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7553834 |
Method for the targeted treatment of depression
A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled...
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7514423 |
Use of vasopeptidase inhibitors in the treatment of metabolic diseases, nephropathy and advanced glycation end-product associated diseases
The invention discloses and claims the use of vasopeptidase inhibitors of formula (II)
for the treatment of nephropathy in non-diabetic patients.
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7390797 |
Fused indazole compounds
The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt...
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6958330 |
Polycyclic α-amino-ε-caprolactams and related compounds
Disclosed are polycyclic α-amino-ε-caprolactams and related compounds which are useful as synthetic intermediates in the preparation of inhibitors of β-amyloid peptide release and/or its synthesis.
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6930103 |
Use of vasopeptidase inhibitors in the treatment of metabolic diseases, nephropathy and advanced glycation end-product associated diseases
The invention describes and claims the use of vasopeptidase inhibitors of formula (I)
for the treatment of nephropathy in diabetic or non-diabetic patients, including diabetic or non-diabetic...
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6894042 |
Azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or...
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6849619 |
Substituted pyridoindoles as serotonin agonists and antagonists
The present invention is directed to certain novel compounds represented by structural Formula (I)
or pharmaceutically acceptable salt forms thereof, wherein R 1 , R 5 , R 6 , R 7 , R 8 , R 9...
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6693096 |
Treatment of inflammation-associated disorders using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods and compositions for preventing and treating inflammation-associated disorders or ameliorating symptoms thereof by the suppression of the activity of a member...
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6683073 |
Pyrimidine linked pyrrolo&lsqb 2,1-c&rsqb &lsqb 1,4&rsqb benzodiazepines as potential antitumour agents
The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepines useful as potential antitumour agents. This invention also relates to a process for the...
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6670371 |
Certain pyrrolopyridine derivatives: novel CRF1 specific ligands
Disclosed are compounds of the formula: wherein Ar is optionally substituted aryl or heteroaryl R 1 is hydrogen or alkyl; R 7 is hydrogen or alkyl; R 2 is hydrogen, halogen, alkyl or alkoxy;...
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6660729 |
Particle-forming compositions containing fused pyrrolocarbazoles
A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into...
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6610683 |
Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the...
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6602866 |
Mercaptoacetylamide derivatives, a process for their preparation and their use
This invention discloses and claims a series of mercaptoacetylamide derivatives of formula I. Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes...
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6552033 |
Imidazo-containing heterocyclic compounds, their compositions and uses
The subject invention involves compounds having the structure: wherein each R1 is independently alkyl, aryl, or heterocycle; each R2-R7 is independently hydrogen or other substituent; B is nil...
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6531467 |
Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing...
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6528506 |
Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viablility of an organ for transplantation, and enhancing...
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6444663 |
Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such...
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6417159 |
Method of enhancing effect of a neurotrophin with analogues of p75NTR367-379.
The present invention provides methods and compositions for enhancing the effect of a neurotrophin on a cell expressing a neurotrophin receptor. The effect is preferably neurotrophin-mediated...
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6294530 |
1-azatricyclic-4-benzylpiperazines
Disclosed are 1-Azatricyclic-4-benzylpiperazine compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania,...
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6207664 |
Squalene synthetase inhibitor agents
This invention relates to certain squalene synthetase inhibitors useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, anti-Alzheimer's...
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6194402 |
Enhancement of return to independent living status with a growth hormone secretagogue
A growth hormone secretagogue is useful for enhancing the return of patients to independent living status following acute deconditioning such as that which may result from immobilization, surgery,...
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6015791 |
Serine protease inhibitors-cycloheptane derivatives
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors,...
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6013645 |
Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
The present invention relates certain mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful in treating patients suffering from hypertriglyceridemia, atherosclerosis and...
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5750521 |
Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to certain mercaptoacetylamide disulfide derivatives of Formula (I) ##STR1## useful as inhibitors of enkephalinase and ACE.
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5679671 |
Amino acid derivative
The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase...
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5650408 |
Thiazolo benzazepine containing dual action inhibitors
Compounds of the formula ##STR1## wherein A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors.
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5639745 |
Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
Disclosed are compounds, compositions and methods for inhibiting interleukin-1β protease activity. The compounds, bicyclic derivatives of aldehydes and α-substituted methyl ketones, have the...
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5635502 |
Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to certain novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and of ACE. These mercaptoacetylamide bicyclic lactam...
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5629309 |
2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.
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5624921 |
Hypotriglyceridemic aminoacetylmercapto derivatives
The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.
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5604221 |
Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.
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5602122 |
Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylmercapto derivatives
The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.
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5591739 |
2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
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5529996 |
2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives which are useful as inhibitors of enkephalinase and ACE.
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5529995 |
Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE
The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
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5529997 |
Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
The present invention relates to compounds of the formula ##STR1## wherein B 1 and B 2 are each independently hydrogen; hydroxy; --OR 2 wherein R 2 is a C 1 -C 4 alkyl or an Ar-Y group...
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5527795 |
Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
The present invention relates to certain novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and of ACE.
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5504080 |
Benzo-fused lactams
Compounds of the formula ##STR1## wherein A is ##STR2## are useful as ACE and NEP inhibitors and those wherein A is ##STR3## are useful as ACE inhibitors. Methods of preparation and intermediates...
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5488047 |
Carboxyalkyl tricylic derivatives useful as inhibitors of enkephalinase and ace
The present invention relates to compounds of the formula ##STR1## wherein B 1 and B 2 are each independently hydrogen; hydroxy; --OR 2 wherein R 2 is a C 1 -C 4 alkyl or an Ar-Y group...
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5472959 |
Carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
The invention relates to compounds of the formula ##STR1## wherein B 1 and B 2 are each independently hydrogen; hydroxy; --OR 2 wherein R 2 is a C 1 -C 4 alkyl or an Ar--Y group wherein Ar is...
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5468745 |
Amino and nitro containing tricyclic compounds useful as inhibitors of ace
The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N--B wherein B is R 1 or COR 2 wherein R 1 is hydrogen, a C 1 -C 4 alkyl or an...
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5362727 |
Substituted azepino[2,1-a]isoquinoline compounds
Compounds of the formula ##STR1## wherein A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective as ACE inhibitors. Methods of preparation and intermediates...
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5200406 |
Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
Imidazole derivatives are described which are useful in restoring learning and treating memory difficulties. A compound of the invention is 2,5-dioxohexahydro-1H-pyrrolo[1,2-a]imidazole.
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4997831 |
Lactam derivatives
The invention provides lactam derivatives of the general formula (I) ##STR1## wherein n represents 2 or 3; Im represents an imidazolyl group of the formula: ##STR2## wherein one of the groups...
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4973585 |
Tricyclic lactams active as antihypertensive agents
This invention relates to derivatives of fused bicyclic or tricyclic lactams, to the intermediates and processes useful for their preparation and to their pharmacological effect in inhibiting the...
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4824832 |
Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
This invention relates to conformationally rigid sulfur containing tricyclic lactams, to the intermediates and processes useful for their preparation, and to their pharmacological effects in...
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4716162 |
Fused 5 ring heterocyclic compounds, their preparation, and their anti-arrhythmic and diuretic use
Fused ring compounds of formula (I): ##STR1## (where R 1 -R 4 , X 1 and X 2 represent hydrogen or various substituents, n and m are 1-3 and 2-7 respectively, the dotted lines are double or...
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4661479 |
Bicyclic lactams as antihypertensives
This invention relates to bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.
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4617301 |
Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
Sulfoxide and sulfone derivatives of bicyclic lactams are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
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4584294 |
Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
The invention relates to fused tricyclic lactams and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
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