|
Match
|
Document |
Document Title |
|
|
8445445 |
Method of promoting hair growth using FGFR4 extracellular domains
The present invention relates to a method of promoting hair growth comprising administering a fibroblast growth factor receptor 4 (FGFR4) extracellular domain (ECD), including native FGFR4 ECDs,...
|
|
|
8445447 |
B7-DC variants immunogenic compositions and methods of use thereof
Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector...
|
|
|
8435951 |
Treating neoplasms with neurotoxin
The present invention provides a method of treating a cancer using a neurotoxin, preferably Botulinum toxin (“BTX”). The application of a neurotoxin around a cancer acts to decrease the con...
|
|
|
8435952 |
Method for retarding progression to definite rheumatoid arthritis in subjects with undifferentiated arthritis
The invention relates to methods and compositions for treating undifferentiated arthritis (UA) and/or preventing the development of rheumatoid arthritis (RA) in subjects with UA by administering to...
|
|
|
8431124 |
Methods for treating a disease characterized by an excess of hyaluronan by administering a soluble hyaluronidase glycoprotein (sHASEGP)
Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan...
|
|
|
8431532 |
FZD8 extracellular domains and FZD8 extracellular domain fusion molecules and treatments using same
Methods of treatment using Fzd8 extracellular domains (ECDs), Fzd8 ECD fusion molecules, and/or antibodies that bind Fzd8 are provided. Such methods include, but are not limited to, methods of...
|
|
|
8420088 |
Methods and compositions using FGF23 fusion polypeptides
The present invention is directed to fusion polypeptides comprising Klotho protein or an active fragment thereof and FGF23 or an active fragment thereof.
|
|
|
8420094 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Fusion proteins comprising a fragment of Vibrio cholerae exotoxin A
The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of...
|
|
|
8420779 |
Compositions and methods for producing bioactive fusion proteins
Disclosed is a composition of matter involving a recombinant fusion protein comprising a a pharmacologically active protein partner, and a small pharmacologically inactive protein domain partner of...
|
|
|
8420106 |
Extramuscular treatment of traumatic-induced migraine headache
A method for selection and treatment of externally caused migraine headache, the method includes identifying a patient group having chronic migraine headache; determining the identified patient...
|
|
|
8420601 |
Biocompatible materials containing stable complexes of TSG-6 and hyaluronan and method of using same
The present invention provides a biocompatible material in the form of a water insoluble cross-linked gel, which contains a stable complex of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.
|
|
|
8415455 |
Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies...
|
|
|
8415303 |
Method of treatment using a soluble human delta protein fragment
The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In...
|
|
|
8414876 |
Methods of using IL-1 antagonists to treat autoinflammatory disease
Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount...
|
|
|
8410058 |
Methods of using insulin-like growth factor antibodies to treat tumors
Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the...
|
|
|
8410060 |
Soluble tumor necrosis factor receptor treatment of medical disorders
The invention pertains to methods and compositions for treating medical disorders characterized by elevated levels or abnormal expression of TNFα by administering a TNFα antagonist, such as r...
|
|
|
8404642 |
Treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
The present invention relates to the use of Meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain. In a preferred embodiment the disorder to be treated is...
|
|
|
8404226 |
Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
Methods and compositions are provided for treating a mammal having inflammation by protecting or enhancing a responsive cell, tissue, organ or body part exhibiting or associated with the...
|
|
|
8404644 |
Agents with angiogenic and wound healing activity
The invention relates to the use of angiogenic crystallin proteins to promote angiogenesis, wound healing and/or endothelial cell migration. Alpha A crystallin and βB2 crystallin have particular ...
|
|
|
8404814 |
Anti-EDB antibody-targeted IL-10 cytokine for therapy of rheumatoid arthritis
The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of...
|
|
|
8399405 |
Peptidomimetic macrocycles
Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
|
|
|
8394771 |
Multimeric proteins and methods of making and using same
The invention provides multimerization polypeptides capable of conferring formation of multimers when the multimerization polypeptide is linked to a molecule, such as a heterologous polypeptide...
|
|
|
8388963 |
Antitumor combinations containing a VEGF-inhibiting agent and 5FU or a derivative thereof
This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of...
|
|
|
8389468 |
Approach to the treatment of compartment syndrome
The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt...
|
|
|
8383575 |
(DI)barnase-barstar complexes
A complex comprising barnase bound with high affinity to barstar, and comprising a therapeutic and/or diagnostic agent bound to barnase and/or barstar.
|
|
|
8383586 |
Compositions and methods for soft tissue repair
Methods and compositions for treating soft tissue defects are provided. The composition, which is injectable directly into the tissue adjacent to the defect, comprises a fibrosis inducing factor in...
|
|
|
8377438 |
Methods of antagonizing signal transduction in spinal cord cells
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include...
|
|
|
8377887 |
Methods of reducing hypoxic stress in a mammal by administering soluble P-selectin
The present invention provides a use of soluble P-selectin in treating systemic hemorrhagic conditions, stabilizing blood pressure, and protecting hypoxic/ischemic tissues. Also provided is a use...
|
|
|
8372798 |
High-concentration protein formulations and method of manufacture
Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated...
|
|
|
8372810 |
Anti-tumor drug, medicament, composition, and use thereof
The present invention relates to an active polypeptide including the amino acid sequence of SEQ ID NO:3, or having at least 50%, preferably 70%, more preferably 90% identity with the amino acid...
|
|
|
8367616 |
Use of a granulin or a granulin-like compound in the therapy or prophylaxis of chronic pains
The invention relates to the use of a granulin or a granulin-like compound for producing a pharmaceutical composition for the therapy or prophylaxis of chronic pain, in particular for neuropathic...
|
|
|
8367619 |
Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression
Compositions and methods are provided for promoting elastin fiber formation (elastogenesis) in a cell, including methods that comprise contacting a cell that is capable of elastogenesis with (i) a...
|
|
|
8361956 |
Recombinant APases nucleic acid sequences
The various embodiments herein provide nucleic acid sequences isolated from Pseudomonas putida strain P13 encoding a family of APases including a phytase and a sugar phosphatase which are highly...
|
|
|
8361795 |
Hepatopoietin and use thereof
Provided are a hepatopoietin PCn (HPPCn) and its homologous proteins, which can promote hepatocyte proliferation in vitro, promote liver regeneration in vivo, inhibit the growth of tumor cells and...
|
|
|
8357372 |
Agent for treating allergic or hypersensitivity condition
The use of an agent in the manufacture of a medicament to affect an allergic condition and/or a hypersensitivity condition is described. The agent is capable of modulating a ganglioside associated...
|
|
|
8354380 |
NY-ESO-1 peptide analogs
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
|
|
|
8354370 |
Administering a biological composition or compositions isolated from self-renewing colony forming somatic cell growth medium to treat diseases and disorders
The present invention relates to methods and uses of cells for the prevention and treatment of a wide variety of diseases and disorders and the repair and regeneration of tissues and organs using...
|
|
|
8343932 |
Protease-sensitive site in apolipoprotein A1, therapeutic and diagnostic implications
The invention relates to the identification of a naturally occurring internal proteolytic cleavage site in the ApoA1 protein, which leads to inactivation of the mature protein. Specific...
|
|
|
8343933 |
Variants derived from ActRIIB and uses therefor
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal...
|
|
|
8338376 |
Compositions comprising variant LT-B-R-IG fusion proteins
This invention relates to methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. This invention also relates to improved LTBR-Ig fusion proteins,...
|
|
|
8338377 |
BMP-ALK3 antagonists and uses for promoting bone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density and strength. In certain embodiments, the present invention...
|
|
|
8334257 |
Methods and compositions for delivering active agents with enhanced pharmacological properties
Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide,...
|
|
|
8333962 |
Controlled release multidrug formulations for spinal cord injury
A controlled release multidrug formulation for improving locomotor recovery after spinal cord injury comprising: (a) a first composition comprising a first bioactive agent, encapsulated within a...
|
|
|
8329641 |
Remedies for ischemic disease of the limbs comprising administration of G-CSF
An effective agent for treating ischemic disease, the agent containing human granulocyte colony-stimulating factor (human G-CSF) as an active ingredient is disclosed. By administering this...
|
|
|
8329659 |
SAP variants and their use
Polypeptides are susceptible to denaturation or enzymatic degradation in the blood, liver or kidney. Due to the low stability of some polypeptides, it has been required to administer polypeptide...
|
|
|
8329660 |
Tim-3 ligands and methods thereof
The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a...
|
|
|
8329657 |
Fn14/TRAIL fusion proteins and method of treating cancer
Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as...
|
|
|
8329653 |
Compositions and methods for suppression of amyloid plaque formation associated with neurodegenerative disorders
The invention provides methods and compositions for reducing or inhibiting net beta-amyloid peptide production and/or amyloid plaque formation. The methods and compositions involve administering a...
|
|
|
8329661 |
Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure
This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and...
|
|
|
8329654 |
Use of IL-6/IL-6 chimera in Huntington's disease
The invention relates to the use of an IL-6R/IL-6 chimera, a mutein, isoform, fused protein, functional derivative, active fraction or circularly permutated derivative or a salt thereof, for the...
|