Patents in Class 514/211.150

Matches 1 - 50 out of 232

1 2 3 4 5 >

Match	Document	Document Title
1	7407950	N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands The invention concerns compounds of general formula (I), wherein n, X 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and W are as defined herein. Said compounds are ligands of the TRPV 1 ...
2	7390799	Apoptosis promoters Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than...
3	7390798	Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
4	7378413	2-amino-3-(alkyl)-pyrimidone derivatives A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C 1-6 alkyl group which may be substituted by a C 6,10 aryl group; R2...
5	7351700	Aminomethylpyrimidines as allosteric enhancers of the GABA_B receptors The present invention relates to compounds of formula wherein X is —S— or —NH—; R 3 /R 4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7...
6	7329652	Diaminotriazole compounds useful as protein kinase inhibitors The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the...
7	7244722	Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones Compounds of the general formula (I): wherein m, n, R 1 , R 2 , R 3 and R 4 are as described in the specification. Further included are pharmaceutical compositions comprising the...
8	7241745	Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds...
9	7229983	4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid derivatives as β-lactamase inhibitors The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic...
10	7223749	Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them The present invention relates to bicyclic heterocycles of general formula wherein R a , R b , R c , R d , R e and X are defined as in claim 1 , the tautomers, the stereoisomers, the mixtures...
11	7214701	Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G...
12	7208487	Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
13	7119084	Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the...
14	RE39112	Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine...
15	7030110	Cyclic oxyguanidine pyrazinones as protease inhibitors Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: wherein R 3 , R 4 , R 5 , W, and A are as set forth in the specification, as well as hydrates,...
16	7030150	Benzimidazole compounds and antiviral uses thereof The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion...
17	6960575	Thiazine derivatives A compound having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine 4-tetrahydropyrazine as a main skeleton. The compound is a chymase inhibitor and is represented by the following formula [I] and salts thereof:...
18	6919359	Azabicyclic-substituted-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: Azabicyclo-N(R 1 )—C(═X)—W Formula I
19	6906057	Methods for modulating FXR receptor activity Methods for modulating the activity of the mammalian FXR receptor. The methods include methods of treating a hyper- or hypocholesterolemic mammal comprising contacting the mammal with synthetic...
20	6861419	Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula I: wherein the dashed lines, A 1 , A 2 , A 3 , X 1 and R 1 are defined...
21	6844335	2-amino-3-(alkyl)-pyrimidone derivatives as GSK3.β.inhibitors A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C 1-6 alkyl group which may be substituted by a C 6,10 aryl group; R2...
22	6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
23	6713472	Thiazine or pyrazine derivatives A compound which is a chymase inhibitor and which is represented by a formula [I] and salts thereof. In the formula [I], X is R 6 —(A 2 ) n —N, R 1 and R 2 are H, alkyl, cycloalkyl or aryl, R...
24	6656932	Benzo thiadiazine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are benzo thiadiazines of the Formula or a pharmaceutically acceptable salt thereof, wherein R 2 is hydrogen or alkyl; R 1 and R 3 include hydrogen, alkyl, and...
25	6635637	Cyclic oxyguanidine protease inhibitors Cyclic oxyguanidine compounds, including compounds of Formulae I and II: wherein R 1 , R 3 -R 6 , R 21 -R 26 , L, Y, Z, and A are set forth in the specification, as well as hydrates, solvates or...
26	6620806	Methods and kits for improving vascular health The present invention provides methods and kits for improving or maintaining vascular health, including preventing myocardial infarction or stroke; maintaining or improving vascular reactivity;...
27	6617329	Aminoquinazolines and their use as medicaments Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the...
28	6610697	Substituted 2-aryl-3-(heteroaryl)-imidazo&lsqb 1,2-a&rsqb pyrimidines, and related pharmaceutical compositions and methods This invention relates to a series of imidazopyrimidines of Formula I, and pharmaceutical compositions containing them. The compounds of the invention inhibit the production of a number of...
29	6608070	2,3-substituted indole compounds as anti-inflammatory and analgesic agents This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the...
30	6608048	Tricyclic protein kinase inhibitors This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the...
31	6599926	Heteroaryl-phenyl substituted factor Xa inhibitors The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of...
32	6566362	Benzo&lsqb f&rsqb naphthyridine derivatives, their preparation and compositions containing them Benzo[f]naphthyridine derivatives of formula (I): benzo[f]naphthyridine derivatives and benzo[f]naphthyridine esters of formula (IVa): aminoquinoline derivatives of formula (X): processes for...
33	6559155	Pyrimidinone derivatives for the treatment of atherosclerosis Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA 2 and thereof use in treating inter alia atherosclerosis, in which: R 1 is COOH or a salt thereof, COOR 10 , CONR 11 R 12 , CN or...
34	6451790	Azadioxacycloalkenes and their use for combating harmful fungi and animal pests Compounds of formula I wherein W is optionally substituted alkylene; Y is N or CR a ; R a is hydrogen, halogen or alkyl; R 1 n represents hydrogen or 1 to 4 substituents; R 2 is hydrogen,...
35	6436943	Use of dihydropyrimidines as medicaments, and novel substances The invention relates to dihydropyrimidines of the general formula and to the use of dihydropyrimidines as medicaments for the treatment and prophylaxis of hepatitis B. The invention further...
36	6362176	Compositions, methods and kits for treating rheumatoid arthritis Disclosed are methods of treating rheumatoid arthritis by coadministering synergistic effective amounts of pentostatin and methotrexate to a host in need thereof, and kits and compositions that...
37	6358978	Substituted benzimidazoles Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.
38	6335325	Acylated 4-aminopyridine derivatives as pesticides and fungicides The present application relates to novel acylated 4-amino-pyridine derivatives in which R 1 , R 2 , R 3 , R 4 , A, X 1 , X 2 , m and n are as defined in the description, to process for their...
39	6294542	Pyrimidinone compounds, pharmaceutical compositions containing the compounds and the process for preparing the same The present invention relates to a novel pyrimidinone compounds and the pharmaceutical acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, thereby, being...
40	6262046	Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists Compounds of the formula (I): ##STR1## where X 1 , A, Ar 1 , X and R are as defined in the specification, and pharmaceutically-acceptable salts thereof, are new, and are useful as tachykinin...
41	6239126	Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives Compounds of the formula ##STR1## are useful for the treatment of disorder of the central nervous system including anxiety, depression, panic, alcohol and drug addiction, sexual dysfunction, sleep...
42	6191125	Small molecule pipecolic acid derivative hair growth compositions and uses This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pipecolic acid derivatives.
43	6107291	Azepine or larger medium ring derivatives and methods of use Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel...
44	6096736	Benzazepine derivatives with vasopressin agonistic activity Novel benzazepine derivative of the formula [1]: ##STR1## wherein R 1 is H or halogen, A is lower alkylene, R 2 and R 3 are the same or different and each H, lower alkoxy, lower alkyl having...
45	6083949	Substituted imidazoles having anti-cancer and cytokine inhibitory activity Compounds represented by formula I: ##STR1## are disclosed. AR represents an aromatic group containing 6-10 atoms; and ##STR2## represents a 4 to 10 membered non-aromatic heterocycle containing at...
46	6080758	Benzenesulfonamide derivatives as bradykinin antagonists The present invention relates to compounds selected from the group consisting of the compounds of formula (I): ##STR1## X is a halogen atom, A is --CH 2 --, --CH(OH)--, --CH(NH--COCH 3 )-- or S, R...
47	6075022	Methods and compositions for controlling biofouling using thiourea compounds The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one thiourea...
48	6048869	Tricyclic compounds The novel compounds of the present invention are those of structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of...
49	6034102	Atherosclerosis treatment A method of treating atherosclerosis, independent of lipid lowering, in mammals, including humans, in need of treatment by inhibiting progression of an atherogenic lesion or by stabilizing plaque....
50	6034082	5-azabicyclo(3.1.0)hexylalkyl-2-piperiodones and --glutarimides as neurokinin receptor antagonists Compounds of formula (I) ##STR1## and salts thereof, wherein: R 1 is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl(C 1 -C 4 )alky aryl or aryl(C 1 -C 4 )alkyl; wherein the C 1 ...

Matches 1 - 50 out of 232

1 2 3 4 5 >