an aqueous solution or suspension is found which is preferably stabilized by methionine, is thickened, and which has a pH of from 2.5...
6110910 Carbocyclic heterocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents  
This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such...
5998409 Condensed indole derivatives as 5HT.sub.4 -receptor antagonists  
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS...
5874427 Substituted heteroaromatic 5-HT.sub.1F agonists  
This invention provides novel 5-HT 1F agonists of the Formula ##STR1## in which X, Y, E, R, A, B, and n are as defined in the specification, which are useful for the treatment of migraine and...
5872134 5-HT4 receptor antagonists  
The use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the treatment of artrial arrhythmia, stroke or CNS disorders X--CO--CH 2 --Z ...
5721230 Substituted pyrroles  
Compounds of the formula ##STR1## wherein R 1 is lower alkyl, lower cycloalkyl, aryl or lower aralkyl; R 2 is hydrogen, aryl or lower alkyl optionally substituted by hydroxy, acyloxy, amino,...
5696129 5-HT.sub.4 antagonists  
Compounds of formula (I), and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in treatment of gastrointestinal...
5688790 Phenylpyrrole derivatives and their use as antipsychotic agents  
This invention relates to compounds of formula (I): ##STR1## wherein R 1 represents C 1 -4 alkyl; and R 2 , R 3 , R 4 and R 5 each independently represent hydrogen, halogen, C 1 -4 alkyl, C 1...
5674876 ρ-heteroatom-substituted phenols and uses thereof  
The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having the structure formula ##STR1## wherein m is 0 to 3, n is 0 to 4 when Het is nitrogen, wherein R...
5620973 Tetracyclic condensed heterocyclic compounds and their use  
A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R 1 represents H or a hydrocarbon group which may be substituted; Y...
5552398 Azabicyclic compounds as 5-HT4 receptor antagonists  
Compounds of formula (I), ##STR1## wherein L is N or CR c , wherein R c is hydrogen, alkoxy, halo, alkyl or cyano; Q is NR 1 , CH 2 , O, or S; R a is hydrogen, halo, alkyl, amino, nitro or...
Matches 1 - 50 out of 85 1 2 >