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8183342 |
Method of treating chemotherapy-induced thrombocytopenia
A method of treating chemotherapy-induced thrombocytopenia includes administering to a subject undergoing chemotherapy a therapeutically effective amount of a Bax-inhibiting peptide.
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8178520 |
Macrocyclic compounds as antiviral agents
The present invention relates to macrocyclic compounds of formula (I): wherein W, n, R1, Ra, Rb, R3, R4, M, Z, ring A and ring B are defined herein, and pharmaceutically acceptable salts thereof,...
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8173770 |
Intermediates for LHRH antagonist synthesis, process for the production, and process for LHRH antagonist production
The peptides Ac-D-2Nal-D-4ClPhe-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the...
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8158590 |
Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
This invention relates to compounds comprising one or more therapeutic and/or diagnostic moieties and one or more functional moieties linked together via one or more triazole-containing linkers and...
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8148322 |
Method and carrier complexes for delivering molecules to cells
The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the...
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8143219 |
Methods for prevention and treatment of acute renal injury
The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or...
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8133864 |
PAR-2 agonist
The present invention relates to a pharmaceutical composition for preventing/treating conditions associated with PAR-2. The present invention also relates to a method for preventing/treating the...
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8129349 |
Treatment of disease by inducing cell apoptosis
The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides...
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8097252 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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8097589 |
Small peptides and methods for inhibiting mucus release into airways
Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucus release into airways of a patient, a method for blocking IgE activation of a...
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8092818 |
Medical devices having bioactive surfaces
According to an aspect of the present invention, medical devices are provided, which contain (a) a substrate and (b) a polymeric region disposed over the substrate which contains at least one block...
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8088741 |
Compounds for enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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8088727 |
Method for reducing the risk, lessening the symptom, or delaying the onset of insulin resistance by administering SS-31
The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic...
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8088597 |
Blood pressure lowering peptides from glycomacropeptide
A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more -I-P-P-...
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8080524 |
Agent for slowing hair loss and/or stimulating hair growth
The cosmetic use of at least one compound of formula (I) wherein: A1 is the radical corresponding to D- or L-Ser; A2 is the radical corresponding to D- or L-Asp or Glu; A3 is the radical...
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8071633 |
Pharmaceutical composition for treating spinocerebellar ataxia
This invention provide to a pharmaceutical composition for treating spinocerebellar ataxia (or atrophy, degeneration) or multiple system atrophy, or for improving ataxia or equilibrium disturbance...
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8071552 |
Peptides and peptidomimetics binding to CD23
The present invention describes compounds comprising new and useful peptides and peptidomimetics that can bind to CD23. They are capable of reducing inflammatory responses associated with...
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8071555 |
Protective skin care peptides
The disclosed invention provides tetrapeptides with the amino acid sequence proline-glutamine-glutamate-X (P-Q-E-X), where X can be either lysine (K) or isoleucine (I). These tetrapeptides inhibit...
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8071556 |
Peptide substance revealing a stress protective effect, pharmaceutical composition on its base, and the method of its application
Disclosed is a peptide glutamyl-aspartyl-glycine with general formula H-Glu-Asp-Gly-OH sequence 1 [SEQ ID NO:1], having a stress protective effect. Also disclosed is a pharmaceutical composition...
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8067380 |
Glutathione-based delivery system
A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound...
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8067379 |
Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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8057810 |
Peptide substance revealing an immunogeroprotective effect, pharmaceutical composition on its base and the method of its application
Disclosed is a pharmaceutical composition for the prevention and correction of age-related disorders of cellular and humoral immunity and having an immunogeroprotective effect. The pharmaceutical...
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8039430 |
Peptidic compounds
The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of...
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8034778 |
Neuroprotective compounds and uses thereof
The present invention relates to a neuroprotective compound consisting of the amino acid sequence DLHW.
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8034787 |
Enzyme-cleavable prodrug compounds
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is...
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8034774 |
Compositions and methods for counteracting effects of reactive oxygen species and free radicals
Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive...
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8022038 |
Composition for acceleration of type I collagen production
It is an object of the present invention to provide a composition for promoting the production of type I collagen by human skin fibroblasts, and the present invention relates to a composition for...
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8017581 |
MSH-agonist tripeptide conjugates
The invention relates to a tripeptide conjugate having general formula I, A-AA1-AA2-AA3-NH2, wherein A represents the radical corresponding to a monocarboxylic acid with general formula II,...
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8012934 |
Small peptides and methods for treatment of inflammation
Methods for treating cutaneous inflammation are described. Also described is a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte,...
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8012488 |
Polyoxyalkylene derivative
A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various...
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8008263 |
Organic compounds and their uses
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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RE42645 |
Nutritional or therapeutic compositions and methods to increase bodily glutathione levels
Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance...
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7994127 |
Treatment of rett syndrome
The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic...
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7994137 |
Small peptides and methods for inhibiting the infiltration of eosinophils into airways
Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, methods for blocking IgE activation and for...
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7977315 |
Conjugated nitro alkene anticancer agents based on isoprenoid metabolism
Conjugated nitro alkene compounds hamper or prevent proliferation of cancer cells in cell culture and in cancer patients, which can result in a decrease in tumor size and/or disappearance of the...
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7972808 |
Protein hydrolysate rich in tripeptides
The present invention describes a protein hydrolysate which is rich in tripeptides whereby the tripeptides are rich in proline at one end of the peptide.
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7973008 |
Metal-binding compounds and uses therefor
The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an...
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7968516 |
Treatment of multiple sclerosis and other autoimmune diseases by use of calpin inhibitors
Described herein are compounds and methods for treating or preventing a neurologic, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as...
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7951782 |
Composition effective to prevent or treat adult disease
Disclosed is a composition comprising, as an active ingredient, an enzyme digest that is produced by digesting a basic fraction of an animal-derived cartilage extract with an enzyme. Also disclosed...
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7943578 |
Angiotensin-converting enzyme inhibitory peptides
It is intended to provide ACE inhibitory tripeptides which are not easily digested by digestive enzymes after being orally taken and thus have fewer tendencies to lose their ACE inhibitory activity...
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7919455 |
Marked peptides having affinity for a phospholipid and uses
The present invention relates to a peptide labelled with fluorine-18 for the specific recognition of lipid vectors. The peptide of the invention comprises the following peptide sequence (PI):...
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7919468 |
Compounds useful as modulators of the proteasome activity
Compounds of the following general formula (I): are provided. The compounds can be used as modulators of the proteasome activity, in the preparation of a medicament useful for the prevention or...
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7914787 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
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7910556 |
PAR-2 agonist
A compound, or a salt or solvate thereof having a structure of Ar—CO-AA1-AA2-AA3-AA4-NH—X—NR1R2 is disclosed. Ar represents an optionally substituted phenyl group or an aromatic heterocyclic group...
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7892547 |
Methods and compositions for administering therapeutic and diagnostic agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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7888314 |
Compositions and methods for treating peripheral vascular disease
The present invention relates to methods of treating intermittent claudication comprising administering glucagon-like peptide-1 (GLP-1) molecules to subjects suffering therefrom.
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7879804 |
Blood pressure lowering peptides in a single enzymatic step
A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein...
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7871981 |
Inhibition of cell motility, angiogenesis, and metastasis
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by...
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7851449 |
Peptide, pharmaceutical composition, and a method of treating microcirculation disorders
The invention is related to the medicinal means of correction of metabolic vascular syndrome and diseases, associated with disordered vascular wall permeability and capillaries fragility, and can...
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7833986 |
Anti-inflammatory peptides
Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the...
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