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7550453 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof  
The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.
7390798 Carboxamide spirolactam CGRP receptor antagonists  
The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
7288278 Process for preparing vegetable oil fractions rich in non-tocolic, high-melting, unsaponifiable matter  
A vegetable oil fraction rich in non-tocolic, high-melting, unsaponifiable matter is prepared by the following steps: A vegetable oil having a slip melting point of not more thatn 30° C. and a...
7109161 Preserved pharmaceutical formulations  
The present invention is directed to the use of benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to provide anti-microbial activity in pharmaceutical...
7101909 Calcium channel drugs and uses  
Novel multibinding compounds are disclosed. The compounds of this invention comprise 2–10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a...
7053081 Cyclic malonamides as inhibitors of A-β protein production  
This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of...
7049308 C-nitroso compounds and use thereof  
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon,...
7030110 Cyclic oxyguanidine pyrazinones as protease inhibitors  
Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: wherein R 3 , R 4 , R 5 , W, and A are as set forth in the specification, as well as hydrates,...
7022693 Treatment of lipodystrophy  
An inhibitor of the renin-angiotensin system is useful for the treatment or prevention of the lipodystrophy syndrome, e.g. in AIDS patients also receiving anti-retroviral therapy.
6977252 Use of 1,4-benzothiazepine derivatives as drugs for overcoming resistance to anticancer drugs  
The present invention relates to use of compounds represented by the following general formula [1] or salts or prodrugs thereof: [where R 1 represents hydrogen atom or lower alkoxy group; R 2 ...
6924277 Cyclized benzamide neurokinin antagonists for use in therapy  
Compounds having the general formula wherein R 1a , R 1b , R 1c , X 1 , X 2 , R 2 , R 3 , R 4 , R 5 , R 6 , n, Y and Z are as defined in the specification, methods of using such compounds for...
6864250 N-acylated lipophilic amino acid derivatives  
Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group...
6716835 Use of diltiazem for treating retinal pathologies  
The invention concerns the use of a calcium channel blocker compound and/or cyclic GMP-dependent channels, namely diltiazem, for treating retinal pathologies, and more particularly retinal diseases...
6624157 Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase  
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formulas and their enantiomers, diastereomers, and their...
6610682 Pharmaceutical compositions and methods for the treatment of arteriosclerosis  
A pharmaceutical composition comprising as its active ingredients one or more drugs selected from the group consisting of angiotensin II receptor antagonists and angiotensin converting enzyme...
6602865 Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds  
Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and...
6544978 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds  
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
6541466 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds  
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
6514963 Methods for the inhibition of egg production in trematodes  
The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective...
6503897 Antibacterial agents  
Compounds of formula (I) are antibacterial agents wherein: R 3 and R 4 , taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated...
6337325 Combined preparation for the therapy of immune diseases  
A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca 2+ content, is suitable...
6319915 Benzazepine derivatives as inhibitors of hyperproliferation diseases  
A method of treating hyperproliferation diseases in mammals in need of such treatment which method includes administering to said mammal a therapeutically effective amount of a compound of the...
6156746 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents  
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formula ##STR1## and their enantiomers, diastereomers, and their...
5990103 Combination preparation for use in immunological diseases  
A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca 2 + content, is suitable...
5968925 Process for continuous sintering of granules  
The invention relates to a process for continuous sintering of granules for the preparation of pellets, in particular medicament formulations in tablet form.
5929122 Combination preparation containing tramadol and a calcium channel antagonist  
A pharmaceutical combination preparation, particularly for the treatment of pain, which contains a combination of the pain killer tramadol with at least one calcium channel antagonist, and a method...
5902609 Composition for the control of wound scar production  
This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars,...
5891845 Drug delivery systems utilizing liquid crystal structures  
Vitamin E TPGS/drug compositions and methods are provided which obviate the need for surfactants or non-evaporated co-solvents because the active drug component is dissolved directly into Vitamin E...
5885979 N-containing condensed heterocyclic compounds, their production, and their uses  
N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing...
5854233 Method of treating liver disease and like indications with vasodilating agents  
Liver diseases, such as cirrhosis of the liver, toxic and medicamentary liver damage, a liver-parenchymic disorder or hepatitis, are treated by administering to a human or animal subject in need...
5795897 Oxohexyl methylxanthine compounds  
There is disclosed a pharmaceutical composition comprising 1-(5-oxohexyl)-3-methylxanthine in admixture with a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is...
5786344 Camptothecin drug combinations and methods with reduced side effects  
This invention provides methods and combination formulations and kits to reduce the toxicity of camptothecin drugs, such as irinotecan (CPT-11). Disclosed are therapeutics and treatment methods...
5698549 Method of treating hyperactive voiding with calcium channel blockers  
The instant invention discloses a method of treating hyperactive voiding associated with excessive nerve growth factor production and nerve growth in patients by administering a Ca + + channel...
5637582 Peripheral circulation improving agent  
There is disclosed (-)-cis-1,5-benzothiazepine represented by the following formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R 1 represents lower alkyl or lower alkoxy; R 2 ...
5618808 Benzothiazepine and benzoxazepine derivatives as cholecystokinin receptor antagonists  
The present invention relates to novel substituted benzothiazepines and benzoxazepines of the formula ##STR1## wherein R 1 , R 2 , R 7 , R 8 , R 9 and X are as defined below, and to novel...
5610153 Benzazepinone derivatives  
The invention relates to substituted 3-amino-1-arylalkyl-benzazepin-2-ones of the general formula ##STR1## wherein Ar is aryl; X is --O-- or --S(O) n -- and n is 0, 1 or 2; X 1 is C 1 -C 2...
5580867 Myocardial protection during ischemia and reperfusion  
Myocardial protection is achieved by administering to a patient an effective amount of a benzothiazepine derivative. The benzothiazepine derivatives have the following general chemical formula:...
5571807 1,5 benzothiazepinone dervatives their preparation and pharmaceutical use  
This invention relates to diltiazem analogs having the formula: ##STR1## where the substituents are defined in the specification. These compounds are useful in treating cardiovascular problems. The...
5569678 Control of wound scar production  
This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The...
5552162 Method for improvement of scar size and appearance  
A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar....
5492904 Composition of angiotensin-II receptor antagonists and calcium channel blockers  
Novel pharmaceutical compositions containing a combination of an angiotensin-II antagonist and a calcium channel blocker such as 2-butyl-4...
RE35095 Benzothiazepine anti-seizure method  
Seizures are ameliorated with certain benzothiazepines.
5462936 Benzothiazepine derivatives  
A compound of the formula: ##STR1## wherein X is N--A--R 1 or C(R 1 )R 2 ; A is a single bond, polymethylerie or --CO--; R 1 and R 2 are each hydrogen, C 1 -6 alkyl, C 3 -7 cycloalkyl,...
5387581 Pharmaceutical composition of aspirin and a benzothiazepine for inhibiting platelet aggregation  
There is disclosed a pharmaceutical composition for inhibiting the platelet aggregation comprising acetylsalicyclic acid or a pharmaceutically acceptable salt thereof and a 1,5-benzothiazepine...
5382577 Pharmaceutical composition for inhibiting platelet aggregation  
There is disclosed a pharmaceutical composition for inhibiting platelet aggregation comprising 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt...
5240922 Fertility enhancement  
The present invention relates to a method of enhancing implantation of an embryo within the uterus of a female mammal. The method comprises administering an amount of a PAF antagonist, effective to...
5202130 Suppression of eczematous dermatitis by calcium transport inhibition  
Treatment of an animal with calcium flux inhibitors results in a decrease in the number of epidermal Langerhans cells and a simultaneous decrease in the ability to respond to contact sensitizing...
H001139 Combination of a calcium channel blocker and thromboxane A.sub.2 receptor antagonist or synthetase inhibitor and method for treating ischemia employing such combination  
A method is provided for treating ischemia in a mammalian species by administering a combination of a calcium channel blocker such as diltiazem, SQ 31,765 or SQ 32,324 and a thromoboxane A 2 ...
5162315 Penetration enhancers  
Pharmaceutical compositions for enhancing absorption of a topically administered formulation through dermal or mucosal membrane, for local or systemic application, comprising one or more agents of...
5134139 1,5-benzothiazepine derivatives and preparation thereof  
Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein X is hydrogen atom, a halogen atom or a lower alkyl group; R 1 is a lower alkyl group or a lower alkoxy group; R 2 is...
Matches 1 - 50 out of 93 1 2 >