Patents in Class 514/211.090

Matches 1 - 50 out of 82

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Match	Document	Document Title
1	7390798	Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
2	7358238	Pharmaceutical use of fused 1,2,4-triazoles The use of fused 1,2,4-triazoles for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions has been described....
3	7323455	7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R 1 to R 7 , X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
4	7320974	Cytoskeletal active compounds, compositions and use The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical...
5	7312208	Quaternary ammonium compounds Drugs useful for the treatment and prevention of hyperlipidemia, moreover drugs useful for the treatment and prevention of cholestasis-caused hepatopathy, particularly primary biliary cirrhosis and...
6	7238685	Benzo-fused heterocycles as endothelin antagonists The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including...
7	7192947	Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions The present invention relates to compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof...
8	7192946	Benzothiazepine derivatives The present invention relates to compounds of formula (I), wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof...
9	7176195	Fused azepine derivatives and their use as antidiuretic agents Compounds according to general formulae (1 and 2), wherein G 1 is an azepine derivative and G 2 is a group according to general formulae (9–11) are new. Compounds according to the invention are...
10	7132416	Benzothiazepine and benzothiazepine derivatives with ileal bile acid transport (IBAT) inhibotory activity for the treatment hyperlipidaemia The present invention relates to compounds of formula (I) wherein R v , R 1 , R 2 , R x , R y , M, R z , v, R 3 , R 4 , R 5 and R 6 are as defined within; pharmaceutically acceptable salts,...
11	7129235	Amides useful for treating pain The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R 6 , R 7 and R 8 are defined herein. The present...
12	7125864	Benzothiazepine derivatives for the treatment of hyperlipidemia The present invention relates to compounds of formula (I): wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof...
13	7122536	(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
14	7101869	2,4-diaminopyrimidine compounds useful as immunosuppressants Novel compounds according to the formula and pharmaceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is...
15	7091198	2,5-disubstituted pyrimidine derivatives The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for...
16	7041661	Use of thiazolobenzoheterocycles for treating multiple sclerosis The invention relates to the use of compound of Formula I in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple sclerosis
17	7018999	Methods for the treatment and prevention of pain Novel methods for the treatment and/or prevention of pain are presented. The methods may comprise administering to a subject in need thereof an effective amount of a stress-activated protein kinase...
18	7008938	Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient A benzene-fused heteroring derivative of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an...
19	6995154	Heterocyclic topoisomerase poisons The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
20	6844347	Substituted 4-amino-2aryl-pyrimidines, their production and use and pharmaceutical preparations containing same The invention relates to compounds of formula I, in which R 1 , R 2 , R 3 and R 4 have the meanings given in the claims. Said compounds are valuable active ingredients for the treatment and...
21	6806267	Apoptosis-inducing compounds The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these...
22	6727258	Allosteric adenosine receptor modulators The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators...
23	6667302	Heterocyclic topoisomerase poisons The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
24	6664249	Bicyclic vasopressin agonists Compounds according to general formula (1), and pharmaceutically acceptable salts thereof, wherein V is a covalent bond or NH, X is selected from CH 2 , O and N-alkyl, Z is either S or...
25	6660729	Particle-forming compositions containing fused pyrrolocarbazoles A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into...
26	6642248	Benzo&lsqb b&rsqb pyrano&lsqb 3,2-h&rsqb acridin-7-one compounds A compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa,...
27	6642223	Benzoheterocyclic derivatives A benzoheterocyclic derivative of the following formula [1]: and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and...
28	6638934	Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 4a , R 4b , R 5 , R 6 , R 7...
29	6602865	Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and...
30	6589934	Kv2.1 antagonists The invention relates to methods of treatment of non insulin dependent diabetes mellitus, antagonists of the delayed rectifier potassium channel Kv2.1, methods of using and preparing the...
31	6544974	(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
32	6537987	4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
33	6506745	Medicinal compositions for treatment of atrial fibrillation The present invention relates to a medical composition for atrial fibrillation treatment, comprising a compound represented by the following formula [I]: Formula [I] [wherein R 1 represents a...
34	6503919	Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo&lsqb b&rsqb pyrano&lsqb 3,2-h&rsqb acridin carboxylate A compound selected from those of formula (I): wherein: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino,...
35	6489322	Amidine derivatives as inhibitors of nitric oxide synthase There are provided novel compounds of formula (I) wherein R 1 represents a 2-thienyl or 3-thienyl ring and R 2 represents hydrogen or C 1 to 4 alkyl and optical isomers and racemates thereof...
36	6489321	Nonpeptide substituted benzothiazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, Z, Bp, W, n, R 1 and R 2 are as described in the specification, which are useful as vasopressin...
37	6476017	Compounds activating pharmacological effect of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R 1 represents hydrogen atom or a C 1-6 alkyl group; R 2 and R 3 independently represent a hydrogen atom or a C 1-6 ...
38	6465451	Hypolipidemic benzothiazepine compounds The invention is concerned with novel hypolipidemic compounds of formula (I), wherein R 1 is H or methyl, and salts, solvates or physiologically functional derivatives thereof, with processes...
39	6372733	Hexahydro-5-imino-1,4-1,4-thiazepine derivatives as inhibitors of nitric oxide synthases Disclosed herein are compounds of Formula I and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders,...
40	6319916	Heterocyclic compounds, their production and use A compound of the formula: ##STR1## wherein ring A is an optionally substituted benzene ring; ring B' is an optionally substituted non-aromatic heterocyclic ring having, the same or different,...
41	6288073	Acronycine derivatives, preparation method and pharmaceutical compositions A compound selected from those of formula (I): ##STR1## in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino,...
42	6277831	1,4-benzothiazepine-1,1-dioxide derivatives substituted by sugar residues, process for their preparation, pharmaceuticals comprising these compounds, and their use The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and their acid addition salts. 1,4-Benzothiazepine-1,1-dioxide derivatives of formula 1, ##STR1## wherein R 1 , R 2...
43	6117898	Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase There are provided compounds of formula (I), ##STR1## wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted...
44	6110910	Carbocyclic heterocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such...
45	6107316	Method for treating protozoal infections A method for treating protozoal infections is described. The method employs N-acetonylbenzamide compounds provided in an effective amount to inhibit the growth of protozoans. The compounds are...
46	6011032	Heterocyclic compounds for treating myocardial ischemia
47	5998409	Condensed indole derivatives as 5HT.sub.4 -receptor antagonists Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS...
48	5998400	Hypolipidemic benzothiazepines The invention is concerned with novel hypolipidemic compounds of formula (I), with processes and novel intermediates for their preparation, pharmaceutical compositions containing them and with...
49	5965553	Squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
50	5939415	A!-annellated pyrrole derivatives and their use in pharmacology The present invention relates to heterocyclic compounds with the formula ##STR1## in which R 1 to R 7 , B, a, and X have the meanings indicated in the specification. These compounds can be used...

Matches 1 - 50 out of 82

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