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7625888 |
Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or...
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7566707 |
Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula
wherein Y and R 1 to R 4 are defined as in claim 1 , the tautomers, enantiomers,...
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7482337 |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
Disclosed are substituted xanthines of general formula
wherein R 1 to R 4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts...
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7429577 |
Augmentation of atypical antipsychotic agent pharmacotherapy with chromium supplementation
The present invention relates to pharmaceutical compositions comprising an antipsychotic agent in combination with a chromium salt, which are used for minimizing side effects in a patient taking an...
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7235541 |
Neurokinin antagonists for use as medicaments
The present application relates to internally cyclized naphthamide compounds of the formula Ia (wherein R 1a , R 1b , R 1c , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X 1 , X 2 , Y, Z, and n are as...
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7229984 |
Dibenzoxazepinone derivatives and uses thereof
Compounds of the Formula I:
wherein m, n, k, A, X, Y, Z, Ar, R 1 , R 2 , R 3 , and R 4 are as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also provided are...
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7041661 |
Use of thiazolobenzoheterocycles for treating multiple sclerosis
The invention relates to the use of compound of Formula I in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple sclerosis
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6943156 |
Dibenzoxazepine αv integrin receptor antagonist
The present invention relates to a novel dibenzoxazepine derivative, its synthesis, and its use as an αv integrin receptor antagonist. More particularly, the compound of the present invention is...
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6908926 |
Substituted imidazoles, their preparation and use
Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders...
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6710041 |
Pyrrolo&lsqb 2,1-B&rsqb &lsqb 3,1&rsqb benzothiazepines and their use for the preparation of medicaments with antipsychotic activity
A compound of formula (I): where: R=H, Cl, Br, F, I, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkyl, or C 5 -C 6 cycloalkyl; R 1 = C 1 -C 4 dialkylamine, where the alkyl groups are the...
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6642222 |
Pyrano, piperidino, and thiopyrano compounds and methods of use
The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder...
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6638938 |
Method for preventing tissue injury from hypoxia
There is disclosed a method for preventing tissue injury caused by tissue hypoxia and reoxygenation, comprising administering a compound that inhibits signal transduction by inhibiting cellular...
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6537987 |
4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors
This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
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6528504 |
Oxazepine derivatives and medicine containing the same
The present invention provides (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmet
hyl]dibenzo[b,e][1,4]oxazepine,...
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6476017 |
Compounds activating pharmacological effect of retinoids
A compound represented by the formula (I) or (II) or a salt thereof wherein R 1 represents hydrogen atom or a C 1-6 alkyl group; R 2 and R 3 independently represent a hydrogen atom or a C 1-6 ...
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6436922 |
5,11-dihydrobenzo&lsqb b,e&rsqb &lsqb 1,4&rsqb oxazepine derivatives and pharmaceutical compositions containing the same
Disclosed are 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidiny
lmethyl]dibenzo[b,e][1,4]oxazepine and...
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6417180 |
Zinc finger-reactive antimicrobial compounds
The invention relates to antimicrobial compounds which interact with zinc in a zinc finger of a bacterial DNA polymerase, methods of screening for such compounds, and methods of using such...
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6362176 |
Compositions, methods and kits for treating rheumatoid arthritis
Disclosed are methods of treating rheumatoid arthritis by coadministering synergistic effective amounts of pentostatin and methotrexate to a host in need thereof, and kits and compositions that...
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6235730 |
3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same
3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): ##STR1## wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of...
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6127361 |
5,11-dihydrodibenzo[b,e][1,4]oxazepine derivatives and pharmaceutical compositions containing the same
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6127362 |
9,10-diazatricyclo[4,4,1,1.sup.2,5 ] decane and 2,7-diazatricyclo [4,4,0,0.sup.3,8 ] decane derivatives having analgesic activity
9,10-DIAZATRICYCLO[4,4,1,1 2 ,5 ]DECANE (la) AND 2,7-DIAZATRICYCLO[4,4,0,0 3 ,8 ]DECANE (1b) DERIVATIVES HAVING ANALGESIC ACTIVITY. ##STR1##
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6063779 |
5-(4-piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents
An objective of the present invention is to provide a compound that has antiarrhythmic activity. The present invention provides a compound of formula (I): ##STR1## wherein R 1 and R 2 each...
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6008213 |
Integrin receptor antagonists
Compounds of formula (I) ##STR1## wherein A 1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R 3 or R 4 ; X 1 --X 2 is CHR 1 ...
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5962449 |
Tricyclic compounds in treating hyperalgesic conditions and NIDDM
The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their...
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5929069 |
Compounds activating pharmacological effects of retinoids
A compound represented by the formula (I) or (II) or a salt thereof wherein R 1 represents hydrogen atom or a C 1 -6 alkyl group; R 2 and R 3 independently represent a hydrogen atom or a C 1 -6...
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5872115 |
2-ureido-benzamide derivatives
This invention is concerned with 2-ureido-benzamide compounds of the formula (1) ##STR1## in which R 1 is H, halogen atom, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy or (C 1 -C 4 )dialkylamino and R 2...
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5846968 |
N-substituted azaheterocyclic carboxylic acids and esters
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to...
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5834459 |
Alkyl-substituted compounds having dopamine receptor affinity
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or...
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5741791 |
Method of reducing blood glucose
The present invention relates to the use of compounds of the general formula ##STR1## for reducing blood glucose and/or inhibit the secretion, circulation or effect of insulin antagonizing peptides...
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5723458 |
Hypolipidaemic compounds
The invention provides novel 1,4-benzothiazepine compounds substituted with hydroxy or a group containing hydroxy, compositions comprising such compounds and their use in the treatment or...
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5719140 |
2, 3-, 4-, 5-, 6-, 7-, 8-, 9- and /or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E 2 antagonists for...
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5512561 |
Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and for the treatment of prostaglandin E...
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5461047 |
2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and for...
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5354746 |
Squaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E 2 antagonists for...
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5286722 |
Tetrahydropyridinyldibenzazepine derivatives
The invention relates to tetrahydropyridinyldibenzazepine derivatives of the formula I ##STR1## wherein R 1 is a substituent selected from the group consisting of hydrogen, halogen, and lower...
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5238936 |
Trisubstituted triazines
The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to...
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5204348 |
Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components
Novel heterocyclic compounds, which are represented by the following general formula, useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs...
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5189033 |
Tricyclic heterocycles
The invention relates to tricyclic heterocycles, or pharmaceutically-acceptable salts thereof, which possess anti-hyperalgesic properties. The invention also relates to processes for the...
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5071844 |
5,11-dihydrodibenzo[b,e][1,4]-thiazepines useful as gastro intestinal selective calcium antagonists
The invention provides compounds of the formula: ##STR1## wherein k is 1, 2 or 3; m is 1, 2 or 3; n is 1, 2 or 3; p is 0, 1 or 2; X is O, S or a direct link, with the proviso that when...
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5036067 |
Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
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5017570 |
Dibenzoxazepine compounds useful in the treatment of cerebral vasospasm or its sequela
Disclosed is a therapeutic agent for the treatment of peripheral circulatory disorders that contains as the effective ingredient a dibenzoxazepin derivative of the following formula or a...
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4886795 |
Treatment and prevention of retinal edema with dopaminergic antagonists
Retinal edema, in particular cystoid macular edema, is prevented or treated by administering to the patient afflicted with retinal edema or in danger of experiencing retinal edema an amount of a...
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4540691 |
Dopamine agonists and use thereof
Compounds are disclosed having the formula: ##STR1## wherein: R 1 is H, OH, --OCH 3 , --CH 2 OH, --NH 2 , --NHMe, --NHEt, --NMe 2 , --NEt 2 , ##STR2## R 2 is H, --CH 3 , or ##STR3## R 3 is...
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4496557 |
Tricyclic ethers, their preparation and the pharmaceutical compositions containing them
Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group, ...
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4435391 |
Dibenzoxazepine derivative, and pharmaceutical composition comprising the same
Dibenzoxazepine derivatives of the formula: ##STR1## wherein R 1 , n, R 2 and R 3 are as defined in the description, process for preparing the same, pharmaceutical composition containing the same...
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4410508 |
Novel aqueous foam formulation and method
A stable high expansion foam formulation for use as a single composite soion containing dibenz-(b,f)-1,4-oxazepine and stabilizers selected from the group consisting of glycerine, carboxyl vinyl...
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4360525 |
Dibenzazepine derivatives, pharmaceutical compositions containing them, and methods of use
Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging...
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3705242 |
Title is not available
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