Patents in Class 514/210.210

Matches 1 - 50 out of 183

1 2 3 4 >

Match	Document	Document Title
1	7354925	Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 independently...
2	7320985	Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
3	7300928	Benzimidazolidinone derivatives as muscarinic agents Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M 1 and/or M 4 receptor...
4	7265125	Neuropeptide Y antagonists Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases,...
5	7244721	Peptides as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
6	7220737	Noribogaine in the treatment of pain and drug addiction The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal...
7	7220735	Benzimidazolone histamine H3 antagonists Disclosed are novel compounds of the formula wherein R 1 is benzimidazolone derivative, M 1 and M 2 are optionally substituted carbon or nitrogen, R 2 includes optionally substituted aryl...
8	7132414	Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R 1 represents a radical —NHCOR 4 or —N(R 5 )—Y—R 6 , Y...
9	7105505	Benzimidazole derivatives useful as histamine H3 antagonists Disclosed are novel compounds of the formula wherein R 1 is optionally substituted benzimidazolyl or a derivative thereof; R 2 is optionally substituted aryl or heteroaryl; M 1 and M 2 are...
10	7094777	5-HT2A receptor ligands Compounds of formula I: are antagonists of the human 5-HT 2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions.
11	7074803	Opioid formulations The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in...
12	7071182	Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or...
13	7049307	Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or...
14	6977261	Azaisoquinoline derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 , Q, Y, R 2 , R 3 , R 4 , R 5 , and n are as defined in the specification....
15	6872717	Pharmacological uses of azetidine derivatives A method of treating or preventing obesity, this method comprising administering to a patient in need of such treatment an effective amount of a compound of formula in which R, R 3 and R 4 ...
16	6858603	Acetindine derivatives, their preparation and medicaments containing them Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them.
17	6734176	Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R 1 represents a radical —NHCOR 4 or —N(R 5 )—Y—R 6 , Y...
18	6649603	Cyclylamine sulfonamides as β3-adrenergic receptor agonists This invention provides compounds of Formula I having the structure wherein R 1 , R 2 , R 3 , W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are...
19	6608070	2,3-substituted indole compounds as anti-inflammatory and analgesic agents This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the...
20	6602864	Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from...
21	6586420	Quinolinecarboxylic acid derivative or its salt The present invention relates a 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-hydroxyaz etidin-1-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxyli c acid or salt thereof; and drugs...
22	6555540	Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
23	6518264	Azetidine derivatives, their preparation and medicaments containing them Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them.
24	6506772	Substituted &lsqb 1,2,4&rsqb triazolo&lsqb 1,5a&rsqb pyridine derivatives with activity as adenosine receptor ligands Substituted [1,2,4]triazolo[1,5a]pyridine derivatives and pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are useful for treatment...
25	6479515	Heterocyclic benzenesulphonamide compounds as bradykinine antagonists The invention concerns compounds selected among the group consisting of (i) compounds of formula (I) wherein: Het1 represents a nitrogenous heterocycle with 5 apices, in particular imidazole,...
26	6479479	Azetidine derivatives, their preparation and pharmaceutical compositions containing them Compounds of formula: in which R represents a CR 1 R 2 , C═C(R 5 )SO 2 R 6 or C═C(R 7 )SO 2 alk radical, their preparation and the pharmaceutical compositions containing them.
27	6426341	Treatment for diabetic complications This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
28	6384028	N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein IIb/IIIa antagonists and fibrinogen-blood platelets binding inhibitors β-alanine compounds or a pharmaceutically acceptable salt thereof, which is useful as a glycoprotein IIB/IIIa antagonist, inhibitor of blood platelet aggregation and inhibitor of the binding of...
29	6369051	Combinations of SSRI and estrogenic agents This invention comprises methods of depression, anxiety, generalized anxiety disorder (GAD), hot flush, post partum depression, premenstrual syndrome, obesity, obsessive compulsive disorder,...
30	6355631	Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as an active ingredient, at least one compound of formula: in which R 1 represents a radical —N(R 4 )R 5 , —N(R 4...
31	6333042	Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained A substance P antagonist is used in a cosmetic composition to treat sensitive skin. More specifically, a cosmetic composition containing a substance P antagonist is used to prevent and/or combat...
32	6329342	Treatment of congestive heart failure with growth hormone secretagogues The present invention is directed to methods for the modulation of cardiac function which comprise the administration of certain compounds, as defined herein, having growth hormone secretagogue...
33	6300335	4-aminoquinazoline derivative cGMP-PDE inhibitors for the treatment of erectile dysfunction 4-aminoquinazoline derivatives which are selective inhibitors of cGMP PDE are useful in the treatment of erectile dysfunction (impotence) in male animals, including man.
34	6251912	Substituted quinazoline derivatives This invention provides compounds of formula 1 having the structure ##STR1## wherein: X, R 1 , R 2 , R 3 , R 4 , Z, X, and n are as defined hereinbefore in the specification, which are useful as...
35	6218397	Pyrazolopyrimidines as CRF antagonists A compound of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein A is NR 1 R 2 , CR 1 R 2 R 11 , or C(CR 1 R 12 )R 2 , NHCR 1 R 2 R 11 , OCR...
36	6169093	Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia Compounds of formula I, ##STR1## wherein R 1 represents C 1 -4 alkoxy optionally substituted by one or more fluorine atoms; R 2 represents H or C 1 -6 alkoxy optionally substituted by one...
37	6150129	Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The...
38	6114338	Heterocyclic compounds The compounds of the formula: ##STR1## wherein Y is bond or alkylene; Z is bond, alkylene or vinylene; E is (i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or...
39	6103730	Amine substituted compounds Compounds and pharmaceutical compositions, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, have the formula: CORE MOIETY--(R) j In these...
40	6100271	Therapeutic compounds containing xanthinyl Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula: CORE MOIETY --(R) j wherein j is an integer from one to three. The core moiety is...
41	6093731	Isoquinolines Isoquinolinylguanidine compounds of formula (I): ##STR1## wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.
42	6080755	1,9-diazabicyclo[4.3.0]nona-3,8-diene derivatives Disclosed are diazabicyclo compounds of formula (I) ##STR1## in which R 1 is a substituted or unsubstituted lower alkyl, lower alkenyl or lower alkynyl; R 2 is a hydroxy; R 3 is a lower...
43	6080745	Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
44	6051572	Azetidine, pyrrolidine and piperidine derivatives A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT 1 -like...
45	6043250	Methods for using therapeutic compounds containing xanthinyl Therapeutic compounds with at least one carboxylic acid, ester or amide-substituted side chain have the formula: CORE MOIETY --(R) j wherein j is an integer from one to three. The core moiety is...
46	6030992	Methods of treating or preventing sleep apnea
47	6030984	Pyridone compounds useful in treating Alzheimer's disease The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R 1 , R 3 , R 4 , and R 7 are described herein and of their pharmaceutically acceptable...
48	6030973	Heterocyclic compounds having antidiabetic hypolipidemia and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable...
49	6020337	Electronegative-substituted long chain xanthine compounds Therapeutic compounds, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, having a formula: ##STR1## wherein R 0 is selected from the group...
50	5998399	Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase Method of treating or reducing the risk of human disease or condition in which the synthesis or oversynthesis of nitric oxide forms a contributory part wherein a therapeutically effective amount of...

Matches 1 - 50 out of 183

1 2 3 4 >