|
Match
|
Document |
Document Title |
|
|
7115595 |
Carbapenem compounds
Carbapenem compounds having a substituted phenyl or a substituted thienyl directly attached to the 3 -position of carbapenem nucleus as represented by the formula:
wherein Ring E is benzene...
|
|
|
6908913 |
Carbapenem derivatives
An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are...
|
|
|
6825187 |
Carbapenem derivatives of quarternary salt type
An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and β-lactamase-producing bacteria and are...
|
|
|
6620785 |
Treatment of Mycobacterial diseases by administration of bactericidal/permeability-increasing protein products
The present invention relates to methods for treating a subject suffering from infection with Mycobacteria, such as M. leprae or M. tuberculosis comprising administering to the subject a...
|
|
|
6602864 |
Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds
The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from...
|
|
|
6514962 |
Stabilized preparations of β-lactam antibiotic
Stabilized preparations which contain a β-lactam antibiotic having an esterified carboxyl group attached directly to the mother nucleus, an oil and a phosphate.
|
|
|
6399597 |
1,8-naphthosultamylmethyl carbapenem antibacterial compounds, compositions containing such compounds and methods treatment
Compounds of formula I are disclosed. as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group...
|
|
|
6346526 |
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
Compounds of formula I: as well as pharmaceutically acceptable salts thereof useful as carbapenem antibacterial agents are disclosed wherein X is CH 2 or C═O.
|
|
|
6310055 |
Halophenoxy substituted carbapenem antibacterial compounds
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2 -position with a iodophenoxy linked through a group --Z--CH 2 --; The...
|
|
|
6294529 |
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
Compounds of formula I are disclosed. ##STR1## as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic...
|
|
|
6288054 |
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with...
|
|
|
6284744 |
Peritoneal induced medicaments
A solution of hyaluronic acid and water-soluble salts thereof in a pharmaceutically acceptable media in which the hyaluronic acid concentration is at least about 0.4% by weight based on the weight...
|
|
|
6281199 |
Method of treatment of heart disease caused by Chlamydia pneumoniae
A method of combatting atherosclerosis by administering an effective amount of a macrolide antibiotic, for example an azalide such as azithromycin, optionally together with one or more...
|
|
|
6274575 |
Isolation of clavulanic acid from fermentation broth by ultrafiltration
Provided is a process for preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof including removing solids from a clavulanic acid containing...
|
|
|
6235506 |
Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes,...
|
|
|
6221859 |
Carbapenem antibacterial compositions and methods of the treatment
The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other β-lactams, which are useful...
|
|
|
6177421 |
Amoxicillin and clavulanate composition
A storage-stable combination of at least one β-lactam antibiotic and at least one β-lactam inhibitor compressed into tablet form having a hardness of greater than 30 KP is disclosed.
|
|
|
6143742 |
Treatment for necrotizing infections
The treatment of for arresting the destructive effects of proteolytic enzymes produced by a host infecting organism, such as "flesh eating bacteria", is carried out using therapy with includes the...
|
|
|
6077536 |
Pharmaceutical formulation
A pharmaceutical formulation comprising an amoxycillin hydrate and an effervescent couple, for example citric acid plus sodium bicarbonate or sodium glycine carbonate, or tartaric acid or malic...
|
|
|
5990101 |
Carbapenem derivatives
Novel carbapenem derivatives, represented by the following formula (I), having a substituted or unsubstituted imidazo[5,1-b]thiazolium-6-ylmethyl group at the 2-position are disclosed. The...
|
|
|
5904929 |
Acylated cyclodextrin-containing pharmaceutical composition
A pharmaceutical composition for trans-mucosal or transdermal administration wherein a per-C 2 -18 acylated cyclodextrin is used as a drug reservoir or carrier. The composition can be used safely...
|
|
|
5869477 |
β-methylcarbapenem derivatives, process for the preparation thereof and pharmaceutical composition comprising same
A β-methylcarbapenem compound of formula (I), a salt or an ester thereof, a process for the preparation thereof and a anti-bacterial composition containing same: ##STR1## wherein: R 1 is a C 1 -6...
|
|
|
5786351 |
Clavulanic acid salts
A di-clavulanate salt derived from clavulanic acid and a diamino ether of the formula ##STR1## wherein R 1 is an alkylene group, optionally having one or more inert substituents: and each of R 2 ...
|
|
|
5646139 |
Antimicrobial carbapenem quinolones
Compounds of Structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzable esters, and hydrates thereof, are effective antiinfective agents, useful in treating and...
|
|
|
5643902 |
Veterinary treatment
A formulation comprising amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier is used...
|
|
|
5607928 |
Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein R 1 is hydroxymethyl, 1-hydroxyethyl or 1-fluoroethyl; R 2 is hydrogen or C 1 -4 alkyl;...
|
|
|
5409920 |
2-(3-pyridyl)-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
|
|
|
5382575 |
(N-pyridiniumphenyl)-carbapenems
Carbapenems of the formula ##STR1## are useful antibacterial agents.
|
|
|
5369102 |
2-substituted alkyl-3-carboxy carbopenems as antibiotics and a method of producing them
The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: ##STR1## with R 1 , R 2 , R 3 , X and Y defined hereafter as antibiotics and beta lactamase inhibitors...
|
|
|
5362723 |
2-(heterocyclylheteroaryliumalkyl) phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
|
|
|
5350746 |
Triazolyl and tetrazolyl phenyl substituted carbapenems, compositions containing such compounds and methods of use
Triazolyl and tetrazolyl phenyl substituted carbapenems of the formula I are disclosed. ##STR1## One or two of the variables X, Y and Z represent nitrogen atoms. The heteroaryl ting may be charged...
|
|
|
5338733 |
Isoxazolidinyl carbapenem derivative
A carbapenem derivative represented by Formula I: ##STR1## wherein R 1 is hydrogen or a hydroxy protecting group; R 2 is substituted or non-substituted lower alkyl; R 3 is hydrogen, an inorganic...
|
|
|
5334590 |
MRSA active 2-phenyl-carbapenems
Carbapenems of the formula ##STR1## are useful antibacterial agents.
|
|
|
5286721 |
1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds of the formula: ##STR1## in which R 1 is carboxy, COO - - or protected carboxy, R 2 is hydroxy(lower)alkyl or protected...
|
|
|
5273973 |
Antimicrobial quinolonyl esters
Antimicrobial quinolnyl lactam esters comprising a lactam-containing moiety linked, by an ester group, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1##...
|
|
|
5208229 |
2-(1,2,3-triazolylsubstituted)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
|
|
|
5192758 |
2-biphenyl-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
|
|
|
5143914 |
2-heteroarylphenyl-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
|
|
|
5128335 |
2-heteroarylphenyl-carbapenem antibacterial agents
Carbapenems of the formula ##STR1## are useful antibacterial agents.
|
|
|
5124323 |
2-(quinoliniumalkyl and isoquinoliniumalkyl) phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## In which Q + is quinolinium or isoquinolinium, are useful antibacterial agents.
|
|
|
5055463 |
Spirocyclic 6-amido carbapenems
Provided are new antibacterial spirocyclic 6-amido carbapenems of the formula: ##STR1## wherein: R 1 is hydrogen, C 1 -8 substituted or unsubstituted alkyl or C 6 -10 substituted or unsubstituted...
|
|
|
5037820 |
Carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
|
|
|
5034385 |
2-(heteroarylsubstituted)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
|
|
|
4978659 |
2-(Heteroaryliumalkyl)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
|
|
|
4962101 |
2-(Heterocyclylalkyl)phenyl carbapenem antibacterial agents
Carbapenems having the formula: ##STR1## are useful antibacterial agents.
|
|
|
4892869 |
2-aza substituted-1-carbadethiapen-2-em-3-carboxylic acids
Disclosed are 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids I, where the generic 2-aza group includes azido, acylamino, amino, alkylamino, dialkylamino, triazolyl, triazolinyl,...
|
|
|
4782051 |
2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
Disclosed are 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids I, where the generic 2-aza group includes azido, acylamino, amino, alkylamino, dialkylamino, trizolyl, triazolinyl,...
|
|
|
4775669 |
1-carba-2-penem-3-carboxylic acid
Disclosed are 1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R 1 , R 2 and R 3 are, inter alia, independently selected from the group consisting of hydrogen,...
|
|
|
4729993 |
Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
Carbapenems having the formula: ##STR1## wherein ##STR2## is mono- or bicyclic quaternary heteroaryl, their preparation and antibiotic use are disclosed.
|
|
|
4725594 |
Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
Carbapenems having the formula: ##STR1## wherein: R 1 is H; R 4 and R 5 are independently H, CH 3 --, CH 3 CH 2 --, (CH 3 ) 2 CH--, HOCH 2 --, CH 3 CH(OH)--, (CH 3 ) 2 C(OH)--, FCH 2 ,...
|