Patents in Class 514/210.170

Matches 1 - 50 out of 82

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Match	Document	Document Title
1	7378440	Substituted benzoylureido-o-benzoylamides, process for their preparation and their use The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of...
2	7354905	Prodrugs of thrombin inhibitors There is provided compounds of formula I, R 1 O(O)C—CH 2 —(R)Cgl-Aze-Pab-R 2 I
3	7309714	Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
4	7273858	Salts There is provided pharmaceutically-acceptable acid addition salts of compounds of formula I, wherein R 1 represents C 1-2 alkyl substituted by one or more fluoro substituents; R 2 ...
5	7241757	Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I wherein R 1 , R x , Y, R y , n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such...
6	7238683	Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or...
7	7232812	Substituted azetidine compounds, their preparation and use as medicaments The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the...
8	7220734	1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
9	7202236	Modified release pharmaceutical formulation A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R 1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents; R...
10	7160874	Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
11	7129233	Mandelic acid derivatives and their use as thrombin inhibitors There is provided a compound of formula I wherein R a , R 1 , R 2 , Y and R 3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof,...
12	7087594	Alkyl ether derivatives or salts thereof An alkyl ether represented by the general formula: or its salt. This compound has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite...
13	7084120	Prodrugs of DP IV-inhibitors Prodrug compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The Prodrug compounds...
14	7060697	Immunosuppressant compounds and compositions The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
15	7056907	Mandelic acid derivatives and their use as thrombin inhibitors There is provided a compound of formula (1) and pharmaceutically-acceptable derivatives (including prodrugs) thereof. Which compound and derivatives are useful as, or are as useful as prodrugs of,...
16	7030147	Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
17	6921758	Amino acid derivatives There is provided amino acid derivatives of formula I, wherein p, q, R 1 , R 2 , R 3 , R 4 , Y, n and B have meanings given in the description which are useful as competitive inhibitors of...
18	6872717	Pharmacological uses of azetidine derivatives A method of treating or preventing obesity, this method comprising administering to a patient in need of such treatment an effective amount of a compound of formula in which R, R 3 and R 4 ...
19	6864249	Piperidine and azetidine thrombin inhibitors The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of...
20	6831078	Azetidinecarboxamide derivatives for treating CNS disorders A compound of formula (1) wherein R 1 is aryl; and R 2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and...
21	6803370	Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4 Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such...
22	6710040	Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such...
23	6599894	Amidinobenzylamine derivatives and their use as thrombin inhibitors There is provided compounds of formula I wherein R 1 , R 2 , Y, R 3 and R 4 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of...
24	6596716	2-propane-sulphonamide derivatives The present invention relates to the potentiation of glutamate receptor function using certain 2-propane-sulphonamide derivatives. It also relates to novel 2-propane-sulphonamide derivatives, to...
25	6528503	Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g....
26	6521619	Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents The present invention relates to novel cyclopropane-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising...
27	6479479	Azetidine derivatives, their preparation and pharmaceutical compositions containing them Compounds of formula: in which R represents a CR 1 R 2 , C═C(R 5 )SO 2 R 6 or C═C(R 7 )SO 2 alk radical, their preparation and the pharmaceutical compositions containing them.
28	6462021	Use of low molecular weight thrombin inhibitor According to the invention there is provided the use of melagatran, or a pharmaceutically-acceptable derivative thereof, for the manufacture of a medicament for the treatment of ischemic disorders...
29	6455531	Hydroxamic acid derivatives Compounds having therapeutic utility are of the formula wherein NB 2 is heterocycloalkyl and R 1 and R 2 are each various substituents or a cyclic group.
30	6417229	α-sulfonylamino hydroxamic acid inhibitors of matrix metalloproteinases for the treatment of peripheral or central nervous system disorders The present invention relates to a method of using a compound of the formula (I): wherein A, X 1 , X 2 and Q are as defined herein, a pharmaceutically acceptable salt thereof, or a...
31	6306880	Triazole antifungal agent A triazole compound having the formula: ##STR1## wherein Ar 1 represents a phenyl group which may be substituted; Ar 2 represents a phenyl group which may be substituted; R 0 represents a...
32	6303636	Arylsulfonylamino hydroxamic acid derivatives A compound of the formula ##STR1## wherein R 1 , R 2 and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration,...
33	6251949	Oxime derivatives, hydrazone derivatives and use thereof Compounds having fungicidal activities and represented by general formula (I) and salts and hydrates thereof ##STR1## wherein R 1 represents an optionally substituted aryl, an optionally...
34	6239175	Carbamoyloxy derivatives of mutiline and their use as antibacterials Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R 1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is...
35	6191168	Methods for the use of nonprotein amino acids as therapeutic agents Provided are compositions comprising nonprotein amino acids and modified amino acids, as well as methods for the use of nonprotein amino acids and modified amino acids in inhibiting the growth of...
36	6051568	Thrombin inhibitors, their preparation and use
37	6034067	Serine protease inhibitors The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can...
38	5932567	Thrombin inhibitors Thrombin inhibitors of the formula ##STR1## where R 1 , A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are...
39	5932196	Buffered emulsion compositions containing actives subject to acid or base hydrolysis The present invention are for emulsion compositions and the process for making such compositions containing biological and cosmetic actives subject to hydrolysis of actives during processing and...
40	5877203	Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of...
41	5859002	HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
42	5798360	N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The...
43	5776927	Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The...
44	5747522	Amino acid derivatives N-Acyl-α-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R"' and Q have the significance given in the description, can be used for the treatment or prophylaxis of...
45	5719141	2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amide derivatives Compounds of the formula I ##STR1## in which R 1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a...
46	5691329	Compounds containing basic and acidic termini useful as fibrinogen receptor antagonists This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using...
47	5639746	Hydroxamic acid-containing inhibitors of matrix metalloproteases The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity...
48	5622984	Amidinophenol derivatives Amidinophenol derivatives of the formula (I): ##STR1## wherein R 1 and R 2 are (i) H, (ii) C1-4 alkoxy, (iv) C2-5 acyl, (v) halogen, (vi) NO 2 , (vii) benzoyl, (viii) COOR 4 (in which R 4 is...
49	5476849	Methods for glycosylation inhibition using amino-benzoic acids and derivatives The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
50	5457114	Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.

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