Patents in Class 514/210.180

Matches 1 - 50 out of 107

1 2 3 >

Match	Document	Document Title
1	7625905	Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R 1 -R 3 and Ar are as defined herein are antagonists of chemokine CCR5...
2	7618967	Indane compounds The invention provides novel indane compounds which are useful in the treatment of affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD), cognitive disorders,...
3	7482335	Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis,...
4	7378409	Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
5	7365061	2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
6	7238683	Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or...
7	7232812	Substituted azetidine compounds, their preparation and use as medicaments The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the...
8	7183270	Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis,...
9	7125863	Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
10	7067509	Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the...
11	6872717	Pharmacological uses of azetidine derivatives A method of treating or preventing obesity, this method comprising administering to a patient in need of such treatment an effective amount of a compound of formula in which R, R 3 and R 4 ...
12	6864249	Piperidine and azetidine thrombin inhibitors The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of...
13	6740647	Thrombin inhibitors Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein....
14	6645957	Cyclic amide compound The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a...
15	6599894	Amidinobenzylamine derivatives and their use as thrombin inhibitors There is provided compounds of formula I wherein R 1 , R 2 , Y, R 3 and R 4 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of...
16	6544976	Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods This invention provides compounds having the following general structure: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to...
17	6518285	Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula: wherein R 1 is a piperidinyl, pyrrolidinyl or azetidinyl moiety as described herein and in which the substituents...
18	6479479	Azetidine derivatives, their preparation and pharmaceutical compositions containing them Compounds of formula: in which R represents a CR 1 R 2 , C═C(R 5 )SO 2 R 6 or C═C(R 7 )SO 2 alk radical, their preparation and the pharmaceutical compositions containing them.
19	6448242	Cyclic amide compounds The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a...
20	6337394	Compounds There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R x , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases,...
21	6306880	Triazole antifungal agent A triazole compound having the formula: ##STR1## wherein Ar 1 represents a phenyl group which may be substituted; Ar 2 represents a phenyl group which may be substituted; R 0 represents a...
22	6262045	4-Oxo-3,5-dihydro-4H-pyridazino[4,5-b]-indole-1-acetamide derivatives, their preparation and their application in therapy Compounds of general formula (I) ##STR1## in which X represents a hydrogen or halogen atom or a methyl, methoxy or phenylmethoxy group, Y represents a hydrogen atom, 1 or 2 halogen atoms or a...
23	6242438	3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof. Such compounds and salts are tachykinin antagonists. ##STR1##
24	6228853	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase According to the invention are provided compounds of formula (I) (relative stereochemistry indicated) wherein R 1 , R 2 and R 3 are as defined in the specification. Compounds of formula (I) are...
25	6214841	Antithrombotic compound This application relates to a novel compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, processes and Intermediates for its preparation, pharmaceutical...
26	6093731	Isoquinolines Isoquinolinylguanidine compounds of formula (I): ##STR1## wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.
27	6077840	Tetrahydrobenzindolone derivatives Compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same are disclosed. The compounds have progesterone receptor binding...
28	6075021	1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics Compounds of general formula (I) ##STR1## in which the variables are as defined in the specification, their preparation and their application in therapeutics.
29	6048869	Tricyclic compounds The novel compounds of the present invention are those of structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of...
30	6034067	Serine protease inhibitors The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can...
31	6030984	Pyridone compounds useful in treating Alzheimer's disease The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R 1 , R 3 , R 4 , and R 7 are described herein and of their pharmaceutically acceptable...
32	5952354	Tris carbamic acid esters: inhibitors of cholesterol absorption Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...
33	5942523	Compounds which are selective antagonists of the human NK.sub.3 receptor and their use as medicinal products and diagnostic tools A compound of formula: in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C 1 -C 4 )alkoxy; R 1 represents a methyl group; ...
34	5932567	Thrombin inhibitors Thrombin inhibitors of the formula ##STR1## where R 1 , A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are...
35	5922755	Immunomodulator, cell adhesion inhibtor, and agent for treating, and preventing autoimmune diseases A 4H-1-benzopyran-4-one derivative of the general formura 1!, ##STR1## or a salt thereof exerts excellent effects on immunomodulation and cell adhesion inhibition, and is further expected to have...
36	5869476	Pyrimidinone derivatives The invention relates to pyrimidinone derivatives and the pharmaceutically acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, and thus useful in...
37	5859002	HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
38	5830854	Method of treating cystic fibrosis using a tachykinin receptor antagonist Tachykinin receptor antagonists are useful for the treatment of cystic fibrosis.
39	5827847	Treatment of cognitive disorders with piperazine derivatives Piperazine derivatives of formula (I) are useful in the treatment of cognitive disorders. In formula (I), X is a group of (IIa): --(CH 2 ) n CR 2 R 3 CONR 4 R 5 or (IIIb): --A--NR 6 COR 7 ...
40	5741799	Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R 1 , R 2 , R 3 , G, G x , R 6 ', Ra, Xa, R 6 , Rb, R 3 , p, Q, A and R 4 are as defined herein.
41	5710149	Piperazine derivatives as 5-ht antagonists This invention concerns compounds of formula (I) ##STR1## where A is a C 1 or C 2 alkylene chain optionally substituted by lower alkyl; Z is a bicyclic oxygen-containing aryl radical (e.g....
42	5705497	3-alkoxycarbonyl-thiadiazinones 3-Alkoxycarbonyl thiadiazinones of the formula I ##STR1## and physiologically unobjectionable salts thereof, in which R 1 , R 2 , R 3 , R 4 , R 5 , Q and n have the meanings described herein,...
43	5693633	Angiotensin II antagonists This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
44	5691329	Compounds containing basic and acidic termini useful as fibrinogen receptor antagonists This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using...
45	5627177	Piperazine derivatives Piperazine derivatives of formula (I) and their pharmaceutically acceptable salts are 5-HT 1A binding agents and may be used, for example, as anxiolytics. In the formula, A is an optionally...
46	5618834	Indole derivatives in the treatment of emesis Compounds of formula I, ##STR1## wherein R 1 represents hydrogen; R 2 represents hydrogen, halogen, cyano, OR 4 , --(CH 2 ) m CONR 5 R 6 , --(CH 2 ) m SO 2 NR 5 R 6 , --(CH 2 ) m NR 7 COR...
47	5614535	Adhesion receptor antagonists Compounds of the formula I ##STR1## in which R 1 and X have the meanings herein defined, their physiologically unobjectionable salts and/or solvates inhibit the binding of fibrinogen to the...
48	5585374	Amide derivatives Amide derivatives of formula (I) and their pharmaceutically acceptable salts (where a and b each represent 0, 1, 2 or 3 such that a+b=0, 1, 2 or 3, the dotted line represents an optional double...
49	5527794	Pyrido[3,4-b]indole derivatives as serotonergic agents The compound of the formula: ##STR1## where R 1 and R 5 are independently hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, CO 2 H, C 1 -C 6 alkyl, C 2 -C 10 ...
50	5491142	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives which are useful as inhibitors of Enkephalise.

Matches 1 - 50 out of 107

1 2 3 >