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8980879 Bromodomain inhibitors  
The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable...
8962610 Fused heterocyclic compounds as ion channel modulators  
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In...
8927536 Tetrahydrothiazepine derivative  
The present invention relates to a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting...
8916549 Thienooxazepine derivative  
Provision of a compound having a serotonin 5-HT2C receptor activating action. A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.
8895545 Acrylamide derivatives as Fab I inhibitors  
In part, the present invention is directed to antibacterial compounds.
8835422 Substituted imidazoheterocycle derivatives  
The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi—...
8828989 Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists  
The present invention provides 4H,6H-5-oxa-2,3,10b-triaza-benzo[e]azulenes of the formula wherein R1 and R2 are as defined herein andwhich act as V1a receptor modulators, and in particular as V1a...
8772301 Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof  
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as...
8614207 Inhibitors of hepatitis C virus  
A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition for treating individuals infected with...
8586574 Benzoxazepin PI3K inhibitor compounds and methods of use  
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2...
8569285 Dihydrobenzoxathiazepine compounds, a process for their preparation and pharmaceutical compositions containing them  
Compounds of formula (I): wherein R1 represents a hydrogen atom or a heterocyclic, cyano, alkoxycarbonyl, alkylsulphonylaminoalkyl or N-hydroxycarboximidamide group. Medicinal products containing...
8557738 Nitrogen-containing heterocyclic derivative and fungicide for agricultural and horticultural use  
The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I) and salt thereof (wherein, R1 to R6 each independently represents a hydrogen atom,...
8546377 Modulators of 5-HT receptors and methods of use thereof  
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine , 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine ,...
8536164 Fused pyridine compounds as casein kinase inhibitors  
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y,...
8530463 Multimodal particulate formulations  
Multimodal particulate formulations of medicaments and methods for their use, e.g. by nasal or pulmonary administration for the treatment of various medical conditions, are provided.
8518933 Modulators of 5-HT receptors and methods of use thereof  
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2 -a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine ,...
8507470 Substituted arylamide oxazepinopyrimidone derivatives  
The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4 and n are as...
8501728 Substituted heteroarylamide oxazepinopyrimidone derivatives  
The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4 and n are as...
8404674 Substituted 9H-purin-2-YL compounds, compositions thereof and uses thereof  
The present invention encompasses compounds of general formula (1) wherein R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or...
8367655 Pyridoindolobenzox—and thiazepine derivatives and uses thereof  
The present invention discloses pyridoindolobenzox- and thiazepine compositions of Formula 1, wherein A is —CH(R9)—X—, —XCH(R9)—; —CO—X— or —X—CO—; X is —O—, —S—, —SO—, or —SO2—. Y is a single...
8343955 Benzoxazepin PI3K inhibitor compounds and methods of use  
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2...
8329687 Pyridooxazepine derivative and use thereof  
The present invention provides a compound having a superior serotonin 5-HT2C receptor activating action, which is represented by the formula wherein A is —OR1 or —S(O)pR2, R1 and R2 are the same...
8324201 Pyrazinooxazepine derivatives  
Provided is a compound having a serotonin 5-HT2C receptor activating action. A compound represented by the formula (I0): wherein each symbol is as defined in the specification, or a salt thereof.
8318720 Acrylamide derivatives as Fab I inhibitors  
In part, the present invention is directed to antibacterial compounds.
8318722 Pyrazinooxazepine derivatives  
Provided is a compound having a serotonin 5-HT2C receptor activating action. A compound represented by the formula (I0): wherein each symbol is as defined in the specification, or a salt thereof.
8314088 Pyrazinooxazepine derivatives  
Provided is a compound having a serotonin 5-HT2C receptor activating action. A compound represented by the formula (I0): wherein each symbol is as defined in the specification, or a salt thereof.
8263586 OXO bridged diazepan orexin receptor antagonists  
The present invention is directed to oxo bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric...
8242104 Benzoxazepin P13K inhibitor compounds and methods of use  
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2...
8158617 Fused heterocyclic compound and use thereof  
The present invention relates to a serotonin 5-HT2C receptor activator containing a compound represented by the formula wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having...
8063038 Heterocyclic condensed compounds useful as antidiuretic agents  
The invention concerns compounds according to general formulae 1, wherein G1 is an amine. Compounds according to the invention are vasopressin V2 receptor agonists. Pharmaceutical compositions of...
8039458 HIV integrase inhibitors  
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for...
7998950 Antiviral compounds  
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
7981879 HIV integrase inhibitors  
Compounds of Formula I are inhibitors of FHV integrase and inhibitors of FHV replication (I), wherein m, n, X, R1, R2, R3, R4, R5, R6, R7; R8, R9 and R10 are defined herein. The compounds are...
7943607 Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes  
Compounds of formula (I), wherein R1, R4, HET-1 and HET-2 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the...
7795246 Particle-forming compositions containing fused pyrrolocarbazoles  
A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into...
7732435 Chromone derivatives useful as antagonists of VR1 receptors  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their...
7666864 Bicyclic nitroimidazole-substituted phenyl oxazolidinones  
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl...
7659263 Thienopyrrole compound and use thereof as HCV polymerase inhibitor  
The present invention relates to a thienopyrrole compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt...
7566707 Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions  
The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers,...
7514421 Use of an IBAT inhibitor for the treatment of constipation  
A method of treatment of functional constipation or C-IBS in a warm-blooded animal is disclosed, which comprises the administration of an IBAT inhibitor.
7407949 Benzamide derivatives as oxytocin agonists and vasopressin antagonists  
Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions...
7390798 Carboxamide spirolactam CGRP receptor antagonists  
The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and...
7320973 Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same  
The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an...
7220736 Pyrimidine compounds  
A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR4—, —S—, —O—, —CH═N—, —N═CH—, —N═N—, —CH═CH—, etc., R1 is a lower...
7192948 Bicyclic heterocycles as HIV integrase inhibitors  
The invention encompasses a series cyclic bicyclic heterocyclic compounds of Formula I which are inhibitors of HIV integrase and prevent viral integration into human DNA. This action makes the...
7179802 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia  
Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment...
7176196 Bicyclic heterocycles as HIV integrase inhibitors  
The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds...
7176195 Fused azepine derivatives and their use as antidiuretic agents  
Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9–11) are new. Compounds according to the invention are...
7148214 Antihistaminic spiro compounds  
This invention concerns the compounds of formula or a prodrug, a N-oxide, an addition salt, a quaternary amine or a stereochemically isomeric form thereof wherein R1, R2, —A—B—, L, and n have the...
7105506 Tetracyclic compounds as PDE5-inhibitors  
Compounds of structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.

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